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LGFSPRRAIPERTVGGVIDVVDMPDPPAFPTLADDEHPGWASRPIRESDATRHYREAFGDCNVDPTDDPM AVVAEAIDVNAAAVRHALESQGDVHAVNALETLLDLSSLEREMIEDGAARRTLALLQVQEALSKLRAVDD VAMIVDRAPRELVESCGFDRAVLFRVHEGRLVMESAYFGEDREGAEKMVAFAQSVAPLLDHMLIETQMIR RHAPAIVRDARNDPRVNRPIVDFSLTHSYVAAPVMPTGKMIGFLHADRLYSGRIVDEIDRDTVWAFAEGF GYAYERTVLLERMRRQHAEVRSALASADEAARALQDADLDLRKIEPVERSPAARSLAEVQTRVMAMLTRR EVEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLHATNRAEAASAYVRLASVSEVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2876 | - | - | 100% (411) | putative regulatory protein |
| M. ulcerans Agy99 | MUL_3814 | - | 6e-07 | 48.00% (50) | two component transcriptional regulatory protein |
| M. ulcerans Agy99 | MUL_0351 | narL | 2e-06 | 35.00% (100) | nitrate/nitrite response regulator protein NarL |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3157c | devR | 2e-06 | 36.84% (95) | two component transcriptional regulatory protein DevR |
| M. gilvum PYR-GCK | Mflv_0277 | - | 5e-08 | 32.03% (153) | response regulator receiver protein |
| M. tuberculosis H37Rv | Rv3133c | devR | 2e-06 | 36.84% (95) | two component transcriptional regulatory protein DevR |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1522 | - | 7e-10 | 36.75% (117) | putative two-component system response regulator LuxR |
| M. marinum M | MMAR_2876 | - | 0.0 | 98.48% (395) | putative regulatory protein |
| M. avium 104 | MAV_2364 | - | 4e-08 | 31.85% (135) | TPR repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_0330 | - | 6e-38 | 36.93% (306) | transcriptional regulator, LuxR family protein |
| M. thermoresistible (build 8) | TH_4501 | - | 0.0 | 86.15% (390) | PUTATIVE conserved hypothetical regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_3973 | - | 0.0 | 83.93% (392) | putative GAF sensor protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2364|M.avium_104 MEFRRSLAALNNGEFHGVALVGDGGVGKSTLARMLAKTVESAGRTVRFAL
Mflv_0277|M.gilvum_PYR-GCK -------------------------MLPAAREAIAAVDADPRAATKSLVT
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2364|M.avium_104 GTQTGWAVPLGAFSRAVSLGVGHEPAIMLAAAHNTLGQDKNLVVVVDEAQ
Mflv_0277|M.gilvum_PYR-GCK GGIGTGKTTLLAAMRTTFRSAGRQVLSRPPDAGTPGDGAGYALVVDDAHL
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2364|M.avium_104 LLDPLSATLVNQLAAGRSARLIVTIRSGEPVLDAVTALLKERLLLTVHVD
Mflv_0277|M.gilvum_PYR-GCK LGDDDLDRLTDLAGDPASTVVIATQALMHRSRLQVLMTVLARENPEVALR
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2364|M.avium_104 PFTREQTELLAGAVLGGPVDTRLVDELFERSAGNLLLLRGFLTAGVESGA
Mflv_0277|M.gilvum_PYR-GCK PLTAAQVQEAATSALGASVGPELTRLLVSVTGGFPFLVSAALSAIPDGAQ
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2364|M.avium_104 LVHTEQGWQLQG-PLRGDRELHDALEYRLQSLSSEEREVVEVLATAELLE
Mflv_0277|M.gilvum_PYR-GCK SARQAAHFALIERLARLDGHLLDTLLVMTLSPGLGPDDVAAALRIPADEA
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2364|M.avium_104 WEILRDICDADAMASLERRGLIQLVTDGSHTLVQLNHPMLGEAATRHAGV
Mflv_0277|M.gilvum_PYR-GCK VAAVDSARATALIDPAHTSQFLAAVHDGIAQIVGAARHHDVEMAVLDSQL
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2364|M.avium_104 VRSRQLNGILAKTLRKHLRAAGRRSQISDPRGRIQLAQFIMRSDLEPDLD
Mflv_0277|M.gilvum_PYR-GCK ALCTLTADLALRIADHGVRDDRLATALTDFAARVPDRPARAARLYRAATD
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2364|M.avium_104 VVIKAAADAMAMSNVVLGEQLATFAVDRGGGLAAALVLAEAVSWQGRGEE
Mflv_0277|M.gilvum_PYR-GCK AGTTAVRPALADALVLTG-----------DCVTAGRLADDLLTSQDPDER
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 ----------------------------------MGFSPRRAIPERTVGG
MMAR_2876|M.marinum_M --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 -----------------------------------------------MTA
MSMEG_0330|M.smegmatis_MC2_155 ---------------------------------------------MSVLI
MAV_2364|M.avium_104 ADSILLGADVDDADEWLIARWGCLRAANLAWGCGDAEGATRVLAEVKQRL
Mflv_0277|M.gilvum_PYR-GCK AAAVRIAASIALHDG-----AARQAADLFAWLGPAPDAVVGAAETIAALA
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 VIDVVDMPDPPAFPTLADDEHPGWASRPIRESDATRHYREAFGDCNVDPT
MMAR_2876|M.marinum_M MIDAVDMPDPPAFPTLADDEHPGWASRPIRESDATRHYREAFGDCNVDPT
TH_4501|M.thermoresistible__bu MTIAGDVPDSGSDETLAG--HPGWASRPAAESDAARRYRETFADWGVDPT
Mvan_3973|M.vanbaalenii_PYR-1 IGDIADSPGIPEIGALADGDHPGWSSRPAVESDAARRYHETFRDCDVDPT
MSMEG_0330|M.smegmatis_MC2_155 GAESSRTAGTGRVRSDRLSKRTEFDERFSALRDRAAAVLGTERPPALE-S
MAV_2364|M.avium_104 ATEGSLQLIDALDVSIGFFRGDIARTIELGPRLCEPDVVPMATVWAAVAT
Mflv_0277|M.gilvum_PYR-GCK VGDAAAVRSTAQGPPSGPPTAVARSARAITEGLVMTLDQPYPAAIARLSQ
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 DDPMAVVAEAIDVNAAAVR--HALESQGDVHAVNALETLLDLSSLEREMI
MMAR_2876|M.marinum_M DDPMAVVAEAIDVNAAAVR--HALESLGDVHAVNALETLLDLSSLEREMI
TH_4501|M.thermoresistible__bu DDPMSVVSEAIDTRANEVR--NALETCGDEEAIAALESVLDLCSLERELI
Mvan_3973|M.vanbaalenii_PYR-1 DDPMAVVGEAVDAKVSIVR--NALEALGDDEALNALDAALDLASLERDLI
MSMEG_0330|M.smegmatis_MC2_155 GSPIRVGEVISDFSQLCVRRLQAVRSSDTEAERQLGSLLLELQQLALDWY
MAV_2364|M.avium_104 CGALTAVGRFSEVGRIAAAGVRATAQCRAGAQRFAIGLAEVMAATAAGDY
Mflv_0277|M.gilvum_PYR-GCK AIAVDAVHGVLPDTPAALVTLAALHGGDPVRARSVIGRAVLADSRPDRAD
Mb3157c|M.bovis_AF2122/97 -----------------MVKVFLVDDHEVVRRGLVDLLGADPELD-----
Rv3133c|M.tuberculosis_H37Rv -----------------MVKVFLVDDHEVVRRGLVDLLGADPELD-----
MAB_1522|M.abscessus_ATCC_1997 -------------MTDTEVGVLLVDDQELVRTGLRRILRRKDGFA-----
MUL_2876|M.ulcerans_Agy99 EDGAARRTLALLQVQEALSKLRAVDDVAMIVDRAPRELVESCGFDRAVLF
MMAR_2876|M.marinum_M EDGAARRTLALLQVQEALSKLRAVDDVAMIVDRAPRELVESCGFDRAVLF
TH_4501|M.thermoresistible__bu EDGAQRRTFALLQVQEGLSKLRAVDDVATIVDRAPRELVESCGFDRAVLF
Mvan_3973|M.vanbaalenii_PYR-1 EDGARRRTFALLQVQEGLSKLRAVDDVAMIVDRAPRELVESCGFDRAVLF
MSMEG_0330|M.smegmatis_MC2_155 LFETGVRSQRLADCAVSLNRLRAMPTTAALLDNACHELVFRLGFRRAVLS
MAV_2364|M.avium_104 PAAERIHKRYAALATGLPAAEAMVDAMLGVLQLTRGELQEACATLDRSIS
Mflv_0277|M.gilvum_PYR-GCK ATFVTSRHRLLQGWAYMQDGQLAAAAAAIPADGDPRLHRRDALWAAALHT
Mb3157c|M.bovis_AF2122/97 ---------------VVGEAGSVAE-----------AMARVPAARP---D
Rv3133c|M.tuberculosis_H37Rv ---------------VVGEAGSVAE-----------AMARVPAARP---D
MAB_1522|M.abscessus_ATCC_1997 ---------------IVGECADGSE-----------VAAAVSRARP---D
MUL_2876|M.ulcerans_Agy99 RVHEGRL---VMESAYFGEDREGAE-----------KMVAFAQSVAPLLD
MMAR_2876|M.marinum_M RVHEGRM---VMESAYFGEDREGAE-----------KMVAFAQSVAPLLD
TH_4501|M.thermoresistible__bu RVHEGRM---FMESAYFGEDRAGAE-----------KMVAFAQSVAPPLD
Mvan_3973|M.vanbaalenii_PYR-1 RVHEGRM---VMESAYFGDDRAGAE-----------KMVAFAQSVAPPLD
MSMEG_0330|M.smegmatis_MC2_155 TVDTRG----WTPMILLDRTEPADR-----------GWFSNWQNQTVPLV
MAV_2364|M.avium_104 QLSQGFP---LPWQLVVGALQAQAEGARGDSAAAAVALRRVEEAYGPHVA
Mflv_0277|M.gilvum_PYR-GCK GIARRSGDTGAMQMHWRSAMDVLAESSADLFTVLPLGELWIAASRLRQVD
. .
Mb3157c|M.bovis_AF2122/97 VAVLDVRLPD----------GNGIELCRDLLSRMPDLRCLILTSYTS---
Rv3133c|M.tuberculosis_H37Rv VAVLDVRLPD----------GNGIELCRDLLSRMPDLRCLILTSYTS---
MAB_1522|M.abscessus_ATCC_1997 VVIMDLRMKQ----------MSGIEAIR-LLHAAQGPPALALTTFDD---
MUL_2876|M.ulcerans_Agy99 HMLIETQMIR----------RHAPAIVRDARNDPRVNRPIVDFSLTHSYV
MMAR_2876|M.marinum_M HMLIETQMIR----------RHAPAIVRDARNDPRVNRPIVDFSLTHSYV
TH_4501|M.thermoresistible__bu HMLLETQMIR----------RHAPAIVRDARNDPRVNRPIVEFSMTRSYV
Mvan_3973|M.vanbaalenii_PYR-1 HMLLETQMIR----------RRSPAIVHDARNDPRVNRPIVDFSMTHSYV
MSMEG_0330|M.smegmatis_MC2_155 QTTPEALSLS----------RRRPCLIEDTTDAPVYRPLIVHAGQSRSYV
MAV_2364|M.avium_104 VFLPELELAR----------AWERAAAGDTAGAQTQAMQAAQTARKAGMH
Mflv_0277|M.gilvum_PYR-GCK QVRHSLDEVFGLLAALGDPLLWSIPLHWAGVHAGILANSPDAVAPHGAAL
.
Mb3157c|M.bovis_AF2122/97 -------------------------DEAMLDAILAGASGY----------
Rv3133c|M.tuberculosis_H37Rv -------------------------DEAMLDAILAGASGY----------
MAB_1522|M.abscessus_ATCC_1997 -------------------------DELLSGALRAGAAGF----------
MUL_2876|M.ulcerans_Agy99 AAPVMPTGKMIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLL
MMAR_2876|M.marinum_M AAPVMPTGKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLL
TH_4501|M.thermoresistible__bu AAPVMPTGKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLL
Mvan_3973|M.vanbaalenii_PYR-1 AAPVMPTGKVIGFLHADRLYSGRRVDEIDRDTVWAFAEGFGYAYERTVLL
MSMEG_0330|M.smegmatis_MC2_155 VAPLVQSGDVMGFLHTDHYPENTPVDEADRDVLWAFADGFSHIYQRAALL
MAV_2364|M.avium_104 LVEMRARHAALRFGDRAQAARVDELASILNSPSAQAVAGHARGLAQHDGD
Mflv_0277|M.gilvum_PYR-GCK TAAAPHAQFAKALAAAGRTWLRVLADRVDVAEVTAAARGLALHGHTWDAT
. *
Mb3157c|M.bovis_AF2122/97 -VVKDIK----------GMELARAVKDVGAGRSLLDNRAAAALMAKLR--
Rv3133c|M.tuberculosis_H37Rv -VVKDIK----------GMELARAVKDVGAGRSLLDNRAAAALMAKLR--
MAB_1522|M.abscessus_ATCC_1997 -ILKDSP----------AEELVRAVHAVARGEAYLDPAVTSRVLNAYRRA
MUL_2876|M.ulcerans_Agy99 ERMRRQH----------AEVRSALASADEAARALQDADLDLRKIEPVERS
MMAR_2876|M.marinum_M ERMRRQH----------AEVRSALASADEAARALQDADLDLRKIEPVERS
TH_4501|M.thermoresistible__bu ERMRRLQ----------AEVRNALASADEAARALQDADLDLRKIEPQERS
Mvan_3973|M.vanbaalenii_PYR-1 ERMRRQH----------AEVRRALASADEAARALQDADLDLRKIEPVERS
MSMEG_0330|M.smegmatis_MC2_155 ENLRRQR----------DHIRDLLISTVDQIDELCDVSVEATAWADENGQ
MAV_2364|M.avium_104 LLDAAAHRFADLGALAFAADAAAQAASEHARRGDRRKEVESSTWAHALAG
Mflv_0277|M.gilvum_PYR-GCK RLAGQAALQ--------TTDSRAAQAMLQLARDLKATVAASDASVPSSAT
Mb3157c|M.bovis_AF2122/97 GAAEKQDP-LSG-----LTDQERTLLGLLSEGLTNKQIADRMFLAEKTVK
Rv3133c|M.tuberculosis_H37Rv GAAEKQDP-LSG-----LTDQERTLLGLLSEGLTNKQIADRMFLAEKTVK
MAB_1522|M.abscessus_ATCC_1997 PAAVSGDA-QDK-----LTARELDVLALIASGATNSEIAEQLVISEVTVK
MUL_2876|M.ulcerans_Agy99 PAARSLAE-VQTRVMAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVK
MMAR_2876|M.marinum_M PAARSLAE-VQTRAMAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVK
TH_4501|M.thermoresistible__bu PAARSLAE-VHTRVMAMLTRREIEVLRLMAAGRTNQQIADELVISAGTVK
Mvan_3973|M.vanbaalenii_PYR-1 AAAQSLAE-VHTRVLGMLTRREVEVLRLMAAGRTNQQIADELVISAGTVK
MSMEG_0330|M.smegmatis_MC2_155 TADDDATTGARPPHRVELTERESEVLRLMVTGASNHEIAEQLVITEGTVK
MAV_2364|M.avium_104 QCGSRTPALDAAARPLPFSGRERQIVNLVAAGLSNREIADRLVISVRTVE
Mflv_0277|M.gilvum_PYR-GCK DTVAPPPAVPQRVSSTQLSEREREVAELLLQGLPYREIGSQLFISAKTVE
:: :* : *: * . :*...:.:: **:
Mb3157c|M.bovis_AF2122/97 NYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
Rv3133c|M.tuberculosis_H37Rv NYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
MAB_1522|M.abscessus_ATCC_1997 SHIGRIFVKLDLRDRAAAIVYAYDHGIVTPK----
MUL_2876|M.ulcerans_Agy99 SHVKRVLRKLHATNRAEAASAYVRLASVSEVG---
MMAR_2876|M.marinum_M SHVKRVLRKLHATNRAEAASAYVRLASVPEVG---
TH_4501|M.thermoresistible__bu SHVKRVLRKLHATNRAEAASAYVRLASVPEVG---
Mvan_3973|M.vanbaalenii_PYR-1 SHVKRVLRKLHATNRAEAASAYVRLAIAPAVDG--
MSMEG_0330|M.smegmatis_MC2_155 SHVKHILRKYGAVNRAQAIAWALQGT---------
MAV_2364|M.avium_104 GHLYRLFTKLGINNRDQLIQLIRRDAS--------
Mflv_0277|M.gilvum_PYR-GCK HHVARIRRRLGAESRSEMLSMLRAALDTPASR---
:: :: : *