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GEADRHRWDERYAANGPPPLSSVAPPGVFARHADVFPAAGRALDLACGQGTAAVWLALRGLRVLGLDVSP VAIGQARDLARRAGVGERCRFDVADLDRGLPVGPPADVIVCCKFRDRRLDRAIVERLAPGGLLAIAVLSE VGAGPGPFRAAPGELTAAFADLQPIAAGEADGQAWLLARASQSEPMVERR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2957 | - | - | 100% (191) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. avium 104 | MAV_2216 | cheR | 1e-12 | 34.55% (191) | CheR methyltransferase SAM binding domain-containing protein |
| M. avium 104 | MAV_0119 | - | 7e-08 | 36.08% (97) | thiopurine S-methyltransferase (tpmt) superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0333 | - | 5e-10 | 34.51% (142) | hypothetical protein Mb0333 |
| M. gilvum PYR-GCK | Mflv_3243 | - | 3e-57 | 59.44% (180) | methyltransferase type 12 |
| M. tuberculosis H37Rv | Rv3322c | - | 2e-09 | 32.91% (158) | methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1977 | - | 6e-09 | 36.84% (114) | putative methyltransferase |
| M. marinum M | MMAR_2640 | - | 4e-69 | 68.51% (181) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_4544 | - | 2e-54 | 60.11% (183) | methyltransferase small subunit |
| M. thermoresistible (build 8) | TH_2727 | - | 9e-30 | 61.11% (108) | PUTATIVE thiopurine S-methyltransferase (tpmt) superfamily |
| M. ulcerans Agy99 | MUL_3115 | - | 1e-70 | 69.61% (181) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2956 | - | 8e-56 | 61.36% (176) | methyltransferase type 12 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2640|M.marinum_M MSRTAERADRLSIRYPVCSPTAQVRRSCRGRRMVARVAE-------SDRR
MUL_3115|M.ulcerans_Agy99 ---------------------------------MARVAE-------SDRR
MAV_2957|M.avium_104 ------------------------------------MGE-------ADRH
TH_2727|M.thermoresistible__bu --------------------------------------------------
Mflv_3243|M.gilvum_PYR-GCK ------------------------------------MAD-------ADRE
Mvan_2956|M.vanbaalenii_PYR-1 ------------------------------------MPATSYSRLMTDRG
MSMEG_4544|M.smegmatis_MC2_155 ------------------------------------MSE-------HDRA
Rv3322c|M.tuberculosis_H37Rv ----------------------------------MSVQTDPALREHPNRV
Mb0333|M.bovis_AF2122/97 ----------------------------MGPKGSLRLVKRQPELLVAQHE
MAB_1977|M.abscessus_ATCC_1997 -----------------------------------MDPAEHARHTRDVYD
MMAR_2640|M.marinum_M RWDRRYASL---GPAAVSAARPPALLQAHLKLVPTAGRALDLGCGQGLGA
MUL_3115|M.ulcerans_Agy99 RWDRRYASL---GPAAVSAVRPPALLQAHLKLVPAAGRALDLGCGQGLGA
MAV_2957|M.avium_104 RWDERYAAN---GPPPLSSVAPPGVFARHADVFPAAGRALDLACGQGTAA
TH_2727|M.thermoresistible__bu --------------------------------------------------
Mflv_3243|M.gilvum_PYR-GCK HWDRRYTAR---DRTLAGHAALPAVFASHSDLFPTAGYAIELACGTGAAA
Mvan_2956|M.vanbaalenii_PYR-1 HWDRRYTAR---GSLSVDDVALPARFTPFADVFPTGGRAVELACGAGAAS
MSMEG_4544|M.smegmatis_MC2_155 RWDAAYTDRPLGAGLPDGPAGPPRAFAGHVDEFPTAGSALDVACGSGENS
Rv3322c|M.tuberculosis_H37Rv DWNARYERAG----SAHAPFAPVPWLADVLRAGVPDGPVLELASGRSGTA
Mb0333|M.bovis_AF2122/97 HWQDTYRAHP---VLYGTRPSEPGVYAAEVFNADGVQRVLELAAGHGRDT
MAB_1977|M.abscessus_ATCC_1997 RLAPVWSATT--DDGPFNGLLERPALRSLIPRPLAGRSVLDAGCGSGAQC
MMAR_2640|M.marinum_M VWLARRGLDVLGLDISPVAIAQARDLAERSGVSARCCFDVVDLDDGLPD-
MUL_3115|M.ulcerans_Agy99 VWLARRGLDVLGLDISPVAIAQARDLAERSGVSARCRFDVVDLDDGLPD-
MAV_2957|M.avium_104 VWLALRGLRVLGLDVSPVAIGQARDLARRAGVGERCRFDVADLDRGLPV-
TH_2727|M.thermoresistible__bu -------MDVLGVDVSPIAIAQARALAAANGVSNRCRFEVFDLDDGLPA-
Mflv_3243|M.gilvum_PYR-GCK VWLARRGLRVWACDISPVAVAAATERARLDGQSERCTFEVVDLDHGIPG-
Mvan_2956|M.vanbaalenii_PYR-1 VWLAKRGLSVWACDASSVAIAQAEDLAERCGQAHRCRFEVVDLDAGLPA-
MSMEG_4544|M.smegmatis_MC2_155 VWLARRGLHVWGIDVSPVAITQATQFAARNGVAQRCRFDVVDLDDGLPD-
Rv3322c|M.tuberculosis_H37Rv LALAAHGRQVTAIDVSDVALLQLDSEAVRRGVADRLNLVQADLGCWEPG-
Mb0333|M.bovis_AF2122/97 LYFAGQGFTVVATDFSDVAVAQLRRSAQARGVSARVQPIVHDLRQPLPVK
MAB_1977|M.abscessus_ATCC_1997 AWLLGEGADVTGLDLSPAMVDQARQRCG-----SAAKLMVADLADDLPLE
* . * * : . ** *
MMAR_2640|M.marinum_M -----GPPVDVIVCHNFRDRRLDAAIIDR---LAPGGLVALVALS----E
MUL_3115|M.ulcerans_Agy99 -----GPPVDLIVCHNFRDRRLDAAIIER---LAPGGLVALVALS----E
MAV_2957|M.avium_104 -----GPPADVIVCCKFRDRRLDRAIVER---LAPGGLLAIAVLS----E
TH_2727|M.thermoresistible__bu -----GPPADVILCHLYRDPRLDRPIIER---LAPGGLLAITVLS----E
Mflv_3243|M.gilvum_PYR-GCK -----VGPADVVLCSMFRDPRLDAALVER---LAPGGLLAVSALS----E
Mvan_2956|M.vanbaalenii_PYR-1 -----GDPVDVLLCNMFRDPRLDGPIVDR---LAVGGVLAISALS----E
MSMEG_4544|M.smegmatis_MC2_155 -----GPPVDVVLCHRFRDPRLYEALRAR---LAPGGLLAICVLS----E
Rv3322c|M.tuberculosis_H37Rv -----ETRFALVLSRLFWDAAIFHRACEA---VMPGGVLAWESLALSGAE
Mb0333|M.bovis_AF2122/97 TGSIDGAFAHMALCMALSTSEIHAVVAEVGRVLRPGGKFIYTVRHTG--D
MAB_1977|M.abscessus_ATCC_1997 PRS-FDGVTCSLALHYLRDWQVPLASFAR--ILRPGGWVVISLDHPFGAP
: : ** .
MMAR_2640|M.marinum_M VGAAAGTYRAAPGE----------LSAAFAELDPIAAGEGDGRAWLLARA
MUL_3115|M.ulcerans_Agy99 VGAAAGTYRAAPGE----------LSTAFAELDPIAAGEGDGRAWLLARA
MAV_2957|M.avium_104 VGAGPGPFRAAPGE----------LTAAFADLQPIAAGEADGQAWLLARA
TH_2727|M.thermoresistible__bu VGVGPX-------------------SHTLAGPAPQAR----SRAWPVAGN
Mflv_3243|M.gilvum_PYR-GCK VGAAPGRFRAGPGE----------LLRAFGAVDVIEHGEADGQAWLLGRR
Mvan_2956|M.vanbaalenii_PYR-1 VGAAPGRFRARPGE----------LVAAFGSLELITHGEEAGQAWLLARR
MSMEG_4544|M.smegmatis_MC2_155 VGAEAGRFRAPAGE----------LRAHFGALQVIAENERDGEAWLLAR-
Rv3322c|M.tuberculosis_H37Rv AGTASAKRRVKPGEPACL------LPADFTVVHEGQGNCDSAPSRIMIAR
Mb0333|M.bovis_AF2122/97 AHYGAGQAHGDDIFECAG------FAVHFFRRELVAR---LATGWVLEEV
MAB_1977|M.abscessus_ATCC_1997 LPDQRGGYFQHQLVSDTWNKADVEVTQHFWRRPLGQVADAFADAGLLIER
: . . :
MMAR_2640|M.marinum_M ---------------------------------------
MUL_3115|M.ulcerans_Agy99 ---------------------------------------
MAV_2957|M.avium_104 SQSEPMVERR-----------------------------
TH_2727|M.thermoresistible__bu RSS------------------------------------
Mflv_3243|M.gilvum_PYR-GCK RGLPQRAPQAHRDPDDRPAHPDELL--------------
Mvan_2956|M.vanbaalenii_PYR-1 R--------------------------------------
MSMEG_4544|M.smegmatis_MC2_155 ---------------------------------------
Rv3322c|M.tuberculosis_H37Rv RSPLPGA--------------------------------
Mb0333|M.bovis_AF2122/97 HDFEEGELPRRLWRVTVTKPA------------------
MAB_1977|M.abscessus_ATCC_1997 ISEPRPSAEAIRRFPAELRNVVDSPSFIVYRLRYWGAPA