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M. thermoresistible (build 8) TH_1968 ()

annotation: POSSIBLE METHYLTRANSFERASE (METHYLASE)
coordinates: 3818830 - 3819534
length: 235

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1968-100% (235)POSSIBLE METHYLTRANSFERASE (METHYLASE)
M. thermoresistible (build 8)TH_2189-8e-1033.33% (129) CONSERVED HYPOTHETICAL PROTEIN
M. thermoresistible (build 8)TH_2937-8e-0724.66% (223) PUTATIVE Methyltransferase type 11

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3374-1e-11182.05% (234) methyltransferase (methylase)
M. gilvum PYR-GCKMflv_4877-1e-11182.28% (237) methyltransferase type 11
M. tuberculosis H37RvRv3342-1e-11182.05% (234) methyltransferase (methylase)
M. leprae Br4923MLBr_01723-4e-0833.64% (110) hypothetical protein MLBr_01723
M. abscessus ATCC 19977MAB_3689-1e-10679.49% (234) putative methyltransferase
M. marinum MMMAR_1183-1e-11183.33% (234) methyltransferase
M. avium 104MAV_4317-1e-10780.34% (234) putative methyltransferase
M. smegmatis MC2 155MSMEG_1650-1e-11383.76% (234) methyltransferase type 11
M. ulcerans Agy99MUL_1436-1e-11283.33% (234) methyltransferase
M. vanbaalenii PYR-1Mvan_1552-1e-11585.47% (234) methyltransferase type 11

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4877|M.gilvum_PYR-GCK          ----------------------MTAE---SDRRSLSFGAEAA--------
Mvan_1552|M.vanbaalenii_PYR-1       ----------------------MTER---PDR-SLSFGAEAA--------
MSMEG_1650|M.smegmatis_MC2_155      ----------------------MTPSDPLKQQRSLSFGSEAA--------
TH_1968|M.thermoresistible__bu      ----------------------------------LSFGAEAA--------
Mb3374|M.bovis_AF2122/97            ----------------------MTCS---RRDMSLSFGSAVG--------
Rv3342|M.tuberculosis_H37Rv         ----------------------MTCS---RRDMSLSFGSAVG--------
MMAR_1183|M.marinum_M               ----------------------MSGS---AQDPSLSFGSAAA--------
MUL_1436|M.ulcerans_Agy99           ---------------------MVSGS---AQDPSLSFGSAAA--------
MAV_4317|M.avium_104                ----------------------MTRS---RHDRSLSFGSAAA--------
MAB_3689|M.abscessus_ATCC_1997      ----------------------MPDA---QAEPSLSFGSQAA--------
MLBr_01723|M.leprae_Br4923          MTRSTEISANAVPNPHATAEQVAAARKDSKLAQVLYHDWEAENYDEKWSI
                                                                      * ..  .         

Mflv_4877|M.gilvum_PYR-GCK          AYERGRPSYPPEAIDWLLADSGSRRL---EVLDLGAGTGKLTTRLVERGL
Mvan_1552|M.vanbaalenii_PYR-1       AYERGRPSYPPEAIDWLLPEHAH------DVLDLGAGTGKLTTRLAERGL
MSMEG_1650|M.smegmatis_MC2_155      AYERGRPSYPPEAIDWLLPDGAH------DVLDLGAGTGKLTTRLVERGL
TH_1968|M.thermoresistible__bu      AYERGRPSYPPEAIDWLLPSDAR------DVLDLGAGTGKLTTRLVERGL
Mb3374|M.bovis_AF2122/97            AYERGRPSYPPEAIDWLLPAAAR------RVLDLGAGTGKLTTRLVERGL
Rv3342|M.tuberculosis_H37Rv         AYERGRPSYPPEAIDWLLPAAAR------RVLDLGAGTGKLTTRLVERGL
MMAR_1183|M.marinum_M               AYERGRPSYPPEAIDWLLPAGAR------DVLDLGAGTGKLTTRLVERGL
MUL_1436|M.ulcerans_Agy99           AYERGRPSYPPEAIDWLLPAGAR------DVLDLGAGTGKLTTRLVERGL
MAV_4317|M.avium_104                AYERGRPSYPPEAIDWLLPVGAR------QVLDLGAGTGKLTTRLVERGL
MAB_3689|M.abscessus_ATCC_1997      AYERGRPSYPPEAIDWLLPPGAH------DVLDLGAGTGKLTTRLVERGL
MLBr_01723|M.leprae_Br4923          SYDQRCVDYVRHCFDAIVPDELFTELPYDCALELGCGTGFFLLNLIQSGV
                                    :*::   .*  ..:* ::.           .*:**.*** :  .* : *:

Mflv_4877|M.gilvum_PYR-GCK          D--VVAVDPIPEMLDLLRTSLP----DTPALLGTAEEIPLPDDSVDAVLV
Mvan_1552|M.vanbaalenii_PYR-1       A--VVAVDPIPEMLELLSTSLP----DTPALLGTAEEIPLPDDSVDAVLV
MSMEG_1650|M.smegmatis_MC2_155      N--VIAVDPLAEMLELLSNSLP----DTPALLGTAEEIPLPDNSVDAVLV
TH_1968|M.thermoresistible__bu      N--VTAVDPIPEMLELLSKSLP----DTPALLGTAEEIPLPDNSVDAVLV
Mb3374|M.bovis_AF2122/97            D--VVAVDPIPEMLDVLRAALP----QTVALLGTAEEIPLDDNSVDAVLV
Rv3342|M.tuberculosis_H37Rv         D--VVAVDPIPEMLDVLRAALP----QTVALLGTAEEIPLDDNSVDAVLV
MMAR_1183|M.marinum_M               D--VVAVDPIPEMLEVLRASLP----RTLALLGTAEEIPLEDNSVDAVLV
MUL_1436|M.ulcerans_Agy99           D--VVAVDPIPEMLEVLRASLP----RTLALLGTAEEIPLEDNSVDAVLV
MAV_4317|M.avium_104                D--VVAVDPIPDMLEVLRSSLP----ETRALLGTAEEIPLEDNSVDVVLV
MAB_3689|M.abscessus_ATCC_1997      N--VVAVDPLAEMLEVLSNSLP----DTPALLGTAEEIPLPDNSVDAVLV
MLBr_01723|M.leprae_Br4923          ARRGSVTDLSPGMVKIATRNGQSLGLDINGRVADAEGIPYDDNTFDLVVG
                                         ..*  . *:.:             . :. ** **  *::.* *: 

Mflv_4877|M.gilvum_PYR-GCK          AQAWHWF-DETRAVKEIARVLRPGGSLGLVWNNRDE---------RLGWV
Mvan_1552|M.vanbaalenii_PYR-1       AQAWHWF-DPERAVKEVARVLRPGGRLGLVWNNRDE---------RLGWV
MSMEG_1650|M.smegmatis_MC2_155      AQAWHWF-DPELAVKEVSRVLRPGGRLGLVWNVRDE---------RLGWV
TH_1968|M.thermoresistible__bu      AQAWHWF-DVDRAVREVARVLRPGGRLGLVWNTRDE---------RMGWV
Mb3374|M.bovis_AF2122/97            AQAWHWV-DPARAIPEVARVLRPGGRLGLVWNTRDE---------RLGWV
Rv3342|M.tuberculosis_H37Rv         AQAWHWV-DPARAIPEVARVLRPGGRLGLVWNTRDE---------RLGWV
MMAR_1183|M.marinum_M               AQAWHWV-DPARAIPEVARVLRPGGRLGLVWNTRDE---------RLGWV
MUL_1436|M.ulcerans_Agy99           AQAWHWV-DPARAIPEVARVLRPGGRLGLVWNTRDE---------RLGWV
MAV_4317|M.avium_104                AQAWHWV-DPERAIPEVARVLRPGGRLGLVWNTRDE---------RLGWV
MAB_3689|M.abscessus_ATCC_1997      AQAWHWV-DPERAIPEVARVLRPGGRLGLVWNVRDE---------RLGWV
MLBr_01723|M.leprae_Br4923          HAVLHHIPDVELSLREVLRVLKPGGRFVFAGEPTDVGNRYARVFADLTWK
                                      . * . *   :: *: ***:*** : :. :  *           : * 

Mflv_4877|M.gilvum_PYR-GCK          KDLGDIIGHEGDPWSQSV-ELPAPFTGVERHHVEWTSYLTPQALIDLVAS
Mvan_1552|M.vanbaalenii_PYR-1       KDLGEIIGHEVDPFAQTV-ELPGPFTDVEHHRVEWTSYLTPQALIDLVAS
MSMEG_1650|M.smegmatis_MC2_155      KDLGNIIGHE-DPFAHEV-TLPAPFTDLERHHVEWTSYLTPQALIDLVAS
TH_1968|M.thermoresistible__bu      KELGRIIGDEHDPLSKTV-TLPEPFTDVQRHQVEWTNYLTPQALIDLVAS
Mb3374|M.bovis_AF2122/97            RELGEIIGRDGDPVRDRV-TLPEPFTTVQRHQVEWTNYLTPQALIDLVAS
Rv3342|M.tuberculosis_H37Rv         RELGEIIGRDGDPVRDRV-TLPEPFTTVQRHQVEWTNYLTPQALIDLVAS
MMAR_1183|M.marinum_M               RELGRIIGRDSDPVRDKV-TLPEPFTGVARHHVEWTNYLTPQALIDLVAS
MUL_1436|M.ulcerans_Agy99           RELGRIIGRDSDPVRDKV-TLPEPFTGVARHHVEWTNYLTPQALIDLVAS
MAV_4317|M.avium_104                RELGRIIGSDGD-GRTHV-ALPEPFTDLAHHEVEWTNYLTPQALIDLVAS
MAB_3689|M.abscessus_ATCC_1997      SDLGHIIGHENAADSADVGALPAPFTGQERHQVEWTNYLTPQALLDMVAS
MLBr_01723|M.leprae_Br4923          VTIRVVQLPGLSAWRRTQVEIDENSRAAALEWVVDLHTFEPKVLETMATN
                                      :  :              :         . *     : *:.*  :.:.

Mflv_4877|M.gilvum_PYR-GCK          R--SYCITSPERVRARTLDR-VRELLTTHP---------ALANSSGLALP
Mvan_1552|M.vanbaalenii_PYR-1       R--SYCITSPEQVRARTLDR-VRELLATHP---------ALASSSGLALP
MSMEG_1650|M.smegmatis_MC2_155      R--SYCITSPEQVRTRTLGQ-VRELLSTHP---------ALANSNGLALP
TH_1968|M.thermoresistible__bu      R--SYCITSPAKVRARTLER-VRELLATHP---------ALANNSGLALP
Mb3374|M.bovis_AF2122/97            R--SYCITSPAQVRTKTLDR-VRQLLATHP---------ALANSNGLALP
Rv3342|M.tuberculosis_H37Rv         R--SYCITSPAQVRTKTLDR-VRQLLATHP---------ALANSNGLALP
MMAR_1183|M.marinum_M               R--SYCITSPAEVRTKTLDQ-VRELLATHP---------ALANSAGLALP
MUL_1436|M.ulcerans_Agy99           R--SYCITSPAEVRTKTLDQ-VRELLATHP---------ALANSAGLALP
MAV_4317|M.avium_104                R--SYCITSPTEVRTRTLDQ-VRHLLATHP---------ALANSTGLALP
MAB_3689|M.abscessus_ATCC_1997      R--SYCITAPEAARKKTLQQ-VRELLATHP---------ALAQSAGLALP
MLBr_01723|M.leprae_Br4923          AGAVQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWARFAFTSWKTLS
                                           * .       *   :* : :* *          :* .   :*.

Mflv_4877|M.gilvum_PYR-GCK          YVTVCVRATLA----------------
Mvan_1552|M.vanbaalenii_PYR-1       YVTVCTRATLS----------------
MSMEG_1650|M.smegmatis_MC2_155      YVTVCMRATLA----------------
TH_1968|M.thermoresistible__bu      YITVCIRATLA----------------
Mb3374|M.bovis_AF2122/97            YVTVCVRATLA----------------
Rv3342|M.tuberculosis_H37Rv         YVTVCVRATLA----------------
MMAR_1183|M.marinum_M               YVTVCVSATLAA---------------
MUL_1436|M.ulcerans_Agy99           YVTVCVSATLAA---------------
MAV_4317|M.avium_104                YVTRCTRATLAG---------------
MAB_3689|M.abscessus_ATCC_1997      YVTVSIRATLNR---------------
MLBr_01723|M.leprae_Br4923          WVDANVWRRVIPKSWFYNIIITGVKPS
                                    ::       :