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IDAVDMPDPPAFPTLADDEHPGWASRPIRESDATRHYREAFGDCNVDPTDDPMAVVAEAIDVNAAAVRHA LESLGDVHAVNALETLLDLSSLEREMIEDGAARRTLALLQVQEALSKLRAVDDVAMIVDRAPRELVESCG FDRAVLFRVHEGRMVMESAYFGEDREGAEKMVAFAQSVAPLLDHMLIETQMIRRHAPAIVRDARNDPRVN RPIVDFSLTHSYVAAPVMPTGKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRRQH AEVRSALASADEAARALQDADLDLRKIEPVERSPAARSLAEVQTRAMAMLTRREVEVLRLMAAGRTNQQI ADELVISAGTVKSHVKRVLRKLHATNRAEAASAYVRLASVPEVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2876 | - | - | 100% (395) | putative regulatory protein |
| M. marinum M | MMAR_0612 | - | 8e-08 | 31.21% (157) | transcriptional regulatory protein |
| M. marinum M | MMAR_0132 | - | 5e-07 | 38.16% (76) | two-component transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3157c | devR | 2e-06 | 36.84% (95) | two component transcriptional regulatory protein DevR |
| M. gilvum PYR-GCK | Mflv_0277 | - | 4e-08 | 30.92% (152) | response regulator receiver protein |
| M. tuberculosis H37Rv | Rv3133c | devR | 2e-06 | 36.84% (95) | two component transcriptional regulatory protein DevR |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1522 | - | 3e-10 | 36.75% (117) | putative two-component system response regulator LuxR |
| M. avium 104 | MAV_5280 | - | 2e-08 | 37.11% (97) | two-component system response regulator |
| M. smegmatis MC2 155 | MSMEG_0330 | - | 1e-38 | 37.09% (302) | transcriptional regulator, LuxR family protein |
| M. thermoresistible (build 8) | TH_4501 | - | 0.0 | 86.48% (392) | PUTATIVE conserved hypothetical regulatory protein |
| M. ulcerans Agy99 | MUL_2876 | - | 0.0 | 98.48% (395) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_3973 | - | 0.0 | 84.69% (392) | putative GAF sensor protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0277|M.gilvum_PYR-GCK MLPAAREAIAAVDADPRAATKSLVTGGIGTGKTTLLAAMRTTFRSAGRQV
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0277|M.gilvum_PYR-GCK LSRPPDAGTPGDGAGYALVVDDAHLLGDDDLDRLTDLAGDPASTVVIATQ
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0277|M.gilvum_PYR-GCK ALMHRSRLQVLMTVLARENPEVALRPLTAAQVQEAATSALGASVGPELTR
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0277|M.gilvum_PYR-GCK LLVSVTGGFPFLVSAALSAIPDGAQSARQAAHFALIERLARLDGHLLDTL
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0277|M.gilvum_PYR-GCK LVMTLSPGLGPDDVAAALRIPADEAVAAVDSARATALIDPAHTSQFLAAV
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0277|M.gilvum_PYR-GCK HDGIAQIVGAARHHDVEMAVLDSQLALCTLTADLALRIADHGVRDDRLAT
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0277|M.gilvum_PYR-GCK ALTDFAARVPDRPARAARLYRAATDAGTTAVRPALADALVLTGDCVTAGR
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 ----------------------------------MGFSPRRAIPERTVGG
TH_4501|M.thermoresistible__bu --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1 -----------------------------------------------MTA
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 ---------------------------------------------MSVLI
Mflv_0277|M.gilvum_PYR-GCK LADDLLTSQDPDERAAAVRIAASIALHDGAARQAADLFAWLGPAPDAVVG
MMAR_2876|M.marinum_M MIDAVDMPDPPAFPTLADDEHPGWASRPIRESDATRHYREAFGDCNVDPT
MUL_2876|M.ulcerans_Agy99 VIDVVDMPDPPAFPTLADDEHPGWASRPIRESDATRHYREAFGDCNVDPT
