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RQLAASGARAVVNGRSQERVDAAVAEVGLQHGSVSGVAADVSTADGVERLLKQLPEVDILINNLGIFGAT PAREITDEQWRNYFEVNVLSAVRLIRAYLPAMIGAGWGRIIQIASDSAIVIPQEMIHYGVSKTALLGVTR GFAKDAAGSGVTINSVIAGPTHTAGVEDFVYQLVDKSLPWDEAQREFMKRHRPQSLVQRLIEPAEIANLV VYLSSPLASATTGAAVRADGGYVDSILP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4665c | - | - | 100% (239) | putative short-chain dehydrogenase/reductase |
| M. abscessus ATCC 19977 | MAB_0952 | - | 1e-20 | 31.36% (236) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4443 | fabG | 1e-18 | 29.18% (233) | 3-ketoacyl-(acyl-carrier-protein) reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1963c | - | 4e-20 | 30.34% (234) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0296 | - | 1e-31 | 32.07% (237) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1928c | - | 4e-20 | 30.34% (234) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 6e-15 | 27.47% (233) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. marinum M | MMAR_0629 | - | 3e-20 | 30.77% (234) | dehydrogenase |
| M. avium 104 | MAV_2549 | - | 2e-24 | 32.91% (237) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_0600 | - | 1e-104 | 78.81% (236) | dehydrogenase |
| M. thermoresistible (build 8) | TH_3893 | - | 3e-31 | 32.93% (246) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 2e-19 | 28.76% (226) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_0398 | - | 1e-102 | 75.21% (238) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0600|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0398|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4665c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MMAR_0629|M.marinum_M --------------------------------------------------
MAV_2549|M.avium_104 --------------------------------------------------
MUL_0315|M.ulcerans_Agy99 --------------------------------------------------
Mb1963c|M.bovis_AF2122/97 --------------------------------------------------
Rv1928c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
MSMEG_0600|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0398|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4665c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MMAR_0629|M.marinum_M --------------------------------------------------
MAV_2549|M.avium_104 --------------------------------------------------
MUL_0315|M.ulcerans_Agy99 --------------------------------------------------
Mb1963c|M.bovis_AF2122/97 --------------------------------------------------
Rv1928c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
MSMEG_0600|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0398|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4665c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MMAR_0629|M.marinum_M --------------------------------------------------
MAV_2549|M.avium_104 --------------------------------------------------
MUL_0315|M.ulcerans_Agy99 --------------------------------------------------
Mb1963c|M.bovis_AF2122/97 --------------------------------------------------
Rv1928c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
MSMEG_0600|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0398|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4665c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MMAR_0629|M.marinum_M --------------------------------------------------
MAV_2549|M.avium_104 --------------------------------------------------
MUL_0315|M.ulcerans_Agy99 --------------------------------------------------
Mb1963c|M.bovis_AF2122/97 --------------------------------------------------
Rv1928c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
MSMEG_0600|M.smegmatis_MC2_155 ------MNIDLTGKTALVTGSTQGIGLAIAETLARSGARVAINGRTASRV
Mvan_0398|M.vanbaalenii_PYR-1 ------MKIDLTGKTALVTGSTQGIGLAIARSLAASGARVAVNGRSRDRV
MAB_4665c|M.abscessus_ATCC_199 -----------------------------MRQLAASGARAVVNGRSQERV
Mflv_0296|M.gilvum_PYR-GCK ------MDMGLSGKRALVTGSSSGLGRAIAESLAAEGASVVVHGRDEVRT
TH_3893|M.thermoresistible__bu ------MDFDLNGKRALVTGSSSGIGAGIVETLAAEGVSVVVHGRNAERA
MMAR_0629|M.marinum_M ----------MAGLTALITGATSGIGRATAHGLAELGATVLVSGRDEARG
MAV_2549|M.avium_104 ------MHYGIDGRSALVVGGSKGIGFEVAKLLAAEGARVAILARTKTDV
MUL_0315|M.ulcerans_Agy99 --MRPDSSPSWCTITSVVTGGASGIGLAIARRLSADGTDVATLDLKTPDG
Mb1963c|M.bovis_AF2122/97 --MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARHLDAL
Rv1928c|M.tuberculosis_H37Rv --MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARHLDAL
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
*. .
MSMEG_0600|M.smegmatis_MC2_155 DETVAQLG--DLDVVGVAADVATQKGTEALLEQLP-----SVDILVNNLG
Mvan_0398|M.vanbaalenii_PYR-1 DEAVATL---DGDVVGVAADVADAAGAQALAAELP-----HIDILVNNLG
MAB_4665c|M.abscessus_ATCC_199 DAAVAEVGLQHGSVSGVAADVSTADGVERLLKQLP-----EVDILINNLG
Mflv_0296|M.gilvum_PYR-GCK GAVADGIRARGGDAWAAVGDLATEGGAGAVAAAAG-----EVDILVNNAG
TH_3893|M.thermoresistible__bu EAVADRIRADGGTAATAVGDLATEDGAAQVADTAAAA-FSGIDILVNNAG
MMAR_0629|M.marinum_M REVVDEVTARGGRGIFLAAELRDVTGVRNLATAAADAGAGKVDILINSAG
MAV_2549|M.avium_104 DAAVEAIRTEGGTAIGVTADVADDGQLTDAVREIAAR-HGAPLIVVGQAK
MUL_0315|M.ulcerans_Agy99 -------------GLAFSADVTNRSQVDAALAAIRQR-LGPVTILVNAAG
Mb1963c|M.bovis_AF2122/97 EKLADEIGTSGGKVVPVCCDVSQHQQVTSMLDQVTAELG-GIDIAVCNAG
Rv1928c|M.tuberculosis_H37Rv EKLADEIGTSGGKVVPVCCDVSQHQQVTSMLDQVTAELG-GIDIAVCNAG
MLBr_02565|M.leprae_Br4923 ALDETANRVGG---TTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAG
:: * :
MSMEG_0600|M.smegmatis_MC2_155 IFGAEP---------AREIT-DEQWRKYFDVNVLAAVRLIRSYLPGMIEK
Mvan_0398|M.vanbaalenii_PYR-1 IFGAVP---------AREIT-DDQWRSYFEVNVLAAARLIRHYLPGMVDR
MAB_4665c|M.abscessus_ATCC_199 IFGATP---------AREIT-DEQWRNYFEVNVLSAVRLIRAYLPAMIGA
Mflv_0296|M.gilvum_PYR-GCK VYDG---L------AWSDLA-PRQWQSIYEVNVVSGVRMIEYLVPGMRQR
TH_3893|M.thermoresistible__bu GSSETGIQ------SWFALP-VSEWGVTYQRNVMSAGYLIHALVPAMKES
MMAR_0629|M.marinum_M AFPFGP---------TADTS-PDDFDAVFALNVRAPYFLVGALAPTMAKR
MAV_2549|M.avium_104 YQRPGD---------FADITDVNVYRESFELHTMSQILLLHAVLPAMQDA
MUL_0315|M.ulcerans_Agy99 LDGFKR---------FSNIT-FEDWQRVIDVNLNGVFHTIQAVLPDMVAA
Mb1963c|M.bovis_AF2122/97 IITVTP---------MLDMP-LEEFQRLQNTNVTGVFLTAQAAAKAMVKQ
Rv1928c|M.tuberculosis_H37Rv IITVTP---------MLDMP-LEEFQRLQNTNVTGVFLTAQAAAKAMVKQ
MLBr_02565|M.leprae_Br4923 ITRDKLLANMDDCR----------WDAVLEVNLLAPQRLTEGLVGNGSIS
: : .
MSMEG_0600|M.smegmatis_MC2_155 GWGRAIQIASDSA---IVIPEEMIHYGVSKT--ALLAVSRGFAKDAAGTG
Mvan_0398|M.vanbaalenii_PYR-1 GWGRVLQIASDSA---IVIPEEMIHYGVSKT--ALLALSRGFAKDASGTG
MAB_4665c|M.abscessus_ATCC_199 GWGRIIQIASDSA---IVIPQEMIHYGVSKT--ALLGVTRGFAKDAAGSG
Mflv_0296|M.gilvum_PYR-GCK GWGRIIQIGGGLA---LQPAADQPHYNATLA--ARHNLTVSLARELAGTG
TH_3893|M.thermoresistible__bu GWGRIIQIASAAG---IIPTSGQPDYGPSKA--AMINMSMGLSKALAGTG
MMAR_0629|M.marinum_M GRGSIVNVTTMVA---EFGAAGTGLYGASKA--AIALLTKSWAAEYGPSG
MAV_2549|M.avium_104 GWGRFVHIGSATA---KEPAGNIHHAVANTSRPSTIGLLKTVSDEYAQFG
MUL_0315|M.ulcerans_Agy99 GWGRIVNISSSST---HSGTPYMTHYVAAKS--AVNGLTKALALEYGPSG
Mb1963c|M.bovis_AF2122/97 GQGGVIINTASMSGHIINVPQQVSHYCASKA--AVIHLTKAMAVELAPHK
Rv1928c|M.tuberculosis_H37Rv GQGGVIINTASMSGHIINVPQQVSHYCASKA--AVIHLTKAMAVELAPHK
MLBr_02565|M.leprae_Br4923 KGGRVIVLSSMAG---IAGNRGQTNYATAKAG--VIGLTQALAPGLAEKG
* : : : : .
MSMEG_0600|M.smegmatis_MC2_155 VTVNSVIAGPTHTAGVEDFVYQLVDK---SLPWDEAQREFMRKHRPQS-L
Mvan_0398|M.vanbaalenii_PYR-1 VTVNSVIAGPTHTAGVEDFVYQLVDK---SLPWEQAQREFMRLHRPQS-L
MAB_4665c|M.abscessus_ATCC_199 VTINSVIAGPTHTAGVEDFVYQLVDK---SLPWDEAQREFMKRHRPQS-L
Mflv_0296|M.gilvum_PYR-GCK VTSNTVAPGAILTEPVREMTYRVAAQRGWGPTWEDVEKAAATTWFPN--D
TH_3893|M.thermoresistible__bu ITVNTVMPGMIMTEGLRDFLRTFADHRGWG---DDLDKAADYILKGTGQT
MMAR_0629|M.marinum_M VRVNAVSPGPTRTEGTVEMG-------------EALDQLAAAAPAGRP--
MAV_2549|M.avium_104 ITVNTVAPGWIETENALAYLEQHLGA-------STDQERREFMLREARVP
MUL_0315|M.ulcerans_Agy99 ITVNAVPPGFIDTP-------MLRNA-------AAQGHLGDIEQNIARTP
Mb1963c|M.bovis_AF2122/97 IRVNSVSPGYILTELVEPYT-------------------EYQPLWEPKIP
Rv1928c|M.tuberculosis_H37Rv IRVNSVSPGYILTELVEPYT-------------------EYQPLWEPKIP
MLBr_02565|M.leprae_Br4923 ITINAVAPGFIETQMTAAIP------------------LATREVGRRLNS
: *:* .* *
MSMEG_0600|M.smegmatis_MC2_155 LQRLIEPEEIANMVAYLASPLASATTGGALRVDGGYVDAILP
Mvan_0398|M.vanbaalenii_PYR-1 IERLIEPEEIANMVTYLASPLASATTGGALRVDGGYVDAILP
MAB_4665c|M.abscessus_ATCC_199 VQRLIEPAEIANLVVYLSSPLASATTGAAVRADGGYVDSILP
Mflv_0296|M.gilvum_PYR-GCK IGRFGRPEEVAAAVAFLAGVHAGYISGADLRVDGGAIRSVA-
TH_3893|M.thermoresistible__bu VHRIGQVSDVAYAVAFLASPRADFLNGINLHLDGGATQSIY-
MMAR_0629|M.marinum_M ----ADPTEIASTIVYLASDAASFIHGAVVPVDGGRAAV---
MAV_2549|M.avium_104 AARMGKPSEIASLIAYLCSEPAGYLTGSWIEVDGGLHRSAF-
MUL_0315|M.ulcerans_Agy99 VRRIGKPEDIAAACAFLVSEEAGYITGQILGVNGGRNT----
Mb1963c|M.bovis_AF2122/97 LGRLGRPEELAGLYLYLASEASSYMTGSDIVIDGGYTCP---
Rv1928c|M.tuberculosis_H37Rv LGRLGRPEELAGLYLYLASEASSYMTGSDIVIDGGYTCP---
MLBr_02565|M.leprae_Br4923 LLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA--
::* :: :. * : *