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MTQAQELSVDFDFRLDGKVALVTGAASGIGAAIASAYATKGARIAAVDLNAEGAEALAAQLGGDRGAHRG FACDVADAASVQAAADAVAAEFGRIDILVNSAGVARLAPAEELSLQDWDSTLAINLSGTFLMCQAVGKRM LEAGGGAIVNMASQAATVALDQHVAYCASKFGVVGVSKVLAAEWGGRGVRVNTISPTVVLTELGHKAWDG PRGDALKKLIPTGRFAYPDEIAAAAVFLASDAAAMINGADLVIDGGYTIK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3607 | - | - | 100% (260) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3262 | - | 1e-53 | 46.18% (249) | L-xylulose reductase |
| M. smegmatis MC2 155 | MSMEG_2206 | fabG | 2e-41 | 39.43% (246) | 3-ketoacyl-(acyl-carrier-protein) reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 2e-42 | 40.73% (248) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_1258 | - | 7e-40 | 36.78% (242) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1941 | - | 2e-42 | 40.73% (248) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 3e-30 | 40.44% (183) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4680c | - | 6e-37 | 39.18% (245) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4033 | fabG | 6e-38 | 36.59% (246) | 3-oxoacyl- |
| M. avium 104 | MAV_1395 | - | 3e-42 | 40.00% (245) | 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4254 | - | 2e-38 | 37.35% (249) | PUTATIVE putative 2,5-dichloro-2,5-cyclohexadiene-1,4-diol |
| M. ulcerans Agy99 | MUL_0478 | - | 1e-37 | 37.60% (250) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0894 | - | 1e-40 | 38.19% (254) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4680c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4254|M.thermoresistible__bu --------------------------------------------------
MMAR_4033|M.marinum_M --------------------------------------------------
Mvan_0894|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3607|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1258|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MAB_4680c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4254|M.thermoresistible__bu --------------------------------------------------
MMAR_4033|M.marinum_M --------------------------------------------------
Mvan_0894|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3607|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1258|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MAB_4680c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4254|M.thermoresistible__bu --------------------------------------------------
MMAR_4033|M.marinum_M --------------------------------------------------
Mvan_0894|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3607|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1258|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MAB_4680c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4254|M.thermoresistible__bu --------------------------------------------------
MMAR_4033|M.marinum_M --------------------------------------------------
Mvan_0894|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3607|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1258|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MAB_4680c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4254|M.thermoresistible__bu --------------------------------------------------
MMAR_4033|M.marinum_M --------------------------------------------------
Mvan_0894|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3607|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1258|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MAB_4680c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4254|M.thermoresistible__bu --------------------------------------------------
MMAR_4033|M.marinum_M --------------------------------------------------
