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FTSLQGRSAAVTGGSKGIGRGIAETFARAGINVVITARTQDDIDATVADLAGLAGTVTGVAADVTSPEDC RRVVETAIERHGGLDIVCPNAGIFPSGRIADLTPDDIEQVLGVNFKGTVYIVQAALDALTASGHGRVIIT SSITGPITGFPGWSHYGASKAAQLGFLRTAAIELAPKKITVNAVLPGNILTEGLVEMGQSYIDQMAAAVP AGKLGEVADIGNAALFFATDEAAYITGQSLVVDGGQILPESPEALADL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1235 | - | - | 100% (259) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1825 | - | 5e-35 | 35.66% (258) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4104 | - | 3e-34 | 38.02% (242) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1963c | - | 2e-37 | 35.89% (248) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1928c | - | 2e-37 | 35.89% (248) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 4e-30 | 32.64% (239) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0952 | - | 5e-90 | 62.85% (253) | short chain dehydrogenase |
| M. marinum M | MMAR_4033 | fabG | 3e-37 | 35.92% (245) | 3-oxoacyl- |
| M. avium 104 | MAV_2775 | - | 3e-37 | 36.55% (249) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0269 | - | 1e-122 | 81.85% (259) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_2589 | - | 2e-36 | 35.12% (242) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3898 | fabG | 2e-35 | 35.29% (238) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_5573 | - | 1e-133 | 91.89% (259) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1963c|M.bovis_AF2122/97 ----------MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAI
Rv1928c|M.tuberculosis_H37Rv ----------MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAI
MAV_2775|M.avium_104 ------------MLDLFDLRGRRALVTGASTGIGKQVAQAYLQAGARVAI
Mflv_1235|M.gilvum_PYR-GCK --------------MFTSLQGRSAAVTGGSKGIGRGIAETFARAGINVVI
Mvan_5573|M.vanbaalenii_PYR-1 --------------MFNSLQGRSAIVTGGSKGIGRGIAETFARAGVNVVI
MSMEG_0269|M.smegmatis_MC2_155 --------------MFTSLEGRSAIVTGGSKGIGRGIAETFANAGVDVVI
MAB_0952|M.abscessus_ATCC_1997 --MVVESAEPAERKVMFDLSARSVLVTGGTKGIGRGIATVFARAGANVAV
TH_2589|M.thermoresistible__bu -------VDRQTFDKLFDMTGRTVVVTGGTRGIGLALAEGYVLAGARVVV
MMAR_4033|M.marinum_M -----------MSVSLLNG--QIAVVTGGAQGLGLAIAERFVSEGARVVL
MUL_3898|M.ulcerans_Agy99 -----------MCGAHRDRGYVYPVVTGGAQGLGLAIAERFVSEGARVVL
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
:**. *:* :* * *.:
Mb1963c|M.bovis_AF2122/97 AARHLDALEKLADEIGTSG-GKVVPVCCDVSQHQQVTSMLDQVTAELGGI
Rv1928c|M.tuberculosis_H37Rv AARHLDALEKLADEIGTSG-GKVVPVCCDVSQHQQVTSMLDQVTAELGGI
MAV_2775|M.avium_104 AARDFEALQRTADELTAGGTGGVVAIRCDVTQPDEVSGMVDRMIAELGGI
Mflv_1235|M.gilvum_PYR-GCK TARTQDDIDATVADLAGL-AGTVTGVAADVTSPEDCRRVVETAIERHGGL
Mvan_5573|M.vanbaalenii_PYR-1 TGRTQADIDGTVAGLAGL-PGTVTGVAADVTSPEDCRRVVATATERNGGL
MSMEG_0269|M.smegmatis_MC2_155 TGRNQDDLDRTVADLSGT-RGKVTAVRADVTDPEDARRTVAETVSRHGGL
MAB_0952|M.abscessus_ATCC_1997 AARSPRELSSVTAELGELGAGNVIGVRLDVSDPGSCADAARTVVDAFGAL
TH_2589|M.thermoresistible__bu ASRKSDACERAAAHLRAL-GGDAIGVPTHLGDIDACEALVRRTVDEFGGI
MMAR_4033|M.marinum_M GDVNLEATEAAAKQLGGG--EVAVAVRCDVTKADEVETLLQTALERFGGL
MUL_3898|M.ulcerans_Agy99 GDVNLEATEAAAKQLGGG--EVAVAVRCDVTKADEVETLLQAALERFGGL
MLBr_01807|M.leprae_Br4923 THR------------ASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPV
: .: . * :
Mb1963c|M.bovis_AF2122/97 DIAVCNAGIITVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQ
Rv1928c|M.tuberculosis_H37Rv DIAVCNAGIITVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQ
MAV_2775|M.avium_104 DIAVCNAGIISVSPMLEMPAAEFQRIQDTNVTGVFLTAQAAARAMVRQGR
Mflv_1235|M.gilvum_PYR-GCK DIVCPNAGIFPSGRIADLTPDDIEQVLGVNFKGTVYIVQAALDALTASGH
Mvan_5573|M.vanbaalenii_PYR-1 DIVCANAGIFPSGRLQDLTPEDIEQVLGVNFKGTVYIVQAALDALTASGH
MSMEG_0269|M.smegmatis_MC2_155 DIVCANAGIFPSGRLEDLTPDDIEQVLGVNFKGTVYIVQAALQALTASGH
MAB_0952|M.abscessus_ATCC_1997 DVVCANAGIFPEARLDTMTPEQLSEVLDVNVKGTVYTVQACLAPLTASGR
TH_2589|M.thermoresistible__bu DVLVNNAANALTQPLGELTVDAWTKSFEVNLRGPVFLVQAALPHLKTSPH
MMAR_4033|M.marinum_M DIMVNNAGITRDATMRKMTEEQFDQVIDVHLKGTWNGIRLAAAIMRENKR
MUL_3898|M.ulcerans_Agy99 DIMVNNAGITRDATMRKMTEEQFDQVIDVHLKGTWNGIRLAAAIMRENKR
MLBr_01807|M.leprae_Br4923 EVLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRF
:: **. : :. . .:. * : . : .
Mb1963c|M.bovis_AF2122/97 GGVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHKIRVN
Rv1928c|M.tuberculosis_H37Rv GGVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHKIRVN
MAV_2775|M.avium_104 GGAIITTASMSGHIINVPQQVGHYCASKAAVIQLTKAMAVEFAPHDIRVN
Mflv_1235|M.gilvum_PYR-GCK G-RVIITSSITGPITGFPGWS-HYGASKAAQLGFLRTAAIELAPKKITVN
Mvan_5573|M.vanbaalenii_PYR-1 G-RVIITSSITGPITGFPGWS-HYGASKAAQMGFLRTAAIELAPKKITVN
MSMEG_0269|M.smegmatis_MC2_155 G-RVVVTSSITGPITGYPGWS-HYGASKAAQLGFLRTAAMELAPKKITIN
MAB_0952|M.abscessus_ATCC_1997 G-RVILTSSITGPVTGYPGWS-HYGASKAAQLGFMRTAAIELAPRGVTVN
TH_2589|M.thermoresistible__bu A-AVLNMVSVG-AFLFSPGTA-MYSAGKAALMSFTRSMAAQFAPLGIRVN
MMAR_4033|M.marinum_M G-AIVNMSSVSGKVGMVGQTN--YSAAKAGIVGMTKAAAKELAHVGVRVN
MUL_3898|M.ulcerans_Agy99 G-AIVNMSSVSGKVGMVGQTN--YSAAKAGIVGMTKAAAKELAHVGVRVN
MLBr_01807|M.leprae_Br4923 G-RYIFMGSVVGLSGVPGQAN--YAASKSGLIGMARSLARELGSRSITAN
. : *: * *.*:. : : :: * ::. : *
Mb1963c|M.bovis_AF2122/97 SVSPGYILTELVEP-YTEYQPLWEPKIPLGRLGRPEELAGLYLYLASEAS
Rv1928c|M.tuberculosis_H37Rv SVSPGYILTELVEP-YTEYQPLWEPKIPLGRLGRPEELAGLYLYLASEAS
MAV_2775|M.avium_104 SVSPGYIRTELVEP-LHEYHRQWQPKIPLGRMGRPDELAGIYLYLASAAS
Mflv_1235|M.gilvum_PYR-GCK AVLPGNILTEGLVEMGQSYIDQMAAAVPAGKLGEVADIGNAALFFATDEA
Mvan_5573|M.vanbaalenii_PYR-1 AVLPGNIITEGLVEMGQTYMDQMAASVPAGKLGEVADIGNAALFFATDEA
MSMEG_0269|M.smegmatis_MC2_155 AVLPGNIMTEGLDEMGQDYLDQMASAIPAGRLGSVADIGNAALFFATDEA
MAB_0952|M.abscessus_ATCC_1997 AILPGNILTEGLVDMGEEYISGMARSIPMGMLGSPVDIGHLAAFLATDEA
TH_2589|M.thermoresistible__bu ALAPGPVDTDMMRNNPQEVVDMMAGATLMKRLATPDEMVGAALLLTSDAG
MMAR_4033|M.marinum_M AIAPGLIRSAMTEAMPQRIWDQKLAEVPMGRAGEPSEVASVALFLACDLS
MUL_3898|M.ulcerans_Agy99 AIAPGLIRSAMTEAMPQRIWDQKLAEVPMGRAGEPSEVASVALFLACDLS
MLBr_01807|M.leprae_Br4923 VVAPGFIDTEMTRAMDSKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDA
: ** : : . :: :: .
Mb1963c|M.bovis_AF2122/97 SYMTGSDIVIDGGYTCP---------
Rv1928c|M.tuberculosis_H37Rv SYMTGSDIVIDGGYTCP---------
MAV_2775|M.avium_104 SYMTGSDIVIDGGYSCP---------
Mflv_1235|M.gilvum_PYR-GCK AYITGQSLVVDGGQILPESPEALADL
Mvan_5573|M.vanbaalenii_PYR-1 SYITGQSLVVDGGQILPESPEALADL
MSMEG_0269|M.smegmatis_MC2_155 AYVTGQTLVVDGGQVLPESHLAIAEL
MAB_0952|M.abscessus_ATCC_1997 GYITGQAIVVDGGQVLPESPDAVNP-
TH_2589|M.thermoresistible__bu SYITGTVLIADGGGTPR---------
MMAR_4033|M.marinum_M SYMTGTVLDVTGGRFI----------
MUL_3898|M.ulcerans_Agy99 SYMTGTVLDVTGGRFI----------
MLBr_01807|M.leprae_Br4923 GYISGAVIPVDGGLGMGH--------
.*::* : **