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MTTADGLHSGDPSPVHRRAFNDQVTRFWGRAARAYDWAPLQQWVYRPAQDEMLAQLRQHKSQRIVDIACG TGILATRIQDELEPEQVHGVDMSEGMLAQAKARSSLVNWQFAPAEKLPFDDGALDAVVSTSAFHFFDQPA ALTEFHRVLTPGGFAAITTFTPDRTSAPILRRVFGDRIPASVPSKAEMRLMFETAGFEVTVQRPVHHPFT LPFIEFDRLTVGIKR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4613 | - | - | 100% (225) | similarity with UbiE/COQ5 methyltransferase |
| M. abscessus ATCC 19977 | MAB_1390c | - | 1e-58 | 52.80% (214) | putative UbiE/COQ5 methyltransferase |
| M. abscessus ATCC 19977 | MAB_4103c | - | 4e-10 | 34.74% (95) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3374 | - | 3e-09 | 33.98% (103) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4877 | - | 4e-08 | 29.63% (135) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3342 | - | 3e-09 | 33.98% (103) | methyltransferase (methylase) |
| M. leprae Br4923 | MLBr_00130 | - | 7e-10 | 32.69% (104) | hypothetical protein MLBr_00130 |
| M. marinum M | MMAR_3533 | - | 8e-61 | 56.87% (211) | methyltransferase (methylase) |
| M. avium 104 | MAV_2111 | - | 3e-59 | 57.14% (210) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_2350 | - | 5e-10 | 30.00% (160) | hypothetical protein MSMEG_2350 |
| M. thermoresistible (build 8) | TH_1968 | - | 2e-08 | 30.47% (128) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_2765 | - | 6e-61 | 56.87% (211) | methyltransferase (methylase) |
| M. vanbaalenii PYR-1 | Mvan_5517 | - | 8e-11 | 28.57% (161) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3533|M.marinum_M MTTVP-----------RRGFNDAVTGIWS----------------LLAPA
MUL_2765|M.ulcerans_Agy99 MTTVP-----------RRGFNDAVTGIWS----------------LLAPA
MAV_2111|M.avium_104 MTAPQ-----------RRGLNDVVTRMWS----------------FLAPA
MAB_4613|M.abscessus_ATCC_1997 MTTADGLHSGDPSPVHRRAFNDQVTRFWG----------------RAARA
Mb3374|M.bovis_AF2122/97 MTCSR----------------RDMSLSFG----------------SAVGA
Rv3342|M.tuberculosis_H37Rv MTCSR----------------RDMSLSFG----------------SAVGA
Mflv_4877|M.gilvum_PYR-GCK MTAES----------------DRRSLSFG----------------AEAAA
TH_1968|M.thermoresistible__bu -------------------------LSFG----------------AEAAA
Mvan_5517|M.vanbaalenii_PYR-1 MVSMD---------HMTENPPHPVARTWGNRHDYLPAAG----RDFFLPA
MSMEG_2350|M.smegmatis_MC2_155 MGDPD----------------NALPSALP-----------------LTGE
MLBr_00130|M.leprae_Br4923 MAFTR-----IHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDEIMFINWA
MMAR_3533|M.marinum_M YD----LAILQQWVYRPPHDEVLAQLRAHNSR-----RIADIACGTGILS
MUL_2765|M.ulcerans_Agy99 YD----LAILQQWVYRPPHDEVLAQLRAHKSR-----RIADIACGTGILS
MAV_2111|M.avium_104 YD----LPFLQQWVYRPPHNEVIAQLRNHGSR-----RIADIACGTGILS
MAB_4613|M.abscessus_ATCC_1997 YD----WAPLQQWVYRPAQDEMLAQLRQHKSQ-----RIVDIACGTGILA
Mb3374|M.bovis_AF2122/97 YE----RGRPS---YPPEAIDWLLPAAARR--------VLDLGAGTGKLT
Rv3342|M.tuberculosis_H37Rv YE----RGRPS---YPPEAIDWLLPAAARR--------VLDLGAGTGKLT
Mflv_4877|M.gilvum_PYR-GCK YE----RGRPS---YPPEAIDWLLADSGSRRL-----EVLDLGAGTGKLT
TH_1968|M.thermoresistible__bu YE----RGRPS---YPPEAIDWLLP-SDAR-------DVLDLGAGTGKLT
Mvan_5517|M.vanbaalenii_PYR-1 YD----LLVRLLG-TYPLYDELVTQAELAGEL-----DVLEIGCGTGNLT
MSMEG_2350|M.smegmatis_MC2_155 RT----IPGLAEENYWFRRHEVVYQRLAHRCAGR---DVLEAGCGEGYGA
MLBr_00130|M.leprae_Br4923 YEEDPPMALPLEASDEPNRAHINLYHRTATQVNLSGKRILEVSCGHGGGA
. : : ..* * :
MMAR_3533|M.marinum_M DRIERELHPDEIYGVDMSHGMLDQARAKSD---RVRWLRGPAEQLPFDDG
MUL_2765|M.ulcerans_Agy99 ARIERELHPDEIYGVDMSHGMLDQARAKSD---RVRWLRGPAEQLPFDDG
MAV_2111|M.avium_104 ERIQRELNPDEIYGVDMSDGMLNQARAKSD---RVQWLRAPAEQLPFDDG
MAB_4613|M.abscessus_ATCC_1997 TRIQDELEPEQVHGVDMSEGMLAQAKARSS---LVNWQFAPAEKLPFDDG
Mb3374|M.bovis_AF2122/97 TRLVERG--LDVVAVDPIPEMLDVLRAALP---QTVALLGTAEEIPLDDN
Rv3342|M.tuberculosis_H37Rv TRLVERG--LDVVAVDPIPEMLDVLRAALP---QTVALLGTAEEIPLDDN
Mflv_4877|M.gilvum_PYR-GCK TRLVERG--LDVVAVDPIPEMLDLLRTSLP---DTPALLGTAEEIPLPDD
TH_1968|M.thermoresistible__bu TRLVERG--LNVTAVDPIPEMLELLSKSLP---DTPALLGTAEEIPLPDN
Mvan_5517|M.vanbaalenii_PYR-1 ARALRAAPSARITATDPDPRAVTRARRKAAGEGPVRFETAYAQELPFADA
MSMEG_2350|M.smegmatis_MC2_155 DLIADVAR--RVIGLDYDEATVAHVRARYP---RVDIRHGNLAELPLPDA
MLBr_00130|M.leprae_Br4923 SYLTRALHPASYTGLDLNPAGIKLCQKRHQLP-GLEFVRGDAENLPFDNE
. * : . ::*: :
MMAR_3533|M.marinum_M ALDAVVTTTAFHFFDQ---PAALREFHRVLAPGGLVAVSSLS--------
MUL_2765|M.ulcerans_Agy99 ALDAVVTITAFHFFDQ---PAALREFHRVLAPGGLVAVSSLS--------
MAV_2111|M.avium_104 ALDAVVTTSAFHFFDQ---PAALREFHRVLAPGGLVAVSALS--------
MAB_4613|M.abscessus_ATCC_1997 ALDAVVSTSAFHFFDQ---PAALTEFHRVLTPGGFAAITTFTPDR-----
Mb3374|M.bovis_AF2122/97 SVDAVLVAQAWHWVDP---ARAIPEVARVLRPGGRLGLVWNTRDERLGWV
Rv3342|M.tuberculosis_H37Rv SVDAVLVAQAWHWVDP---ARAIPEVARVLRPGGRLGLVWNTRDERLGWV
Mflv_4877|M.gilvum_PYR-GCK SVDAVLVAQAWHWFDE---TRAVKEIARVLRPGGSLGLVWNNRDERLGWV
TH_1968|M.thermoresistible__bu SVDAVLVAQAWHWFDV---DRAVREVARVLRPGGRLGLVWNTRDERMGWV
