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VLATDFGALPPEVNSGLLYAGPGAAPMLTAATAWDGLATVLNSAAASYASVVSGLTLESRMGPASASMAA AAAPYATWLAVANEQARQTAAQARAAATAFETAFAVVVPPPLIAANRSQVASLVVANVLGQNTPAIETLQ AEYAEMWAQDAAVMYQYSAASEAASTLAAFTSPVQSTDPSRAQASTAAGAAAAGTTAQTTASQPTTAATD TAQGLAAEVPTIPAGSDLAAPAAISIPTPVGELDLLAAYIAVAATASLSLSAVNTARPWSYSTNNDHAQP NGGGVAPTQGNTLGTERPDAEVLVSAPNVVPTSAFVGHAALVGALSVPHSWAMAAPEIRLAVESLPSAGG LSAPAGPDMGGVAPTGLLSGMALASLAGRGATGAGSRSPSESATNEDEQPQRKPTVVVIQKPPPAGGPPA ARP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4463 | - | - | 100% (423) | PPE family protein |
| M. ulcerans Agy99 | MUL_3072 | - | 6e-71 | 41.42% (408) | PPE family protein |
| M. ulcerans Agy99 | MUL_4621 | - | 2e-66 | 40.89% (384) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0939c | PPE14 | 1e-109 | 53.02% (430) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-27 | 39.32% (206) | PPE protein |
| M. tuberculosis H37Rv | Rv0915c | PPE14 | 1e-109 | 53.02% (430) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-41 | 30.99% (413) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 3e-26 | 28.64% (412) | PPE family protein |
| M. marinum M | MMAR_4612 | - | 0.0 | 97.87% (422) | PPE family protein |
| M. avium 104 | MAV_2906 | - | 3e-73 | 42.36% (399) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-28 | 28.17% (426) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 3e-28 | 36.84% (209) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 8e-29 | 38.12% (202) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
MUL_4463|M.ulcerans_Agy99 ----------MLATDFGALPPEVNSGLLYAGPGAAPMLTAATAWDGLATV
MMAR_4612|M.marinum_M -----------MATDFGALPPEVNSGLLYTGPGAAPMLTAATAWDGLATV
Mb0939c|M.bovis_AF2122/97 -------------MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAE
Rv0915c|M.tuberculosis_H37Rv -------------MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAE
MAV_2906|M.avium_104 -------------MDFGALPPEVNSGRMYGGAGSGPLLAAAAAWDALGAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: .**.:* : *.*. .:*:*. * :.
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
MUL_4463|M.ulcerans_Agy99 LNSAAASYASVVSGLTLESRMGPASASMAAAAAPYATWLAVANEQARQTA
MMAR_4612|M.marinum_M LNSAAASYASVVSGLTLESWMGPASASMAAAAAPYATWLAVANEQARQTA
Mb0939c|M.bovis_AF2122/97 LTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETA
Rv0915c|M.tuberculosis_H37Rv LTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETA
MAV_2906|M.avium_104 LYSFAAAYTSTIAGLTVGSWLGPAATSMSAAAAPFIAWATTTAGQAEQVA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
: * : : . * :: :*: * . *
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
MUL_4463|M.ulcerans_Agy99 AQARAAATAFETAFAVVVPPPLIAANRSQVASLVVANVLGQNTPAIETLQ
MMAR_4612|M.marinum_M AQARAAATAFETAFAVVVPPPLIAANRSQVASLVVANVLGQNTPAIETLQ
Mb0939c|M.bovis_AF2122/97 TQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQ
Rv0915c|M.tuberculosis_H37Rv TQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQ
MAV_2906|M.avium_104 TQARLAAAAYETAFAATVPPPVIAANRSLLMTLIATNILGQNTAAIAAAE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: ** *: **:: . : *:: *: :*.:* *: .* :
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQA-VSGAAVAAAPVSAPAPFLLKPGVGEAGSAS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQA-VAGTAVMSAPASSPAPLLLAPGVSEAADAM
