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MFDGSLPDPGRLARLSDGELIDAVTGWARASAAAEARKVAAIAELHQRLCTDAAATHAFWVCDDCDALAA QLSCALTINHGRALSQIELATAMRHRFPKVGAKFLAGDIPISTVTSILARTELVTDERALAQLDSKLSER AVAWGSLTKYSLEKALDVWVDRFDPDAVKRTRSSSRGCYFTVGSGSDNADGTTTVHGRVSNADAAIMEQR IASMARNVCEDDPRTLDQRRSAAIGAIHAGSMFLACACDNPDCTAKVDDGRGSTFVINVIADRESLDAPQ DPLLHGDDVKDGETAEDRGPAKHTKTTEHTETTTEPRRKAALIPAARNAILPPAMLAELIAQGATIRFVG DPTGAEDHYRPSTALQRFIRSRDITCRFPGCDRPAAHADIDHTTAWPCGVTHSANCKCYCRLHHLIKTFW PGFSDAQHPDGTVVVTTPTGHAYSTKPLSGLIFPGWDTAAESPPPPAQATQRSVGRHLKMPTRRRSRAQN RAARIKAERMRNAALRASQVRPVASRQTYRAENSHDEHTFRPAGHEPDYGNDPPPF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4927 | - | - | 100% (546) | hypothetical protein Mflv_4927 |
| M. gilvum PYR-GCK | Mflv_3422 | - | e-150 | 48.63% (621) | hypothetical protein Mflv_3422 |
| M. gilvum PYR-GCK | Mflv_1180 | - | e-100 | 40.71% (560) | hypothetical protein Mflv_1180 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2126 | - | 1e-119 | 46.05% (519) | hypothetical protein Mb2126 |
| M. tuberculosis H37Rv | Rv2100 | - | 1e-119 | 46.05% (519) | hypothetical protein Rv2100 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 3e-61 | 33.66% (505) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_1213 | - | 2e-82 | 37.33% (525) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 2e-85 | 36.91% (531) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_3957 | - | 1e-103 | 39.96% (518) | 13e12 repeat-containing protein |
| M. thermoresistible (build 8) | TH_0334 | - | 8e-60 | 34.75% (400) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 2e-72 | 34.85% (485) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0728 | - | 1e-101 | 40.25% (559) | hypothetical protein Mvan_0728 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1213|M.marinum_M ---------------------------MRAQALRPTVSVDQHMIEHVFD-
MUL_2679|M.ulcerans_Agy99 --------------------------------------MDQHIIEYVFD-
MAV_4456|M.avium_104 -------------------------------MCEDATAWFDELMERCYPS
TH_0334|M.thermoresistible__bu ----------------------------------------------MFES
MAB_4752|M.abscessus_ATCC_1997 ----------------------------------------------MFDE
Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
Rv2100|M.tuberculosis_H37Rv MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
MSMEG_3957|M.smegmatis_MC2_155 --------------------------------------MCET--------
Mflv_4927|M.gilvum_PYR-GCK --------------------------------------MFDGSLPDPGRL
Mvan_0728|M.vanbaalenii_PYR-1 --------------------------------------MFDVLVPDPADL
MMAR_1213|M.marinum_M --TDSSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQHG--NREDWV
MUL_2679|M.ulcerans_Agy99 --TDDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQHG--NREDWV
MAV_4456|M.avium_104 ATPESAALVQRIGVFARVENRAAAEQLAAIGELFAYRLSRCS--ECEDWA
TH_0334|M.thermoresistible__bu --LDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPEDDT-ERANWA
MAB_4752|M.abscessus_ATCC_1997 --LGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHA
Mb2126|M.bovis_AF2122/97 CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG--AD-QRADWA
Rv2100|M.tuberculosis_H37Rv CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG--AD-QRADWA
MSMEG_3957|M.smegmatis_MC2_155 --LDDAALIAGIAGESRAESAAAARRFAFIAEFVDRRTADSED-TVVWWA
Mflv_4927|M.gilvum_PYR-GCK ARLSDGELIDAVTGWARASAAAEARKVAAIAELHQRLCTDAAA-THAFWV
Mvan_0728|M.vanbaalenii_PYR-1 AALSDAELLDAATATTRAENAVCARKLAVMAELFIRRTTLAPQ-DRLDWW
. : * . . .... :. :
MMAR_1213|M.marinum_M ADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDF
MUL_2679|M.ulcerans_Agy99 ADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDF
MAV_4456|M.avium_104 VDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDF
TH_0334|M.thermoresistible__bu IDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDF
MAB_4752|M.abscessus_ATCC_1997 LDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDF
Mb2126|M.bovis_AF2122/97 CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
Rv2100|M.tuberculosis_H37Rv CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
MSMEG_3957|M.smegmatis_MC2_155 CDDWDAASAEVAAALNIGQRSASRLMRIAVALRDRLPLVAAQFAEGAVST
Mflv_4927|M.gilvum_PYR-GCK CDDCDALAAQLSCALTINHGRALSQIELATAMRHRFPKVGAKFLAGDIPI
Mvan_0728|M.vanbaalenii_PYR-1 VDPEAAVTAELAAAHHITQGLATHQAYRAVVLRDRLPKIGALFLQGLLSE
* ::::. . : :. *: :. * * :
MMAR_1213|M.marinum_M RLFRTIVFRTDLITDSDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVA
MUL_2679|M.ulcerans_Agy99 RLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVA
MAV_4456|M.avium_104 RLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVA
TH_0334|M.thermoresistible__bu RMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVE
MAB_4752|M.abscessus_ATCC_1997 RTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVL
Mb2126|M.bovis_AF2122/97 RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
Rv2100|M.tuberculosis_H37Rv RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
MSMEG_3957|M.smegmatis_MC2_155 RVVETLTWRTRLIDDTQTMAAVDAQLASRIAEFGAMTIAELEGAVDKVVD
Mflv_4927|M.gilvum_PYR-GCK STVTSILARTELVTDERALAQLDSKLSERAVAWGSLTKYSLEKALDVWVD
Mvan_0728|M.vanbaalenii_PYR-1 LLVRAIITRTGLITDPDLIAAVDADLATDILDWGPLSVKATEAEIDAIID
. : *: : : :: :*: : : : :* :
MMAR_1213|M.marinum_M KFDRDAVRRSRRDAADRYVDCAP-LEPG--MALVNGQVFAATAEALARRL
MUL_2679|M.ulcerans_Agy99 KFDRDAVRRSRRDAADRYVDCAP-LEPG--MALVNRQVFSATAEALARRL
MAV_4456|M.avium_104 KADADAVRRTEKQAASRHVWIAE-MGEG--LSHLEGTVSSPDAHALDKRL
TH_0334|M.thermoresistible__bu RFDPTGVREPRSPGEDRYVVVTP-AGQG--MVDVSARLTFEAGFAFXTRL
MAB_4752|M.abscessus_ATCC_1997 HFDQDAVRRNRSATDKRHLEIRP-LGNGEPVAEVWGTLQAVHAVALDKRL
Mb2126|M.bovis_AF2122/97 RYDPGALRRSRISARTRDLCIGD-PDEDAGTAALWGRLYATDAAMLDRRL
Rv2100|M.tuberculosis_H37Rv RYDPGALRRSRISARTRDLCIGD-PDEDAGTAALWGRLYATDAAMLDRRL
MSMEG_3957|M.smegmatis_MC2_155 SVDPAAVRRTRTAVRSRGVWFGH-PDDETGITSVHARLTNVDAVALKNRV
Mflv_4927|M.gilvum_PYR-GCK RFDPDAVKRTRSSSRGCYFTVGSGSDNADGTTTVHGRVSNADAAIMEQRI
Mvan_0728|M.vanbaalenii_PYR-1 RHDPDAVRKSRAPETGRTVQFGN-PGDAPGYTSMWARMYASDAAAADRTL
* .::. . . : : . :
MMAR_1213|M.marinum_M DELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCP-AAGAPQ
