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VNIDLTGKTALVTGSTQGIGLAIAETLARSGARVAINGRTASRVDETVAQLGDLDVVGVAADVATQKGTE ALLEQLPSVDILVNNLGIFGAEPAREITDEQWRKYFDVNVLAAVRLIRSYLPGMIEKGWGRAIQIASDSA IVIPEEMIHYGVSKTALLAVSRGFAKDAAGTGVTVNSVIAGPTHTAGVEDFVYQLVDKSLPWDEAQREFM RKHRPQSLLQRLIEPEEIANMVAYLASPLASATTGGALRVDGGYVDAILP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0600 | - | - | 100% (260) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1689 | - | 2e-34 | 39.04% (251) | 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_6753 | - | 7e-31 | 36.22% (254) | oxidoreductase, short chain dehydrogenase/reductase family |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2788c | fabG | 3e-25 | 32.30% (257) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_0296 | - | 7e-39 | 35.47% (265) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2766c | fabG | 3e-25 | 32.30% (257) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 3e-26 | 36.36% (253) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_4665c | - | 1e-104 | 78.81% (236) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_1568 | - | 1e-26 | 31.70% (265) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_2438 | - | 2e-29 | 33.58% (265) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3893 | - | 2e-36 | 36.06% (269) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1166 | fabG | 6e-25 | 34.52% (252) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_0398 | - | 1e-122 | 84.23% (260) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2788c|M.bovis_AF2122/97 --------------------------------------------------
Rv2766c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0600|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0398|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4665c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MMAR_1568|M.marinum_M --------------------------------------------------
MAV_2438|M.avium_104 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
MUL_1166|M.ulcerans_Agy99 MAPRLSSDLFSQVVNSGPGTFVAKQLGVPQAETLRRYRPGDPPLAGSLLI
Mb2788c|M.bovis_AF2122/97 --------------------------------------------------
Rv2766c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0600|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0398|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4665c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MMAR_1568|M.marinum_M --------------------------------------------------
MAV_2438|M.avium_104 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
MUL_1166|M.ulcerans_Agy99 GGEGRVAEPLRAALAKDYDQVSNNLGGRWADSFGGLVFDATGITDPAGLK
Mb2788c|M.bovis_AF2122/97 --------------------------------------------------
Rv2766c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0600|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0398|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4665c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MMAR_1568|M.marinum_M --------------------------------------------------
MAV_2438|M.avium_104 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
MUL_1166|M.ulcerans_Agy99 GLHDFFKPVLRNLGASARVVVVGTTPDAIDNSHERIAQRALEGFTRSLAK
Mb2788c|M.bovis_AF2122/97 --------------------------------------------------
Rv2766c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0600|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0398|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4665c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0296|M.gilvum_PYR-GCK --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MMAR_1568|M.marinum_M --------------------------------------------------
MAV_2438|M.avium_104 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
MUL_1166|M.ulcerans_Agy99 ELRRASTAALVYLSPEAKPAATGLESTVRFILSAKSAYVDGQVFYVGAAD
Mb2788c|M.bovis_AF2122/97 -----MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVLTARRQEAA
Rv2766c|M.tuberculosis_H37Rv -----MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVLTARRQEAA
MSMEG_0600|M.smegmatis_MC2_155 ------MNIDLTGKTALVTGSTQGIGLAIAETLARSGARVAINGRTASRV
Mvan_0398|M.vanbaalenii_PYR-1 ------MKIDLTGKTALVTGSTQGIGLAIARSLAASGARVAVNGRSRDRV
MAB_4665c|M.abscessus_ATCC_199 -----------------------------MRQLAASGARAVVNGRSQERV
Mflv_0296|M.gilvum_PYR-GCK ------MDMGLSGKRALVTGSSSGLGRAIAESLAAEGASVVVHGRDEVRT
TH_3893|M.thermoresistible__bu ------MDFDLNGKRALVTGSSSGIGAGIVETLAAEGVSVVVHGRNAERA
MMAR_1568|M.marinum_M ------MDLGFSGSKAVVTGGSKGMGLAIAETLAAEGASVAVIARGKRAL
MAV_2438|M.avium_104 ------MDLGLAGSTAVVTGGSKGMGLAVAETLAAEGAKVAVMARGRHAL
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
MUL_1166|M.ulcerans_Agy99 STPPADWDRPLEGKVAIVTGAARGIGQTIAEVFARDGASVVAIDVESAAD
. .* *. ..
Mb2788c|M.bovis_AF2122/97 DEAAAQVGDR----ALGVGAHAVDEDAARRCVDLTLERFGSVDILINNAG
Rv2766c|M.tuberculosis_H37Rv DEAAAQVGDR----ALGVGAHAVDEDAARRCVDLTLERFGSVDILINNAG
MSMEG_0600|M.smegmatis_MC2_155 DETVAQLG---DLDVVGVAADVATQKGTEALLEQLP----SVDILVNNLG
Mvan_0398|M.vanbaalenii_PYR-1 DEAVATL----DGDVVGVAADVADAAGAQALAAELP----HIDILVNNLG
MAB_4665c|M.abscessus_ATCC_199 DAAVAEVGLQ-HGSVSGVAADVSTADGVERLLKQLP----EVDILINNLG
Mflv_0296|M.gilvum_PYR-GCK GAVADGIRAR-GGDAWAAVGDLATEGGAGAVAAAAG----EVDILVNNAG
TH_3893|M.thermoresistible__bu EAVADRIRAD-GGTAATAVGDLATEDGAAQVADTAAAAFSGIDILVNNAG
MMAR_1568|M.marinum_M DSAVERLSQAGAPDAVAISADMADAASITSAFAAVSERWGQLNCLVHTIG
MAV_2438|M.avium_104 DAAVALLREAGAPDAVGVSVDMADAESIADGFAAVAQRWGRLNSLVHTIG
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQG---GHADILVNNAG
MUL_1166|M.ulcerans_Agy99 ALAETAASVGGTPLWLDVTADDAVDKITEHLRDHHG---GKADILVNNAG
. : *::. *
Mb2788c|M.bovis_AF2122/97 TNPAYG--PLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGEHGGAVVN
Rv2766c|M.tuberculosis_H37Rv TNPAYG--PLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGEHGGAVVN
MSMEG_0600|M.smegmatis_MC2_155 IFGAEP---AREITDEQWRKYFDVNVLAAVRLIRSYLPGMIEKGWGRAIQ
Mvan_0398|M.vanbaalenii_PYR-1 IFGAVP---AREITDDQWRSYFEVNVLAAARLIRHYLPGMVDRGWGRVLQ
MAB_4665c|M.abscessus_ATCC_199 IFGATP---AREITDEQWRNYFEVNVLSAVRLIRAYLPAMIGAGWGRIIQ
Mflv_0296|M.gilvum_PYR-GCK VYDG---LAWSDLAPRQWQSIYEVNVVSGVRMIEYLVPGMRQRGWGRIIQ
TH_3893|M.thermoresistible__bu GSSETGIQSWFALPVSEWGVTYQRNVMSAGYLIHALVPAMKESGWGRIIQ
MMAR_1568|M.marinum_M PGDGY----FEELDDAAWDAAFTLGTMSGVRAIRAALPLLRAADWARVVT
MAV_2438|M.avium_104 PGDGD----FEELDDTGWDEAFALGTMSAVRSIRNALPLLRAADWGRIVT
MLBr_02565|M.leprae_Br4923 ITRDKL---LANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIV
MUL_1166|M.ulcerans_Agy99 ITRDKL---LANMDDARWDSVIAVNLLAPLRLTEGLVGNGSIGAGGRVIG
: . : : . :
Mb2788c|M.bovis_AF2122/97 TASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-IRVNAICPGVVR
Rv2766c|M.tuberculosis_H37Rv TASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-IRVNAICPGVVR
MSMEG_0600|M.smegmatis_MC2_155 IASDSAIVIPEEMIHYGVSKTALLAVSRGFAKDAAGTGVTVNSVIAGPTH
Mvan_0398|M.vanbaalenii_PYR-1 IASDSAIVIPEEMIHYGVSKTALLALSRGFAKDASGTGVTVNSVIAGPTH