TH_4501|M.thermoresistible__bu MTIAGDVPDSGSDETLAG--HPGWASRPAAESDAARRYRETFADWGVDPT
Mvan_3973|M.vanbaalenii_PYR-1 IGDIADSPGIPEIGALADGDHPGWSSRPAVESDAARRYHETFRDCDVDPT
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 GAESSRTAGTGRVRSDRLSKRTEFDERFSALRDRAAAVLGTERPPALE-S
Mflv_0277|M.gilvum_PYR-GCK AAETIAALAVGDAAAVRSTAQGPPSGPPTAVARSARAITEGLVMTLDQPY
MMAR_2876|M.marinum_M DDPMAVVAEAIDVNAAAVR--HALESLGDVHAVNALETLLDLSSLEREMI
MUL_2876|M.ulcerans_Agy99 DDPMAVVAEAIDVNAAAVR--HALESQGDVHAVNALETLLDLSSLEREMI
TH_4501|M.thermoresistible__bu DDPMSVVSEAIDTRANEVR--NALETCGDEEAIAALESVLDLCSLERELI
Mvan_3973|M.vanbaalenii_PYR-1 DDPMAVVGEAVDAKVSIVR--NALEALGDDEALNALDAALDLASLERDLI
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155 GSPIRVGEVISDFSQLCVRRLQAVRSSDTEAERQLGSLLLELQQLALDWY
Mflv_0277|M.gilvum_PYR-GCK PAAIARLSQAIAVDAVHGVLPDTPAALVTLAALHGGDPVRARSVIGRAVL
MMAR_2876|M.marinum_M EDGAA--------RRTLALLQVQEALSKLRAVDDVAMIVDRAPRELVESC
MUL_2876|M.ulcerans_Agy99 EDGAA--------RRTLALLQVQEALSKLRAVDDVAMIVDRAPRELVESC
TH_4501|M.thermoresistible__bu EDGAQ--------RRTFALLQVQEGLSKLRAVDDVATIVDRAPRELVESC
Mvan_3973|M.vanbaalenii_PYR-1 EDGAR--------RRTFALLQVQEGLSKLRAVDDVAMIVDRAPRELVESC
Mb3157c|M.bovis_AF2122/97 -------------------------MVKVFLVDDHEVVRRGLVDLLGADP
Rv3133c|M.tuberculosis_H37Rv -------------------------MVKVFLVDDHEVVRRGLVDLLGADP
MAB_1522|M.abscessus_ATCC_1997 -------------------MTD--TEVGVLLVDDQELVRTGLRRILRRKD
MAV_5280|M.avium_104 -------------------MTDPAPEITVLLVDDQDLVRSGLRRILRRKD
MSMEG_0330|M.smegmatis_MC2_155 LFETG--------VRSQRLADCAVSLNRLRAMPTTAALLDNACHELVFRL
Mflv_0277|M.gilvum_PYR-GCK ADSRPDRADATFVTSRHRLLQGWAYMQDGQLAAAAAAIPADGDPRLHRRD
: *
MMAR_2876|M.marinum_M GFDRAVLFRVHEGRMVMESAYFGEDREGAEKMVAFAQSVAPLLDHMLIET
MUL_2876|M.ulcerans_Agy99 GFDRAVLFRVHEGRLVMESAYFGEDREGAEKMVAFAQSVAPLLDHMLIET
TH_4501|M.thermoresistible__bu GFDRAVLFRVHEGRMFMESAYFGEDRAGAEKMVAFAQSVAPPLDHMLLET
Mvan_3973|M.vanbaalenii_PYR-1 GFDRAVLFRVHEGRMVMESAYFGDDRAGAEKMVAFAQSVAPPLDHMLLET
Mb3157c|M.bovis_AF2122/97 ELD-----------------VVGEAGSVAEAMARVPAARP---DVAVLDV
Rv3133c|M.tuberculosis_H37Rv ELD-----------------VVGEAGSVAEAMARVPAARP---DVAVLDV
MAB_1522|M.abscessus_ATCC_1997 GFA-----------------IVGECADGSEVAAAVSRARP---DVVIMDL
MAV_5280|M.avium_104 GFV-----------------IVAECADGDEVPAAVAAHRP---DVVVMDL
MSMEG_0330|M.smegmatis_MC2_155 GFRRAVLSTVDTRG-WTPMILLDRTEPADRGWFSNWQNQTVPLVQTTPEA
Mflv_0277|M.gilvum_PYR-GCK ALWAAALHTGIARRSGDTGAMQMHWRSAMDVLAESSADLFTVLPLGELWI
:
MMAR_2876|M.marinum_M QMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSY-----------------
MUL_2876|M.ulcerans_Agy99 QMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSY-----------------
TH_4501|M.thermoresistible__bu QMIRRHAPAIVRDARNDPRVNRPIVEFSMTRSY-----------------
Mvan_3973|M.vanbaalenii_PYR-1 QMIRRRSPAIVHDARNDPRVNRPIVDFSMTHSY-----------------
Mb3157c|M.bovis_AF2122/97 RLPDGNGIELCRDLLSRMPDLRCLILTSYTS-------------------
Rv3133c|M.tuberculosis_H37Rv RLPDGNGIELCRDLLSRMPDLRCLILTSYTS-------------------
MAB_1522|M.abscessus_ATCC_1997 RMKQMSGIEAIRLLHAAQ-GPPALALTTFDD-------------------
MAV_5280|M.avium_104 RMRRVDGIEATRRLGGR---PPVLALTTFNE-------------------
MSMEG_0330|M.smegmatis_MC2_155 LSLSRRRPCLIEDTTDAPVYRPLIVHAGQSRSY-----------------
Mflv_0277|M.gilvum_PYR-GCK AASRLRQVDQVRHSLDEVFGLLAALGDPLLWSIPLHWAGVHAGILANSPD
.
MMAR_2876|M.marinum_M --------VAAPVMPTGKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFG
MUL_2876|M.ulcerans_Agy99 --------VAAPVMPTGKMIGFLHADRLYSGRIVDEIDRDTVWAFAEGFG
TH_4501|M.thermoresistible__bu --------VAAPVMPTGKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFG
Mvan_3973|M.vanbaalenii_PYR-1 --------VAAPVMPTGKVIGFLHADRLYSGRRVDEIDRDTVWAFAEGFG
Mb3157c|M.bovis_AF2122/97 ----------------------------------DEAMLDAILAGASGYV
Rv3133c|M.tuberculosis_H37Rv ----------------------------------DEAMLDAILAGASGYV
MAB_1522|M.abscessus_ATCC_1997 ----------------------------------DELLSGALRAGAAGFI
MAV_5280|M.avium_104 ----------------------------------DELLSGALRAGAAGFV
MSMEG_0330|M.smegmatis_MC2_155 --------VVAPLVQSGDVMGFLHTDHYPENTPVDEADRDVLWAFADGFS
Mflv_0277|M.gilvum_PYR-GCK AVAPHGAALTAAAPHAQFAKALAAAGRTWLRVLADRVDVAEVTAAARGLA
*. : * * *
MMAR_2876|M.marinum_M YA--YERTVLLERMRRQHAEVRSALASADEAARALQDADLDLRKIEPVE-
MUL_2876|M.ulcerans_Agy99 YA--YERTVLLERMRRQHAEVRSALASADEAARALQDADLDLRKIEPVE-
TH_4501|M.thermoresistible__bu YA--YERTVLLERMRRLQAEVRNALASADEAARALQDADLDLRKIEPQE-
Mvan_3973|M.vanbaalenii_PYR-1 YA--YERTVLLERMRRQHAEVRRALASADEAARALQDADLDLRKIEPVE-
Mb3157c|M.bovis_AF2122/97 VK--DIKGMELARAVKDVGA-----------GRSLLDNRAAAALMAKLR-
Rv3133c|M.tuberculosis_H37Rv VK--DIKGMELARAVKDVGA-----------GRSLLDNRAAAALMAKLR-
MAB_1522|M.abscessus_ATCC_1997 LK--DSPAEELVRAVHAVAR-----------GEAYLDPAVTSRVLNAYR-
MAV_5280|M.avium_104 LK--DSSAEELIRAVRAVAR-----------GEGYLDPAVTSRVLTTYR-
MSMEG_0330|M.smegmatis_MC2_155 HI--YQRAALLENLRRQRDHIRDLLISTVDQIDELCDVSVEATAWADENG
Mflv_0277|M.gilvum_PYR-GCK LHGHTWDATRLAGQAALQTTDSRAAQAMLQLARDLKATVAASDASVPSSA
*
MMAR_2876|M.marinum_M RSPAARSLAEVQTRAMAMLTRREVEVLRLMAAGRTNQQIADELVISAGTV
MUL_2876|M.ulcerans_Agy99 RSPAARSLAEVQTRVMAMLTRREVEVLRLMAAGRTNQQIADELVISAGTV
TH_4501|M.thermoresistible__bu RSPAARSLAEVHTRVMAMLTRREIEVLRLMAAGRTNQQIADELVISAGTV
Mvan_3973|M.vanbaalenii_PYR-1 RSAAAQSLAEVHTRVLGMLTRREVEVLRLMAAGRTNQQIADELVISAGTV
Mb3157c|M.bovis_AF2122/97 GAAE-------KQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTV
Rv3133c|M.tuberculosis_H37Rv GAAE-------KQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTV
MAB_1522|M.abscessus_ATCC_1997 RAPAA-----VSGDAQDKLTARELDVLALIASGATNSEIAEQLVISEVTV
MAV_5280|M.avium_104 KAAPG-----PHGAAIAELTTRERDVLTLIGKGLSNSEIADELCISGVTV
MSMEG_0330|M.smegmatis_MC2_155 QTADDDATTGARPPHRVELTERESEVLRLMVTGASNHEIAEQLVITEGTV
Mflv_0277|M.gilvum_PYR-GCK TDTVAPPPAVPQRVSSTQLSEREREVAELLLQGLPYREIGSQLFISAKTV
. *: :* : *: * . :*...: :: **
MMAR_2876|M.marinum_M KSHVKRVLRKLHATNRAEAASAYVRLASVPEVG---
MUL_2876|M.ulcerans_Agy99 KSHVKRVLRKLHATNRAEAASAYVRLASVSEVG---
TH_4501|M.thermoresistible__bu KSHVKRVLRKLHATNRAEAASAYVRLASVPEVG---
Mvan_3973|M.vanbaalenii_PYR-1 KSHVKRVLRKLHATNRAEAASAYVRLAIAPAVDG--
Mb3157c|M.bovis_AF2122/97 KNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
Rv3133c|M.tuberculosis_H37Rv KNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
MAB_1522|M.abscessus_ATCC_1997 KSHIGRIFVKLDLRDRAAAIVYAYDHGIVTPK----
MAV_5280|M.avium_104 KSHIGRIFGKLDLRDRAAAIVYAYDNGIVAPR----
MSMEG_0330|M.smegmatis_MC2_155 KSHVKHILRKYGAVNRAQAIAWALQGT---------
Mflv_0277|M.gilvum_PYR-GCK EHHVARIRRRLGAESRSEMLSMLRAALDTPASR---
: :: :: : *: