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RLHDRLGEVASHIRRSLERTIPELGGDLRIEELLGTSIEANVDTMLHALRYDIAVERVEAPTTALEYARR LAQHGVPVNALVRAYRLGQRLMNELIFDELRATDIPESMRVPVIEAISVAMFEYIDWMSQQVVVYEDERE RWLENQNSLRGVRVRETLAADKEIDADAAITSVRHPLRWHHPALVMWYPDQGSEVDELPRLQRFLRELGE AAGVDASPLFVAADPSCGWGWLPYRAAPERAVAAVADFVRSRPDSPNVAIGTPASGVDGFRRSHREAAEA RSVGILCDRRPPLMISAGEPGLSVVARFGGDLAGTREWVAQVLGELARDGDSDARLRDTLRVYLACGSSY KLAAQRLNMHFNTVKYRVGRAVARRGRAIGSDRLDVELALLVCHWYGGSVLQSK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2557 | - | - | 100% (405) | hypothetical protein MUL_2557 |
| M. ulcerans Agy99 | MUL_3452 | - | e-108 | 50.87% (401) | hypothetical protein MUL_3452 |
| M. ulcerans Agy99 | MUL_3434 | - | 5e-94 | 44.42% (403) | hypothetical protein MUL_3434 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1464 | - | 9e-37 | 31.28% (406) | hypothetical protein Mb1464 |
| M. gilvum PYR-GCK | Mflv_4621 | - | 3e-84 | 42.11% (399) | hypothetical protein Mflv_4621 |
| M. tuberculosis H37Rv | Rv1429 | - | 1e-36 | 31.28% (406) | hypothetical protein Rv1429 |
| M. leprae Br4923 | MLBr_01052 | - | 3e-12 | 23.01% (339) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_2657c | - | 6e-13 | 24.31% (325) | hypothetical protein MAB_2657c |
| M. marinum M | MMAR_1323 | - | 0.0 | 99.26% (405) | hypothetical protein MMAR_1323 |
| M. avium 104 | MAV_4933 | - | 7e-07 | 23.94% (330) | hypothetical protein MAV_4933 |
| M. smegmatis MC2 155 | MSMEG_1456 | - | 3e-06 | 30.87% (149) | hypothetical protein MSMEG_1456 |
| M. thermoresistible (build 8) | TH_2938 | - | 1e-100 | 50.13% (379) | PUTATIVE putative conserved hypothetical protein |
| M. vanbaalenii PYR-1 | Mvan_5765 | - | 6e-06 | 26.69% (251) | transcriptional regulator, CdaR |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2557|M.ulcerans_Agy99 -------------------------------------MRLHDRLGEVASH
MMAR_1323|M.marinum_M -----------------MENPHLDGEVGVSRYVAAVAVRLHDRLGEVASH
TH_2938|M.thermoresistible__bu -------------------------------------------VGYGPGS
Mflv_4621|M.gilvum_PYR-GCK ------------------MLDSSEVQDTPGHAVHHLFRDLGDLVRELPES
Mb1464|M.bovis_AF2122/97 ------------------------MAEAGGGPISVIARHMQLIRDDFISE
Rv1429|M.tuberculosis_H37Rv ------------------------MAEAGGGPISVIARHMQLIRDDFISE
MLBr_01052|M.leprae_Br4923 -------------------MARQHPSPRVRELIREGARIALNPTQEWIDQ
MAB_2657c|M.abscessus_ATCC_199 ---MNEGSERVHTQSMTPDQLWPDASEPVRRLIRELAEKMLARSGEVAGD
MAV_4933|M.avium_104 -----MKDFRAPVNGVDGDSASALVAVPKSQGAQTIRPDSVSRLVGALLD
MSMEG_1456|M.smegmatis_MC2_155 MTAPPIDSGRMTVRGLLDESLMAGSRIVAGEDLLDEELTWVLPLNEVLSQ
