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LATDFGALPPEVNSGLLYTGPGAAPMLTAATAWDGLATVLNSAAASYASVVSGLTLESWMGPASASMAAA AAPYATWLAVANEQARQTAAQARAAATAFETAFAVVVPPPLIAANRSQVASLVVANVLGQNTPAIETLQA EYAEMWAQDAAVMYQYSAASEAASTLAAFTSPMQSTDPSGAQASTAAGAAAAGTTAQTTASQPTTTATDT AQGLAAEVPTIPTGSDLAAPAAISIPTPVGELDLLAAYIAVAATASLSLSAVNTARPWSYSTNNDHAQPN GGGVAPTQGNTLGTERPDAEVLVSAPNIVPTSAFVGHAALVGALSVPHSWAMAAPEIRLAVESLPSAGGL SAPAGPDIGGMAPTGLLSGMALASLAGRGATGAGSRSPSESATNEDEQPQRKPTVVVIQKPPPAGGPPAA RP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4612 | - | - | 100% (422) | PPE family protein |
| M. marinum M | MMAR_1449 | - | e-126 | 58.03% (417) | PPE family protein |
| M. marinum M | MMAR_2534 | - | e-103 | 51.32% (417) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0939c | PPE14 | 1e-111 | 53.26% (430) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-29 | 37.76% (196) | PPE protein |
| M. tuberculosis H37Rv | Rv0915c | PPE14 | 1e-111 | 53.26% (430) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 7e-42 | 30.75% (413) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 1e-27 | 28.57% (406) | PPE family protein |
| M. avium 104 | MAV_2906 | - | 2e-74 | 42.16% (408) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-30 | 28.40% (426) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 3e-29 | 37.32% (209) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4463 | - | 0.0 | 97.87% (422) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-30 | 39.29% (196) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
MMAR_4612|M.marinum_M -----------MATDFGALPPEVNSGLLYTGPGAAPMLTAATAWDGLATV
MUL_4463|M.ulcerans_Agy99 ----------MLATDFGALPPEVNSGLLYAGPGAAPMLTAATAWDGLATV
Mb0939c|M.bovis_AF2122/97 -------------MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAE
Rv0915c|M.tuberculosis_H37Rv -------------MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAE
MAV_2906|M.avium_104 -------------MDFGALPPEVNSGRMYGGAGSGPLLAAAAAWDALGAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: .**.:* : *.*. .:::*. :* :.
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
MMAR_4612|M.marinum_M LNSAAASYASVVSGLTLESWMGPASASMAAAAAPYATWLAVANEQARQTA
MUL_4463|M.ulcerans_Agy99 LNSAAASYASVVSGLTLESRMGPASASMAAAAAPYATWLAVANEQARQTA
Mb0939c|M.bovis_AF2122/97 LTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETA
Rv0915c|M.tuberculosis_H37Rv LTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETA
MAV_2906|M.avium_104 LYSFAAAYTSTIAGLTVGSWLGPAATSMSAAAAPFIAWATTTAGQAEQVA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
: * : : : * :: .*: * . .*
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
MMAR_4612|M.marinum_M AQARAAATAFETAFAVVVPPPLIAANRSQVASLVVANVLGQNTPAIETLQ
MUL_4463|M.ulcerans_Agy99 AQARAAATAFETAFAVVVPPPLIAANRSQVASLVVANVLGQNTPAIETLQ
Mb0939c|M.bovis_AF2122/97 TQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQ
Rv0915c|M.tuberculosis_H37Rv TQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQ
MAV_2906|M.avium_104 TQARLAAAAYETAFAATVPPPVIAANRSLLMTLIATNILGQNTAAIAAAE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: ** *: *:: . : *:: *: :*.:* *: .* :
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPG-VGEAGSAS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPG-VSEAADAM
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPG-VGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPG-VGEAGRAA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPD-SGAAARTA
MMAR_4612|M.marinum_M AEYAEMWAQDAAVMYQYSAASEAASTLAAFTSPMQSTDPSG----AQAST
MUL_4463|M.ulcerans_Agy99 AEYAEMWAQDAAVMYQYSAASEAASTLAAFTSPVQSTDPSR----AQAST
Mb0939c|M.bovis_AF2122/97 AEYAEMWAQDAAVMYSYEGASAAASALPPFTPPVQGTGPAGPAAAAAATQ
Rv0915c|M.tuberculosis_H37Rv AEYAEMWAQDAAVMYSYEGASAAASALPPFTPPVQGTGPAGPAAAAAATQ
MAV_2906|M.avium_104 AEYAEMWAQDAAAMYAYAAASAAAAELTPFTEPPRTTESSA----AARQS
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
*:* .** * *: * * . : . .
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDP
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDP
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDP
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDP
MAB_4783|M.abscessus_ATCC_1997 A-------QDATKPPPIVPDPNDPIEMLLKNSQHFL-GMYRALKGLITDP
MMAR_4612|M.marinum_M AAGAAAAGTTAQTTASQPTTTATDTAQGLAAEVPTIPTG---------SD
MUL_4463|M.ulcerans_Agy99 AAGAAAAGTTAQTTASQPTTAATDTAQGLAAEVPTIPAG---------SD
Mb0939c|M.bovis_AF2122/97 AAGAGAVADAQATLAQLPPGILSDILSALAANADPLTSGLLGIASTLNPQ
Rv0915c|M.tuberculosis_H37Rv AAGAGAVADAQATLAQLPPGILSDILSALAANADPLTSGLLGIASTLNPQ
MAV_2906|M.avium_104 AAVAQSAASDLPAQLSTLIDVTPTMLQGLATTPSAAAAT-----------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVN--------
. :
MSMEG_0619|M.smegmatis_MC2_155 LGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASP
TH_3569|M.thermoresistible__bu IGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASP
Mflv_0325|M.gilvum_PYR-GCK IGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLP
Mvan_0415|M.vanbaalenii_PYR-1 LGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLP
MAB_4783|M.abscessus_ATCC_1997 VGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGPA
MMAR_4612|M.marinum_M LAAPAAISIPTPVGELDLLAAYIAVAATASLSLSAVNTARPWSYSTNNDH
MUL_4463|M.ulcerans_Agy99 LAAPAAISIPTPVGELDLLAAYIAVAATASLSLSAVNTARPWSYSTNNDH
Mb0939c|M.bovis_AF2122/97 VGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTARPWHIGLYG--
Rv0915c|M.tuberculosis_H37Rv VGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTARPWHIGLYG--
MAV_2906|M.avium_104 -PAASIIEAIYPI-TAALRPFFAAVTGAYSPIGAIILPGGWWLLSLQALG
MLBr_01182|M.leprae_Br4923 VDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGL
:
MSMEG_0619|M.smegmatis_MC2_155 FLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAV
TH_3569|M.thermoresistible__bu VLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP--------
Mflv_0325|M.gilvum_PYR-GCK LLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPA
Mvan_0415|M.vanbaalenii_PYR-1 LVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAI
MAB_4783|M.abscessus_ATCC_1997 AGISIPLAITLASLSQMPEAPPV---------DAPAETVPARIDQPHAVA
MMAR_4612|M.marinum_M AQPNGGGVAPTQG--NTLGTERP-----DAEVLVSAPN-IVPTSAF----
MUL_4463|M.ulcerans_Agy99 AQPNGGGVAPTQG--NTLGTERP-----DAEVLVSAPN-VVPTSAF----
Mb0939c|M.bovis_AF2122/97 ---NAGGLGPTQG--HPLSSATD-----EPEPHWGPFGGAAPVSAG----
Rv0915c|M.tuberculosis_H37Rv ---NAGGLGPTQG--HPLSSATD-----EPEPHWGPFGGAAPVSAG----
MAV_2906|M.avium_104 LAQNAPGVAELLGGGKAIAGGLS-----PLAPLRGGYVSAVTPDAGGVAG
MLBr_01182|M.leprae_Br4923 SLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTA
MSMEG_0619|M.smegmatis_MC2_155 GISPAGVPGSAATAAAPAPAPAGTTVA---APAPAAATFVPYAVANRDPG
TH_3569|M.thermoresistible__bu -----------VRAEPQNPLPLTXXX------------------------
Mflv_0325|M.gilvum_PYR-GCK TMSAPPPPSGAPIAANTVSAGSPPAPG---APAAAAATFVPYVVAGRDPY
Mvan_0415|M.vanbaalenii_PYR-1 AVSAPPPPSSAAATVGTVATGTAPAPG---APAAATASFVPYAVAGRDPG
MAB_4783|M.abscessus_ATCC_1997 MGGAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRGDGPG
MMAR_4612|M.marinum_M -VGHAALVGALSVPHSWAMAAPEIRLAVESLPSAGGLSAPAGPDIGGMAP
MUL_4463|M.ulcerans_Agy99 -VGHAALVGALSVPHSWAMAAPEIRLAVESLPSAGGLSAPAGPDMGGVAP
Mb0939c|M.bovis_AF2122/97 -VGHAALVGALSVPHSWTTAAPEIQLAVQATPTFS-SSAGADPTALNGMP
Rv0915c|M.tuberculosis_H37Rv -VGHAALVGALSVPHSWTTAAPEIQLAVQATPTFS-SSAGADPTALNGMP
MAV_2906|M.avium_104 SMGRSTLVGSLSVPPGWTTAAPVLRTVASVLPAASSATAAAMPASGG---
MLBr_01182|M.leprae_Br4923 QLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATES--------
.
MSMEG_0619|M.smegmatis_MC2_155 EGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGY
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK EGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGY
Mvan_0415|M.vanbaalenii_PYR-1 TGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAY
MAB_4783|M.abscessus_ATCC_1997 FGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGY
MMAR_4612|M.marinum_M TGLLSGMALASLAGRGATGAGSRSPSESATNEDEQPQRKPTVVVIQKPPP
MUL_4463|M.ulcerans_Agy99 TGLLSGMALASLAGRGATGAGSRSPSESATNEDEQPQRKPTVVVIQKPPP
Mb0939c|M.bovis_AF2122/97 AGLLSGMALASLAARGTTGGGG-TRSGTSTDGQED-GRKPPVVVIREQPP
Rv0915c|M.tuberculosis_H37Rv AGLLSGMALASLAARGTTGGGG-TRSGTSTDGQED-GRKPPVVVIREQPP
MAV_2906|M.avium_104 -AVFGEMAAASLAGRALAGAGVRTVGNGTTGAATAAAADGAATTATIIVV
MLBr_01182|M.leprae_Br4923 -------ESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNP
MSMEG_0619|M.smegmatis_MC2_155 ADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGL
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK ADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGL
Mvan_0415|M.vanbaalenii_PYR-1 ADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGL
MAB_4783|M.abscessus_ATCC_1997 RHEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGL
MMAR_4612|M.marinum_M AGGPPAARP-----------------------------------------
MUL_4463|M.ulcerans_Agy99 AGGPPAARP-----------------------------------------
Mb0939c|M.bovis_AF2122/97 PGNPPR--------------------------------------------
Rv0915c|M.tuberculosis_H37Rv PGNPPR--------------------------------------------
MAV_2906|M.avium_104 PAD-----------------------------------------------
MLBr_01182|M.leprae_Br4923 AAG-----------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 TTLTGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu ----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_4783|M.abscessus_ATCC_1997 STLDGDAEN--RTIPMLPGTWDVTDDDR------------------
MMAR_4612|M.marinum_M ----------------------------------------------
MUL_4463|M.ulcerans_Agy99 ----------------------------------------------
Mb0939c|M.bovis_AF2122/97 ----------------------------------------------
Rv0915c|M.tuberculosis_H37Rv ----------------------------------------------
MAV_2906|M.avium_104 ----------------------------------------------
MLBr_01182|M.leprae_Br4923 ----------------------------------------------