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VTCSRRDMSLSFGSAVGAYERGRPSYPPEAIDWLLPAAARRVLDLGAGTGKLTTRLVERGLDVVAVDPIP EMLDVLRAALPQTVALLGTAEEIPLDDNSVDAVLVAQAWHWVDPARAIPEVARVLRPGGRLGLVWNTRDE RLGWVRELGEIIGRDGDPVRDRVTLPEPFTTVQRHQVEWTNYLTPQALIDLVASRSYCITSPAQVRTKTL DRVRQLLATHPALANSNGLALPYVTVCVRATLA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3342 | - | - | 100% (243) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. tuberculosis H37Rv | Rv0329c | - | 3e-09 | 31.67% (120) | hypothetical protein Rv0329c |
| M. tuberculosis H37Rv | Rv1405c | - | 1e-07 | 32.32% (99) | putative methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3374 | - | 1e-139 | 100.00% (243) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4877 | - | 1e-107 | 77.64% (246) | methyltransferase type 11 |
| M. leprae Br4923 | MLBr_00551 | - | 2e-07 | 29.63% (108) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_3689 | - | 1e-102 | 76.67% (240) | putative methyltransferase |
| M. marinum M | MMAR_1183 | - | 1e-124 | 89.71% (243) | methyltransferase |
| M. avium 104 | MAV_4317 | - | 1e-117 | 84.77% (243) | putative methyltransferase |
| M. smegmatis MC2 155 | MSMEG_1650 | - | 1e-106 | 77.82% (239) | methyltransferase type 11 |
| M. thermoresistible (build 8) | TH_1968 | - | 1e-111 | 82.05% (234) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_1436 | - | 1e-124 | 89.71% (243) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1552 | - | 1e-107 | 79.08% (239) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3342|M.tuberculosis_H37Rv -MTCS---RRDMSLSFGSAVGAYERGRPSYPPEAID-----WLLPAAAR-
Mb3374|M.bovis_AF2122/97 -MTCS---RRDMSLSFGSAVGAYERGRPSYPPEAID-----WLLPAAAR-
MMAR_1183|M.marinum_M -MSGS---AQDPSLSFGSAAAAYERGRPSYPPEAID-----WLLPAGAR-
MUL_1436|M.ulcerans_Agy99 MVSGS---AQDPSLSFGSAAAAYERGRPSYPPEAID-----WLLPAGAR-
MAV_4317|M.avium_104 -MTRS---RHDRSLSFGSAAAAYERGRPSYPPEAID-----WLLPVGAR-
Mflv_4877|M.gilvum_PYR-GCK -MTAE---SDRRSLSFGAEAAAYERGRPSYPPEAID-----WLLADSGSR
Mvan_1552|M.vanbaalenii_PYR-1 -MTER---PDR-SLSFGAEAAAYERGRPSYPPEAID-----WLLPEHAH-
TH_1968|M.thermoresistible__bu -------------LSFGAEAAAYERGRPSYPPEAID-----WLLPSDAR-
MSMEG_1650|M.smegmatis_MC2_155 -MTPSDPLKQQRSLSFGSEAAAYERGRPSYPPEAID-----WLLPDGAH-
MAB_3689|M.abscessus_ATCC_1997 -MPDA---QAEPSLSFGSQAAAYERGRPSYPPEAID-----WLLPPGAH-
MLBr_00551|M.leprae_Br4923 -MNLYTPIHEDQSLAAIHRAMWALGDYALMAEEVMAPLGPILVTATGIRP
*: . . . . *.: : .