MUL_2679|M.ulcerans_Agy99 DELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCP-AAGAPQ
MAV_4456|M.avium_104 DALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADC--AAGTRP
TH_0334|M.thermoresistible__bu DQIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCP-ADPADT
MAB_4752|M.abscessus_ATCC_1997 DLLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDC---SGRDT
Mb2126|M.bovis_AF2122/97 TEMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDE
Rv2100|M.tuberculosis_H37Rv TEMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDE
MSMEG_3957|M.smegmatis_MC2_155 GAMSSGQCPDDPRTKGQRLSDAMGVLGHYGDRLTCRCGDPECP-AAGIDP
Mflv_4927|M.gilvum_PYR-GCK ASMARNVCEDDPRTLDQRRSAAIGAIHAGSMFLACACDNPDCT-AKVDDG
Mvan_0728|M.vanbaalenii_PYR-1 TALAYSVCDNDPRTLDERRNDAHTALLTGITTLACQCGNPDCH-ASTNPR
:: * ***: :* * .: : * *. :*
MMAR_1213|M.marinum_M QPSRVVIHVVAGRETVDGAGE---------------------APGVLPG-
MUL_2679|M.ulcerans_Agy99 QPSRVVIHVVAGCQTVDGAGE---------------------APGVLPG-
MAV_4456|M.avium_104 AAGPVVIHLIAERASVEGTGG---------------------GPAVEVGA
TH_0334|M.thermoresistible__bu AATRLVINVIAEQATVEGRSD---------------------NPGYLPG-
MAB_4752|M.abscessus_ATCC_1997 ADVPVVVNVVINQSTLAGSDD---------------------CPAHVPG-
Mb2126|M.bovis_AF2122/97 RAAGVVIHVVADASALDAQPDPHLSGDEP--PSRPLTPETTLFEALTPD-
Rv2100|M.tuberculosis_H37Rv RAAGVVIHVVADASALDAQPDPHLSGDEP--PSRPLTPETTLFEALTPD-
MSMEG_3957|M.smegmatis_MC2_155 RAANTMVHVFAEPAAVHGPVDRYLDGDHESNPIPYFEPTPTPEPEPTPEP
Mflv_4927|M.gilvum_PYR-GCK RGSTFVINVIADRESLDAPQDPLLHGDDVK-DGETAEDRGPAKHTKTTEH
Mvan_0728|M.vanbaalenii_PYR-1 PPRDITVYALTDHTTTTDTGDADTTTDTKP-PTPPAPQPRRSKPILIPG-
: . :
MMAR_1213|M.marinum_M ----------------------------DGIIPAEIVRELAKS-AKLQPM
MUL_2679|M.ulcerans_Agy99 ----------------------------DGIIPAEIVRELAKS-AKLQPM
MAV_4456|M.avium_104 ----------------------------EGLLPAQLVAELAAS-ARLMPL
TH_0334|M.thermoresistible__bu ----------------------------YGAVPASILRAKAAT-ATLRPV
MAB_4752|M.abscessus_ATCC_1997 ----------------------------FGVLAAESARAAVAG-TPTRNL
Mb2126|M.bovis_AF2122/97 ----PEPDP----PATHAP--AELITTGGGVVPAPLLAELIRGGATISQV
Rv2100|M.tuberculosis_H37Rv ----PEPDP----PATHAP--AELITTGGGVVPAPLLAELIRGGATISQV
MSMEG_3957|M.smegmatis_MC2_155 VRKPPEPEPKPWTPQSAHPGRGGAVVLGGGVVPAPLVAQLIADGAKVKEL
Mflv_4927|M.gilvum_PYR-GCK TETTTEPRR----KAALIP------AARNAILPPAMLAELIAQGATIRFV
Mvan_0728|M.vanbaalenii_PYR-1 -----RPAY----------------LFGAGFMPAPLFDALLAE-ATIREI
. :.. : :
MMAR_1213|M.marinum_M STP-ILA--ETGYVPSPALMDFVRARDLTCRAPGCDRPATQCDVDHTIPY
MUL_2679|M.ulcerans_Agy99 STP-ILA--ETGYVPSPALMDFVRARDLTCRAPGCDRPATQCDVDHTIPY
MAV_4456|M.avium_104 VHP-ADAPPENRYTPSAALADFVRCRDLTCRWPGCDRPATECDLDHTIPY
TH_0334|M.thermoresistible__bu ALP-QPCA-EAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVCQIDHTIPY
MAB_4752|M.abscessus_ATCC_1997 TDS-RST----GYRPSAKLAAFVRSRDQLCRFPGCEAVADRADIDHTVPW
Mb2126|M.bovis_AF2122/97 RHPGD-LAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDIDHSAPW
Rv2100|M.tuberculosis_H37Rv RHPGD-LAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDIDHSAPW
MSMEG_3957|M.smegmatis_MC2_155 TVPDD-ICAS--YRPSVAMDCFVRMRDMTCRFPGCSRPADFCDVDHTTPW
Mflv_4927|M.gilvum_PYR-GCK GDP---TGAEDHYRPSTALQRFIRSRDITCRFPGCDRPAAHADIDHTTAW
Mvan_0728|M.vanbaalenii_PYR-1 IHPGNRSAPEPRYTPSQALAEFIRCRDLTCRFPGCDKPATEADIDHTVPY
. * ** : *:* ** ** ***. * .::**: .:
MMAR_1213|M.marinum_M SDGGATHPSNLKCLCRKHHLLKTFWG----WHDKQLPDATVIWSLPDGQT
MUL_2679|M.ulcerans_Agy99 SDGGATHPSNLKCLCRKHHLLKTFWG----WHDEQLPDATVIWSLPDGQT
MAV_4456|M.avium_104 AEGGPTHASNLKCYCRTHHLVKTFWG----WREQQLPDATLILTSPAGRT
TH_0334|M.thermoresistible__bu PAG-PTHPSNLKLLCVFHCRQAELRF----THDQHKHQSSCLP------A
MAB_4752|M.abscessus_ATCC_1997 ATGGPTTGANLKALCRKHHLLKTFGQ----WTELQEPDGTVIWKSPTGHR
Mb2126|M.bovis_AF2122/97 PLG-PTHPSNLKCACRKHHLLKTFWT---GWRDVQLPDGTVIWTAPNGHT
Rv2100|M.tuberculosis_H37Rv PLG-PTHPSNLKCACRKHHLLKTFWT---GWRDVQLPDGTVIWTAPNGHT
MSMEG_3957|M.smegmatis_MC2_155 PTG-VTHPSNTKCLCRIHHLLKTFWL---GWSDRQLPDGTVIWTSPTGHV
Mflv_4927|M.gilvum_PYR-GCK PCG-VTHSANCKCYCRLHHLIKTFWP---GFSDAQHPDGTVVVTTPTGHA
Mvan_0728|M.vanbaalenii_PYR-1 PIG-PTHPSNLKCLCRFHHLLKTFWLGATGWHDRQHPDGTITWTAPTGHT
. * * :* * * * : : : :.:
MMAR_1213|M.marinum_M YVTTPGSAWLLPGLFAPSPELPPPARK----PQDHCGNRDAMMPKRARTR
MUL_2679|M.ulcerans_Agy99 YVTTPGSAWLLPGLFAPSPELPPPPR------------------------
MAV_4456|M.avium_104 YVTTPGSALLFPSLCVPTGEPARPVAA----GSQPCGERTAMMPTRRRTR
TH_0334|M.thermoresistible__bu YFQRP---------HGPATRRPPSAR------------------------
MAB_4752|M.abscessus_ATCC_1997 YATTPVSWFLFPALTRHHTRQQARDR------------------------
Mb2126|M.bovis_AF2122/97 YTTHPGSRIFFPTWHTTTAELPQTST-----AAVNVDARGLMMPRRRRTR
Rv2100|M.tuberculosis_H37Rv YTTHPGSRIFFPTWHTTTAELPQTST-----AAVNVDARGLMMPRRRRTR
MSMEG_3957|M.smegmatis_MC2_155 YTTVPASRALFPQWDTTTAALPPPPTPPPPMTPSEIAARAAMMPRRRRTR
Mflv_4927|M.gilvum_PYR-GCK YSTKPLSGLIFPGWDTAAESPPPPAQ-----ATQRSVGRHLKMPTRRRSR
Mvan_0728|M.vanbaalenii_PYR-1 YTTHPGSRLLFPTLCQPTATLWTGEPP----QVPQSQQRGAMMPRRRNTR
* *
MMAR_1213|M.marinum_M AQSSAARIAAERNHNMTSRQARRRRWEECYFGPRDASASD----------
MUL_2679|M.ulcerans_Agy99 SEATGSLRKPRRDDAQTRPNSRPK------LGRTHCDRTQ----------
MAV_4456|M.avium_104 GQNRAARVAAERRANRAARLARATRPAPAASQSWPAGHGP----------
TH_0334|M.thermoresistible__bu ----GLREAVPRQGVDPRRVSGQ---------------------------
MAB_4752|M.abscessus_ATCC_1997 ------RRRTERNLNREQRLQREA----------ALAALA----------
Mb2126|M.bovis_AF2122/97 AAELAHRINAERALNDAYMAERNKPPSF----------------------
Rv2100|M.tuberculosis_H37Rv AAELAHRINAERALNDAYMAERNKPPSF----------------------
MSMEG_3957|M.smegmatis_MC2_155 AAEEARRLAAERARNEAYLAQRDRPPPDAHGPGMQ---------------
Mflv_4927|M.gilvum_PYR-GCK AQNRAARIKAERMRNAALRASQVRPVASRQTYRAENSHDEHTFRPAGHEP
Mvan_0728|M.vanbaalenii_PYR-1 AHNHAAYITAERRRNAQTRYATTGNTPPYLPRDHIPYQSSTGWR----EP
*
MMAR_1213|M.marinum_M --DEEPPPF
MUL_2679|M.ulcerans_Agy99 --PQHD---
MAV_4456|M.avium_104 --DADPPPF
TH_0334|M.thermoresistible__bu ---------
MAB_4752|M.abscessus_ATCC_1997 --AKDPPPF
Mb2126|M.bovis_AF2122/97 ---------
Rv2100|M.tuberculosis_H37Rv ---------
MSMEG_3957|M.smegmatis_MC2_155 ---------
Mflv_4927|M.gilvum_PYR-GCK DYGNDPPPF
Mvan_0728|M.vanbaalenii_PYR-1 DYGNDPPPF