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQS-VSGAALAATPTSAPAPSVLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQA-VSGAALAATPTATPAPFVLAPGVGEAGRAA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQT-ASEVALASAPPSTPPPSILHD---------
MUL_4463|M.ulcerans_Agy99 AEYAEMWAQDAAVMYQYSA-ASEAASTLAAFTSPVQSTDPSR--------
MMAR_4612|M.marinum_M AEYAEMWAQDAAVMYQYSA-ASEAASTLAAFTSPMQSTDPSG--------
Mb0939c|M.bovis_AF2122/97 AEYAEMWAQDAAVMYSYEG-ASAAASALPPFTPPVQGTGPAGPA------
Rv0915c|M.tuberculosis_H37Rv AEYAEMWAQDAAVMYSYEG-ASAAASALPPFTPPVQGTGPAGPA------
MAV_2906|M.avium_104 AEYAEMWAQDAAAMYAYAA-ASAAAAELTPFTEPPRTTESSA--------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVG--------
*:*..** * *: * * . .. . : *
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDP
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDP
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDP
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDP
MAB_0809c|M.abscessus_ATCC_199 ---HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAGEM
MUL_4463|M.ulcerans_Agy99 -----AQASTAAGAAAAGTTAQTTASQPTTAATDTAQGLAAEVPTIPAG-
MMAR_4612|M.marinum_M -----AQASTAAGAAAAGTTAQTTASQPTTTATDTAQGLAAEVPTIPTG-
Mb0939c|M.bovis_AF2122/97 ---AAAAATQAAGAGAVADAQATLAQLPPGILSDILSALAANADPLTSGL
Rv0915c|M.tuberculosis_H37Rv ---AAAAATQAAGAGAVADAQATLAQLPPGILSDILSALAANADPLTSGL
MAV_2906|M.avium_104 -----AARQSAAVAQSAASDLPAQLSTLIDVTPTMLQGLATTPSAAAAT-
MLBr_01182|M.leprae_Br4923 -LAQEVVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQV
MSMEG_0619|M.smegmatis_MC2_155 LGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASP
TH_3569|M.thermoresistible__bu IGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASP
Mflv_0325|M.gilvum_PYR-GCK IGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLP
Mvan_0415|M.vanbaalenii_PYR-1 LGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLP
MAB_0809c|M.abscessus_ATCC_199 VEHFELLLNNLLTDPAALLTNLPMVLADVAFHAAQLASTIGQFAPALIQP
MUL_4463|M.ulcerans_Agy99 --------SDLAAPAAISIPTPVGELDLLAAYIAVAATASLSLSAVNTAR
MMAR_4612|M.marinum_M --------SDLAAPAAISIPTPVGELDLLAAYIAVAATASLSLSAVNTAR
Mb0939c|M.bovis_AF2122/97 LGIASTLNPQVGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTAR
Rv0915c|M.tuberculosis_H37Rv LGIASTLNPQVGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTAR
MAV_2906|M.avium_104 -----------PAASIIEAIYPI-TAALRPFFAAVTGAYSPIGAIILPGG
MLBr_01182|M.leprae_Br4923 NVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAG
MSMEG_0619|M.smegmatis_MC2_155 FLIPALAAL----GITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQ
TH_3569|M.thermoresistible__bu VLIPLAITL----GVAGLVMIADQAQP-----PAEEAAPEEDVAAP----
Mflv_0325|M.gilvum_PYR-GCK LLATTLAIV----AGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LVATTLAIV----LGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQP
MAB_0809c|M.abscessus_ATCC_199 ALALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMAASAGTALAP
MUL_4463|M.ulcerans_Agy99 PWSYSTNNDHAQPNGGGVAPTQG--NTLGTERPDAEVLVSAPN-VVPTSA
MMAR_4612|M.marinum_M PWSYSTNNDHAQPNGGGVAPTQG--NTLGTERPDAEVLVSAPN-IVPTSA
Mb0939c|M.bovis_AF2122/97 PWHIGLYG-----NAGGLGPTQG--HPLSSATDEPEPHWGPFGGAAPVSA
Rv0915c|M.tuberculosis_H37Rv PWHIGLYG-----NAGGLGPTQG--HPLSSATDEPEPHWGPFGGAAPVSA
MAV_2906|M.avium_104 WWLLSLQALGLAQNAPGVAELLGGGKAIAGGLSPLAPLRGGYVSAVTPDA
MLBr_01182|M.leprae_Br4923 LSLVNGMGS----AMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSG
.
MSMEG_0619|M.smegmatis_MC2_155 PLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDP
TH_3569|M.thermoresistible__bu ---------------VRAEPQNPLPLTXXX--------------------
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDP
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDP
MAB_0809c|M.abscessus_ATCC_199 SPPASAAAPAAPASAPAPTASGTAPAPPSPPPVGDPGFSFPYAVGGGPRL
MUL_4463|M.ulcerans_Agy99 F-----VGHAALVGALSVPHSWAMAAPEIRLAVESLPSAGGLSAPAGPDM
MMAR_4612|M.marinum_M F-----VGHAALVGALSVPHSWAMAAPEIRLAVESLPSAGGLSAPAGPDI
Mb0939c|M.bovis_AF2122/97 G-----VGHAALVGALSVPHSWTTAAPEIQLAVQATPTFS-SSAGADPTA
Rv0915c|M.tuberculosis_H37Rv G-----VGHAALVGALSVPHSWTTAAPEIQLAVQATPTFS-SSAGADPTA
MAV_2906|M.avium_104 GGVAGSMGRSTLVGSLSVPPGWTTAAPVLRTVASVLPAASSATAAAMPAS
MLBr_01182|M.leprae_Br4923 GHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESE--
.
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRG
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRA
MAB_0809c|M.abscessus_ATCC_199 GTGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGRG
MUL_4463|M.ulcerans_Agy99 GGVAPTGLLSGMALASLAGRGATGAGSRSPSESATNE-------------
MMAR_4612|M.marinum_M GGMAPTGLLSGMALASLAGRGATGAGSRSPSESATNE-------------
Mb0939c|M.bovis_AF2122/97 LNGMPAGLLSGMALASLAARGTTGGGG-TRSGTSTDG-------------
Rv0915c|M.tuberculosis_H37Rv LNGMPAGLLSGMALASLAARGTTGGGG-TRSGTSTDG-------------
MAV_2906|M.avium_104 GG----AVFGEMAAASLAGRALAGAGVRTVGNGTTGA-------------
MLBr_01182|M.leprae_Br4923 ---SAPLLGGGLPMAPMVPGGGSGTGGVNTALR-----------------
MSMEG_0619|M.smegmatis_MC2_155 YADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGL
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK YADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGL
Mvan_0415|M.vanbaalenii_PYR-1 YADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGL
MAB_0809c|M.abscessus_ATCC_199 -----IEYMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGATASGL
MUL_4463|M.ulcerans_Agy99 ------------DEQPQRKPTVVVIQKPPPAGGPPAARP-----------
MMAR_4612|M.marinum_M ------------DEQPQRKPTVVVIQKPPPAGGPPAARP-----------
Mb0939c|M.bovis_AF2122/97 ------------QED-GRKPPVVVIREQPPPGNPPR--------------
Rv0915c|M.tuberculosis_H37Rv ------------QED-GRKPPVVVIREQPPPGNPPR--------------
MAV_2906|M.avium_104 ------------ATAAAADGAATTATIIVVPAD-----------------
MLBr_01182|M.leprae_Br4923 -----------------LQPRAFVMPRNPAAG------------------
MSMEG_0619|M.smegmatis_MC2_155 TTLT-GDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu -----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TTLA-GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TTLP-GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_0809c|M.abscessus_ATCC_199 AMLSRDDDLFEGVRAPMVPNTWDPEHGRQD-----------------
MUL_4463|M.ulcerans_Agy99 -----------------------------------------------
MMAR_4612|M.marinum_M -----------------------------------------------
Mb0939c|M.bovis_AF2122/97 -----------------------------------------------
Rv0915c|M.tuberculosis_H37Rv -----------------------------------------------
MAV_2906|M.avium_104 -----------------------------------------------
MLBr_01182|M.leprae_Br4923 -----------------------------------------------