MAB_4665c|M.abscessus_ATCC_199 IASDSAIVIPQEMIHYGVSKTALLGVTRGFAKDAAGSGVTINSVIAGPTH
Mflv_0296|M.gilvum_PYR-GCK IGGGLALQPAADQPHYNATLAARHNLTVSLARELAGTGVTSNTVAPGAIL
TH_3893|M.thermoresistible__bu IASAAGIIPTSGQPDYGPSKAAMINMSMGLSKALAGTGITVNTVMPGMIM
MMAR_1568|M.marinum_M LSAHSIQRQNPRLVAYTASKAALSSVTKNLSKSLAKEGILVNCVCPGTIV
MAV_2438|M.avium_104 FAAHSIQRQNPRIVAYTASKAALASITKNLSKSLAAEGILVNCVCPGTIV
MLBr_02565|M.leprae_Br4923 LSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIE
MUL_1166|M.ulcerans_Agy99 LSSIAGIAGNRGQTNYGATKAGMIGIAQALAPSLAEKDITINAVAPGFIE
.. * : :. :: :: : : * : .*
Mb2788c|M.bovis_AF2122/97 TRLAEALWKDHEDP------------------LAATIALGRIGEPADIAS
Rv2766c|M.tuberculosis_H37Rv TRLAEALWKDHEDP------------------LAATIALGRIGEPADIAS
MSMEG_0600|M.smegmatis_MC2_155 TAGVEDFVYQLVDK---SLPWDEAQREFMRKHRPQS-LLQRLIEPEEIAN
Mvan_0398|M.vanbaalenii_PYR-1 TAGVEDFVYQLVDK---SLPWEQAQREFMRLHRPQS-LIERLIEPEEIAN
MAB_4665c|M.abscessus_ATCC_199 TAGVEDFVYQLVDK---SLPWDEAQREFMKRHRPQS-LVQRLIEPAEIAN
Mflv_0296|M.gilvum_PYR-GCK TEPVREMTYRVAAQRGWGPTWEDVEKAAATTWFPN--DIGRFGRPEEVAA
TH_3893|M.thermoresistible__bu TEGLRDFLRTFADHRGWG---DDLDKAADYILKGTGQTVHRIGQVSDVAY
MMAR_1568|M.marinum_M TASFTEQLKDLLAADGLDATNPYDVMAWIDKYFHQPCDLGRAGLPEEVAS
MAV_2438|M.avium_104 TASFTEALKGVLAADGLDATDPVDVMTWIDDNFHQPCDLGRAGLPEEVAS
MLBr_02565|M.leprae_Br4923 TQMTAAIPLATREVG------------------RRLNSLLQGGLPVDVAE
MUL_1166|M.ulcerans_Agy99 TKMTAAIPLATREVG------------------RRLNSLLQGGQPVDVAE
* : : ::*
Mb2788c|M.bovis_AF2122/97 AVAFLVSDAASWITGETMIIDGGLLLGNALGFRAAPSTEH
Rv2766c|M.tuberculosis_H37Rv AVAFLVSDAASWITGETMIIDGGLLLGNALGFRAAPSTEH
MSMEG_0600|M.smegmatis_MC2_155 MVAYLASPLASATTGGALRVDGGYVDAILP----------
Mvan_0398|M.vanbaalenii_PYR-1 MVTYLASPLASATTGGALRVDGGYVDAILP----------
MAB_4665c|M.abscessus_ATCC_199 LVVYLSSPLASATTGAAVRADGGYVDSILP----------
Mflv_0296|M.gilvum_PYR-GCK AVAFLAGVHAGYISGADLRVDGGAIRSVA-----------
TH_3893|M.thermoresistible__bu AVAFLASPRADFLNGINLHLDGGATQSIY-----------
MMAR_1568|M.marinum_M ITAYLVSRRNGYVTGATVNADGGSDFI-------------
MAV_2438|M.avium_104 ITVYLASRRNGYVTGAMVNVDGGSDFI-------------
MLBr_02565|M.leprae_Br4923 TIAYFAIPASNAVTGNVIRVCGQAMLGA------------
MUL_1166|M.ulcerans_Agy99 AIAYFASPASNAVTGNVIRVCGQAMIGA------------
.:: . .* : *