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TNHHPRFGLQHSGESRDYLPAAGHDALLPAYDLLSRLLGMNKIHRTLITQAELADCGRILEIGCGTGNLA IKAKRAQPRAEVIGSDPDPRALQRAQRKTGNVEEVRFDQGYAQRLPYADGEFDRVLSSMMLHHLDEDAKS AAAAEAFRVLRPGGRLHLVDVGGDMSAHDGLASRFIRHNLHVAGNLGDGIRRLLDTAGFDVAEVGAQRHP LLGRLVYYRATRPCA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0820 | - | - | 100% (226) | methyltransferase |
| M. ulcerans Agy99 | MUL_2765 | - | 1e-12 | 32.49% (197) | methyltransferase (methylase) |
| M. ulcerans Agy99 | MUL_2377 | - | 9e-09 | 36.07% (122) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1440c | - | 6e-13 | 30.81% (211) | putative methyltransferase |
| M. gilvum PYR-GCK | Mflv_1100 | - | 2e-09 | 36.11% (108) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1405c | - | 6e-13 | 30.81% (211) | putative methyltransferase |
| M. leprae Br4923 | MLBr_00551 | - | 2e-10 | 29.82% (114) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_1390c | - | 1e-10 | 30.30% (132) | putative UbiE/COQ5 methyltransferase |
| M. marinum M | MMAR_1062 | - | 1e-129 | 99.12% (226) | methyltransferase |
| M. avium 104 | MAV_3373 | - | 1e-12 | 35.65% (115) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_3041 | - | 3e-11 | 32.89% (149) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. thermoresistible (build 8) | TH_3395 | - | 2e-13 | 34.62% (156) | PUTATIVE putative ubiquinone/menaquinone biosynthesis |
| M. vanbaalenii PYR-1 | Mvan_5517 | - | 6e-57 | 54.98% (211) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1440c|M.bovis_AF2122/97 ------MTIDTPAREDQTLAATHRAMWALG-DYALMAEEVMAPLG-----
Rv1405c|M.tuberculosis_H37Rv ------MTIDTPAREDQTLAATHRAMWALG-DYALMAEEVMAPLG-----
MLBr_00551|M.leprae_Br4923 ------MNLYTPIHEDQSLAAIHRAMWALG-DYALMAEEVMAPLG-----
MAV_3373|M.avium_104 ------MTLDTTT-ADASVAARHRTVWALG-DYALMAEEVMAPLG-----
MUL_0820|M.ulcerans_Agy99 ------MTNHHPRFGLQHSGESRDYLPAAGHDALLPAYDLLSRLLGMNKI
MMAR_1062|M.marinum_M ------MTNHHPRFGLQHSGESRDYLPAAGHDALLPAYDLLSRLLGMNKI
Mvan_5517|M.vanbaalenii_PYR-1 MVSMDHMTENPPHPVARTWGNRHDYLPAAGRDFFLPAYDLLVRLLGTYPL
TH_3395|M.thermoresistible__bu ---MADVAANWAGRGGRFAGGLYDFG--VEREVLARPAGLLMWGTDTRLL
MAB_1390c|M.abscessus_ATCC_199 ------MPAIAQRRSLNELVTRYWTLMSRVYNFPLVQRHIYSPAQ-----
MSMEG_3041|M.smegmatis_MC2_155 ------MTGPTGSEFDFDALYRGESPAEGVPPITSVPWDTKAPKE-----
Mflv_1100|M.gilvum_PYR-GCK -------------------------------------------------M
Mb1440c|M.bovis_AF2122/97 -PILVAAAGIGPGVRVLDVAAGSGNISLPAAKTG--ATVISTDLTP----
Rv1405c|M.tuberculosis_H37Rv -PILVAAAGIGPGVRVLDVAAGSGNISLPAAKTG--ATVISTDLTP----
MLBr_00551|M.leprae_Br4923 -PILVTATGIRPGMQVLDVAAGSGNISLPAAKTG--ATIVSTDLTP----
MAV_3373|M.avium_104 -PTLVEAAGIGPGVRVLDVAAGSGNITLPAAAAG--ASVVSTDLTP----
MUL_0820|M.ulcerans_Agy99 HRTLITQAELADCGRILEIGCGTGNLAIKAKRAQPRAEVIGSDPDP----
MMAR_1062|M.marinum_M HRTLITQAELADCGRILEIGCGTGNLAIKAKRAQPRAEVIGSDPDP----
Mvan_5517|M.vanbaalenii_PYR-1 YDELVTQAELAGELDVLEIGCGTGNLTARALRAAPSARITATDPDP----
TH_3395|M.thermoresistible__bu FDSIRRIGDLPDGTAVLDIPCG-GGLALRGLRHGRRLRYVAADISA----
MAB_1390c|M.abscessus_ATCC_199 -TDTIAQLCEHDARRVADIACGTGILASRIRAELHQATVFGVDMSD----
MSMEG_3041|M.smegmatis_MC2_155 -NVVAWEQAGLVHGHVLDIGCGLGDNAIYLAQQG--YRVTALDISP----
Mflv_1100|M.gilvum_PYR-GCK LTVDFDRLGVGAGTKVIDVGCGAGRHTFEAFRRG--ADVIGFDQSASDLN
: :: .* * : . *
Mb1440c|M.bovis_AF2122/97 ---ELLQRSQARAAQQGLT-LQYQEANAQALPFADDEFDTVISAIGVMFA
Rv1405c|M.tuberculosis_H37Rv ---ELLQRSQARAAQQGLT-LQYQEANAQALPFADDEFDTVISAIGVMFA
MLBr_00551|M.leprae_Br4923 ---ELLQRSQARATELGLT-LEYREADAQALPFGDGEFDVVMSAIGVMFA
MAV_3373|M.avium_104 ---ELLQRSRDRAAGMGLT-IDYREANAQALPFGDGEFDAVVSAIGVQFA
MUL_0820|M.ulcerans_Agy99 ---RALQRAQRKTGNVEE--VRFDQGYAQRLPYADGEFDRVLSSMMLHHL
MMAR_1062|M.marinum_M ---RALQRAQRKTGNVEG--VRFDQGYAQRLPYADGEFDRVLSSMMLHHL
Mvan_5517|M.vanbaalenii_PYR-1 ---RAVTRARRKAAGEGP--VRFETAYAQELPFADASFDRVLSSLMLHHL
TH_3395|M.thermoresistible__bu ---DMLARAQRRAATLGRTDVRFVVADIERMPFGDGEFDCCVTFNGLHCV
MAB_1390c|M.abscessus_ATCC_199 ---GMLAKARARCA-----QVQWRKAPAEQLPFADSSLDAVVTTSAFHFF
MSMEG_3041|M.smegmatis_MC2_155 ---TALITAERRAADAGVD-VTFAVADATRLDGYDDVFDTVVDSGMFHCL
Mflv_1100|M.gilvum_PYR-GCK DVDEILQAMKEQGEAPASAKGEAVKGDALELPYADGTFDCVIASEILEHV
: . : . : * :* : .
Mb1440c|M.bovis_AF2122/97 PD--HQAAADELVRVCRPGGTIGVISWTCEGFFGRMLATIRPYRPSVSAD
Rv1405c|M.tuberculosis_H37Rv PD--HQAAADELVRVCRPGGTIGVISWTCEGFFGRMLATIRPYRPSVSAD
MLBr_00551|M.leprae_Br4923 PD--HRRAASELVRVCRPNGTIGVISWTQEGFFGRMLATIRPYRPSLSAA
MAV_3373|M.avium_104 PD--HQRAADELVRVCRPGGRIGLISWTPEGFFGRMLATIRPYRPSLSHP
MUL_0820|M.ulcerans_Agy99 DEDAKSAAAAEAFRVLRPGGRLHLVDVGGD---------------MSAHD
MMAR_1062|M.marinum_M DEDAKSAAAAEAFRVLRPGGRLHLVDVGGD---------------MSAHD
Mvan_5517|M.vanbaalenii_PYR-1 DDGTKVSALAEAWRVLRPGGRLHIVDVGG----------------ADQPE
TH_3395|M.thermoresistible__bu PD--PAAAVAEIARCVKPGGRLIGDAVVRG--------------AGRRQD
MAB_1390c|M.abscessus_ATCC_199 DQ---PAALAEFYRVLVPGGMASVATICPR------------------ER
MSMEG_3041|M.smegmatis_MC2_155 SDDAKGSYAAAVHRATRAGATLLLGAFSDAN---------------LQHD
Mflv_1100|M.gilvum_PYR-GCK PA--DDKAISELVRVLKPGGALAITVPRWLP----ERICWALSDEYHANE
* ...
Mb1440c|M.bovis_AF2122/97 LPPSALWGREAYVTGLLGDGVTGLKTARGLLEVKRFDTAQAVHDYFKNNY
Rv1405c|M.tuberculosis_H37Rv LPPSALWGREAYVTGLLGDGVTGLKTARGLLEVKRFDTAQAVHDYFKNNY
MLBr_00551|M.leprae_Br4923 LPPAALWGREAYIRGLLDDTVTNVKTERRQLEVKRFNSAEGVHNYFKNHY
MAV_3373|M.avium_104 VPPAALWGRPGYVRALLGERIGEITTARGMLPVNRFGSAEDVHAYFKQHY
MUL_0820|M.ulcerans_Agy99 GLASRFIRHNLHVAGNLGDGIRRLLDTAG------FDVAEVGAQRHP---
MMAR_1062|M.marinum_M GLASRFIRHNLHVAGNLGDGIRRLLDTAG------FDVAEVGAQRHP---
Mvan_5517|M.vanbaalenii_PYR-1 GLMSRLTGHRHAAAG---ARLPQLVEAAG------FDTTVVATRRLR---
TH_3395|M.thermoresistible__bu ALIAVFRRAGVFGPGGTTDELQGWLTRAG------FEVEDFRR-------
MAB_1390c|M.abscessus_ATCC_199 RWARNRTGERGPAHFPTATEMERLFAGAG------FEVVVHRPVARP---
MSMEG_3041|M.smegmatis_MC2_155 NWQAAWVSEDTLRSSLDDGGWDITSLTTETIRVPGAALAGSGDEGGAD--
Mflv_1100|M.gilvum_PYR-GCK GGHIRIYRADELRDKVLAHGLTLTHTHHSHALHSPFWWLKCAVGTEKNDH
Mb1440c|M.bovis_AF2122/97 GPTIEAYAHIGDNAVLAAELDRQLVELAAQYLSDGVMEWEYLLLTAEKR-
Rv1405c|M.tuberculosis_H37Rv GPTIEAYAHIGDNAVLAAELDRQLVELAAQYLSDGVMEWEYLLLTAEKR-
MLBr_00551|M.leprae_Br4923 GPTIEAYTNIGDNSVLAAELDAQLTELAQKYLTNSTMGWEYLLLTAQKH-
MAV_3373|M.avium_104 GPTIEAYANIGHNRVLAAELDAQLVELAAQHLSDGTMGWEYLLVTAEKRS
MUL_0820|M.ulcerans_Agy99 --------LLGRLVYYRATRPCA---------------------------
MMAR_1062|M.marinum_M --------LLGRLVYYRATRPCA---------------------------
Mvan_5517|M.vanbaalenii_PYR-1 --------VFGPVSFIRATRPGE---------------------------
TH_3395|M.thermoresistible__bu ---------SGAVAHFTAVRS-----------------------------
MAB_1390c|M.abscessus_ATCC_199 -----VTPPLVSVDWICVGLKT----------------------------
MSMEG_3041|M.smegmatis_MC2_155 --------EFDAAFFLVQAQRR----------------------------
Mflv_1100|M.gilvum_PYR-GCK PAVAAYHKLLVWDMMSQPWLTRTAEAALNPLIGKSVALYFRKPADTDA--
Mb1440c|M.bovis_AF2122/97 -
Rv1405c|M.tuberculosis_H37Rv -
MLBr_00551|M.leprae_Br4923 -
MAV_3373|M.avium_104 G
MUL_0820|M.ulcerans_Agy99 -
MMAR_1062|M.marinum_M -
Mvan_5517|M.vanbaalenii_PYR-1 -
TH_3395|M.thermoresistible__bu -
MAB_1390c|M.abscessus_ATCC_199 -
MSMEG_3041|M.smegmatis_MC2_155 -
Mflv_1100|M.gilvum_PYR-GCK -