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MSEHESPTVMVVDDHPIWRDAVARDLSDDGFAVVATADGVATAQRRAAIVKPDVVVMDMRLADGDGVQAT TEVLKVSPATRVLVLSTSDEREDVLEAVKTGATGYLVKSASKAELADAVRATAAGRAVFTPSLAGLVLGE YRRIAQTADSSQDRPSLTERETEILRYVAKGLSAKQIAEKLSLSHRTVENHVQATFRKLQLANRVELTRY AIEHGLDK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3814 | - | - | 100% (218) | two component transcriptional regulatory protein |
| M. ulcerans Agy99 | MUL_0351 | narL | 4e-30 | 37.33% (217) | nitrate/nitrite response regulator protein NarL |
| M. ulcerans Agy99 | MUL_2423 | devR | 6e-29 | 33.82% (207) | two component transcriptional regulatory protein DevR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3157c | devR | 9e-29 | 34.47% (206) | two component transcriptional regulatory protein DevR |
| M. gilvum PYR-GCK | Mflv_3579 | - | 1e-95 | 82.46% (211) | two component LuxR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3133c | devR | 9e-29 | 34.47% (206) | two component transcriptional regulatory protein DevR |
| M. leprae Br4923 | MLBr_02123 | - | 3e-12 | 32.74% (168) | two-component response regulator |
| M. abscessus ATCC 19977 | MAB_4519c | - | 8e-82 | 71.56% (218) | two-component LuxR family response regulator |
| M. marinum M | MMAR_3959 | - | 1e-116 | 98.62% (218) | two-component transcriptional regulatory protein |
| M. avium 104 | MAV_4114 | - | 4e-96 | 81.74% (219) | response regulator receiver domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3240 | - | 3e-94 | 82.24% (214) | DNA-binding response regulator, LuxR family protein |
| M. thermoresistible (build 8) | TH_3563 | - | 8e-92 | 77.98% (218) | PUTATIVE DNA-binding response regulator, LuxR family protein |
| M. vanbaalenii PYR-1 | Mvan_2836 | - | 7e-91 | 80.95% (210) | two component LuxR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3157c|M.bovis_AF2122/97 --------MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMAR
Rv3133c|M.tuberculosis_H37Rv --------MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMAR
MUL_3814|M.ulcerans_Agy99 MS--EHESP-TVMVVDDHPIWRDAVARDLSDD-GFAVVATADGVATAQRR
MMAR_3959|M.marinum_M MS--EHESP-TVMVVDDHPIWRDAVARDLSDD-GFAVVATADGVATAQRR
MAV_4114|M.avium_104 MT--DDATPTTVMVVDDHPIWRDAVARDLAES-GFAVVATADGVATAQRR
Mflv_3579|M.gilvum_PYR-GCK -M--GIDRT-SVMVVDDHPIWRDAVARDLADD-GFDVVATADGVASAKRR
Mvan_2836|M.vanbaalenii_PYR-1 -----------MMVVDDHPIWRDAVARDLADD-GFDVVATADGVASAKRR
MSMEG_3240|M.smegmatis_MC2_155 MM--TDAAP-TVMVVDDHPIWRDAVARDLADD-GFDVVATADGVASASRR
TH_3563|M.thermoresistible__bu MG--EPQQP-TVMVVDDHPIWREAVARDLAEA-GLSVVATADGVAAARRR
MAB_4519c|M.abscessus_ATCC_199 MTGNTDSEQISVMVVDDHPMWRDGVSRDLQAA-GLRVVATADGVASSGRI
MLBr_02123|M.leprae_Br4923 --MDTGVSSPRVLVVDDDSDVLASLERGLRLS-GFEVSTAIDG-AEALRN
:::***. .: * : * .. * :
Mb3157c|M.bovis_AF2122/97 VPAARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLD
Rv3133c|M.tuberculosis_H37Rv VPAARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLD
MUL_3814|M.ulcerans_Agy99 AAIVKPDVVVMDMRLADGDGVQATTEVLKVSPATRVLVLSTSDEREDVLE
MMAR_3959|M.marinum_M AAIVKPDVVVMDMRLADGDGVQATTEVLKVSPATRVLVLSASDEREDVLE
MAV_4114|M.avium_104 AGVVRPDVVVMDMQLPDGDGAQATAAVLAVSPSSRVLVLSASDERDDVLQ
Mflv_3579|M.gilvum_PYR-GCK AAVVRPDVVVMDMRLGDGDGAQATTEVLAVSPSSRILVLSASDERDDVLE
Mvan_2836|M.vanbaalenii_PYR-1 AAVVQPAVVLMDMRLADGDGAQATAEVLAVSPSSRVLVLSASDERDDVLE
MSMEG_3240|M.smegmatis_MC2_155 AAVVRPDVVLMDMRLGDGSGAQATAEVLAVSPRSRVLVLSASDERDDVLQ
TH_3563|M.thermoresistible__bu AAAVRPDVVLMDMRLPDGDGARATAEVRAVSPDSRVLVLSASEERDDVLE
MAB_4519c|M.abscessus_ATCC_199 AATVKPDVVLMDMQLTDGDGAQATAAVLSASPHSHILVLSASAEREDVLE
MLBr_02123|M.leprae_Br4923 ATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVA
. .:* . ::*:.: .* : :*:: . : :
Mb3157c|M.bovis_AF2122/97 AILAGASGYVVKDIKGMELARAVKDVGAGR-SLLDNRAAAALMAKLRG-A
Rv3133c|M.tuberculosis_H37Rv AILAGASGYVVKDIKGMELARAVKDVGAGR-SLLDNRAAAALMAKLRG-A
MUL_3814|M.ulcerans_Agy99 AVKTGATGYLVKSASKAELADAVRATAAGR-AVFTPSLAGLVLGEYRR-I
MMAR_3959|M.marinum_M AVKAGATGYLVKSASKAELADAVRATAAGR-AVFTPSLAGLVLGEYRR-I
MAV_4114|M.avium_104 AVKAGAAGYLVKSASKAELAQAVTDTAAGR-AVFTPSLAGLVLGEYRR-I
Mflv_3579|M.gilvum_PYR-GCK AVKAGATGYLVKSASKQELGDAVRATAQGR-AVFTPGLAGLVLGEFRR-I
Mvan_2836|M.vanbaalenii_PYR-1 AVKAGATGYLVKSASKQELGDAVRATAQGR-AVFTPGLAGLVLGEFRR-I
MSMEG_3240|M.smegmatis_MC2_155 AVKAGATGYLVKSASRTELADAVRATAEGR-AVFTPGLAGLVLGEYRR-I
TH_3563|M.thermoresistible__bu AVKAGATGYLVKSASKTELVDAVHATAQGR-AVFTPGLAGLVLGEYRR-I
MAB_4519c|M.abscessus_ATCC_199 AVKAGATGYLVKSASAAELIDAVRATAKGQ-AVFTPGLAGLVLGEFRR-M
MLBr_02123|M.leprae_Br4923 GLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSETIAVGPLEVDI
.: :** .*:** ** * : : :. .
Mb3157c|M.bovis_AF2122/97 AEK----QDPLSGLTDQERTLLGLLSEG----LTNKQIADRMF-----LA
Rv3133c|M.tuberculosis_H37Rv AEK----QDPLSGLTDQERTLLGLLSEG----LTNKQIADRMF-----LA
MUL_3814|M.ulcerans_Agy99 AQT-ADSSQDRPSLTERETEILRYVAKG----LSAKQIAEKLS-----LS
MMAR_3959|M.marinum_M AQT-ADSSQDRPSLTERETEILRYVAKG----LSAKQIAEKLS-----LS
MAV_4114|M.avium_104 AQS-KDDGPTRPRLTDRETEVLRYVAKG----LSAKQIAEKLS-----LS
Mflv_3579|M.gilvum_PYR-GCK EQS-SPAGADGPTLTERETEILRYVAKG----LTAKQIASRLS-----LS
Mvan_2836|M.vanbaalenii_PYR-1 ERD-SPAG---PTLTERETEILRHVAKG----LTAKQIASRLS-----LS
MSMEG_3240|M.smegmatis_MC2_155 AQQPAQEGPATPTLTERETEILRYVAKG----LTAKQIAARLS-----LS
TH_3563|M.thermoresistible__bu SRQ-PGAGPDAPRLTERETEILRYVAKG----LTAKQIAAQLS-----LS
MAB_4519c|M.abscessus_ATCC_199 SSAPAADADETPRLSDRETEVLRLVAKG----LSAKQIATRLS-----LS
MLBr_02123|M.leprae_Br4923 PGRRARVNGVDVDLTKREFDLLAVLAEHKTTVLSRAQLLELVWGYDFAAD
*:.:* :* ::: *: *: :
Mb3157c|M.bovis_AF2122/97 EKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
Rv3133c|M.tuberculosis_H37Rv EKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
MUL_3814|M.ulcerans_Agy99 HRTVENHVQATFRKLQLANRVELTRYAIEHGLDK------
MMAR_3959|M.marinum_M HRTVENHVQATFRKLQVANRVELTRYAIEHGLDK------
MAV_4114|M.avium_104 HRTVENHVQATFRKLQVANRVELARYAIEHGLDEEP----
Mflv_3579|M.gilvum_PYR-GCK HRTVENHVQATFRKLQVGNRVELARYAIEHGLDE------
Mvan_2836|M.vanbaalenii_PYR-1 HRTVENHVQATFRKLQIGNRVELARYAIEHGLDE------
MSMEG_3240|M.smegmatis_MC2_155 HRTVENHVQATFRKLQVANRVELARYAIEHGLDE------
TH_3563|M.thermoresistible__bu HRTVENHVQATFRKLQVANRVELARYAIEHGLDE------
MAB_4519c|M.abscessus_ATCC_199 HRTVENHVQSTLRKLQLGNRVELTRYAIEHGLDE------
MLBr_02123|M.leprae_Br4923 TNVVDVFIGYLRRKLEANSGPRLLHTVRGVGFVLRMQ---
..*. .: ** . .