Mvan_5765|M.vanbaalenii_PYR-1 -MSSRTLSTALPFEHWLSALAEIGEAVGGDEPVAEVLDRVARTACTLLGY
MUL_2557|M.ulcerans_Agy99 IRRSLERTI-----PELGGDLRIEELLGTSIEANVDTMLH----------
MMAR_1323|M.marinum_M IRRSLERTI-----PELGGDLRIEELLGTSIEANVDTMLH----------
TH_2938|M.thermoresistible__bu RQGSGCR--------------QLLELLRDSVEGNIDTIFS----------
Mflv_4621|M.gilvum_PYR-GCK IHGLLIEQV-----AELAADQQLKELLSDTVAANVDTWFS----------
Mb1464|M.bovis_AF2122/97 LFDKMKAEI-----RGLDYDARMADLWRASITENFVTAVH----------
Rv1429|M.tuberculosis_H37Rv LFDKMKAEI-----RGLDYDARMADLWRASITENFVTAVH----------
MLBr_01052|M.leprae_Br4923 LDRATFAAN-----PAIANDPVLAKVVRRASRAHLVHWAT----------
MAB_2657c|M.abscessus_ATCC_199 LTAASLEDPR---YRTIADDPVIAEVDARLTVSNLKHWLT----------
MAV_4933|M.avium_104 DHAAVVGRVR---SVIRSRLPVYRSVADEALEAELEWVLR----------
MSMEG_1456|M.smegmatis_MC2_155 HDRLDAVAVY---ARPESLTARASTLSALAARGATTLLVDGVAPPDLGGL
Mvan_5765|M.vanbaalenii_PYR-1 DFCAVFLPDEQGRALTIEGSYGLSADYIAQVNANRPILLDVRG-------
MUL_2557|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1323|M.marinum_M --------------------------------------------------
TH_2938|M.thermoresistible__bu --------------------------------------------------
Mflv_4621|M.gilvum_PYR-GCK --------------------------------------------------
Mb1464|M.bovis_AF2122/97 --------------------------------------------------
Rv1429|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MAB_2657c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4933|M.avium_104 --------------------------------------------------
MSMEG_1456|M.smegmatis_MC2_155 PAGLVVVELGIPVGFAALNRLLAERALSQEVHVMRYSTHVHATLAGLFHR
Mvan_5765|M.vanbaalenii_PYR-1 ----------------------------------------------DHEA
MUL_2557|M.ulcerans_Agy99 ----ALRYDIAVERVEAP-TTALEYARRLAQHGVP-------------VN
MMAR_1323|M.marinum_M ----ALRYDIAVERVEAP-TTALEYARRLAQHGVP-------------VN
TH_2938|M.thermoresistible__bu ----AIQHDIPIEEVAPP-TAALEYARRLARHGVE-------------PH
Mflv_4621|M.gilvum_PYR-GCK ----VVRHSIPFDRMESP-TAALEHARRMAQREVP-------------VN
Mb1464|M.bovis_AF2122/97 ----YLDRDTPQSLVEAP-AAALAYARAAAQRDIP-------------LS
Rv1429|M.tuberculosis_H37Rv ----YLDRDTPQSLVEAP-AAALAYARAAAQRDIP-------------LS
MLBr_01052|M.leprae_Br4923 ----ANLRDPGAPVPAHLGPEPLTMARDLVRRGRD-------------VL
MAB_2657c|M.abscessus_ATCC_199 ----SNISEPGHRVRPATGSAMRTYARDVVLRGLT-------------TD
MAV_4933|M.avium_104 ----SAVGG-REALHEPQIAGLAAIGEARARDGVP-------------VD
MSMEG_1456|M.smegmatis_MC2_155 GAGLQILVREVSNLARNPAVALDARGHVVAHHGLPPEAVAALADSVSRML
Mvan_5765|M.vanbaalenii_PYR-1 PTSLAYRTGDVVTLEDIELVPDFTWGGVAQEQGYRALISAPLRRP-GTVV
.
MUL_2557|M.ulcerans_Agy99 ALVRAYRLGQRLMNELIFDELRATDIPESMRVPVIEAISVAMFEYIDWMS
MMAR_1323|M.marinum_M ALVRAYRLGQRLMNELIFDELRATDIPESMRVPVIEAISVAMFEYIDWMS
TH_2938|M.thermoresistible__bu ALLRAYRLGQQKLLDIVLHEIRSLDWEREVSLEFVVGVTNATFGYIDGIS
Mflv_4621|M.gilvum_PYR-GCK ALLRAYRLGHQYGLNLIIAGLRSADLPPEEKLALIEHITRVSFRYIDWMS
Mb1464|M.bovis_AF2122/97 GLVRAHRLGHARFLEVAMQYVSLLEP--ADRVSTIIELVNRSARLVDLVA
Rv1429|M.tuberculosis_H37Rv GLVRAHRLGHARFLEVAMQYVSLLEP--ADRVSTIIELVNRSARLVDLVA
MLBr_01052|M.leprae_Br4923 ALD-IYRVGQYTAWRRWMEIAFTLTSDPQELREILNVSAQSINEYVAATL
MAB_2657c|M.abscessus_ATCC_199 DIQ-SWRAVQRVGWKWWLAACFQVTDDKEQLCELIEVTSNSLTTFVDDSI
MAV_4933|M.avium_104 DMLRAWRIG----VEVVVECAREAARRLGVDDARVLELVQSALAWSDIAM
MSMEG_1456|M.smegmatis_MC2_155 AADLPASERRHDGHDTRTQQVTGPEDSRWTCVASAIRLGKSFEGWVAVLV
Mvan_5765|M.vanbaalenii_PYR-1 GALNGYRTAPHRFDRAEVSLVTTLATQVAIALGTAQLRAKEQATIRELRR
MUL_2557|M.ulcerans_Agy99 QQ-VVVYED----------------------------------ERERWLE
MMAR_1323|M.marinum_M QQVVVVYED----------------------------------ERERWLE
TH_2938|M.thermoresistible__bu QRVVEVYQQ----------------------------------ERERWLE
Mflv_4621|M.gilvum_PYR-GCK EQVLETYQT----------------------------------ERAEWDE
Mb1464|M.bovis_AF2122/97 DQLIVAYEH----------------------------------EHDRWLS
Rv1429|M.tuberculosis_H37Rv DQLIVAYEH----------------------------------EHDRWLS
MLBr_01052|M.leprae_Br4923 EAIATHMQL----------------------------------ERDELTR
MAB_2657c|M.abscessus_ATCC_199 AELAEHVRR----------------------------------VREELAG
MAV_4933|M.avium_104 ATSAKAHRR----------------------------------TERALAL
MSMEG_1456|M.smegmatis_MC2_155 PTLAPDHADGPSKHDLARHEVLTEQATAI--------IGSEMLRQRSVDE
Mvan_5765|M.vanbaalenii_PYR-1 AEEVHTLLTATALRGEGVSGVAAALSELLGRGVLIEDVYDEPLTDANWTA
MUL_2557|M.ulcerans_Agy99 NQNSLRGVRVRETLAADK---EIDADAAITSVR-HPLRWHHPALVMWYP-
MMAR_1323|M.marinum_M NQNSLRGVRVREILAADK---EIDADAAITSVR-HPLRWHHLALVMWYP-
TH_2938|M.thermoresistible__bu NRNSLRAMRVRELLDGG----EVDVDTASATVG-YPLRRTHLAVCVWTP-
Mflv_4621|M.gilvum_PYR-GCK RRRSLRAQAIRDILNGR----DVDLTEASSAMR-YFLGATHVALMVWLDR
Mb1464|M.bovis_AF2122/97 RRSGLQQQWVSELLADT----PVDVPRAERALG-YRLDGVHIAAVVWVDS
Rv1429|M.tuberculosis_H37Rv RRSGLQQQWVSELLADT----PVDVPRAERALG-YRLDGVHIAAVVWVDS
MLBr_01052|M.leprae_Br4923 STHAERLEVVDLILEGA----PVTQERAEARLG-YRLGLTHTAAVIWSD-
MAB_2657c|M.abscessus_ATCC_199 GSQLQRYATVELLLQGA----DIAPARAEAQLG-YALTGSHIGAVVWVD-
MAV_4933|M.avium_104 EAEESDAEFVRGALMGSL---PAAELRMHAELRGLDPGAEYVAVRARLG-
MSMEG_1456|M.smegmatis_MC2_155 AEERARGDFVQALVHGSF--SSEHDMRARAEHHDIELDARFGVFVAPGVL
Mvan_5765|M.vanbaalenii_PYR-1 PDPRAQDHVVATVTLDGSPVARIHVAASDSELSRLDVRAVEHATVVTALE
:
MUL_2557|M.ulcerans_Agy99 --DQGSEVDELPRLQRFLR-----ELGEAAGVDASPLFVAADPSCGWGWL
MMAR_1323|M.marinum_M --DQGSEVDELPRLQRFLR-----ELGEAAGVDASPLFVAADPSCGWGWL
TH_2938|M.thermoresistible__bu --DGSAGDNELDRLQRYVR-----GLAEALGAPGDSLFIALDRLTGCGWI
Mflv_4621|M.gilvum_PYR-GCK --DAGADTDEFIAMERFMQ-----HAVSATGAKQS-VYFSIDRLVGCAWM
Mb1464|M.bovis_AF2122/97 AVPIGDVVAQFDQVRCLLAG----ELGPELGPVANSLMVPTDEREARLWF
Rv1429|M.tuberculosis_H37Rv AVPIGDVVAQFDQVRCLLAG----ELGPELGPVANSLMVPTDEREARLWF
MLBr_01052|M.leprae_Br4923 --DLDGDHGYLDQAAEAFS---------HVVESTQQLIVVASAATRWVWL
MAB_2657c|M.abscessus_ATCC_199 --SEK-EIAALERASEQVM---------RACGADRRLTVVAGTVALWLWI
MAV_4933|M.avium_104 ------GDGPHLRLEQSLG-------FQDPAHSRRGLCALLDGDLAGFLI
MSMEG_1456|M.smegmatis_MC2_155 PRGPDSPTTPMVRLARYAAGVAAHPSVHAYVTVIGDVLVVVRTLRGEDAA
Mvan_5765|M.vanbaalenii_PYR-1 LLRARTAAEVEQRIRGSLVADLLSSDDAGIPALLDRARRLGWDLSGVQSL
MUL_2557|M.ulcerans_Agy99 PYR-AAPERAVAAVADFVRSRPDSPNVAIGT-------------------
MMAR_1323|M.marinum_M PYR-AAPERAVAAVADFVRSRPDSPNVAIGT-------------------
TH_2938|M.thermoresistible__bu PLPGDAATGAVAGVRRYAAEHPDGPHLALGD-------------------
Mflv_4621|M.gilvum_PYR-GCK TVH--RPSDYLSQLRDFVRAQPDGPRLSVGE-------------------
Mb1464|M.bovis_AF2122/97 SPA-PTRAFAPSRIRAAFESAGIRARLACGR-------------------
Rv1429|M.tuberculosis_H37Rv SPA-PTRAFAPSRIRAAFESAGIRARLACGR-------------------
MLBr_01052|M.leprae_Br4923 ADA---LALDVPEVQKALLNLS-KARVAIGT-------------------
MAB_2657c|M.abscessus_ATCC_199 PAK---TTPTVAVLMDSLGRRS-GVRVALGR-------------------
MAV_4933|M.avium_104 EPP-----------------RDVEGVVGFGP-------------------
MSMEG_1456|M.smegmatis_MC2_155 AMRSEMAEYAEAMSGELQRRRGLPAPVAYGR-------------------
Mvan_5765|M.vanbaalenii_PYR-1 IALRPADERTLAAADRFTAGVTPHPLVALHRGDLVFVWPADTGPAVPVAH
:.
MUL_2557|M.ulcerans_Agy99 -----------------PASGVDGFRRSHREAAEARSVGILCDRRP-PLM
MMAR_1323|M.marinum_M -----------------PASGVDGFRRSHREAAEARSVGILCDRRP-PLM
TH_2938|M.thermoresistible__bu -----------------PLPGLDGFRRSYRQALRTRAVAVAAGASA-PRV
Mflv_4621|M.gilvum_PYR-GCK -----------------PLPGIEGFRRTYRQAEQARVVAVAADGSSRHRI
Mb1464|M.bovis_AF2122/97 -----------------VGDGLRGFRASLKQAERVKALALAGGARPGGRV
Rv1429|M.tuberculosis_H37Rv -----------------VGDGLRGFRASLKQAERVKALALAGGARPGGRV
MLBr_01052|M.leprae_Br4923 -----------------SSAGIEGFRRSHLEALTAQRTLARLKSHQ--QV
MAB_2657c|M.abscessus_ATCC_199 -----------------AATGMAGFRRTHMDAAAAQRLLARLGSPL--SV
MAV_4933|M.avium_104 -----------------PRP-LTRLSESYRMAARALVTAEACGLRG----
MSMEG_1456|M.smegmatis_MC2_155 -----------------PALGAGEVRESYREARVALGIARRLHRTG---A
Mvan_5765|M.vanbaalenii_PYR-1 RLLEFLNAATIPEAPTAAVSRQAAARELPGIFRTVRGALDLAGDRDTATV
.
MUL_2557|M.ulcerans_Agy99 ISAGEPGLSVVARFGGDLAGTREWVAQVLG-ELARDGDSDARLRDTLRVY
MMAR_1323|M.marinum_M ISAGEPGLSVVARFGGDLAGTREWVAQVLG-ELARDGDSDARLRDTLRVY
TH_2938|M.thermoresistible__bu TAAADPGLSAAALLTGDLAEARTWVQEVLG-PLSADTKNDARLRETLGVF
Mflv_4621|M.gilvum_PYR-GCK VAARDPGVALASMLMTDDATLKEWIHDVLG-PLAQNTASDQRLRDTLRVF
Mb1464|M.bovis_AF2122/97 MFYDD--VAPVALLADDLEELRRFVTDVLG-DLSVDDERNSWLRETLREF
Rv1429|M.tuberculosis_H37Rv MFYDD--VAPVALLADDLEELRRFVTDVLG-DLSVDDERNSWLRETLREF
MLBr_01052|M.leprae_Br4923 AFFAD--VQLVSLITQNPEDAKEFITSTLG-DFES---ASPALQQTLLTF
MAB_2657c|M.abscessus_ATCC_199 VRYED--VHLMDLLSADPASADQFVTDVLG-EFQS---ASPVLHQTVLTY
MAV_4933|M.avium_104 -AYDIAALGLRTAVAIDADVGELLRKRYLE-PLSVGG-SSRELIATVRTY
MSMEG_1456|M.smegmatis_MC2_155 TSYQQLRGFTVLAQVAETEDSRQLVRDVLG-PLRS----SPDLLETLEAY
Mvan_5765|M.vanbaalenii_PYR-1 IDLDEPTIDHLLLQLDDPARLRDFASAVLGPAVDYDRTRSTELLHTVRVL
: * . . * *:
MUL_2557|M.ulcerans_Agy99 LACGSSYKLAAQRLNMHFNTVKYRVGRAVARRGRAIGS--DRLDVELALL
MMAR_1323|M.marinum_M LACGSSYKLAAQRLNMHFNTVKYRVGRAVARRGRAIGS--DRLDVELALL
TH_2938|M.thermoresistible__bu LRHGSSYTAAADELNLHFNTVKYRVQRAVERRGRPIVP--DRLDVELALL
Mflv_4621|M.gilvum_PYR-GCK LRAGSSFKAAANELQIHANTVKYRVNRALERRGRPIAA--ERLDVEVALL
Mb1464|M.bovis_AF2122/97 LLRNRSYVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALE
Rv1429|M.tuberculosis_H37Rv LLRNRSYVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALE
MLBr_01052|M.leprae_Br4923 INEQCNASRAAKRLFTHRNTLLRRIESAEKLLPRPLDH--TSVHIAVALE
MAB_2657c|M.abscessus_ATCC_199 VEEALNRTSTAERLYTHRNTIDRRLARVDELLPKPFAR--NPIEVAAALT
MAV_4933|M.avium_104 LACGMHVERTATRLFVHQNTVRYRLARFEELTGASLRDTEVVTEVWWVLE
MSMEG_1456|M.smegmatis_MC2_155 LSEGGNINATARTLNVHRNTMLAKLDRISRMLGMDVRDPEHQFTVWLAIR
Mvan_5765|M.vanbaalenii_PYR-1 LEHGLDRRAAAQALHLHPNTVAQRVRRLEELTGLSLARPADLLRLTAALT
: :* : * **: :: . : .:
MUL_2557|M.ulcerans_Agy99 VCHWYGGSVLQSK-----------
MMAR_1323|M.marinum_M VCHWYGGSVLQSM-----------
TH_2938|M.thermoresistible__bu ICQWFGAAVLRPQR----------
Mflv_4621|M.gilvum_PYR-GCK MCYWLGEVALNPTQALGRS-----
Mb1464|M.bovis_AF2122/97 VCRWMAPAVLRAKQ----------
Rv1429|M.tuberculosis_H37Rv VCRWMAPAVLRAKQ----------
MLBr_01052|M.leprae_Br4923 ALQWRGDQTNTSGPRAGRNDGVPA
MAB_2657c|M.abscessus_ATCC_199 LLRVRAGR----------------
MAV_4933|M.avium_104 LAAMRL------------------
MSMEG_1456|M.smegmatis_MC2_155 LDLLDEVHSAVEREASFR------
Mvan_5765|M.vanbaalenii_PYR-1 VSRIASLS----------------