Mvan_0894|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3607|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1258|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MAB_4680c|M.abscessus_ATCC_199 ------------------MNGNSALLQGKNVIVTGGARGLGAAFSRHIVS
TH_4254|M.thermoresistible__bu ------------------MTAGSTRLAGKVVLVTGAGGGLGTAIARRLAD
MMAR_4033|M.marinum_M ------------------MS--VSLLNGQIAVVTGGAQGLGLAIAERFVS
Mvan_0894|M.vanbaalenii_PYR-1 ----MTVDIAREQPATAPRPDQMFDLTGRTALVTGASSGLGVQFALALRS
MSMEG_3607|M.smegmatis_MC2_155 -----------MTQAQELSVDFDFRLDGKVALVTGAASGIGAAIASAYAT
Mflv_1258|M.gilvum_PYR-GCK -------------------------MVSRVAVVTGGASGLGEAICAGLAA
MAV_1395|M.avium_104 -----------------------------MAVVTGGGSGIGRAIVERLAH
MUL_0478|M.ulcerans_Agy99 ----------------------MGQFENKVAIVTGAAQGIGQAYADALAR
Mb1976|M.bovis_AF2122/97 --------------------MNHPDLAGKVAIVTGAGAGIGLAVARRLAD
Rv1941|M.tuberculosis_H37Rv --------------------MNHPDLAGKVAIVTGAGAGIGLAVARRLAD
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
. ***.. *:*
MAB_4680c|M.abscessus_ATCC_199 QGGRVVIADVLDGDGRQLAAELGDAARFTH---LDVTDAEQWRELIDTTL
TH_4254|M.thermoresistible__bu EGARLVLADLQESQCAALADELPAPAGAHHPLGFDVADETAWISAISTVS
MMAR_4033|M.marinum_M EGARVVLGDVNLEATEAAAKQLGGGEVAVAVR-CDVTKADEVETLLQTAL
Mvan_0894|M.vanbaalenii_PYR-1 AGAEVVVAARRADR----LAELCEAHEGLSAVSCDVADPASIESAYQCVE
MSMEG_3607|M.smegmatis_MC2_155 KGARIAAVDLNAEGAEALAAQLGGDRGAHRGFACDVADAASVQAAADAVA
Mflv_1258|M.gilvum_PYR-GCK DGHRVAVLDLDADAANRVAASLRGNGASAVGVAVDVSDEDAVVRAFDAVR
MAV_1395|M.avium_104 DGHRVAVLDVNEEAAEKVAARVAADGAHAIAVPTDVAESASVAAAFESVR
MUL_0478|M.ulcerans_Agy99 EGARVVVADINAEAAEKTAKQIVADGGTAIHVPVDVSDEESARAMADRTV
Mb1976|M.bovis_AF2122/97 EGCHVLCADIDGDAADAAATKIGCGAAACR---VDVSDEQQIIAMVDACV
Rv1941|M.tuberculosis_H37Rv EGCHVLCADIDGDAADAAATKIGCGAAACR---VDVSDEQQIIAMVDACV
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
* .: : **:. .
MAB_4680c|M.abscessus_ATCC_199 AGFGTITGLVNNAGISS---AAMVADEPLEHFRKVIEINLVGVFIGMQAV
TH_4254|M.thermoresistible__bu AQYGALHALVNNAAIGA---LGNVAEERLERWDRILDVGATGVWLGMKHA
MMAR_4033|M.marinum_M ERFGGLDIMVNNAGITR---DATMRKMTEEQFDQVIDVHLKGTWNGIRLA
Mvan_0894|M.vanbaalenii_PYR-1 ERVGAVDILVNNAGTSI---PARAEDESLTDFQYVLDVNLVGAFRLTQLV
MSMEG_3607|M.smegmatis_MC2_155 AEFGRIDILVNSAGVAR---LAPAEELSLQDWDSTLAINLSGTFLMCQAV
Mflv_1258|M.gilvum_PYR-GCK TEFGPVEILVTSAAIGG---FTRFDKITLDEWNRYLAVNLTGTFLSIRAA
MAV_1395|M.avium_104 RALGSVQVLVTSAAITG---FKPFAEITIEDWNRHLAVNLTGTFLCLQAA
MUL_0478|M.ulcerans_Agy99 SEFGGIDYLVNNAAIYGGMKLDLQLTVPLDYYKKFMSVNHDGVLVCTRAV
Mb1976|M.bovis_AF2122/97 AAFGGVDKLVANAGVVH---LASLIDTTVEDFDRVIAINLRGAWLCTKHA
Rv1941|M.tuberculosis_H37Rv AAFGGVDKLVANAGVVH---LASLIDTTVEDFDRVIAINLRGAWLCTKHA
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQ---AGRFLDTPPEEFDRVLAVNLGGVVNCCRAF
* :* .*. : : : *. :
MAB_4680c|M.abscessus_ATCC_199 IPAMRAHGCG-SIVNISSAAGLVG--LALTSGYGASKWGVRGLSKVAAIE
TH_4254|M.thermoresistible__bu VPLIRRSGGG-SVVNICSIFGTVGG-FGDSAAYHAAKGAVRTLTKNAALH
MMAR_4033|M.marinum_M AAIMRENKRG-AIVNMSSVSGKVGM-VGQTN-YSAAKAGIVGMTKAAAKE
Mvan_0894|M.vanbaalenii_PYR-1 GRKMIERGEG-SIVNVASILGMVAAAPNRQAAYCASKGGLINLTRELAVQ
MSMEG_3607|M.smegmatis_MC2_155 GKRMLEAGGG-AIVNMASQAATVA--LDQHVAYCASKFGVVGVSKVLAAE
Mflv_1258|M.gilvum_PYR-GCK LSDMVAAQWG-RVVTISSAAGQQGA--PRQGHYSATKGGVIAMTKTVARD
MAV_1395|M.avium_104 LPDMVEAGWG-RVVTISSTAAQTGS--PRQGHYSASKGGVIALTRTIALE
MUL_0478|M.ulcerans_Agy99 YKHMAKRGGG-AIVNQSSTAAWLYS-----NFYGLAKVGVNGLTQQLSRE
Mb1976|M.bovis_AF2122/97 APRMIERGGG-AIVNLSSLAGQVAV--GGTGAYGMSKAGIIQLSRITAAE
Rv1941|M.tuberculosis_H37Rv APRMIERGGG-AIVNLSSLAGQVAV--GGTGAYGMSKAGIIQLSRITAAE
MLBr_00862|M.leprae_Br4923 GQRLVERGTGGHIVNVSSMAAYAPL--QSLSAYCTSKAATYMFSDCLRAE
: * :*. .* . * :* . .: .
MAB_4680c|M.abscessus_ATCC_199 LGRERIRVNSVHPGVIYTPMT----AKEGFREGE-------GNMPIAAMG
TH_4254|M.thermoresistible__bu WAPDGVRVNSLHPGFIETPQLR--ELYKGTERYE-------RMLAGTPLG
MMAR_4033|M.marinum_M LAHVGVRVNAIAPGLIRSAMT----EAMPQRIWD-------QKLAEVPMG
Mvan_0894|M.vanbaalenii_PYR-1 WARYNVRVNALAPGFFPSELTT--ELLDDDAGGA-------YIRRNTPMA
MSMEG_3607|M.smegmatis_MC2_155 WGGRGVRVNTISPTVVLTELGH--KAWDGPR-GD-------ALKKLIPTG
Mflv_1258|M.gilvum_PYR-GCK YARHGITANSLPPFAIETPMLRRQQSEGKLPPDE-------FLTQAIPAG
MAV_1395|M.avium_104 YAAHGITANTVPPFSVDTPMLRAAQEAGNLPPVK-------YLAKASPVG
MUL_0478|M.ulcerans_Agy99 LGGMKIRINAIAPGPIDTEATR-TVTPGEFVKD---------MVKQIPLS
Mb1976|M.bovis_AF2122/97 LRSSGIRSNTLLPAFVDTPMQQTAMAMFDGALGAGG----ARSMIARLQG
Rv1941|M.tuberculosis_H37Rv LRSSGIRSNTLLPAFVDTPMQQTAMAMFDGALGAGG----ARSMIARLQG
MLBr_00862|M.leprae_Br4923 LDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLR
: .:: * . :
MAB_4680c|M.abscessus_ATCC_199 RVGNADEVAGAVAYLLSDAASYVTGAELAVDGGWTAGPTLTTITGQ----
TH_4254|M.thermoresistible__bu RLGRPDEIAAVVAFLVSDDASFITGSEVYADGGWTAR-------------
MMAR_4033|M.marinum_M RAGEPSEVASVALFLACDLSSYMTGTVLDVTGGRFI--------------
Mvan_0894|M.vanbaalenii_PYR-1 RAGRAGELSGALLLLASGAGSFITGQVIAVDGGWTAR-------------
MSMEG_3607|M.smegmatis_MC2_155 RFAYPDEIAAAAVFLASDAAAMINGADLVIDGGYTIK-------------
Mflv_1258|M.gilvum_PYR-GCK RVGAPSDVAAVCSFLCSDAAGYVTGQVIGVNGGAVL--------------
MAV_1395|M.avium_104 RLGTGEDIAAACAFLCSDEAGYITGQIIGVNGGEVI--------------
MUL_0478|M.ulcerans_Agy99 RMGTPEDLVGMCLFLLGDQASRITGQIFNVDGGQIIRS------------
Mb1976|M.bovis_AF2122/97 RMAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW-----------
Rv1941|M.tuberculosis_H37Rv RMAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW-----------
MLBr_00862|M.leprae_Br4923 RYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRV
* . : . . *
MAB_4680c|M.abscessus_ATCC_199 -
TH_4254|M.thermoresistible__bu -
MMAR_4033|M.marinum_M -
Mvan_0894|M.vanbaalenii_PYR-1 -
MSMEG_3607|M.smegmatis_MC2_155 -
Mflv_1258|M.gilvum_PYR-GCK -
MAV_1395|M.avium_104 -
MUL_0478|M.ulcerans_Agy99 -
Mb1976|M.bovis_AF2122/97 -
Rv1941|M.tuberculosis_H37Rv -
MLBr_00862|M.leprae_Br4923 I