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VGPKGSLRLVKRQPELLVAQHEHWQDTYRAHPVLYGTRPSEPGVYAAEVFNADGVQRVLELAAGHGRDTL YFAGQGFTVVATDFSDVAVAQLRRSAQARGVSARVQPIVHDLRQPLPVKTGSIDGAFAHMALCMALSTSE IHAVVAEVGRVLRPGGKFIYTVRHTGDAHYGAGQAHGDDIFECAGFAVHFFRRELVARLATGWVLEEVHD FEEGELPRRLWRVTVTKPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0333 | - | - | 100% (229) | hypothetical protein Mb0333 |
| M. bovis AF2122 / 97 | Mb3351c | - | 2e-05 | 41.56% (77) | methyltransferase |
| M. bovis AF2122 / 97 | Mb2446 | - | 3e-05 | 26.11% (226) | hypothetical protein Mb2446 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2895 | - | 3e-09 | 28.03% (157) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv0326 | - | 1e-84 | 100.00% (151) | hypothetical protein Rv0326 |
| M. leprae Br4923 | MLBr_02273 | ubiE | 6e-05 | 32.69% (104) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. abscessus ATCC 19977 | MAB_1977 | - | 6e-06 | 30.84% (107) | putative methyltransferase |
| M. marinum M | MMAR_3750 | - | 4e-08 | 26.42% (212) | hypothetical protein MMAR_3750 |
| M. avium 104 | MAV_2957 | - | 7e-10 | 34.51% (142) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4303 | - | 2e-07 | 26.43% (140) | methyltransferase |
| M. thermoresistible (build 8) | TH_1722 | - | 2e-05 | 26.15% (130) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3115 | - | 1e-07 | 32.17% (115) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_3615 | - | 7e-09 | 26.81% (138) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 MENKPWDSIIVGGGAAGLSAALVLGRARRRVLLVDAGEQSNLPAHGIGGL
MAV_2957|M.avium_104 --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0333|M.bovis_AF2122/97 --------------------------------------------------
Rv0326|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1977|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3750|M.marinum_M --------------------------------------------------
TH_1722|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 LGSDGRAPADLYAAGHAELAAYPSVQVRRGEVIAGRRGFALDLADGGHEH
MAV_2957|M.avium_104 --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0333|M.bovis_AF2122/97 --------------------------------------------------
Rv0326|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1977|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3750|M.marinum_M --------------------------------------------------
TH_1722|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ARTVLLAAGMDYLPPNIPGLGELWGRSVFHCPFCHGWEVRDAPLAVIARG
MAV_2957|M.avium_104 --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0333|M.bovis_AF2122/97 --------------------------------------------------
Rv0326|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1977|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3750|M.marinum_M --------------------------------------------------
TH_1722|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ERAVHSALLLRAWSDDIVVLTNGPDGLDDAQTEKLGAAGIPVNDASIARL
MAV_2957|M.avium_104 --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0333|M.bovis_AF2122/97 --------------------------------------------------
Rv0326|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1977|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3750|M.marinum_M --------------------------------------------------
TH_1722|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 VAHDGELVAVEFTDGTRLSRRGALVATTLHQRSPLAAQLGAIGAPTPLAG
MAV_2957|M.avium_104 --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0333|M.bovis_AF2122/97 --------------------------------------------------
Rv0326|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1977|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3750|M.marinum_M ---------------MPLSSVDSQQSLKNSMTRRFYSRSEVTGKITLPAV
TH_1722|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 DAVVVDTFGRTTVPGLFAAGDLTGNLPQVATAVAAGSQTAAAIVQHLLAE
MAV_2957|M.avium_104 --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0333|M.bovis_AF2122/97 ----------------------------------------------MGPK
Rv0326|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1977|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3750|M.marinum_M PAMIDEYVKMCDGMFADVGRKFSEEELAHLRSVLEGQLAQAYSASPRSSI
TH_1722|M.thermoresistible__bu --------------------------------------------------
MLBr_02273|M.leprae_Br4923 -------------------------------------------------M
Mflv_2895|M.gilvum_PYR-GCK -----------MT-DVKQHWEERYSQRDRIWSGHVNR-----------WL
Mvan_3615|M.vanbaalenii_PYR-1 -----------MTSEVKQHWEERYAERDRIWSGRVNR-----------WL
MSMEG_4303|M.smegmatis_MC2_155 DIGLPTPPWPTEGLSPAEYWERHYGEREQIWSGRVNP-----------QL
MAV_2957|M.avium_104 -----------MGEADRHRWDERYAANGPPPLSSVAPPGV--------FA
MUL_3115|M.ulcerans_Agy99 --------MARVAESDRRRWDRRYASLGPAAVSAVRPPAL--------LQ
Mb0333|M.bovis_AF2122/97 GSLRLVKRQPELLVAQHEHWQDTYRAHPVLYGTRPSEPGV--------YA
Rv0326|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1977|M.abscessus_ATCC_1997 ----------MDPAEHARHTRDVYDRLAPVWSATTDDGPFNGLLERPALR
MMAR_3750|M.marinum_M IISFNAPVGPTLNYEVNARWWTVEAAYENWIDTRKPPLFGTEPDARVWAL
TH_1722|M.thermoresistible__bu ---MATEDPGTGDPTDTIDWDSVYRQEAPGFDGPPPWNIGE---PQPELA
MLBr_02273|M.leprae_Br4923 PPGSVDVVSRAALDKDPRDVVAMFDDVAHRYDLTNTVLSLGQDRYWRRAT
Mflv_2895|M.gilvum_PYR-GCK AEVAAPLKPGRALDLGCGEGGDTLWLAEHGWEVVGVDISDTALRRAAEEA
Mvan_3615|M.vanbaalenii_PYR-1 AEVAASEKPGHALDLGCGEGGDTVWLAEHGWQVLGVDISDTALGRAAAEA
MSMEG_4303|M.smegmatis_MC2_155 EKVASDLPAGHALDLGCGEGGDAVWLAERGWRVTAVDISHTALSRAAAEA
MAV_2957|M.avium_104 RHADVFPAAGRALDLACGQGTAAVWLALRGLRVLGLDVSPVAIGQARDLA
MUL_3115|M.ulcerans_Agy99 AHLKLVPAAGRALDLGCGQGLGAVWLARRGLDVLGLDISPVAIAQARDLA
Mb0333|M.bovis_AF2122/97 AEVFNADGVQRVLELAAGHGRDTLYFAGQGFTVVATDFSDVAVAQLRRSA
Rv0326|M.tuberculosis_H37Rv --------------------------------MVATDFSDVAVAQLRRSA
MAB_1977|M.abscessus_ATCC_1997 SLIPRPLAGRSVLDAGCGSGAQCAWLLGEGADVTGLDLSPAMVDQARQRC
MMAR_3750|M.marinum_M ANEAADPSTHRVLEIGAGTGRNALALARRGHPVDVVELTPKFAEMIRADA
TH_1722|M.thermoresistible__bu ALHRAGAFRSDVLDAGCGHAEISMALAADGYTVVGIDLSPTAIAAANRTA
MLBr_02273|M.leprae_Br4923 RSALRIGPGQKVLDLAAGTAVSTAELSKSGAWCVAADFSVRMLATGGARK
:.:
Mflv_2895|M.gilvum_PYR-GCK DKRGLADRVQL-RQTDLSASFP------DGVFDLVSAQFLQSMV-HLDRE
