For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTDVKQHWEERYSQRDRIWSGHVNRWLAEVAAPLKPGRALDLGCGEGGDTLWLAEHGWEVVGVDISDTAL RRAAEEADKRGLADRVQLRQTDLSASFPDGVFDLVSAQFLQSMVHLDRERIFAAAARAVAPGGVLIVVDH AAAPPWAPPEVHEHRFSTVDEVLATIDLGEGSWERLRADVVERDAIGPDGEAGVLRDNLIVVRRCA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2895 | - | - | 100% (206) | methyltransferase type 11 |
| M. gilvum PYR-GCK | Mflv_3243 | - | 5e-13 | 35.25% (139) | methyltransferase type 12 |
| M. gilvum PYR-GCK | Mflv_1324 | - | 4e-09 | 34.00% (150) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3351c | - | 2e-13 | 38.81% (134) | methyltransferase |
| M. tuberculosis H37Rv | Rv3322c | - | 2e-13 | 38.81% (134) | methyltransferase |
| M. leprae Br4923 | MLBr_02334 | - | 1e-06 | 37.33% (75) | hypothetical protein MLBr_02334 |
| M. abscessus ATCC 19977 | MAB_3178 | - | 7e-33 | 49.28% (138) | hypothetical protein MAB_3178 |
| M. marinum M | MMAR_2640 | - | 1e-12 | 34.87% (152) | methyltransferase |
| M. avium 104 | MAV_2216 | cheR | 2e-60 | 55.84% (197) | CheR methyltransferase SAM binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4303 | - | 1e-62 | 56.28% (199) | methyltransferase |
| M. thermoresistible (build 8) | TH_0144 | - | 6e-61 | 59.36% (187) | methyltransferase |
| M. ulcerans Agy99 | MUL_3115 | - | 4e-14 | 32.62% (187) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_3615 | - | 7e-90 | 76.35% (203) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3351c|M.bovis_AF2122/97 --------------------------------------------------
Rv3322c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 MENKPWDSIIVGGGAAGLSAALVLGRARRRVLLVDAGEQSNLPAHGIGGL
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02334|M.leprae_Br4923 --------------------------------------------------
Mb3351c|M.bovis_AF2122/97 --------------------------------------------------
Rv3322c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 LGSDGRAPADLYAAGHAELAAYPSVQVRRGEVIAGRRGFALDLADGGHEH
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02334|M.leprae_Br4923 --------------------------------------------------
Mb3351c|M.bovis_AF2122/97 --------------------------------------------------
Rv3322c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ARTVLLAAGMDYLPPNIPGLGELWGRSVFHCPFCHGWEVRDAPLAVIARG
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02334|M.leprae_Br4923 --------------------------------------------------
Mb3351c|M.bovis_AF2122/97 --------------------------------------------------
Rv3322c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ERAVHSALLLRAWSDDIVVLTNGPDGLDDAQTEKLGAAGIPVNDASIARL
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02334|M.leprae_Br4923 ---------MAEILGILTATGQQPLKFTAYDGSTAGHDDAEIGLDLCSPR
Mb3351c|M.bovis_AF2122/97 --------------------------------------------------
Rv3322c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 VAHDGELVAVEFTDGTRLSRRGALVATTLHQRSPLAAQLGAIGAPTPLAG
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02334|M.leprae_Br4923 GATYLATAPGELGIARAYVAGDLQARGVHPGDPYTLLKTLTDRVQFKRPS
Mb3351c|M.bovis_AF2122/97 --------------------------------------------------
Rv3322c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2640|M.marinum_M -------------------------MSRTAERADRLSIRYPVCSPTAQVR
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 DAVVVDTFGRTTVPGLFAAGDLTGNLPQVATAVAAGSQTAAAIVQHLLAE
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02334|M.leprae_Br4923 LRVLASVVRSLGVEHLLPIAPPPQETPPRWRRITDGLLHSKTRDAEAIRH
Mb3351c|M.bovis_AF2122/97 --MSVQTDPALREHPNRVDWNARYERAG-SAHAPFAPVPWLADVLRAGVP
Rv3322c|M.tuberculosis_H37Rv --MSVQTDPALREHPNRVDWNARYERAG-SAHAPFAPVPWLADVLRAGVP
MMAR_2640|M.marinum_M RSCRGRRMVARVAESDRRRWDRRYASLGPAAVSAARPPALLQAHLKLVPT
MUL_3115|M.ulcerans_Agy99 --------MARVAESDRRRWDRRYASLGPAAVSAVRPPALLQAHLKLVPA
Mflv_2895|M.gilvum_PYR-GCK -----------MT-DVKQHWEERYSQRD--RIWSGHVNRWLAEVAAPLKP
Mvan_3615|M.vanbaalenii_PYR-1 -----------MTSEVKQHWEERYAERD--RIWSGRVNRWLAEVAASEKP
MAV_2216|M.avium_104 ------MDTSCEPGEAGRFWEERYRGAE--RVWSGRVNPRLAELAADLPA
TH_0144|M.thermoresistible__bu -------------------------------MWSGRVNARLAEVAGELPP
MSMEG_4303|M.smegmatis_MC2_155 DIGLPTPPWPTEGLSPAEYWERHYGERE--QIWSGRVNPQLEKVASDLPA
MAB_3178|M.abscessus_ATCC_1997 ------MHDHNNPPSDEKSWDEFYQSHD--ALWSGNANPQLVAEISSLPP
MLBr_02334|M.leprae_Br4923 HYDVSNRFYEWVLGPSMTYTCAVYPNAEATLEEAQENKYRLIFEKLRLQP
. * .
Mb3351c|M.bovis_AF2122/97 DGPVLELASGRSGTALALAAHGRQVTAIDVSDVALLQLDSEAVRR--GVA
Rv3322c|M.tuberculosis_H37Rv DGPVLELASGRSGTALALAAHGRQVTAIDVSDVALLQLDSEAVRR--GVA
MMAR_2640|M.marinum_M AGRALDLGCGQGLGAVWLARRGLDVLGLDISPVAIAQARDLAERS--GVS
MUL_3115|M.ulcerans_Agy99 AGRALDLGCGQGLGAVWLARRGLDVLGLDISPVAIAQARDLAERS--GVS
Mflv_2895|M.gilvum_PYR-GCK -GRALDLGCGEGGDTLWLAEHGWEVVGVDISDTALRRAAEEADKR--GLA
Mvan_3615|M.vanbaalenii_PYR-1 -GHALDLGCGEGGDTVWLAEHGWQVLGVDISDTALGRAAAEAATR--GLT
MAV_2216|M.avium_104 -GRALDLGCGEGADALWLAQRGWTVLAVDISATALRRAAEAAASR--KLL
TH_0144|M.thermoresistible__bu -GRALDVGCGEGADAMWLAERGWQVTAVDISQTALDRAAAEAASR--GLT
MSMEG_4303|M.smegmatis_MC2_155 -GHALDLGCGEGGDAVWLAERGWRVTAVDISHTALSRAAAEAGRR--GVA
MAB_3178|M.abscessus_ATCC_1997 -RTALDAGCGEGGDAIWLAQHGWQVTGMDFAHTALRRAADNAVKVDPELA
MLBr_02334|M.leprae_Br4923 GDRLLDVGCGWGGMVRYAARRGVRVIGATLSAEQAKWARKAIDNE--GLA
*: ..* . . * :* * . .: :
Mb3351c|M.bovis_AF2122/97 DRLNLVQADLGCWEPGETRFALVLSRLFW-------DAAIFHRACEAVMP
Rv3322c|M.tuberculosis_H37Rv DRLNLVQADLGCWEPGETRFALVLSRLFW-------DAAIFHRACEAVMP
MMAR_2640|M.marinum_M ARCCFDVVDLDDGLPDGPPVDVIVCHNFR-------DRRLDAAIIDRLAP
MUL_3115|M.ulcerans_Agy99 ARCRFDVVDLDDGLPDGPPVDLIVCHNFR-------DRRLDAAIIERLAP
Mflv_2895|M.gilvum_PYR-GCK DRVQLRQTDLSASFPDGV-FDLVSAQFLQSMVHLD-RERIFAAAARAVAP
Mvan_3615|M.vanbaalenii_PYR-1 DRVRFVQMNLSEAFPEGV-FDLVSAQFLQSMVHLD-RERIFAAAARAVAP
MAV_2216|M.avium_104 ARIDFQRHDLNESFPEGM-FDLISAQYFHSPVHLD-RDAVLRRAATRVKP
TH_0144|M.thermoresistible__bu --IDFQRHELPATFPDGQ-FELVSAHFLHSEVELD-RVRILRRAAEAVVP
MSMEG_4303|M.smegmatis_MC2_155 DRITFERHDLSESFPDGE-FDLVSAQFLHSTVRLE-RPRILSTAARAIRP
MAB_3178|M.abscessus_ATCC_1997 NRISWTQADLTAWQPNRQ-FDLVTSHFMHLPTNL--REPVFAALAAAVAP
MLBr_02334|M.leprae_Br4923 EIAQVRYSDYRDIR--ETEFDAVSSIGLTEHIGVKNYPAYFNFLKLKLRT
: . : . : : .
Mb3351c|M.bovis_AF2122/97 GGVLAWESLALSG-------------------------------------
Rv3322c|M.tuberculosis_H37Rv GGVLAWESLALSG-------------------------------------
MMAR_2640|M.marinum_M GGLVALVALSEVG-------------------------------------
MUL_3115|M.ulcerans_Agy99 GGLVALVALSEVG-------------------------------------
Mflv_2895|M.gilvum_PYR-GCK GGVLIVVDHAAAPPWAPPEVH--------------------------EHR
Mvan_3615|M.vanbaalenii_PYR-1 GGVLVIVDHGAAPSWAPEHIR--------------------------EHV
MAV_2216|M.avium_104 GGVLLIVDHGAAPPWAQHDGH--------------------------H--
TH_0144|M.thermoresistible__bu GGLLLIVDHGAPPPWAPDHVH--------------------------EFE
MSMEG_4303|M.smegmatis_MC2_155 GGHLVIVDHGKMPPNATRVPH--------------------------DHP
MAB_3178|M.abscessus_ATCC_1997 GGTLLIVGHHPSDMQAAIGRP--------------------------DLP
MLBr_02334|M.leprae_Br4923 GGLLLNHCITRRDNKSTSFAGGFTDRYVFPDGELTGSGRITTEIQEVGLE
** :
Mb3351c|M.bovis_AF2122/97 -AEAGTASAKRRVKPGEPACLLPADFTVVHEGQGNCDSAPSRIMIARRSP
Rv3322c|M.tuberculosis_H37Rv -AEAGTASAKRRVKPGEPACLLPADFTVVHEGQGNCDSAPSRIMIARRSP
MMAR_2640|M.marinum_M -AAAGTY----RAAPGELSAAF-AELDPIAAGEG-----DGRAWLLARA-
MUL_3115|M.ulcerans_Agy99 -AAAGTY----RAAPGELSTAF-AELDPIAAGEG-----DGRAWLLARA-
Mflv_2895|M.gilvum_PYR-GCK FSTVDEVLATIDLGEGSWERLRADVVERDAIGPDGEAGVLRDNLIVVRRC
Mvan_3615|M.vanbaalenii_PYR-1 FPGVEEVLATVDLGDGQWRRVRADRVERDATGPDGQQAVLIDNLIVLRRL
MAV_2216|M.avium_104 FPGVEEVLGSLRLDPDGWTRLRAEAAGREMTGPNGEVGTLMDNIMMLRRT
TH_0144|M.thermoresistible__bu FPSAQEVVESLQLPEGQWELLRAEPVKRDAVGPDGQQGTLIDNVIMLRRR
MSMEG_4303|M.smegmatis_MC2_155 FPSAEEVLAGLDLPASEWERVRVEAVHREATGPDGQPMPMVDNVMVLRRT
MAB_3178|M.abscessus_ATCC_1997 DWYFTAEDIADTLNPKEWTIIVAESRSRKFTR-DDEEFDIADTVLRAERK
MLBr_02334|M.leprae_Br4923 VLHEENFRHHYAMTLRDWCHNLVEHWEDAVAEVGLPIAKVWGLYMAASRV
. :
Mb3351c|M.bovis_AF2122/97 LPGA-----------------------------
Rv3322c|M.tuberculosis_H37Rv LPGA-----------------------------
MMAR_2640|M.marinum_M ---------------------------------
MUL_3115|M.ulcerans_Agy99 ---------------------------------
Mflv_2895|M.gilvum_PYR-GCK A--------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 ---------------------------------
MAV_2216|M.avium_104 EQAYAAS--------------------------
TH_0144|M.thermoresistible__bu ---------------------------------
MSMEG_4303|M.smegmatis_MC2_155 S--------------------------------
MAB_3178|M.abscessus_ATCC_1997 PTTESA---------------------------
MLBr_02334|M.leprae_Br4923 AFEQNNLQLHHILATKVDVWGDNSLPTRPWWTP