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SFDFTGTAALITGGTSGIGHGIAMLFRDAGAQVTVTGTKPGSADYDTDLSGMTYRQLQLTDPDSIAQLTQ HFDRLDVLVNNAGANFSGGLDESKPDGFDASVQLNLTGPYRLTMGLYRSLKASTAVGGASVVNMASMSAL RAVTLVPGYGAAKAGIICVTRNLAVKWAAKGIRVNAVAPGTIDTPMTAPMHLATELVDAELAHIPVRRFG SVGDIAPTVAFLCTEHSSYTNGAVFVVDGASDCV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4361 | - | - | 100% (245) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_4820 | - | 4e-28 | 33.47% (239) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_4111 | - | 2e-27 | 31.98% (247) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3579c | - | 2e-27 | 31.17% (247) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1783 | - | 7e-28 | 33.87% (248) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3549c | - | 2e-27 | 31.17% (247) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 7e-25 | 34.03% (238) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0607 | - | 8e-28 | 34.30% (242) | short chain dehydrogenase |
| M. marinum M | MMAR_5288 | - | 1e-138 | 99.59% (245) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_4175 | - | 9e-64 | 51.65% (242) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_6753 | - | 3e-29 | 33.61% (244) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_2488 | - | 7e-33 | 38.93% (244) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4967 | - | 6e-30 | 33.90% (236) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4361|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5288|M.marinum_M --------------------------------------------------
MAV_4175|M.avium_104 --------------------------------------------------
MSMEG_6753|M.smegmatis_MC2_155 --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
Mb3579c|M.bovis_AF2122/97 --------------------------------------------------
Rv3549c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0607|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4361|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5288|M.marinum_M --------------------------------------------------
MAV_4175|M.avium_104 --------------------------------------------------
MSMEG_6753|M.smegmatis_MC2_155 --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
Mb3579c|M.bovis_AF2122/97 --------------------------------------------------
Rv3549c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0607|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4361|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5288|M.marinum_M --------------------------------------------------
MAV_4175|M.avium_104 --------------------------------------------------
MSMEG_6753|M.smegmatis_MC2_155 --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
Mb3579c|M.bovis_AF2122/97 --------------------------------------------------
Rv3549c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0607|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4361|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5288|M.marinum_M --------------------------------------------------
MAV_4175|M.avium_104 --------------------------------------------------
MSMEG_6753|M.smegmatis_MC2_155 --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
Mb3579c|M.bovis_AF2122/97 -----------------------------------------------MTL
Rv3549c|M.tuberculosis_H37Rv -----------------------------------------------MTL
MAB_0607|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mflv_1783|M.gilvum_PYR-GCK ---------MQTAQVAIVTGASSGIGFGCATALADRGMVVLGTGRDAGRL
Mvan_4967|M.vanbaalenii_PYR-1 ------------MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDPGRL
MUL_4361|M.ulcerans_Agy99 ------MSFDFTGTAALITGGTSGIGHGIAMLFRDAGAQVTVTGTKPGSA
MMAR_5288|M.marinum_M --MTARVSFDFTGTAALITGGTSGIGHGIAMLFRDAGAQVTVTGTKPGSA
MAV_4175|M.avium_104 ---MNTVHFDFTDAQVLVTGGTSGIGNAIATAFADSGATVTVTGTRAAAT
MSMEG_6753|M.smegmatis_MC2_155 --------MELEGLTALVTGGTSGIGLESARLMAAEGADVVITGRDAQRG
TH_2488|M.thermoresistible__bu --------MEFQGLHVLVTGGTGGIGLACARAFAEAGAEVTVTGRDAGRG
Mb3579c|M.bovis_AF2122/97 AEAADAINFGLAGRVVLVTGGVRGVGAGISSVFAEQGATVITCARRAVDG
Rv3549c|M.tuberculosis_H37Rv AEAADAINFGLAGRVVLVTGGVRGVGAGISSVFAEQGATVITCARRAVDG
MAB_0607|M.abscessus_ATCC_1997 --MRTPYDLGLEGRVVLVTGGVRGVGAGISQVFADQGATVVTCARRPGD-
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
.::**. *:* : . * * .
