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ENKPWDSIIVGGGAAGLSAALVLGRARRRVLLVDAGEQSNLPAHGIGGLLGSDGRAPADLYAAGHAELAA YPSVQVRRGEVIAGRRGFALDLADGGHEHARTVLLAAGMDYLPPNIPGLGELWGRSVFHCPFCHGWEVRD APLAVIARGERAVHSALLLRAWSDDIVVLTNGPDGLDDAQTEKLGAAGIPVNDASIARLVAHDGELVAVE FTDGTRLSRRGALVATTLHQRSPLAAQLGAIGAPTPLAGDAVVVDTFGRTTVPGLFAAGDLTGNLPQVAT AVAAGSQTAAAIVQHLLAEDIGLPTPPWPTEGLSPAEYWERHYGEREQIWSGRVNPQLEKVASDLPAGHA LDLGCGEGGDAVWLAERGWRVTAVDISHTALSRAAAEAGRRGVADRITFERHDLSESFPDGEFDLVSAQF LHSTVRLERPRILSTAARAIRPGGHLVIVDHGKMPPNATRVPHDHPFPSAEEVLAGLDLPASEWERVRVE AVHREATGPDGQPMPMVDNVMVLRRTS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4303 | - | - | 100% (518) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_0670 | - | 1e-88 | 54.90% (306) | FAD dependent oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_4544 | - | 1e-13 | 39.81% (103) | methyltransferase small subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3944 | trxB2 | 3e-13 | 28.57% (315) | thioredoxin reductase TRXB2 |
| M. gilvum PYR-GCK | Mflv_2894 | - | 1e-97 | 60.00% (300) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv3913 | trxB2 | 1e-13 | 29.19% (322) | thioredoxin reductase TRXB2 |
| M. leprae Br4923 | MLBr_02703 | trx | 1e-12 | 30.12% (322) | bifunctional thioredoxin reductase/thioredoxin |
| M. abscessus ATCC 19977 | MAB_3177 | - | 1e-46 | 35.95% (306) | putative FAD-dependent pyridine nucleotide-disulphide |
| M. marinum M | MMAR_1902 | trxB2_2 | 7e-55 | 38.87% (301) | thioredoxin reductase TrxB2_2 |
| M. avium 104 | MAV_2216 | cheR | 2e-62 | 58.00% (200) | CheR methyltransferase SAM binding domain-containing protein |
| M. thermoresistible (build 8) | TH_1468 | - | 1e-102 | 59.55% (309) | methyltransferase |
| M. ulcerans Agy99 | MUL_5066 | trxB2 | 2e-13 | 30.31% (320) | thioredoxin reductase TrxB2 |
| M. vanbaalenii PYR-1 | Mvan_3616 | - | 1e-101 | 63.18% (296) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02703|M.leprae_Br4923 --------------------------------------------------
Mflv_2894|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1468|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 MENKPWDSIIVGGGAAGLSAALVLGRARRRVLLVDAGEQSNLPAHGIGGL
MAV_2216|M.avium_104 --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02703|M.leprae_Br4923 --------------------------------------------------
Mflv_2894|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1468|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 LGSDGRAPADLYAAGHAELAAYPSVQVRRGEVIAGRRGFALDLADGGHEH
MAV_2216|M.avium_104 --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02703|M.leprae_Br4923 --------------------------------------------------
