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M. thermoresistible (build 8) TH_4501 (-)

annotation: conserved hypothetical regulatory protein
coordinates: 403593 - 404774
length: 394

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4501--100% (394)conserved hypothetical regulatory protein
M. thermoresistible (build 8)TH_3563-2e-0750.00% (52) PUTATIVE DNA-binding response regulator, LuxR family protein
M. thermoresistible (build 8)TH_3071-3e-0736.59% (82) PUTATIVE -

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0867cnarL2e-0631.58% (95) nitrate/nitrite response transcriptional regulatory protein
M. gilvum PYR-GCKMflv_4809-3e-0736.15% (130) regulatory protein, LuxR
M. tuberculosis H37RvRv0844cnarL2e-0631.58% (95) nitrate/nitrite response transcriptional regulatory protein
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_1522-1e-0942.35% (85) putative two-component system response regulator LuxR
M. marinum MMMAR_2876-0.086.48% (392) putative regulatory protein
M. avium 104MAV_5280-9e-0937.11% (97) two-component system response regulator
M. smegmatis MC2 155MSMEG_0330-2e-4135.00% (360) transcriptional regulator, LuxR family protein
M. ulcerans Agy99MUL_2876-0.086.15% (390) putative regulatory protein
M. vanbaalenii PYR-1Mvan_3973-0.083.88% (397) putative GAF sensor protein

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_2876|M.marinum_M               --------------------------------------------------
MUL_2876|M.ulcerans_Agy99           --------------------------------------------------
TH_4501|M.thermoresistible__bu      --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb0867c|M.bovis_AF2122/97           --------------------------------------------------
Rv0844c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_5280|M.avium_104                --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_4809|M.gilvum_PYR-GCK          MGRPRIADRVVPRPDLLKRLESSAGGDLVVLTAPAGYGKTTVTAMWDAED
                                                                                      

MMAR_2876|M.marinum_M               --------------------------------------------------
MUL_2876|M.ulcerans_Agy99           --------------------------------------------------
TH_4501|M.thermoresistible__bu      --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb0867c|M.bovis_AF2122/97           --------------------------------------------------
Rv0844c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_5280|M.avium_104                --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_4809|M.gilvum_PYR-GCK          RRQFAWARIDHLDDDPGHLLLHIATAVVRLGAGDDHLLNYLRGPGREPEH
                                                                                      

MMAR_2876|M.marinum_M               --------------------------------------------------
MUL_2876|M.ulcerans_Agy99           --------------------------------------------------
TH_4501|M.thermoresistible__bu      --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb0867c|M.bovis_AF2122/97           --------------------------------------------------
Rv0844c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_5280|M.avium_104                --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_4809|M.gilvum_PYR-GCK          LLPAVVRLLEEFGPIVVILDDVHKLSTPQSISALHAFVDAAPLTTTVALL
                                                                                      

MMAR_2876|M.marinum_M               --------------------------------------------------
MUL_2876|M.ulcerans_Agy99           --------------------------------------------------
TH_4501|M.thermoresistible__bu      --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb0867c|M.bovis_AF2122/97           --------------------------------------------------
Rv0844c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_5280|M.avium_104                --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_4809|M.gilvum_PYR-GCK          GRFLLPLDIARRRLAGNLVEVDQDALRLTAEETVAALESVRGPSDDATVA
                                                                                      

MMAR_2876|M.marinum_M               --------------------------------------------------
MUL_2876|M.ulcerans_Agy99           --------------------------------------------------
TH_4501|M.thermoresistible__bu      --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb0867c|M.bovis_AF2122/97           --------------------------------------------------
Rv0844c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_5280|M.avium_104                --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_4809|M.gilvum_PYR-GCK          TVIDLCEGWAAGVILTAMALRDGTAPEALAGRNNLVVEYVVEEVIDRVDD
                                                                                      

MMAR_2876|M.marinum_M               --------------------------------------------------
MUL_2876|M.ulcerans_Agy99           ----------------------------------------MGFSPRRAIP
TH_4501|M.thermoresistible__bu      --------------------------------------------------
Mvan_3973|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb0867c|M.bovis_AF2122/97           --------------------------------------------------
Rv0844c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_5280|M.avium_104                --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_4809|M.gilvum_PYR-GCK          DTRSFLLESAMLDRFTAEHLDAVLGRVDAAWMLEQLATSGNPFLISLDSQ
                                                                                      

MMAR_2876|M.marinum_M               ------MIDAVDMPDPPAFP---TLADDEHPGWASRPIRESDATRHYREA
MUL_2876|M.ulcerans_Agy99           ERTVGGVIDVVDMPDPPAFP---TLADDEHPGWASRPIRESDATRHYREA
TH_4501|M.thermoresistible__bu      ------MTIAGDVPDSGSDE---TLAG--HPGWASRPAAESDAARRYRET
Mvan_3973|M.vanbaalenii_PYR-1       ------MTAIGDIADSPGIPEIGALADGDHPGWSSRPAVESDAARRYHET
Mb0867c|M.bovis_AF2122/97           --------------------------------------------------
Rv0844c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_5280|M.avium_104                --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155      ----MSVLIGAESSRTAGTGRVRSDRLSKRTEFDERFSALRDRAAAVLGT
Mflv_4809|M.gilvum_PYR-GCK          GDSFRYHHLFGDVLRARLRASEPARFRELASRAADLLEREGDIDGALVHA
                                                                                      

MMAR_2876|M.marinum_M               FGDCNVDPTDDPMAVVAEAIDVNAAAVR--HALESLGDVHAVNALETLLD
MUL_2876|M.ulcerans_Agy99           FGDCNVDPTDDPMAVVAEAIDVNAAAVR--HALESQGDVHAVNALETLLD
TH_4501|M.thermoresistible__bu      FADWGVDPTDDPMSVVSEAIDTRANEVR--NALETCGDEEAIAALESVLD
Mvan_3973|M.vanbaalenii_PYR-1       FRDCDVDPTDDPMAVVGEAVDAKVSIVR--NALEALGDDEALNALDAALD
Mb0867c|M.bovis_AF2122/97           --------------------------------------------------
Rv0844c|M.tuberculosis_H37Rv        --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997      --------------------------------------------------
MAV_5280|M.avium_104                --------------------------------------------------
MSMEG_0330|M.smegmatis_MC2_155      ERPPALE-SGSPIRVGEVISDFSQLCVRRLQAVRSSDTEAERQLGSLLLE
Mflv_4809|M.gilvum_PYR-GCK          LEAGDRARAAALVGREAVRLGFDGRAGVLARRLGMLDARTFAEQPDAAVA
                                                                                      

MMAR_2876|M.marinum_M               LSSLEREMIEDGAARRTLALLQVQEA----LSKLRAVDDVAMIVDRAPRE
MUL_2876|M.ulcerans_Agy99           LSSLEREMIEDGAARRTLALLQVQEA----LSKLRAVDDVAMIVDRAPRE
TH_4501|M.thermoresistible__bu      LCSLERELIEDGAQRRTFALLQVQEG----LSKLRAVDDVATIVDRAPRE
Mvan_3973|M.vanbaalenii_PYR-1       LASLERDLIEDGARRRTFALLQVQEG----LSKLRAVDDVAMIVDRAPRE
Mb0867c|M.bovis_AF2122/97           ------------------------------MSNPQPEKVRVVVGDDHP--
Rv0844c|M.tuberculosis_H37Rv        ------------------------------MSNPQPEKVRVVVGDDHP--
MAB_1522|M.abscessus_ATCC_1997      ------------------------------MTD---TEVGVLLVDDQE--
MAV_5280|M.avium_104                ------------------------------MTDP-APEITVLLVDDQD--
MSMEG_0330|M.smegmatis_MC2_155      LQQLALDWYLFETGVRSQRLADCAVS----LNRLRAMPTTAALLDNACHE
Mflv_4809|M.gilvum_PYR-GCK          RAWLGVTTADAELIQRSLMLALHSDHGGPLADGTPSVSVAVALISSLVGV
                                                                            . : .     

MMAR_2876|M.marinum_M               LVESCGFDRAVLFRVHEGRMVM----ESAYFGEDREGAEKMVAFAQSVAP
MUL_2876|M.ulcerans_Agy99           LVESCGFDRAVLFRVHEGRLVM----ESAYFGEDREGAEKMVAFAQSVAP
TH_4501|M.thermoresistible__bu      LVESCGFDRAVLFRVHEGRMFM----ESAYFGEDRAGAEKMVAFAQSVAP
Mvan_3973|M.vanbaalenii_PYR-1       LVESCGFDRAVLFRVHEGRMVM----ESAYFGDDRAGAEKMVAFAQSVAP
Mb0867c|M.bovis_AF2122/97           -----------LFREGVVRALS----LSGSVNVVGEADDGAAALELIKAH
Rv0844c|M.tuberculosis_H37Rv        -----------LFREGVVRALS----LSGSVNVVGEADDGAAALELIKAH
MAB_1522|M.abscessus_ATCC_1997      -----------LVRTGLRRILR----RKDGFAIVGECADGSEVAAAVSRA
MAV_5280|M.avium_104                -----------LVRSGLRRILR----RKDGFVIVAECADGDEVPAAVAAH
MSMEG_0330|M.smegmatis_MC2_155      LVFRLGFRR-AVLSTVDTRGWT----PMILLDRTEPADRGWFSNWQNQTV
Mflv_4809|M.gilvum_PYR-GCK          GGVAEVIRHADTVRAAGDNLVNPWWGAATVMKGAAEAMRGQGGRARLLLE
                                                .     .           .                   

MMAR_2876|M.marinum_M               LLDHMLIETQMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSYVAAPVMPT
MUL_2876|M.ulcerans_Agy99           LLDHMLIETQMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSYVAAPVMPT
TH_4501|M.thermoresistible__bu      PLDHMLLETQMIRRHAPAIVRDARNDPRVNRPIVEFSMTRSYVAAPVMPT
Mvan_3973|M.vanbaalenii_PYR-1       PLDHMLLETQMIRRRSPAIVHDARNDPRVNRPIVDFSMTHSYVAAPVMPT
Mb0867c|M.bovis_AF2122/97           LPDVALLDYRMPGMDGAQVPAAVRSYELPTRVLLISAHDEPAIVYQALQQ
Rv0844c|M.tuberculosis_H37Rv        LPDVALLDYRMPGMDGAQVAAAVRSYELPTRVLLISAHDEPAIVYQALQQ
MAB_1522|M.abscessus_ATCC_1997      RPDVVIMDLRMKQMSGIEAIRLLHAAQGPPALALTTFDDD-ELLSGALRA
MAV_5280|M.avium_104                RPDVVVMDLRMRRVDGIEATRRLGGR--PPVLALTTFNED-ELLSGALRA
MSMEG_0330|M.smegmatis_MC2_155      PLVQTTPEALSLSRRRPCLIEDTTDAPVYRPLIVHAGQSRSYVVAPLVQS
Mflv_4809|M.gilvum_PYR-GCK          SALPVIEDLPGFHAAALAHLALLDLAAGDDEAAVERCDAARTLADKYDLS
                                           :                         :        :       

MMAR_2876|M.marinum_M               GKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRRQH
MUL_2876|M.ulcerans_Agy99           GKMIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRRQH
TH_4501|M.thermoresistible__bu      GKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRRLQ
Mvan_3973|M.vanbaalenii_PYR-1       GKVIGFLHADRLYSGRRVDEIDRDTVWAFAEGFGYAYERTVLLERMRRQH
Mb0867c|M.bovis_AF2122/97           G-AAGFLLKD-------------------------------------STR
Rv0844c|M.tuberculosis_H37Rv        G-AAGFLLKD-------------------------------------STR
MAB_1522|M.abscessus_ATCC_1997      G-AAGFILKD-------------------------------------SPA
MAV_5280|M.avium_104                G-AAGFVLKD-------------------------------------SSA
MSMEG_0330|M.smegmatis_MC2_155      GDVMGFLHTDHYPENTPVDEADRDVLWAFADGFSHIYQRAALLENLRRQR
Mflv_4809|M.gilvum_PYR-GCK          DVVPMIVVYSTSAVMSARVGDVPAALHAVQITQTLLERLGNLSARTALLG
                                    .    ::  .                                        

MMAR_2876|M.marinum_M               AEVRSALASADEAARALQDADLDLRKIEPV-----ERSPAARSLAEVQTR
MUL_2876|M.ulcerans_Agy99           AEVRSALASADEAARALQDADLDLRKIEPV-----ERSPAARSLAEVQTR
TH_4501|M.thermoresistible__bu      AEVRNALASADEAARALQDADLDLRKIEPQ-----ERSPAARSLAEVHTR
Mvan_3973|M.vanbaalenii_PYR-1       AEVRRALASADEAARALQDADLDLRKIEPV-----ERSAAAQSLAEVHTR
Mb0867c|M.bovis_AF2122/97           TEIVKAVLDCAKGRDVVAPSLVGG-----------LAGEIRQRAAPVA--
Rv0844c|M.tuberculosis_H37Rv        TEIVKAVLDCAKGRDVVAPSLVGG-----------LAGEIRQRAAPVA--
MAB_1522|M.abscessus_ATCC_1997      EELVRAVHAVARGEAYLDPAVTSR-----------VLNAYRRAPAAVSGD
MAV_5280|M.avium_104                EELIRAVRAVARGEGYLDPAVTSR-----------VLTTYRKAAPGPHGA
MSMEG_0330|M.smegmatis_MC2_155      DHIRDLLISTVDQIDELCDVSVEATAWADEN----GQTADDDATTGARPP
Mflv_4809|M.gilvum_PYR-GCK          HGLLAWTAAALQDRALLSRHLTAAERVRHREPDAVALVQRVERVKAMAVG
                                      :             :                                 

MMAR_2876|M.marinum_M               AMAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLHAT
MUL_2876|M.ulcerans_Agy99           VMAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLHAT
TH_4501|M.thermoresistible__bu      VMAMLTRREIEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLHAT
Mvan_3973|M.vanbaalenii_PYR-1       VLGMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLHAT
Mb0867c|M.bovis_AF2122/97           --PVLSAREREVLNRIACGQSIPAIAAELYVAPSTVKTHVQRLYEKLGVS
Rv0844c|M.tuberculosis_H37Rv        --PVLSAREREVLNRIACGQSIPAIAAELYVAPSTVKTHVQRLYEKLGVS
MAB_1522|M.abscessus_ATCC_1997      AQDKLTARELDVLALIASGATNSEIAEQLVISEVTVKSHIGRIFVKLDLR
MAV_5280|M.avium_104                AIAELTTRERDVLTLIGKGLSNSEIADELCISGVTVKSHIGRIFGKLDLR
MSMEG_0330|M.smegmatis_MC2_155      HRVELTERESEVLRLMVTGASNHEIAEQLVITEGTVKSHVKHILRKYGAV
Mflv_4809|M.gilvum_PYR-GCK          GTRPLTAAELRLLPHLATHLSLQRIAEELVIGRETAKSQATSIYRKLGVS
                                        *:  *  :*  :    :   ** :* :   *.*::   :  *    

MMAR_2876|M.marinum_M               NRAEAASAYVRLASVPEVG-
MUL_2876|M.ulcerans_Agy99           NRAEAASAYVRLASVSEVG-
TH_4501|M.thermoresistible__bu      NRAEAASAYVRLASVPEVG-
Mvan_3973|M.vanbaalenii_PYR-1       NRAEAASAYVRLAIAPAVDG
Mb0867c|M.bovis_AF2122/97           DRAAAVAEAMRQRLLD----
Rv0844c|M.tuberculosis_H37Rv        DRAAAVAEAMRQRLLD----
MAB_1522|M.abscessus_ATCC_1997      DRAAAIVYAYDHGIVTPK--
MAV_5280|M.avium_104                DRAAAIVYAYDNGIVAPR--
MSMEG_0330|M.smegmatis_MC2_155      NRAQAIAWALQGT-------
Mflv_4809|M.gilvum_PYR-GCK          SRGQAVSEAIRIGLLAD---
                                    .*. *