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SVLIGAESSRTAGTGRVRSDRLSKRTEFDERFSALRDRAAAVLGTERPPALESGSPIRVGEVISDFSQLC VRRLQAVRSSDTEAERQLGSLLLELQQLALDWYLFETGVRSQRLADCAVSLNRLRAMPTTAALLDNACHE LVFRLGFRRAVLSTVDTRGWTPMILLDRTEPADRGWFSNWQNQTVPLVQTTPEALSLSRRRPCLIEDTTD APVYRPLIVHAGQSRSYVVAPLVQSGDVMGFLHTDHYPENTPVDEADRDVLWAFADGFSHIYQRAALLEN LRRQRDHIRDLLISTVDQIDELCDVSVEATAWADENGQTADDDATTGARPPHRVELTERESEVLRLMVTG ASNHEIAEQLVITEGTVKSHVKHILRKYGAVNRAQAIAWALQGT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0330 | - | - | 100% (395) | transcriptional regulator, LuxR family protein |
| M. smegmatis MC2 155 | MSMEG_0331 | - | 8e-32 | 31.88% (298) | transcriptional regulator, LuxR family protein |
| M. smegmatis MC2 155 | MSMEG_1494 | - | 1e-10 | 45.56% (90) | transcriptional regulatory protein DegU |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0201 | - | 1e-06 | 36.54% (104) | LuxR family two component transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_5014 | - | 8e-11 | 41.35% (104) | two component LuxR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0195 | - | 1e-06 | 36.54% (104) | two component transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1522 | - | 2e-09 | 55.36% (56) | putative two-component system response regulator LuxR |
| M. marinum M | MMAR_2876 | - | 1e-38 | 37.09% (302) | putative regulatory protein |
| M. avium 104 | MAV_4201 | - | 4e-08 | 49.25% (67) | transcriptional regulator, LuxR family protein |
| M. thermoresistible (build 8) | TH_4501 | - | 1e-41 | 35.00% (360) | PUTATIVE conserved hypothetical regulatory protein |
| M. ulcerans Agy99 | MUL_2876 | - | 4e-38 | 36.93% (306) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0349 | - | 1e-121 | 57.22% (395) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5014|M.gilvum_PYR-GCK --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0201|M.bovis_AF2122/97 --------------------------------------------------
Rv0195|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0349|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------MGFSPR
TH_4501|M.thermoresistible__bu --------------------------------------------------
MAV_4201|M.avium_104 MMLMAQAVLPTRAELLAALSVAIDLGLGQPAEHMLRAALIATRLCDRLGL
Mflv_5014|M.gilvum_PYR-GCK --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0201|M.bovis_AF2122/97 --------------------------------------------------
Rv0195|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 ------------MSVLIGAESSRTAGTGRVRSDRLSKRTEFDERFSALRD
Mvan_0349|M.vanbaalenii_PYR-1 ------------MSVSMISDSARTAAGARPGGEWWAREIELVDQLRGLRE
MMAR_2876|M.marinum_M ----------MIDAVDMPDPPAFPTLADDEHPGWASRPIRESDATRHYRE
MUL_2876|M.ulcerans_Agy99 RAIPERTVGGVIDVVDMPDPPAFPTLADDEHPGWASRPIRESDATRHYRE
TH_4501|M.thermoresistible__bu ----------MTIAGDVPDSGSDETLAG--HPGWASRPAAESDAARRYRE
MAV_4201|M.avium_104 SRQQRDCVYYTTLVMWVGCHADSHEYARWFGDDIAVRHDSYLVDWSGIPY
Mflv_5014|M.gilvum_PYR-GCK --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0201|M.bovis_AF2122/97 -------------------------------------------------M
Rv0195|M.tuberculosis_H37Rv -------------------------------------------------M
MSMEG_0330|M.smegmatis_MC2_155 RAAAVL-GTERPPALESGSPIRVGEVISDFSQLCVRRLQAVRSSDTEAER
Mvan_0349|M.vanbaalenii_PYR-1 RAARELRGAVTLPAVEWDVPGRSAEAISALTHLCIDSLRRLSGGEVERAQ
MMAR_2876|M.marinum_M AFGDCNVDPTDDPMA------VVAEAIDVNAAAVRHALESLGD---VHAV
MUL_2876|M.ulcerans_Agy99 AFGDCNVDPTDDPMA------VVAEAIDVNAAAVRHALESQGD---VHAV
TH_4501|M.thermoresistible__bu TFADWGVDPTDDPMS------VVSEAIDTRANEVRNALETCGD---EEAI
MAV_4201|M.avium_104 LRFLASNVGRGQPLAHRLSVMATLFANARGHISRLIHSHCASAALLADRI
Mflv_5014|M.gilvum_PYR-GCK MSSEPVRIVLVDDHEMVIEG------------LKAMLAAFADRVCVVGQS
MAB_1522|M.abscessus_ATCC_1997 MTDTEVGVLLVDDQELVRTG------------LRRILRR-KDGFAIVGEC
Mb0201|M.bovis_AF2122/97 APVNVISVAVVASDPLTRDG------------ALARLSSHRELDVRAWQA
Rv0195|M.tuberculosis_H37Rv APVNVISVAVVASDPLTRDG------------ALARLSSHRELDVRAWQA
MSMEG_0330|M.smegmatis_MC2_155 QLGSLLLELQQLALDWYLFE------------TGVRSQRLADCAVSLNRL
Mvan_0349|M.vanbaalenii_PYR-1 RLCDLVLDLQRLAMDWYLHD------------TAMRSQRLAECAAGLSRL
MMAR_2876|M.marinum_M NALETLLDLSSLEREMIEDG------------AARRTLALLQVQEALSKL
MUL_2876|M.ulcerans_Agy99 NALETLLDLSSLEREMIEDG------------AARRTLALLQVQEALSKL
TH_4501|M.thermoresistible__bu AALESVLDLCSLERELIEDG------------AQRRTFALLQVQEGLSKL
MAV_4201|M.avium_104 GLGPNVQAALAYTFERYDGGGLPTGARGEDIPIQMRIAQLADMVEVHHRS
: : .
Mflv_5014|M.gilvum_PYR-GCK VGADQVMGVVTDLDP-------DIVL------------------------
