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TAIGDIADSPGIPEIGALADGDHPGWSSRPAVESDAARRYHETFRDCDVDPTDDPMAVVGEAVDAKVSIV RNALEALGDDEALNALDAALDLASLERDLIEDGARRRTFALLQVQEGLSKLRAVDDVAMIVDRAPRELVE SCGFDRAVLFRVHEGRMVMESAYFGDDRAGAEKMVAFAQSVAPPLDHMLLETQMIRRRSPAIVHDARNDP RVNRPIVDFSMTHSYVAAPVMPTGKVIGFLHADRLYSGRRVDEIDRDTVWAFAEGFGYAYERTVLLERMR RQHAEVRRALASADEAARALQDADLDLRKIEPVERSAAAQSLAEVHTRVLGMLTRREVEVLRLMAAGRTN QQIADELVISAGTVKSHVKRVLRKLHATNRAEAASAYVRLAIAPAVDG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3973 | - | - | 100% (399) | putative GAF sensor protein |
| M. vanbaalenii PYR-1 | Mvan_0349 | - | 6e-47 | 38.72% (328) | response regulator receiver protein |
| M. vanbaalenii PYR-1 | Mvan_0348 | - | 8e-37 | 34.16% (322) | putative GAF sensor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3157c | devR | 2e-06 | 36.84% (95) | two component transcriptional regulatory protein DevR |
| M. gilvum PYR-GCK | Mflv_4288 | - | 1e-08 | 40.59% (101) | metal dependent phosphohydrolase |
| M. tuberculosis H37Rv | Rv3133c | devR | 2e-06 | 36.84% (95) | two component transcriptional regulatory protein DevR |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1522 | - | 2e-09 | 37.89% (95) | putative two-component system response regulator LuxR |
| M. marinum M | MMAR_2876 | - | 0.0 | 84.69% (392) | putative regulatory protein |
| M. avium 104 | MAV_5280 | - | 6e-09 | 35.78% (109) | two-component system response regulator |
| M. smegmatis MC2 155 | MSMEG_0330 | - | 2e-41 | 36.90% (336) | transcriptional regulator, LuxR family protein |
| M. thermoresistible (build 8) | TH_4501 | - | 0.0 | 83.88% (397) | PUTATIVE conserved hypothetical regulatory protein |
| M. ulcerans Agy99 | MUL_2876 | - | 0.0 | 83.93% (392) | putative regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MMAR_2876|M.marinum_M ----------------MIDAVDMPDPPAFPTLADDEHPGWASRPIRESDA
MUL_2876|M.ulcerans_Agy99 MGFSPRRAIPERTVGGVIDVVDMPDPPAFPTLADDEHPGWASRPIRESDA
TH_4501|M.thermoresistible__bu ----------------MTIAGDVPDSGSDETLAG--HPGWASRPAAESDA
Mvan_3973|M.vanbaalenii_PYR-1 -------------MTAIGDIADSPGIPEIGALADGDHPGWSSRPAVESDA
MSMEG_0330|M.smegmatis_MC2_155 -----------MSVLIGAESSRTAGTGRVRSDRLSKRTEFDERFSALRDR
Mflv_4288|M.gilvum_PYR-GCK -----------MAPPAQPPVRTPSRAELLAALSIAIDLGLGQPAEHMLRS
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MMAR_2876|M.marinum_M TRHYREAFGDCNVDPTDDPMAVVAEAIDVNAAAVR--HALESLGDVHAVN
MUL_2876|M.ulcerans_Agy99 TRHYREAFGDCNVDPTDDPMAVVAEAIDVNAAAVR--HALESQGDVHAVN
TH_4501|M.thermoresistible__bu ARRYRETFADWGVDPTDDPMSVVSEAIDTRANEVR--NALETCGDEEAIA
Mvan_3973|M.vanbaalenii_PYR-1 ARRYHETFRDCDVDPTDDPMAVVGEAVDAKVSIVR--NALEALGDDEALN
MSMEG_0330|M.smegmatis_MC2_155 AAAVLGTERPPALE-SGSPIRVGEVISDFSQLCVRRLQAVRSSDTEAERQ
Mflv_4288|M.gilvum_PYR-GCK AVIATRIADRLGLDRAERDCTYYTALIMWIGCHADSHEYARWFGDDIAVR
Mb3157c|M.bovis_AF2122/97 ---------------------------------MVKVFLVDD---HEVVR
Rv3133c|M.tuberculosis_H37Rv ---------------------------------MVKVFLVDD---HEVVR
MAB_1522|M.abscessus_ATCC_1997 ---------------------------MTD--TEVGVLLVDD---QELVR
MAV_5280|M.avium_104 ---------------------------MTDPAPEITVLLVDD---QDLVR
MMAR_2876|M.marinum_M ALETLLDLSSLEREMIEDGAARRTLALLQVQEALSKLRAVDD---VAMIV
MUL_2876|M.ulcerans_Agy99 ALETLLDLSSLEREMIEDGAARRTLALLQVQEALSKLRAVDD---VAMIV
TH_4501|M.thermoresistible__bu ALESVLDLCSLERELIEDGAQRRTFALLQVQEGLSKLRAVDD---VATIV
Mvan_3973|M.vanbaalenii_PYR-1 ALDAALDLASLERDLIEDGARRRTFALLQVQEGLSKLRAVDD---VAMIV
MSMEG_0330|M.smegmatis_MC2_155 LGSLLLELQQLALDWYLFETGVRSQRLADCAVSLNRLRAMPT---TAALL
Mflv_4288|M.gilvum_PYR-GCK RDSYLVDWSGLPYLRFLMANTGRGQPVLRRLSVLATLLADARGQIAELIH
: :
Mb3157c|M.bovis_AF2122/97 RGLVDLLGADPELD-----------------VVGEAGSVAEAMARVPAAR
Rv3133c|M.tuberculosis_H37Rv RGLVDLLGADPELD-----------------VVGEAGSVAEAMARVPAAR
MAB_1522|M.abscessus_ATCC_1997 TGLRRILRRKDGFA-----------------IVGECADGSEVAAAVSRAR
MAV_5280|M.avium_104 SGLRRILRRKDGFV-----------------IVAECADGDEVPAAVAAHR
MMAR_2876|M.marinum_M DRAPRELVESCGFDRAVLFRVHEGRMVMESAYFGEDREGAEKMVAFAQSV
MUL_2876|M.ulcerans_Agy99 DRAPRELVESCGFDRAVLFRVHEGRLVMESAYFGEDREGAEKMVAFAQSV
TH_4501|M.thermoresistible__bu DRAPRELVESCGFDRAVLFRVHEGRMFMESAYFGEDRAGAEKMVAFAQSV
Mvan_3973|M.vanbaalenii_PYR-1 DRAPRELVESCGFDRAVLFRVHEGRMVMESAYFGDDRAGAEKMVAFAQSV
MSMEG_0330|M.smegmatis_MC2_155 DNACHELVFRLGFRRAVLSTVDTRG-WTPMILLDRTEPADRGWFSNWQNQ
Mflv_4288|M.gilvum_PYR-GCK SHCSSAGILADRLGLSADVQTVLGYTFERFDGGGLPGGVGGDAIPIPMRV
:
Mb3157c|M.bovis_AF2122/97 P---DVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAI
Rv3133c|M.tuberculosis_H37Rv P---DVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAI
MAB_1522|M.abscessus_ATCC_1997 P---DVVIMDLRMKQMSGIEAIRLLHAAQ-GPPALALTTFDDDELLSGAL
MAV_5280|M.avium_104 P---DVVVMDLRMRRVDGIEATRRLGGR---PPVLALTTFNEDELLSGAL
MMAR_2876|M.marinum_M APLLDHMLIETQMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSYVAAPVM
MUL_2876|M.ulcerans_Agy99 APLLDHMLIETQMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSYVAAPVM
TH_4501|M.thermoresistible__bu APPLDHMLLETQMIRRHAPAIVRDARNDPRVNRPIVEFSMTRSYVAAPVM
Mvan_3973|M.vanbaalenii_PYR-1 APPLDHMLLETQMIRRRSPAIVHDARNDPRVNRPIVDFSMTHSYVAAPVM
MSMEG_0330|M.smegmatis_MC2_155 TVPLVQTTPEALSLSRRRPCLIEDTTDAPVYRPLIVHAGQSRSYVVAPLV
Mflv_4288|M.gilvum_PYR-GCK AQLADTAEVHHRTFGVDGAVAMARSRSGGQFDPRVVDAFLADADAILEPP
. . :
Mb3157c|M.bovis_AF2122/97 LAG-----------------------------------------------
Rv3133c|M.tuberculosis_H37Rv LAG-----------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 RAG-----------------------------------------------
MAV_5280|M.avium_104 RAG-----------------------------------------------
MMAR_2876|M.marinum_M PTGKVIGFLHADRLYSGRIVDEIDRDTVWA--------------------
MUL_2876|M.ulcerans_Agy99 PTGKMIGFLHADRLYSGRIVDEIDRDTVWA--------------------
TH_4501|M.thermoresistible__bu PTGKVIGFLHADRLYSGRIVDEIDRDTVWA--------------------
Mvan_3973|M.vanbaalenii_PYR-1 PTGKVIGFLHADRLYSGRRVDEIDRDTVWA--------------------
MSMEG_0330|M.smegmatis_MC2_155 QSGDVMGFLHTDHYPENTPVDEADRDVLWA--------------------
Mflv_4288|M.gilvum_PYR-GCK EDAWSAALREAPDYGTGLADGELDELLVALGDFVDLKCPFTLGHSRAVAE
.
Mb3157c|M.bovis_AF2122/97 ----ASGYVVKDIKGMELARAV----------------------------
Rv3133c|M.tuberculosis_H37Rv ----ASGYVVKDIKGMELARAV----------------------------
MAB_1522|M.abscessus_ATCC_1997 ----AAGFILKDSPAEELVRAV----------------------------
MAV_5280|M.avium_104 ----AAGFVLKDSSAEELIRAV----------------------------
MMAR_2876|M.marinum_M -FAEGFGYAYERTVLLERMRRQ----------------------------
MUL_2876|M.ulcerans_Agy99 -FAEGFGYAYERTVLLERMRRQ----------------------------
TH_4501|M.thermoresistible__bu -FAEGFGYAYERTVLLERMRRL----------------------------
Mvan_3973|M.vanbaalenii_PYR-1 -FAEGFGYAYERTVLLERMRRQ----------------------------
MSMEG_0330|M.smegmatis_MC2_155 -FADGFSHIYQRAALLENLRRQ----------------------------
Mflv_4288|M.gilvum_PYR-GCK LAAGAAALMGMDAGGVDLLRRAGHVHDVGRIGVSNQVWSKPSTLTTGEME
. . : *
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4288|M.gilvum_PYR-GCK RVRLHPYLTVRILSQVGGLDAVARVAGNHHECLDGSGYPRGLPAAALSVP
Mb3157c|M.bovis_AF2122/97 -----KDVGA---------GRSLLDNRAAAALMAKLR-----------GA
Rv3133c|M.tuberculosis_H37Rv -----KDVGA---------GRSLLDNRAAAALMAKLR-----------GA
MAB_1522|M.abscessus_ATCC_1997 -----HAVAR---------GEAYLDPAVTSRVLNAYR-----------RA
MAV_5280|M.avium_104 -----RAVAR---------GEGYLDPAVTSRVLTTYR-----------KA
MMAR_2876|M.marinum_M -----HAEVRSALASADEAARALQDADLDLRKIEPVE-----------RS
MUL_2876|M.ulcerans_Agy99 -----HAEVRSALASADEAARALQDADLDLRKIEPVE-----------RS
TH_4501|M.thermoresistible__bu -----QAEVRNALASADEAARALQDADLDLRKIEPQE-----------RS
Mvan_3973|M.vanbaalenii_PYR-1 -----HAEVRRALASADEAARALQDADLDLRKIEPVE-----------RS
MSMEG_0330|M.smegmatis_MC2_155 -----RDHIRDLLISTVDQIDELCDVSVEATAWADENG----------QT
Mflv_4288|M.gilvum_PYR-GCK DRVLAAAVAYRSAVEPRPYRVALSPAAAATRLRDRVREGHLDELAVDAVL
.
Mb3157c|M.bovis_AF2122/97 AE-------KQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTVKN
Rv3133c|M.tuberculosis_H37Rv AE-------KQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTVKN
MAB_1522|M.abscessus_ATCC_1997 PAA-----VSGDAQDKLTARELDVLALIASGATNSEIAEQLVISEVTVKS
MAV_5280|M.avium_104 APG-----PHGAAIAELTTRERDVLTLIGKGLSNSEIADELCISGVTVKS
MMAR_2876|M.marinum_M PAARSLAEVQTRAMAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKS
MUL_2876|M.ulcerans_Agy99 PAARSLAEVQTRVMAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKS
TH_4501|M.thermoresistible__bu PAARSLAEVHTRVMAMLTRREIEVLRLMAAGRTNQQIADELVISAGTVKS
Mvan_3973|M.vanbaalenii_PYR-1 AAAQSLAEVHTRVLGMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKS
MSMEG_0330|M.smegmatis_MC2_155 ADDDATTGARPPHRVELTERESEVLRLMVTGASNHEIAEQLVITEGTVKS
Mflv_4288|M.gilvum_PYR-GCK SAAGHAARRVSARPGGLTPREIEVLCLVARGASNKEIAATLGISGKTARN
. ** :* :* *: * :* :** : :: *.:.
Mb3157c|M.bovis_AF2122/97 YVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
Rv3133c|M.tuberculosis_H37Rv YVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
MAB_1522|M.abscessus_ATCC_1997 HIGRIFVKLDLRDRAAAIVYAYDHGIVTPK----
MAV_5280|M.avium_104 HIGRIFGKLDLRDRAAAIVYAYDNGIVAPR----
MMAR_2876|M.marinum_M HVKRVLRKLHATNRAEAASAYVRLASVPEVG---
MUL_2876|M.ulcerans_Agy99 HVKRVLRKLHATNRAEAASAYVRLASVSEVG---
TH_4501|M.thermoresistible__bu HVKRVLRKLHATNRAEAASAYVRLASVPEVG---
Mvan_3973|M.vanbaalenii_PYR-1 HVKRVLRKLHATNRAEAASAYVRLAIAPAVDG--
MSMEG_0330|M.smegmatis_MC2_155 HVKHILRKYGAVNRAQAIAWALQGT---------
Mflv_4288|M.gilvum_PYR-GCK HVERTYAKIGATNRIGASMFALGHGLITPA----
:: : * * *