Mflv_2894|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1468|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ARTVLLAAGMDYLPPNIPGLGELWGRSVFHCPFCHGWEVRDAPLAVIARG
MAV_2216|M.avium_104 --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02703|M.leprae_Br4923 --------------------------------------------------
Mflv_2894|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1468|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ERAVHSALLLRAWSDDIVVLTNGPDGLDDAQTEKLGAAGIPVNDASIARL
MAV_2216|M.avium_104 --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
Mb3944|M.bovis_AF2122/97 ----------------------------------------MTAPPVHDRA
Rv3913|M.tuberculosis_H37Rv ----------------------------------------MTAPPVHDRA
MUL_5066|M.ulcerans_Agy99 ----------------------------------------MTT---DSSA
MLBr_02703|M.leprae_Br4923 ----------------------------------------MNT---TPSA
Mflv_2894|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1468|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 VAHDGELVAVEFTDGTRLSRRGALVATTLHQRSPLAAQLGAIGAPTPLAG
MAV_2216|M.avium_104 --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 MNKLWDVAIIGGGAAGLSAAITLARSRRSTVVIDDHHP--RNAPADRVHN
MMAR_1902|M.marinum_M MTDPHDVVVIGSGPAGLSSALTLARARRSVLVIDGGQP--RNARSAGVHD
Mb3944|M.bovis_AF2122/97 HHPVRDVIVIGSGPAGYTAALYAARAQLAPLVFEGTSFGGALMTTTGVEN
Rv3913|M.tuberculosis_H37Rv HHPVRDVIVIGSGPAGYTAALYAARAQLAPLVFEGTSFGGALMTTTDVEN
MUL_5066|M.ulcerans_Agy99 DATIHDVIVIGSGPAGYTAALYTARAQLAPLVFEGTSFGGALMTTTEVEN
MLBr_02703|M.leprae_Br4923 HETIHEVIVIGSGPAGYTAALYAARAQLTPLVFEGTSFGGALMTTTEVEN
Mflv_2894|M.gilvum_PYR-GCK MEDIWDCVIVGGGAAGLSAALVLGRARRRTLLVDAGAQ--SNLAAHGIGG
Mvan_3616|M.vanbaalenii_PYR-1 MDKLWDCVIIGGGAAGLSAALVLGRARRRTLVVDAGAQ--SNLAATGIGG
TH_1468|M.thermoresistible__bu -VAMWDCIVIGGGAAGLSATLVLGRAKRQTLMIDAGRQ--SNLAARQVGG
MSMEG_4303|M.smegmatis_MC2_155 DAVVVDTFGRTTVPGLFAAGDLTGNLPQVATAVAAGSQTAAAIVQHLLAE
MAV_2216|M.avium_104 --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 YLG-RESTPPAELFGIGRDEAAQYGATFLDGR--ATAVSHAENHFDVSLD
MMAR_1902|M.marinum_M FLT-RDGCAPADLISAGHTEIAGYGGQLRQGQ--VVAAHRNGSMFEVSIT
Mb3944|M.bovis_AF2122/97 YPGFRNGITGPELMDEMREQALRFGADLRMED--VESVSLHGPLKSVVTA
Rv3913|M.tuberculosis_H37Rv YPGFRNGITGPELMDEMREQALRFGADLRMED--VESVSLHGPLKSVVTA
MUL_5066|M.ulcerans_Agy99 YPGFREGITGPELMDEMREQALRFGADLRMED--VQSVSLDGPIKSVVTS
MLBr_02703|M.leprae_Br4923 YPGFRNGITGPELMDDMREQALRFGAELRTED--VESVSLRGPIKSVVTA
Mflv_2894|M.gilvum_PYR-GCK LLG-FDGVPPAQLYAQGRRELTRYPDVAVCDG-DVTGAVAVEGGFTVELA
Mvan_3616|M.vanbaalenii_PYR-1 LLG-FDGVPPGQLYAQGRSQLAAYPSVEVRDG-EVVTGAASDGGFTLELA
TH_1468|M.thermoresistible__bu LLG-QDGRAPADFYAAGRAEVASYPGVVVRHGAEVVDGERTADGHRVTLA
MSMEG_4303|M.smegmatis_MC2_155 DIGLPTPPWPTEGLSPAEYWERHYGEREQIWS------GRVNPQLEKVAS
MAV_2216|M.avium_104 ---MDTSCEPGE---AGRFWEERYRGAERVWS------GRVNPRLAELAA
: . :
MAB_3177|M.abscessus_ATCC_1997 GGPALRARRVLVATGVEDELPDIEGLAERWGRDVLHCVYCHGWEVRDRTI
MMAR_1902|M.marinum_M DGSTIRARKLLIASGLVDHLPDITGLAELWGTDVLYCPYCHGWEVRDQPI
Mb3944|M.bovis_AF2122/97 DGQTHRARAVILAMGAAARYLQVPGEQELLGRGVSSCATCDGFFFRDQDI
Rv3913|M.tuberculosis_H37Rv DGQTHRARAVILAMGAAARYLQVPGEQELLGRGVSSCATCDGFFFRDQDI
MUL_5066|M.ulcerans_Agy99 DGETHRARAVILAMGAAARYLHVPGEQELLGRGVSSCATCDGFFFRDQDI
MLBr_02703|M.leprae_Br4923 EGQTYQARAVILAMGTSVRYLQIPGEQELLGRGVSACATCDGSFFRGQDI
Mflv_2894|M.gilvum_PYR-GCK GRSDVRTRRILLAMGMRYDMPALPGLAELWGDSVFHCPFCHGWEARDRPL
Mvan_3616|M.vanbaalenii_PYR-1 DGGVVQARRVLLAMGMRYEAPSLPGLAELWGRSVFHCPFCHGWEVRDRPL
TH_1468|M.thermoresistible__bu DGTSECARRLLLATGMQYRPPELPGVAELWGKTVFHCPFCDGWEMRDRPL
MSMEG_4303|M.smegmatis_MC2_155 DLPAGHALDLGCGEGGDAVWLAERG-WRVTAVDISHTALSR---------
MAV_2216|M.avium_104 DLPAGRALDLGCGEGADALWLAQRG-WTVLAVDISATALRR---------
: : . * * . :
MAB_3177|M.abscessus_ATCC_1997 AVLGTGPLAVHHALIFRQLSDNVTLLRHN-DFPMSIDEAAQLARR-NIRI
MMAR_1902|M.marinum_M GVLATGPESVHQALMFRQWSPRITLFLNG-AVDPSEPERARLHAR-QIEV
Mb3944|M.bovis_AF2122/97 AVIGGGDSAMEEATFLTRFARSVTLVHRRDEFRASKIMLDRARNNDKIRF
Rv3913|M.tuberculosis_H37Rv AVIGGGDSAMEEATFLTRFARSVTLVHRRDEFRASKIMLDRARNNDKIRF
MUL_5066|M.ulcerans_Agy99 AVIGGGDSAMEEATFLTRFARSVTLVHRRDEFRASKIMTNRAQANDKIRI
MLBr_02703|M.leprae_Br4923 AVIGGGDSAMEEALFLTRFARSVTLVHRRDEFRASKIMLGRARNNDKIKF
Mflv_2894|M.gilvum_PYR-GCK AVLADGDRGVHMATLLSGWSDDVVLLTSGPADLTDAQRDRLAEAG--IAI
Mvan_3616|M.vanbaalenii_PYR-1 AVLANGERATHMATLLRGWSDDVVLLTGGPAELTDTDRSRLADAG--AAV
TH_1468|M.thermoresistible__bu AVLARGEKALAESLMLRGWSDDVVLLTDGPSELDGPACERLNAAG--VRI
MSMEG_4303|M.smegmatis_MC2_155 AAAEAGRRGVADRITFERHDLSESFPDGEFDLVSAQFLHSTVRLE--RPR
MAV_2216|M.avium_104 AAEAAASRKLLARIDFQRHDLNESFPEGMFDLISAQYFHSPVHLD--RDA
.. . : :
MAB_3177|M.abscessus_ATCC_1997 IDGPVSRLHVTQDSLRGVQLETGATIACEALVVATVVSARVDMLAPV--Q
MMAR_1902|M.marinum_M IISPVTEVVSNDGRLEAVALADGNRVALAALALLPRMVANTDFLDPLGLR
Mb3944|M.bovis_AF2122/97 LTNHTVVAVDGDTTVTGLRVRDTNTGAETTLPVTGVFVAIGHEPRSGLVR
Rv3913|M.tuberculosis_H37Rv LTNHTVVAVDGDTTVTGLRVRDTNTGAETTLPVTGVFVAIGHEPRSGLVR
MUL_5066|M.ulcerans_Agy99 LTNKIVLAVDGETTVTGLQLRDTVTGEETTLPVTGVFVAIGHEPRSSLVR
MLBr_02703|M.leprae_Br4923 ITNHTVVAVNGYTTVTGLRLRNTTTGEETTLVVTGVFVAIGHEPRSSLVS
Mflv_2894|M.gilvum_PYR-GCK DERAVAELVSADGQLAQVVFADGSGIARSGLLIATTLHQRSSLAAELGVA
Mvan_3616|M.vanbaalenii_PYR-1 DERAVSHLVSAGGELAAVVFADGTSLGRRGLLVAVTLHQRSALAAKLGVS
TH_1468|M.thermoresistible__bu DQRPVARLIGADGQLSGIEFADGDRLDRCGLLAETTLHQRSDLADRLGAR
MSMEG_4303|M.smegmatis_MC2_155 ILSTAARAIRPGGHLVIVDHGKMPPNATRVPHD-HPFPSAEEVLAGLDLP
MAV_2216|M.avium_104 VLRRAATRVKPGGVLLIVDHGAAPP---WAQHDGHHFPGVEEVLGSLRLD
: : .
MAB_3177|M.abscessus_ATCC_1997 LAPQEMRLGEHLLGTYLPVTRGATAVPGIYAAGNVTD-IKAQVITSAAAG
MMAR_1902|M.marinum_M LVAHPSGFGENLQTD----GSGRTSVPGVYAAGNAAD-ISAHVVNSASSG
Mb3944|M.bovis_AF2122/97 EAIDVDPDGYVLVQG----RTTSTSLPGVFAAGDLVDRTYRQAVTAAGSG
Rv3913|M.tuberculosis_H37Rv EAIDVDPDGYVLVQG----RTTSTSLPGVFAAGDLVDRTYRQAVTAAGSG
MUL_5066|M.ulcerans_Agy99 DAVDVDPDGYVLVNG----RTTGTSLEGVFAAGDLVDRTYRQAVTAAGSG
MLBr_02703|M.leprae_Br4923 DVVDIDPDGYVLVKG----RTTSTSMDGVFAAGDLVDRTYRQAITAAGSG
Mflv_2894|M.gilvum_PYR-GCK FAAPSPVTAEAVDVD----AMYRTTVPGVFAAGDVSARMPQVAAAIAAGS
Mvan_3616|M.vanbaalenii_PYR-1 FAAPGPVSVEAIEID----ATHRTSVPGVFAAGDACVQMPQVAAAIAAGS
TH_1468|M.thermoresistible__bu SGESTPLAQHPIDVD----GMGRTAAPGVFAAGDVSAQVPQVAAAMSAGL
MSMEG_4303|M.smegmatis_MC2_155 ASEWERVRVEAVHRE----ATGPDGQPMPMVDNVMVLRRTS---------
MAV_2216|M.avium_104 PDGWTRLRAEAAGRE----MTGPNGEVGTLMDNIMMLRRTEQAYAAS---
.
MAB_3177|M.abscessus_ATCC_1997 TEVAVAINADLAVAD----------AQELQYA------------------
MMAR_1902|M.marinum_M LLAAMAINADLVDED----------TEQALLAV----------ADR----
Mb3944|M.bovis_AF2122/97 CAAAIDAERWLAEHA---------ATGEADSTD------ALIGAQR----
Rv3913|M.tuberculosis_H37Rv CAAAIDAERWLAEHA---------ATGEADSTD------ALIGAQR----
MUL_5066|M.ulcerans_Agy99 CAAAIDAERWLAEHE---------ATGDADSTD------TLIGAQQ----
MLBr_02703|M.leprae_Br4923 CAAAIDAERWLAEHAGSKANETTEETGDVDSTDTTDWSTAMTDAKNAGVT
Mflv_2894|M.gilvum_PYR-GCK GAAASVVASFLEEEK-----------------------------------
Mvan_3616|M.vanbaalenii_PYR-1 AAAASIVASFQEER------------------------------------
TH_1468|M.thermoresistible__bu IAATSTVQSLLAEDSGLPFPPWRDDAGE----------------------
MSMEG_4303|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02703|M.leprae_Br4923 IEVTDASFFADVLSSNKPVLVDFWATWCGPCKMVAPVLEEIASEQRNQLT
Mflv_2894|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1468|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02703|M.leprae_Br4923 VAKLDVDTNPEMAREFQVVSIPTMILFQGGQPVKRIVGAKGKAALLRDLS
Mflv_2894|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1468|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 -------
MMAR_1902|M.marinum_M -------
Mb3944|M.bovis_AF2122/97 -------
Rv3913|M.tuberculosis_H37Rv -------
MUL_5066|M.ulcerans_Agy99 -------
MLBr_02703|M.leprae_Br4923 DVVPNLN
Mflv_2894|M.gilvum_PYR-GCK -------
Mvan_3616|M.vanbaalenii_PYR-1 -------
TH_1468|M.thermoresistible__bu -------
MSMEG_4303|M.smegmatis_MC2_155 -------
MAV_2216|M.avium_104 -------