Rv3342|M.tuberculosis_H37Rv --RVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLDVLRAALPQTVALLG
Mb3374|M.bovis_AF2122/97 --RVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLDVLRAALPQTVALLG
MMAR_1183|M.marinum_M --DVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLEVLRASLPRTLALLG
MUL_1436|M.ulcerans_Agy99 --DVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLEVLRASLPRTLALLG
MAV_4317|M.avium_104 --QVLDLGAGTGKLTTRLVERGLDVVAVDPIPDMLEVLRSSLPETRALLG
Mflv_4877|M.gilvum_PYR-GCK RLEVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLDLLRTSLPDTPALLG
Mvan_1552|M.vanbaalenii_PYR-1 --DVLDLGAGTGKLTTRLAERGLAVVAVDPIPEMLELLSTSLPDTPALLG
TH_1968|M.thermoresistible__bu --DVLDLGAGTGKLTTRLVERGLNVTAVDPIPEMLELLSKSLPDTPALLG
MSMEG_1650|M.smegmatis_MC2_155 --DVLDLGAGTGKLTTRLVERGLNVIAVDPLAEMLELLSNSLPDTPALLG
MAB_3689|M.abscessus_ATCC_1997 --DVLDLGAGTGKLTTRLVERGLNVVAVDPLAEMLEVLSNSLPDTPALLG
MLBr_00551|M.leprae_Br4923 GMQVLDVAAGSGNISLPAAKTGATIVSTDLTPELLQRSQARATELGLTLE
***:.**:*::: .: * : :.* .::*: . *
Rv3342|M.tuberculosis_H37Rv ----TAEEIPLDDNSVDAVLVAQAWHWVDPAR-AIPEVARVLRPGGRLGL
Mb3374|M.bovis_AF2122/97 ----TAEEIPLDDNSVDAVLVAQAWHWVDPAR-AIPEVARVLRPGGRLGL
MMAR_1183|M.marinum_M ----TAEEIPLEDNSVDAVLVAQAWHWVDPAR-AIPEVARVLRPGGRLGL
MUL_1436|M.ulcerans_Agy99 ----TAEEIPLEDNSVDAVLVAQAWHWVDPAR-AIPEVARVLRPGGRLGL
MAV_4317|M.avium_104 ----TAEEIPLEDNSVDVVLVAQAWHWVDPER-AIPEVARVLRPGGRLGL
Mflv_4877|M.gilvum_PYR-GCK ----TAEEIPLPDDSVDAVLVAQAWHWFDETR-AVKEIARVLRPGGSLGL
Mvan_1552|M.vanbaalenii_PYR-1 ----TAEEIPLPDDSVDAVLVAQAWHWFDPER-AVKEVARVLRPGGRLGL
TH_1968|M.thermoresistible__bu ----TAEEIPLPDNSVDAVLVAQAWHWFDVDR-AVREVARVLRPGGRLGL
MSMEG_1650|M.smegmatis_MC2_155 ----TAEEIPLPDNSVDAVLVAQAWHWFDPEL-AVKEVSRVLRPGGRLGL
MAB_3689|M.abscessus_ATCC_1997 ----TAEEIPLPDNSVDAVLVAQAWHWVDPER-AIPEVARVLRPGGRLGL
MLBr_00551|M.leprae_Br4923 YREADAQALPFGDGEFDVVMSAIGVMFAPDHRRAASELVRVCRPNGTIGV
*: :*: *...*.*: * . : * *: ** **.* :*:
Rv3342|M.tuberculosis_H37Rv VWNTRDERLG--------WVRELGEIIGRDGDPVRDRV---TLPEPFTTV
Mb3374|M.bovis_AF2122/97 VWNTRDERLG--------WVRELGEIIGRDGDPVRDRV---TLPEPFTTV
MMAR_1183|M.marinum_M VWNTRDERLG--------WVRELGRIIGRDSDPVRDKV---TLPEPFTGV