MAB_1522|M.abscessus_ATCC_1997 ADGSEVAAAVSRARP-------DVVI------------------------
Mb0201|M.bovis_AF2122/97 GCETSVLLVLATTIT-------APLL------------------------
Rv0195|M.tuberculosis_H37Rv GCETSVLLVLATTIT-------APLL------------------------
MSMEG_0330|M.smegmatis_MC2_155 RAMPTTAALLDNACH-------ELVFRLGFRRAVLSTVDT-RGWTPMILL
Mvan_0349|M.vanbaalenii_PYR-1 RGVPSSAALLDNACQ-------ELVLRCGFHRAVLSKVES-HGWKPLMLH
MMAR_2876|M.marinum_M RAVDDVAMIVDRAPR-------ELVESCGFDRAVLFRVHEGRMVMESAYF
MUL_2876|M.ulcerans_Agy99 RAVDDVAMIVDRAPR-------ELVESCGFDRAVLFRVHEGRLVMESAYF
TH_4501|M.thermoresistible__bu RAVDDVATIVDRAPR-------ELVESCGFDRAVLFRVHEGRMFMESAYF
MAV_4201|M.avium_104 YGVAGAVAMVGARRGGQFDPGIADVFLRDADAILAGPQTGDAWAAALREA
: :
Mflv_5014|M.gilvum_PYR-GCK -------------------------CDVRMQGSSGLDVCQQLRRRDPDRK
MAB_1522|M.abscessus_ATCC_1997 -------------------------MDLRMKQMSGIEAIRLLHAAQ-GPP
Mb0201|M.bovis_AF2122/97 -------------------------CQIEDVQKDGPSHAPKL--------
Rv0195|M.tuberculosis_H37Rv -------------------------CQIEDVQKDGPSHAPKL--------
MSMEG_0330|M.smegmatis_MC2_155 DRTEPADRGWFSNWQNQTVPLVQTTPEALSLSRRRPCLIEDTTDAPVYRP
Mvan_0349|M.vanbaalenii_PYR-1 DRSADAGDSWFSDWINQTVPLVRDAPEAEMMSRRRPSLVHDTDTAPVYRP
MMAR_2876|M.marinum_M GEDREGAEKMVAFAQSVAPLLDHMLIETQMIRRHAPAIVRDARNDPRVNR
MUL_2876|M.ulcerans_Agy99 GEDREGAEKMVAFAQSVAPLLDHMLIETQMIRRHAPAIVRDARNDPRVNR
TH_4501|M.thermoresistible__bu GEDRAGAEKMVAFAQSVAPPLDHMLLETQMIRRHAPAIVRDARNDPRVNR
MAV_4201|M.avium_104 PDRHRVDEQSLDAALVALGDFVDLKCPFTLGHSRAVARLAGQAARAAGLD
Mflv_5014|M.gilvum_PYR-GCK IVMLSVYDDEQYLFQAMRVG-ASGYLLKS-ISSEDLVEQLE---------
MAB_1522|M.abscessus_ATCC_1997 ALALTTFDDDELLSGALRAG-AAGFILKD-SPAEELVRAVH---------
Mb0201|M.bovis_AF2122/97 VVVADEFS-AEQVFRMIKLG-LTGLLYRSQSTFDCIVETIR---------
Rv0195|M.tuberculosis_H37Rv VVVADEFS-AEQVFRMIKLG-LTGLLYRSQSTFDCIVETIR---------
MSMEG_0330|M.smegmatis_MC2_155 LIVHAGQSRSYVVAPLVQSGDVMGFLHTDHYPENTPVDEADRDVLWAF--
Mvan_0349|M.vanbaalenii_PYR-1 LIVHAGRSRSYVVAPVLHGRDVVGFLHTDHHPLARRVDEADREVAWVF--
MMAR_2876|M.marinum_M PIVDFSLTHSYVAAPVMPTGKVIGFLHADRLYSGRIVDEIDRDTVWAF--
MUL_2876|M.ulcerans_Agy99 PIVDFSLTHSYVAAPVMPTGKMIGFLHADRLYSGRIVDEIDRDTVWAF--
TH_4501|M.thermoresistible__bu PIVEFSMTRSYVAAPVMPTGKVIGFLHADRLYSGRIVDEIDRDTVWAF--
MAV_4201|M.avium_104 ADAVALTRRAGHVHDLGRIGVSNQIWSRPGPLSGSQFERVRLHPYLTVRI
.
Mflv_5014|M.gilvum_PYR-GCK ----------------------------SVHSGKTAIDPTMAARAVEWPG
MAB_1522|M.abscessus_ATCC_1997 ----------------------------AVARGEAYLDPAVTSRVLNAYR
Mb0201|M.bovis_AF2122/97 ----------------------------LSAEGRLRLPERVQRYLVGRIK
Rv0195|M.tuberculosis_H37Rv ----------------------------LSAEGRLRLPERVQRYLVGRIK
MSMEG_0330|M.smegmatis_MC2_155 ---ADGFSHIYQRAALLENLRRQRDHIRDLLISTVDQIDELCDVSVEATA
Mvan_0349|M.vanbaalenii_PYR-1 ---ADGFSHLYERAVLLERLRAQRESVRELFFGAVDRIDELCESGLDTPR
MMAR_2876|M.marinum_M ---AEGFGYAYERTVLLERMRRQHAEVRSALASADEAARALQDADLDLRK
MUL_2876|M.ulcerans_Agy99 ---AEGFGYAYERTVLLERMRRQHAEVRSALASADEAARALQDADLDLRK
TH_4501|M.thermoresistible__bu ---AEGFGYAYERTVLLERMRRLQAEVRNALASADEAARALQDADLDLRK
MAV_4201|M.avium_104 LDQVPGLRRLAEVAGNHHECLDGSGYPRGLAGSALGMPDRILAAAVCYQS
. : :
Mflv_5014|M.gilvum_PYR-GCK --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 RAPAA-----------------------------------------VSGD
Mb0201|M.bovis_AF2122/97 STPTA-----------------------------------------EPDT
Rv0195|M.tuberculosis_H37Rv STPTA-----------------------------------------EPDT
MSMEG_0330|M.smegmatis_MC2_155 WADENG-------------------------------QTADDDATTGARP
Mvan_0349|M.vanbaalenii_PYR-1 GAEAD--------------------------------RCGDTDGQTG-RP
MMAR_2876|M.marinum_M IEPVE--------------------------------RSPAARSLAEVQT
MUL_2876|M.ulcerans_Agy99 IEPVE--------------------------------RSPAARSLAEVQT
TH_4501|M.thermoresistible__bu IEPQE--------------------------------RSPAARSLAEVHT
MAV_4201|M.avium_104 GREPRPYREQLSEAEAARRLRGRVRCGELDPVAAEAVLHAAGQPVGPRPN
Mflv_5014|M.gilvum_PYR-GCK -ARQGLTQRESEILALVVNGLSNRAIAAKLIIGDETVKTHLSSIYRKLGV
MAB_1522|M.abscessus_ATCC_1997 -AQDKLTARELDVLALIASGATNSEIAEQLVISEVTVKSHIGRIFVKLDL
Mb0201|M.bovis_AF2122/97 PCAAALAEREVAVLRLLADGLSTHQVAVQLNYCERTIKNIVHDIVTRLKL
Rv0195|M.tuberculosis_H37Rv PCAAALAEREVAVLRLLADGLSTHQVAVQLNYCERTIKNIVHDIVTRLKL
MSMEG_0330|M.smegmatis_MC2_155 PHRVELTERESEVLRLMVTGASNHEIAEQLVITEGTVKSHVKHILRKYGA
Mvan_0349|M.vanbaalenii_PYR-1 P--VTLTEREADVFDLMVTGASNQEIADRLVITEGTVKSHVKHILRKYGA
MMAR_2876|M.marinum_M RAMAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLHA
MUL_2876|M.ulcerans_Agy99 RVMAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLHA
TH_4501|M.thermoresistible__bu RVMAMLTRREIEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLHA
MAV_4201|M.avium_104 PRPDGLTPREIEVLGHVARGASNKEIAAALVISEKTARNHVERTYAKIGV
*: ** :: :. * :. :* * * :. : :
Mflv_5014|M.gilvum_PYR-GCK SDRTAAVATALREGIFQ------
MAB_1522|M.abscessus_ATCC_1997 RDRAAAIVYAYDHGIVTPK----
Mb0201|M.bovis_AF2122/97 RNRTHAVAHALRAGLI-------
Rv0195|M.tuberculosis_H37Rv RNRTHAVAHALRAGLI-------
MSMEG_0330|M.smegmatis_MC2_155 VNRAQAIAWALQGT---------
Mvan_0349|M.vanbaalenii_PYR-1 VNRAQAIAWALNGG---------
MMAR_2876|M.marinum_M TNRAEAASAYVRLASVPEVG---
MUL_2876|M.ulcerans_Agy99 TNRAEAASAYVRLASVSEVG---
TH_4501|M.thermoresistible__bu TNRAEAASAYVRLASVPEVG---
MAV_4201|M.avium_104 SNRIGASMYALQHGLVPAAPPHS
:* *