Mvan_5517|M.vanbaalenii_PYR-1 SFDRVLSSLMLHHLDDGTKVSALAEAWRVLRPGGRLHIVDVG--------
MSMEG_2350|M.smegmatis_MC2_155 SVDVVVNFQVIEHLWD--QAQFVSECFRVLRPGGVFLVSTPNRITFSPGR
MLBr_00130|M.leprae_Br4923 SFDVVINIEASHCYPH--FPRFLAEVVRVLRPGGHLAYADLRPSNK----
:.* *: . : * *** ***
MMAR_3533|M.marinum_M ------------------ARQPLLQLPAASKWKPQHSPSPAEMRALFEGA
MUL_2765|M.ulcerans_Agy99 ------------------ARQPLLQLPAASKWKPQHSPSPAEMRALFEGA
MAV_2111|M.avium_104 ------------------TRRPLLQASADSRWKPQHNASAPEMRKLFEDA
MAB_4613|M.abscessus_ATCC_1997 ------------------TSAPILRRVFGDR-IPASVPSKAEMRLMFETA
Mb3374|M.bovis_AF2122/97 RELGEIIGRDGDPVRDRVTLPEPFTTVQRHQVEWTNYLTPQALIDLVASR
Rv3342|M.tuberculosis_H37Rv RELGEIIGRDGDPVRDRVTLPEPFTTVQRHQVEWTNYLTPQALIDLVASR
Mflv_4877|M.gilvum_PYR-GCK KDLGDIIGHEGDPWSQSVELPAPFTGVERHHVEWTSYLTPQALIDLVASR
TH_1968|M.thermoresistible__bu KELGRIIGDEHDPLSKTVTLPEPFTDVQRHQVEWTNYLTPQALIDLVASR
Mvan_5517|M.vanbaalenii_PYR-1 -------------------GADQPEGLMSRLTGHRHAAAGARLPQLVEAA
MSMEG_2350|M.smegmatis_MC2_155 DTPLNPFHTRELNAAELTELLETAGFEVEDTLGVFHGAGLAELDARHGGS
MLBr_00130|M.leprae_Br4923 ------------------VGEWEVDFANSRLQQLSQREINAEVLRGIASN
:
MMAR_3533|M.marinum_M GFTISDQHRVRRPVWTRLVP-------------------------DLITV
MUL_2765|M.ulcerans_Agy99 GFTISDQHRVRRPVWTRLVP-------------------------DLITV
MAV_2111|M.avium_104 GFVIGDQYRIPRPAWTRLVS-------------------------DLLTV
MAB_4613|M.abscessus_ATCC_1997 GFEVTVQRPVHHPFTLPFIEF------------------------DRLTV
Mb3374|M.bovis_AF2122/97 SYCITSPAQVRTKTLDRVRQLLATHP---------ALANSNGLALPYVTV
Rv3342|M.tuberculosis_H37Rv SYCITSPAQVRTKTLDRVRQLLATHP---------ALANSNGLALPYVTV
Mflv_4877|M.gilvum_PYR-GCK SYCITSPERVRARTLDRVRELLTTHP---------ALANSSGLALPYVTV
TH_1968|M.thermoresistible__bu SYCITSPAKVRARTLERVRELLATHP---------ALANNSGLALPYITV
Mvan_5517|M.vanbaalenii_PYR-1 GFDTTVVATRRLRVFG---------------------------PVSFIRA
MSMEG_2350|M.smegmatis_MC2_155 IIEAQVQRAVADAPWDEQLLADVAAVRTDDFDLTPAAERDIDDSLDLVAI
MLBr_00130|M.leprae_Br4923 SQKSRDLVDRHLPAFLRFAGREFIGVQG-----TQLSRYLEGGELSYRMY
MMAR_3533|M.marinum_M GAKS---
MUL_2765|M.ulcerans_Agy99 GTKS---
MAV_2111|M.avium_104 GTKRD--
MAB_4613|M.abscessus_ATCC_1997 GIKR---
Mb3374|M.bovis_AF2122/97 CVRATLA
Rv3342|M.tuberculosis_H37Rv CVRATLA
Mflv_4877|M.gilvum_PYR-GCK CVRATLA
TH_1968|M.thermoresistible__bu CIRATLA
Mvan_5517|M.vanbaalenii_PYR-1 TRPGE--
MSMEG_2350|M.smegmatis_MC2_155 AVRP---
MLBr_00130|M.leprae_Br4923 SFAKD--