Mflv_1783|M.gilvum_PYR-GCK AELEKAAPEPGRIATLAVDLTDDDAPQRIVSAALDRWGR-IDFLVNNAGI
Mvan_4967|M.vanbaalenii_PYR-1 AALEKSS---DRIATLAVDLTDDDAPQRIVSAALERWGR-IDFLVNNAGI
MUL_4361|M.ulcerans_Agy99 DY----DTDLSGMTYRQLQLTDPDSIAQLT----QHFDR-LDVLVNNAGA
MMAR_5288|M.marinum_M DY----DTDLSGMTYRQLQLTDPDSIAQLT----QHFDR-LDVLVNNAGA
MAV_4175|M.avium_104 DYP---DTDLGAFSYRQCHIQDPESVDALA----NSLSG-LDILVNNAGG
MSMEG_6753|M.smegmatis_MC2_155 EQA--AADIGHGARFVQADLGDLDSVADLA----AQAPD-VDILVNNAGI
TH_2488|M.thermoresistible__bu -AA--AAGAHPRLRFIRGDLADLASVQNLI----RYADA-VDVLVNNAAS
Mb3579c|M.bovis_AF2122/97 ----------QPYEFHRCDIRDEDSVKRLVGEIGERHGR-LDMLVNNAGG
Rv3549c|M.tuberculosis_H37Rv ----------QPYEFHRCDIRDEDSVKRLVGEIGERHGR-LDMLVNNAGG
MAB_0607|M.abscessus_ATCC_1997 ----------APYEFHSCDVRDEESVDTLIGAIVAAHGR-LDAVVNNAGG
MLBr_02565|M.leprae_Br4923 ALD--ETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGI
.: : : * :****.
Mflv_1783|M.gilvum_PYR-GCK GSPKPLHETDDETLDHFLGVMLRAPFRLARDVIVHMQPGS-----AIINV
Mvan_4967|M.vanbaalenii_PYR-1 GSPKPLHETDDETLDRFLDIMLRAPFRLARDVIVHMQPGS-----AIINI
MUL_4361|M.ulcerans_Agy99 NFSGGLDESKPDGFDASVQLNLTGPYRLTMGLYRSLKASTAVGGASVVNM
MMAR_5288|M.marinum_M NFPGGLDESKPDGFDASVQLNLTGPYRLTMGLYRSLKASTAVGGASVVNM
MAV_4175|M.avium_104 PYPAG-DEYDPDGYVASVAQNMFGPMRLTMRCHDLLKSSRAAGGASVVNV
MSMEG_6753|M.smegmatis_MC2_155 YPQASTFDQDVAGFQQLFDTNVRGTYFLVAAAAKGMVAR---GHGSIVNI
TH_2488|M.thermoresistible__bu FPGALTVEQDAESFTRTFATNVTGTYFLTAGLIPGMLAR---GRGSIVNI
Mb3579c|M.bovis_AF2122/97 SPYALAAEATHNFHRKIVELNVLAPLLVSQHANVLMQAQP--NGGSIVNI
Rv3549c|M.tuberculosis_H37Rv SPYALAAEATHNFHRKIVELNVLAPLLVSQHANVLMQAQP--NGGSIVNI
MAB_0607|M.abscessus_ATCC_1997 APFALAADASHNFHRKIIELNLLSALLVSQRANAVMQKQD--GGGTIVNI
MLBr_02565|M.leprae_Br4923 TRDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISK---GGRVIVL
: . : .. : :: :
Mflv_1783|M.gilvum_PYR-GCK TSTFAVVGGLRGGAYSAAKGGLTALTSHIACQYGAQGIRCNAVAPGVTLT
Mvan_4967|M.vanbaalenii_PYR-1 TSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPGVTLT
MUL_4361|M.ulcerans_Agy99 ASMSALRAVTLVPGYGAAKAGIICVTRNLAVKWAAKGIRVNAVAPGTIDT
MMAR_5288|M.marinum_M ASMSALRAVTLVPGYGAAKAGIICVTRNLAVKWAAKGIRVNAVAPGTIDT
MAV_4175|M.avium_104 VSMSAFRSAVFVPGYASSKMGLVALTMNLSRRWAGDGIRVNAIAPGLIDT
MSMEG_6753|M.smegmatis_MC2_155 TTLAAHKGFPGTSVYGATKAALESLTRTWAAEFGANGVRVNSVSPGPTRT
TH_2488|M.thermoresistible__bu TSMVATKAVPGASVYSSSKAAVESLTRSWAVEFAAHGIRVNAVAPGPTST
Mb3579c|M.bovis_AF2122/97 CSVSGRRPTPGTAAYGAAKAGLENLTTTLAVEWAPK-VRVNAVVVGMVET
Rv3549c|M.tuberculosis_H37Rv CSVSGRRPTPGTAAYGAAKAGLENLTTTLAVEWAPK-VRVNAVVVGMVET
MAB_0607|M.abscessus_ATCC_1997 TSVSAGRPSPGTAAYGAAKAGLESLTRSLAVEWAPK-VRVNALAAGMIRT
MLBr_02565|M.leprae_Br4923 SSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIET
: . *.::* .: :* : . . : *:: * *
Mflv_1783|M.gilvum_PYR-GCK PMVATRLEDERFRKINT-EMTPHQRLGRVEDIASTVAFLCSDGGEFINGQ
Mvan_4967|M.vanbaalenii_PYR-1 PMVASRLEDERFRKINT-EMTPHQRLGRVEDVASTVAFLCSEGGSFINGQ
MUL_4361|M.ulcerans_Agy99 PMTAPMHLATELVDAEL-AHIPVRRFGSVGDIAPTVAFLCTEHSSYTNGA
MMAR_5288|M.marinum_M PMTAPMHLATELVDAEL-AHIPVRRFGSVGDIAPTVAFLCTEHSSYTNGA
MAV_4175|M.avium_104 RMTHPAMGIPEVMDVEIGFHTPLGRPGTPADCAGATLFLCTEAASYITGS
MSMEG_6753|M.smegmatis_MC2_155 PTTLEQLG--DFIDDVA-AGLPLRRTAAPEEIAQAVLFLASPRASFVTGS
TH_2488|M.thermoresistible__bu DGVATEWG--ETNEALG-RALPIGRTADPDEIAQAVVFLASSRASFITGA
Mb3579c|M.bovis_AF2122/97 ERSELFYGDAESIARVA-ATVPLGRLARPADIGWAAAFLASDAASYISGA
Rv3549c|M.tuberculosis_H37Rv ERSELFYGDAESIARVA-ATVPLGRLARPADIGWAAAFLASDAASYISGA
MAB_0607|M.abscessus_ATCC_1997 ELSEMHYGDEDGIAAVG-ATVPLGRLANPDEIGWTAAFLASPLSSYVTGS
MLBr_02565|M.leprae_Br4923 QMTAAIPLATREVGRRL---NSLLQGGLPVDVAETIAYFAIPASNAVTGN
. : . : . : ::. .. .*
Mflv_1783|M.gilvum_PYR-GCK TIVVDGGWSSTKYLSDFALNSEWVARQGTS
Mvan_4967|M.vanbaalenii_PYR-1 TIVVDGGWSTTKYLSDFALNAHWVER----
MUL_4361|M.ulcerans_Agy99 VFVVDGASDCV-------------------
MMAR_5288|M.marinum_M VFVVDGASDCV-------------------
MAV_4175|M.avium_104 TIAVDGGYLTV-------------------
MSMEG_6753|M.smegmatis_MC2_155 TLYVDGGGYAV-------------------
TH_2488|M.thermoresistible__bu VLHVDGGGIAV-------------------
Mb3579c|M.bovis_AF2122/97 TLEVHGGGEPPPYLGASSANK---------
Rv3549c|M.tuberculosis_H37Rv TLEVHGGGEPPPYLGASSANK---------
MAB_0607|M.abscessus_ATCC_1997 VLTVHGGGERPAFLDAANVNSNENGEKE--
MLBr_02565|M.leprae_Br4923 VIRVCGQAMLGA------------------
.: * *