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SFVVASEAYGRFMGRYAEPLAEAFVAFAGVGVGDKVLDVGCGPGALTARLRSVGADIAAIDPSPPFIDAI RRSFPDVDVRQGPAEELPYDSAAFDAALAQLVVHFMTDPVAGLRQMSRVTRPGGVVAACVWDGPTGALAP FWDAVHVVDPEAEDEALLSGARSGHLTELFEAAGLRDVVEDSIAVDVVHPTFEQWWEPYTYGVGPAGDYV QQLDDEGRARLESAARERLGKGPFTVTAVAWAARGTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4620 | - | - | 100% (248) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_4690 | - | 2e-14 | 30.45% (220) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_1552 | - | 9e-14 | 36.07% (122) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3374 | - | 3e-15 | 39.80% (98) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4877 | - | 3e-15 | 32.47% (154) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3342 | - | 3e-15 | 39.80% (98) | methyltransferase (methylase) |
| M. leprae Br4923 | MLBr_02273 | ubiE | 7e-12 | 37.27% (110) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. abscessus ATCC 19977 | MAB_3689 | - | 1e-13 | 34.81% (158) | putative methyltransferase |
| M. marinum M | MMAR_1183 | - | 5e-15 | 38.35% (133) | methyltransferase |
| M. avium 104 | MAV_4317 | - | 5e-15 | 37.59% (133) | putative methyltransferase |
| M. smegmatis MC2 155 | MSMEG_1650 | - | 5e-13 | 36.36% (132) | methyltransferase type 11 |
| M. thermoresistible (build 8) | TH_1968 | - | 4e-13 | 38.14% (97) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_1436 | - | 3e-15 | 38.35% (133) | methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3374|M.bovis_AF2122/97 -----------------MTCSR---RDMSLSFGSAVGAYERGRPSYPPEA
Rv3342|M.tuberculosis_H37Rv -----------------MTCSR---RDMSLSFGSAVGAYERGRPSYPPEA
MMAR_1183|M.marinum_M -----------------MSGSA---QDPSLSFGSAAAAYERGRPSYPPEA
MUL_1436|M.ulcerans_Agy99 ----------------MVSGSA---QDPSLSFGSAAAAYERGRPSYPPEA
MAV_4317|M.avium_104 -----------------MTRSR---HDRSLSFGSAAAAYERGRPSYPPEA
Mflv_4877|M.gilvum_PYR-GCK -----------------MTAES---DRRSLSFGAEAAAYERGRPSYPPEA
TH_1968|M.thermoresistible__bu -----------------------------LSFGAEAAAYERGRPSYPPEA
MSMEG_1650|M.smegmatis_MC2_155 -----------------MTPSDPLKQQRSLSFGSEAAAYERGRPSYPPEA
MAB_3689|M.abscessus_ATCC_1997 -----------------MPDAQ---AEPSLSFGSQAAAYERGRPSYPPEA
Mvan_4620|M.vanbaalenii_PYR-1 -----------------------------MSFVVASEAYGRFMGRYAEPL
MLBr_02273|M.leprae_Br4923 MPPGSVDVVSRAALDKDPRDVVAMFDDVAHRYDLTNTVLSLGQDRYWRRA
: . *
Mb3374|M.bovis_AF2122/97 IDWLLP-AAAR---RVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLDVL
Rv3342|M.tuberculosis_H37Rv IDWLLP-AAAR---RVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLDVL
MMAR_1183|M.marinum_M IDWLLP-AGAR---DVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLEVL
MUL_1436|M.ulcerans_Agy99 IDWLLP-AGAR---DVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLEVL
MAV_4317|M.avium_104 IDWLLP-VGAR---QVLDLGAGTGKLTTRLVERGLDVVAVDPIPDMLEVL
Mflv_4877|M.gilvum_PYR-GCK IDWLLADSGSRR-LEVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLDLL
TH_1968|M.thermoresistible__bu IDWLLP-SDAR---DVLDLGAGTGKLTTRLVERGLNVTAVDPIPEMLELL
MSMEG_1650|M.smegmatis_MC2_155 IDWLLP-DGAH---DVLDLGAGTGKLTTRLVERGLNVIAVDPLAEMLELL
MAB_3689|M.abscessus_ATCC_1997 IDWLLP-PGAH---DVLDLGAGTGKLTTRLVERGLNVVAVDPLAEMLEVL
Mvan_4620|M.vanbaalenii_PYR-1 AEAFVAFAGVGVGDKVLDVGCGPGALTARLRSVGADIAAIDPSPPFIDAI
MLBr_02273|M.leprae_Br4923 TRSALRIGPGQ---KVLDLAAGTAVSTAELSKSGAWCVAADFSVRMLATG
: ***:..*.. *:.* . * * * ::
Mb3374|M.bovis_AF2122/97 RAALPQTVALLGTAEEIPLDDNSVDAVLVAQAWHWV-DPARAIPEVARVL
Rv3342|M.tuberculosis_H37Rv RAALPQTVALLGTAEEIPLDDNSVDAVLVAQAWHWV-DPARAIPEVARVL
MMAR_1183|M.marinum_M RASLPRTLALLGTAEEIPLEDNSVDAVLVAQAWHWV-DPARAIPEVARVL
MUL_1436|M.ulcerans_Agy99 RASLPRTLALLGTAEEIPLEDNSVDAVLVAQAWHWV-DPARAIPEVARVL
MAV_4317|M.avium_104 RSSLPETRALLGTAEEIPLEDNSVDVVLVAQAWHWV-DPERAIPEVARVL
Mflv_4877|M.gilvum_PYR-GCK RTSLPDTPALLGTAEEIPLPDDSVDAVLVAQAWHWF-DETRAVKEIARVL
TH_1968|M.thermoresistible__bu SKSLPDTPALLGTAEEIPLPDNSVDAVLVAQAWHWF-DVDRAVREVARVL
MSMEG_1650|M.smegmatis_MC2_155 SNSLPDTPALLGTAEEIPLPDNSVDAVLVAQAWHWF-DPELAVKEVSRVL
MAB_3689|M.abscessus_ATCC_1997 SNSLPDTPALLGTAEEIPLPDNSVDAVLVAQAWHWV-DPERAIPEVARVL
Mvan_4620|M.vanbaalenii_PYR-1 RRSFPDVDVRQGPAEELPYDSAAFDAALAQLVVHFMTDPVAGLRQMSRVT
MLBr_02273|M.leprae_Br4923 --GARKVPKVAADATQLPFSDGVFDAVTISFGLRNIADYQAALREMARVT
. . . * ::* . .*.. : . * .: :::**
Mb3374|M.bovis_AF2122/97 RPGGRLG-LVWNTRDERLGWVRELGEIIGRDGDPVRDRV-TLPEPFTTVQ
Rv3342|M.tuberculosis_H37Rv RPGGRLG-LVWNTRDERLGWVRELGEIIGRDGDPVRDRV-TLPEPFTTVQ
MMAR_1183|M.marinum_M RPGGRLG-LVWNTRDERLGWVRELGRIIGRDSDPVRDKV-TLPEPFTGVA
MUL_1436|M.ulcerans_Agy99 RPGGRLG-LVWNTRDERLGWVRELGRIIGRDSDPVRDKV-TLPEPFTGVA
MAV_4317|M.avium_104 RPGGRLG-LVWNTRDERLGWVRELGRIIGSDGD-GRTHV-ALPEPFTDLA
Mflv_4877|M.gilvum_PYR-GCK RPGGSLG-LVWNNRDERLGWVKDLGDIIGHEGDPWSQSV-ELPAPFTGVE
TH_1968|M.thermoresistible__bu RPGGRLG-LVWNTRDERMGWVKELGRIIGDEHDPLSKTV-TLPEPFTDVQ
MSMEG_1650|M.smegmatis_MC2_155 RPGGRLG-LVWNVRDERLGWVKDLGNIIGHE-DPFAHEV-TLPAPFTDLE
MAB_3689|M.abscessus_ATCC_1997 RPGGRLG-LVWNVRDERLGWVSDLGHIIGHENAADSADVGALPAPFTGQE
Mvan_4620|M.vanbaalenii_PYR-1 RPGGVVAACVWDGPTGALAPFWDAVHVVDPEAEDEALLSGARSGHLTEL-
MLBr_02273|M.leprae_Br4923 RPGGQLVVCEFSTPTNALVANVYTEYLMRALPQVARLVS-----------
**** : :. : ::
Mb3374|M.bovis_AF2122/97 RHQVEWTNYLTPQALIDLVAS--------RSYCITSPAQVRTKTLDRVRQ
Rv3342|M.tuberculosis_H37Rv RHQVEWTNYLTPQALIDLVAS--------RSYCITSPAQVRTKTLDRVRQ
MMAR_1183|M.marinum_M RHHVEWTNYLTPQALIDLVAS--------RSYCITSPAEVRTKTLDQVRE
MUL_1436|M.ulcerans_Agy99 RHHVEWTNYLTPQALIDLVAS--------RSYCITSPAEVRTKTLDQVRE
MAV_4317|M.avium_104 HHEVEWTNYLTPQALIDLVAS--------RSYCITSPTEVRTRTLDQVRH
Mflv_4877|M.gilvum_PYR-GCK RHHVEWTSYLTPQALIDLVAS--------RSYCITSPERVRARTLDRVRE
TH_1968|M.thermoresistible__bu RHQVEWTNYLTPQALIDLVAS--------RSYCITSPAKVRARTLERVRE
MSMEG_1650|M.smegmatis_MC2_155 RHHVEWTSYLTPQALIDLVAS--------RSYCITSPEQVRTRTLGQVRE
MAB_3689|M.abscessus_ATCC_1997 RHQVEWTNYLTPQALLDMVAS--------RSYCITAPEAARKKTLQQVRE
Mvan_4620|M.vanbaalenii_PYR-1 FEAAGLRDVVEDSIAVDVVHPTFEQWWEPYTYGVGPAGDYVQQLDDEGRA
MLBr_02273|M.leprae_Br4923 ---------SNPDAYIYLAES------------IRAWPDQVTLACQLSRT
. : :. . : . *
Mb3374|M.bovis_AF2122/97 LLATHPALANSNG-LALPYVTVCVRATLA-
Rv3342|M.tuberculosis_H37Rv LLATHPALANSNG-LALPYVTVCVRATLA-
MMAR_1183|M.marinum_M LLATHPALANSAG-LALPYVTVCVSATLAA
MUL_1436|M.ulcerans_Agy99 LLATHPALANSAG-LALPYVTVCVSATLAA
MAV_4317|M.avium_104 LLATHPALANSTG-LALPYVTRCTRATLAG
Mflv_4877|M.gilvum_PYR-GCK LLTTHPALANSSG-LALPYVTVCVRATLA-
TH_1968|M.thermoresistible__bu LLATHPALANNSG-LALPYITVCIRATLA-
MSMEG_1650|M.smegmatis_MC2_155 LLSTHPALANSNG-LALPYVTVCMRATLA-
MAB_3689|M.abscessus_ATCC_1997 LLATHPALAQSAG-LALPYVTVSIRATLNR
Mvan_4620|M.vanbaalenii_PYR-1 RLESAARERLGKGPFTVTAVAWAARGTA--
MLBr_02273|M.leprae_Br4923 GWASPRWRNLTGGIVALHAADKPVR-----
: * .::