Mvan_3615|M.vanbaalenii_PYR-1 ATRGLTDRVRF-VQMNLSEAFP------EGVFDLVSAQFLQSMV-HLDRE
MSMEG_4303|M.smegmatis_MC2_155 GRRGVADRITF-ERHDLSESFP------DGEFDLVSAQFLHSTV-RLERP
MAV_2957|M.avium_104 RRAGVGERCRF-DVADLDRGLP------VGPPADVIVCCKFRDR-RLDRA
MUL_3115|M.ulcerans_Agy99 ERSGVSARCRF-DVVDLDDGLP------DGPPVDLIVCHNFRDR-RLDAA
Mb0333|M.bovis_AF2122/97 QARGVSARVQP-IVHDLRQPLPVKTGSIDGAFAHMALCMALSTS-EIH--
Rv0326|M.tuberculosis_H37Rv QARGVSARVQP-IVHDLRQPLPVKTGSIDGAFAHMALCMALSTS-EIH--
MAB_1977|M.abscessus_ATCC_1997 G-----SAAKL-MVADLADDLP-----LEPRSFDGVTCSLALHY-LRDWQ
MMAR_3750|M.marinum_M EKEGLDVRVIVRDVFTTIADLR-----RDYQLIVLSEVVSDFRT-TQQLR
TH_1722|M.thermoresistible__bu QERGLATASFV--QGDITDFGG-----YDGRFNTIIDSTLFHSIPVQARD
MLBr_02273|M.leprae_Br4923 VPKVAADATQL--------PFS------DGVFDAVTISFGLRNI--ADYQ
Mflv_2895|M.gilvum_PYR-GCK RIFAAAARAVAPGG-VLIVVDHAAAPPWAPP-------EVHEHRFSTVDE
Mvan_3615|M.vanbaalenii_PYR-1 RIFAAAARAVAPGG-VLVIVDHGAAPSWAPE-------HIREHVFPGVEE
MSMEG_4303|M.smegmatis_MC2_155 RILSTAARAIRPGG-HLVIVDHGKMPPNATR-------VPHDHPFPSAEE
MAV_2957|M.avium_104 IVERLAPGGLLAIA-VLSEVGAGPGPFRAAP-------GELTAAFADLQP
MUL_3115|M.ulcerans_Agy99 IIERLAPGGLVALV-ALSEVGAAAGTYRAAP-------GELSTAFAELDP
Mb0333|M.bovis_AF2122/97 AVVAEVGRVLRPGGKFIYTVRHTGDAHYGAG-------QAHGDDIFECAG
Rv0326|M.tuberculosis_H37Rv AVVAEVGRVLRPGGKFIYTVRHTGDAHYGAG-------QAHGDDIFECAG
MAB_1977|M.abscessus_ATCC_1997 VPLASFARILRPGGWVVISLDHPFGAPLPDQRG-----GYFQHQLVSDTW
MMAR_3750|M.marinum_M ELFELAAQCLAPGARLVFNAFLACGGYTPDQAAREFGQQAYTTIFTRHEL
TH_1722|M.thermoresistible__bu GYLRSIHRAAAPGARYFALVFAKGAFPEEME-------QGPGPNPVDEDE
MLBr_02273|M.leprae_Br4923 AALREMARVTRPGGQLVVCEFSTPTNALVAN-----VYTEYLMRALPQVA
. .
Mflv_2895|M.gilvum_PYR-GCK VLATIDLGEGSWERLRADVVERDAIG---------PDGEAGVLRDNLIVV
Mvan_3615|M.vanbaalenii_PYR-1 VLATVDLGDGQWRRVRADRVERDATG---------PDGQQAVLIDNLIVL
MSMEG_4303|M.smegmatis_MC2_155 VLAGLDLPASEWERVRVEAVHREATG---------PDGQPMPMVDNVMVL
MAV_2957|M.avium_104 IAAGEADGQ-AWLLARASQSEPMVER---------R--------------
MUL_3115|M.ulcerans_Agy99 IAAGEGDGR-AWLLARA---------------------------------
Mb0333|M.bovis_AF2122/97 FAVHFFRRELVARLATGWVLEEVHDF---------EEGELPRRLWRVTVT
Rv0326|M.tuberculosis_H37Rv FAVHFFRRELVARLATGWVLEEVHDF---------EEGELPRRLWRVTVT
MAB_1977|M.abscessus_ATCC_1997 NKADVEVTQHFWRRPLGQVADAFADAGLLIERISEPRPSAEAIRRFPAEL
MMAR_3750|M.marinum_M SVAAAGLPVELIADDSVYDYEKAHLPADAWPPTSWYADWVSGLDVFPVAR
TH_1722|M.thermoresistible__bu LREAVSKYWEIDEIRPAFIHANMPPDVPGVESFDTDEKGRTKLPAFLLSA
MLBr_02273|M.leprae_Br4923 RLVSSNPDAYIYLAESIRAWPDQVTLACQLSRTGWASPRWRNLTGGIVAL
Mflv_2895|M.gilvum_PYR-GCK RRCA-----------------
Mvan_3615|M.vanbaalenii_PYR-1 RRL------------------
MSMEG_4303|M.smegmatis_MC2_155 RRTS-----------------
MAV_2957|M.avium_104 ---------------------
MUL_3115|M.ulcerans_Agy99 ---------------------
Mb0333|M.bovis_AF2122/97 KPA------------------
Rv0326|M.tuberculosis_H37Rv KPA------------------
MAB_1977|M.abscessus_ATCC_1997 RNVVDSPSFIVYRLRYWGAPA
MMAR_3750|M.marinum_M EMSPIELRWLVFRKTH-----
TH_1722|M.thermoresistible__bu HKA------------------
MLBr_02273|M.leprae_Br4923 HAADKPVR-------------