MUL_1436|M.ulcerans_Agy99 VWNTRDERLG--------WVRELGRIIGRDSDPVRDKV---TLPEPFTGV
MAV_4317|M.avium_104 VWNTRDERLG--------WVRELGRIIGSDGD-GRTHV---ALPEPFTDL
Mflv_4877|M.gilvum_PYR-GCK VWNNRDERLG--------WVKDLGDIIGHEGDPWSQSV---ELPAPFTGV
Mvan_1552|M.vanbaalenii_PYR-1 VWNNRDERLG--------WVKDLGEIIGHEVDPFAQTV---ELPGPFTDV
TH_1968|M.thermoresistible__bu VWNTRDERMG--------WVKELGRIIGDEHDPLSKTV---TLPEPFTDV
MSMEG_1650|M.smegmatis_MC2_155 VWNVRDERLG--------WVKDLGNIIGHE-DPFAHEV---TLPAPFTDL
MAB_3689|M.abscessus_ATCC_1997 VWNVRDERLG--------WVSDLGHIIGHENAADSADVG--ALPAPFTGQ
MLBr_00551|M.leprae_Br4923 ISWTQEGFFGRMLATIRPYRPSLSAALPPAALWGREAYIRGLLDDTVTNV
: :: :* : .*. : * ..*
Rv3342|M.tuberculosis_H37Rv --QRHQVEWTNYLTPQALIDLVASRS----YCITSPAQVRTKTLDRVRQL
Mb3374|M.bovis_AF2122/97 --QRHQVEWTNYLTPQALIDLVASRS----YCITSPAQVRTKTLDRVRQL
MMAR_1183|M.marinum_M --ARHHVEWTNYLTPQALIDLVASRS----YCITSPAEVRTKTLDQVREL
MUL_1436|M.ulcerans_Agy99 --ARHHVEWTNYLTPQALIDLVASRS----YCITSPAEVRTKTLDQVREL
MAV_4317|M.avium_104 --AHHEVEWTNYLTPQALIDLVASRS----YCITSPTEVRTRTLDQVRHL
Mflv_4877|M.gilvum_PYR-GCK --ERHHVEWTSYLTPQALIDLVASRS----YCITSPERVRARTLDRVREL
Mvan_1552|M.vanbaalenii_PYR-1 --EHHRVEWTSYLTPQALIDLVASRS----YCITSPEQVRARTLDRVREL
TH_1968|M.thermoresistible__bu --QRHQVEWTNYLTPQALIDLVASRS----YCITSPAKVRARTLERVREL
MSMEG_1650|M.smegmatis_MC2_155 --ERHHVEWTSYLTPQALIDLVASRS----YCITSPEQVRTRTLGQVREL
MAB_3689|M.abscessus_ATCC_1997 --ERHQVEWTNYLTPQALLDMVASRS----YCITAPEAARKKTLQQVREL
MLBr_00551|M.leprae_Br4923 KTERRQLEVKRFNSAEGVHNYFKNHYGPTIEAYTNIGDNSVLAAELDAQL
::.:* . : :.:.: : . .: . * : .*
Rv3342|M.tuberculosis_H37Rv LATHPALANSNGLALPYVTVCVRATLA-
Mb3374|M.bovis_AF2122/97 LATHPALANSNGLALPYVTVCVRATLA-
MMAR_1183|M.marinum_M LATHPALANSAGLALPYVTVCVSATLAA
MUL_1436|M.ulcerans_Agy99 LATHPALANSAGLALPYVTVCVSATLAA
MAV_4317|M.avium_104 LATHPALANSTGLALPYVTRCTRATLAG
Mflv_4877|M.gilvum_PYR-GCK LTTHPALANSSGLALPYVTVCVRATLA-
Mvan_1552|M.vanbaalenii_PYR-1 LATHPALASSSGLALPYVTVCTRATLS-
TH_1968|M.thermoresistible__bu LATHPALANNSGLALPYITVCIRATLA-
MSMEG_1650|M.smegmatis_MC2_155 LSTHPALANSNGLALPYVTVCMRATLA-
MAB_3689|M.abscessus_ATCC_1997 LATHPALAQSAGLALPYVTVSIRATLNR
MLBr_00551|M.leprae_Br4923 TELAQKYLTNSTMGWEYLLLTAQKH---
. :. *: