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TAPPIDSGRMTVRGLLDESLMAGSRIVAGEDLLDEELTWVLPLNEVLSQHDRLDAVAVYARPESLTARAS TLSALAARGATTLLVDGVAPPDLGGLPAGLVVVELGIPVGFAALNRLLAERALSQEVHVMRYSTHVHATL AGLFHRGAGLQILVREVSNLARNPAVALDARGHVVAHHGLPPEAVAALADSVSRMLAADLPASERRHDGH DTRTQQVTGPEDSRWTCVASAIRLGKSFEGWVAVLVPTLAPDHADGPSKHDLARHEVLTEQATAIIGSEM LRQRSVDEAEERARGDFVQALVHGSFSSEHDMRARAEHHDIELDARFGVFVAPGVLPRGPDSPTTPMVRL ARYAAGVAAHPSVHAYVTVIGDVLVVVRTLRGEDAAAMRSEMAEYAEAMSGELQRRRGLPAPVAYGRPAL GAGEVRESYREARVALGIARRLHRTGATSYQQLRGFTVLAQVAETEDSRQLVRDVLGPLRSSPDLLETLE AYLSEGGNINATARTLNVHRNTMLAKLDRISRMLGMDVRDPEHQFTVWLAIRLDLLDEVHSAVEREASFR *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1456 | - | - | 100% (561) | hypothetical protein MSMEG_1456 |
| M. smegmatis MC2 155 | MSMEG_6688 | - | 7e-16 | 22.40% (549) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_4044 | - | 2e-11 | 25.52% (384) | GAF domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1226c | - | 2e-08 | 24.65% (284) | hypothetical protein Mb1226c |
| M. gilvum PYR-GCK | Mflv_0356 | - | 2e-13 | 22.87% (494) | purine catabolism PurC domain-containing protein |
| M. tuberculosis H37Rv | Rv1194c | - | 2e-08 | 24.65% (284) | hypothetical protein Rv1194c |
| M. leprae Br4923 | MLBr_01052 | - | 1e-07 | 29.79% (141) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_4347 | - | 1e-11 | 23.78% (576) | putative regulatory protein |
| M. marinum M | MMAR_3335 | - | 1e-07 | 41.33% (75) | hypothetical protein MMAR_3335 |
| M. avium 104 | MAV_2195 | - | 8e-09 | 26.57% (271) | hypothetical protein MAV_2195 |
| M. thermoresistible (build 8) | TH_1338 | - | 2e-07 | 38.96% (77) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1307 | - | 8e-08 | 41.33% (75) | hypothetical protein MUL_1307 |
| M. vanbaalenii PYR-1 | Mvan_1323 | - | 0.0 | 68.76% (557) | transcriptional regulator, CdaR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1456|M.smegmatis_MC2_155 MTAPPIDSGRMTVRGLLDESLMA-GSRIVAGEDLLDEELTWVLPLNEVLS
Mvan_1323|M.vanbaalenii_PYR-1 ---MRHDDDRMTVAGLLDESLMS-GAHVLTGADRLDQQVHWVLPLSEVMS
Mflv_0356|M.gilvum_PYR-GCK --------MPLTLADVIALPVVQRGRPEVLSSRRWDDTIRWVH-VSDLAD
MAB_4347|M.abscessus_ATCC_1997 ----------MTVAEILALPVVLAGDPQVVGGGSLDRPVRWVH-VSDVAD
MMAR_3335|M.marinum_M ---------------------------------MNDNQFSAIARLGSARS
MUL_1307|M.ulcerans_Agy99 ---------------------------------MNNNQFSAIARLGSARS
MAV_2195|M.avium_104 ---------------------------------MNDNPFAGPFAK-HPRS
TH_1338|M.thermoresistible__bu ---------------------------------VPDNRFVP------PQS
Mb1226c|M.bovis_AF2122/97 -------------------------MAWQQPSPRIRELIREGARIALNPS
Rv1194c|M.tuberculosis_H37Rv -------------------------MAWQQPSPRIRELIREGARIALNPS
MLBr_01052|M.leprae_Br4923 -------------------------MARQHPSPRVRELIREGARIALNPT
.
MSMEG_1456|M.smegmatis_MC2_155 QHDRLDAVAVYARPESLTAR----ASTLSALAARGATTLLVDG-----VA
Mvan_1323|M.vanbaalenii_PYR-1 RHDALDGVAVYTRPEALLGN----GGTLAPLAARGATALLVDG-----TV
Mflv_0356|M.gilvum_PYR-GCK LSTLLQGGELVLTTGAAMAR--SPRTYLRGLAEAGAVGVVVEVGAVVPEV
MAB_4347|M.abscessus_ATCC_1997 LSGLLQGGELVLTTGGPLADPDACTRYLGGLFAAGAAGVVVELGTSLQAI
MMAR_3335|M.marinum_M PLELLET-----VPDSLLRR----LKQYSGRLATEAVSAMQER-------
MUL_1307|M.ulcerans_Agy99 PLELLET-----VPDSLLRR----LKQYSGRLATEAVSAMQER-------
MAV_2195|M.avium_104 PLETLDT-----VPESVLRR----LKQYSGRLATEAVSVMQDR-------
TH_1338|M.thermoresistible__bu TLEVLES-----VPESVLRR----LKQYSGRLATEAVHTMEER-------
Mb1226c|M.bovis_AF2122/97 PEWIEELDRATIAANPAIAN----DPVLAKVVQTANRANLVYW-------
Rv1194c|M.tuberculosis_H37Rv PEWIEELDRATIAANPAIAN----DPVLAKVVQTANRANLVYW-------
MLBr_01052|M.leprae_Br4923 QEWIDQLDRATFAANPAIAN----DPVLAKVVRRASRAHLVHW-------
: . :
MSMEG_1456|M.smegmatis_MC2_155 PPDLG--GLPAGLVVVELGIPVGFAALNRLLAERALSQEVHVMRYSTHVH
Mvan_1323|M.vanbaalenii_PYR-1 PADFPTAAVPADMVVVEMAFPVGFAALNRLLAERALSQEVHAMRYATHVH
Mflv_0356|M.gilvum_PYR-GCK PPGVGGIAEQLDLALVVLHRTVRFVEVTEAVHRMIVAEQYDVVEFDRRVH
MAB_4347|M.abscessus_ATCC_1997 PSGVAREADKLQLPVIALHRKIRFVDVTEQVHRSIVAEQYDEVAFARHVH
MMAR_3335|M.marinum_M -LPFFADLEASQRASVALVVQTAVVNFAEWMQNPRSDVSYTAQAFELVPQ
MUL_1307|M.ulcerans_Agy99 -LPFFADLEASQRASVALVVQTAVVNFAEWMQNPRSDVSYTAQAFELVPQ
MAV_2195|M.avium_104 -LPFFADLEASQRASVSLVVQTAVVNFAEWMQDPKSNVRHTAQAFELVPQ
TH_1338|M.thermoresistible__bu -LPFFADLEASQRASVHLVVQTAVVNFVEWMRDPRSNVTYTMQAFEVVPQ
Mb1226c|M.bovis_AF2122/97 --------AAANLRDPGARVPANLGTEPLRMARDLVRRGLDTVAFNIYRT
Rv1194c|M.tuberculosis_H37Rv --------AAANLRDPGARVPANLGTEPLRMARDLVRRGLDTVAFNIYRT
MLBr_01052|M.leprae_Br4923 --------ATANLRDPGAPVPAHLGPEPLTMARDLVRRGRDVLALDIYRV
. :
MSMEG_1456|M.smegmatis_MC2_155 ATLAGLFHRGAGLQILVREVSNLARNPAVALDARGHVVAHHGLPPEAVAA
Mvan_1323|M.vanbaalenii_PYR-1 ASLAGLFHRGAGLQLLVREVSNLARNPAMALDARGNVVAHNGFTAETAAA
Mflv_0356|M.gilvum_PYR-GCK ETFTDLSMKRASLSGIVDAAAKLLGEHVVLEDLS----------------
MAB_4347|M.abscessus_ATCC_1997 EVFTELTMRRATLGEIVDACGQIAESAIVLEDLN----------------
MMAR_3335|M.marinum_M DLTRRIALRHT--VDMVRVTMEFFEEVVPLLARS----------------
MUL_1307|M.ulcerans_Agy99 DLTRRIALRHT--VDMVRVTMEFFEEVVPLLARS----------------
MAV_2195|M.avium_104 DLARRIALRHS--VEMVRVTMEFFEEVVPLLARS----------------
TH_1338|M.thermoresistible__bu DLTRRIALRQT--VEMVRTTMEFFEQVVPLLARS----------------
Mb1226c|M.bovis_AF2122/97 GEHIGWRFWMGIAFELTSDPQELRELLDVSARSVN---------------
Rv1194c|M.tuberculosis_H37Rv GEHIGWRFWMGIAFELTSDPQELRELLDVSARSVN---------------
MLBr_01052|M.leprae_Br4923 GQYTAWRRWMEIAFTLTSDPQELREILNVSAQSIN---------------
:. ::
MSMEG_1456|M.smegmatis_MC2_155 LADSVSRMLAADLPASERRHDGHDTRTQQVTGPEDSRWTCVASAIRLGKS
Mvan_1323|M.vanbaalenii_PYR-1 LTESILPLLTADLPAAARLSAHHDTRVERFGAPGGGVWTVISTAIRLGKA
Mflv_0356|M.gilvum_PYR-GCK -HQALVASTG--IPADLLTDWARRSRRSP----GGGAGAEPWSATDVGPR
MAB_4347|M.abscessus_ATCC_1997 -RQVVAFTTHGDSPTGVIHDWERRSRLTPVLPETGETGPESWLTTPVGPG
MMAR_3335|M.marinum_M --------------------------------------EEQLTALTVG--
MUL_1307|M.ulcerans_Agy99 --------------------------------------EEQLTALTVG--
MAV_2195|M.avium_104 --------------------------------------EEQLTALTVG--
TH_1338|M.thermoresistible__bu --------------------------------------EEQVTALTAG--
Mb1226c|M.bovis_AF2122/97 --------------------------------------------------
Rv1194c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MSMEG_1456|M.smegmatis_MC2_155 FEGWVAVLVPTLAPDHADGPSKHDLARHEVLTEQATAIIGSEMLRQRSVD
Mvan_1323|M.vanbaalenii_PYR-1 FEGWVLVVVPSAE------PGGHDLARHIVVTEQATAIIGSEMLRQHSVD
Mflv_0356|M.gilvum_PYR-GCK FEQWGRLVVPYAP---------ADATRAATVLERAAAALAMHRMVEQNRT
MAB_4347|M.abscessus_ATCC_1997 RQEWGRLIAPSG----------GSSLRGRMALERAAQALALHRMIEQHQT
MMAR_3335|M.marinum_M --------------------------ILKYSRDLAFTAASAYADAAEARG
MUL_1307|M.ulcerans_Agy99 --------------------------ILKYSRDLAFTAASAYADAAEARG
MAV_2195|M.avium_104 --------------------------VLKYSRDLAFTAATAYADAAEARG
TH_1338|M.thermoresistible__bu --------------------------ILRYSRDLAFAAATAYADAAEARG
Mb1226c|M.bovis_AF2122/97 ----------------------------DFIEATLTGIAAQVQSEHDELT
Rv1194c|M.tuberculosis_H37Rv ----------------------------DFIEATLTGIAAQVQSEHDELT
MLBr_01052|M.leprae_Br4923 ----------------------------EYVAATLEAIATHMQLERDELT
MSMEG_1456|M.smegmatis_MC2_155 EAEERARGDFVQALVHGSFSSEHDMRARAEHHDIELDARFGVFVAPGVLP
Mvan_1323|M.vanbaalenii_PYR-1 EAEERARGDFVQALVHGHFSSEHDMRARADYHEIDIDSVFGVFVAPGAVP
Mflv_0356|M.gilvum_PYR-GCK GLQHQAQSGLIDDVLRGRVVDDRDAAARAQALGLRSNAQYLPVVVRVARP
MAB_4347|M.abscessus_ATCC_1997 TLEQQAQSGLVEELRRGRIKDEAEASARARALGVKPALSYIPLTVRVRE-
MMAR_3335|M.marinum_M TWDSRMEASVVDAVVRG--DTGPELLSRAAALNWDTTAPATVVVGTPASA
MUL_1307|M.ulcerans_Agy99 TWDSRMEASVVDAVVRG--DTGPELLSRAAALNWDTTAPATVVVGTPASA
MAV_2195|M.avium_104 TWDSRMEASVVDAVVRG--DTGPELLSRAAALNWDTTAPATVVVGTPAPG
TH_1338|M.thermoresistible__bu AWDTRMEANVVDAVVRG--AVGPELQSQAAALNWDATAPATVVVGLPRPD
Mb1226c|M.bovis_AF2122/97 RSTHAERLEVVGLILDG-----APISPERAEAKLGYPLSRAHTAAIIWSD
Rv1194c|M.tuberculosis_H37Rv RSTHAERLEVVGLILDG-----APISPERAEAKLGYPLSRAHTAAIIWSD
MLBr_01052|M.leprae_Br4923 RSTHAERLEVVDLILEG-----APVTQERAEARLGYRLGLTHTAAVIWSD
. .: : * . .
MSMEG_1456|M.smegmatis_MC2_155 RGPDSPTTPMVRLARYAAGVAAHPSVHAYVTVIG----DVLVVVRTLRGE
Mvan_1323|M.vanbaalenii_PYR-1 RGVDNPAASMVRLARYAANVAPDPAVRSYVTVLG----DVLVVVRSLRGA
Mflv_0356|M.gilvum_PYR-GCK AEIDDPVAGHRRNVAVLDAVAHTVNACGHTGLFSLRGDGEVGAVLSLKDS
MAB_4347|M.abscessus_ATCC_1997 EPCADQVLLQRRQIRLLDAVRHAVRTARLSALTANPRPGQIDVLLSQ--T
MMAR_3335|M.marinum_M RDGSDG---SERAIQDVRDAAAQHGRAALTDVHG-------TWLVAIVSG
MUL_1307|M.ulcerans_Agy99 RDGSDG---SERAIQDVRDAAAQHGRAALTDVHG-------TWLVAIVSG
MAV_2195|M.avium_104 RDGSTGPGDSERASQHVRDIAAQHGRAALTDVHG-------TWLVAIVSG
TH_1338|M.thermoresistible__bu R--------LEVVSQDVHHVANRHGRTALSDVHG-------TWLVTIVSG
Mb1226c|M.bovis_AF2122/97 ELDGDHSYLDRAADLFCHAVGSTRPLTVVAGAAS-----RWAWVTDADGL
Rv1194c|M.tuberculosis_H37Rv ELDGDHSYLDRAADLFCHAVGSTRPLTVVAGAAS-----RWAWVTDADGL
MLBr_01052|M.leprae_Br4923 DLDGDHGYLDQAAEAFSHVVESTQQLIVVASAAT-----RWVWLADALAL
:
MSMEG_1456|M.smegmatis_MC2_155 DAAAMRSEMAEYAEAMSGELQRRRGLPAPVAYGRPALG-----AGEVRES
Mvan_1323|M.vanbaalenii_PYR-1 DDTAMRKEMTRYAEAMADELQNRRGTPAAVAYSRPARG-----AQEVAGS
Mflv_0356|M.gilvum_PYR-GCK RTRSVDQALGALARRIHTEIRRVDGSDRVVVTLGPSARNVTDAIAGLAEA
MAB_4347|M.abscessus_ATCC_1997 HASSAEEILTNVSSVIRASLQRLDDISRCVVGVGPASTRLIDAAVSLDDS
MMAR_3335|M.marinum_M HLSPTDKVFKDLLEAFSDGP----------VVIGPTAP-------MLTAA
MUL_1307|M.ulcerans_Agy99 HLSPTDKVFKDLLEAFSDGP----------VVIGPTAP-------MLTAA
MAV_2195|M.avium_104 QLSPTDKFLGDLLEAFSDGP----------VVVGPTAP-------MLTAA
TH_1338|M.thermoresistible__bu ALSPTDRFLTDLLDVFADGP----------VVLGPTAP-------TLSAA
Mb1226c|M.bovis_AF2122/97 DIDTVQAAVDNAPGAR--------------IAIGTTAN-------GVEGF
Rv1194c|M.tuberculosis_H37Rv DIDTVQAAVDNAPGAR--------------IAIGTTAN-------GVEGF
MLBr_01052|M.leprae_Br4923 DVPEVQKALLNLSKAR--------------VAIGTSSA-------GIEGF
. .: :
MSMEG_1456|M.smegmatis_MC2_155 YREARVALGIARRLHRTGATSYQQLRGFTVLAQVAETED---SRQLVRDV
Mvan_1323|M.vanbaalenii_PYR-1 YREARIALGIARRLGHTGAVSYQDLRSFTVLADVADTDQ---SRALVADV
Mflv_0356|M.gilvum_PYR-GCK IDTAEVALSLRGDVRDFYRTSDIRLRGLISLLRDDPRIRRFAETELRALL
MAB_4347|M.abscessus_ATCC_1997 AHVAEVALSLPDDAKAFHRASDTRLRGLLALIRSDPRVQAFAEVELRGVL
MMAR_3335|M.marinum_M YHSASEAISGMNAVAGWRGAPRPVLARELLPERALMGDASAIVALHTDVM
MUL_1307|M.ulcerans_Agy99 YHSASEAISGMNAVAGWRGASRPVLARELLPERALMGDASAIVALHTDVM
MAV_2195|M.avium_104 YHSASEAISGMNAVGGWRGAPRPVLARELLPERALMGDASAIVALHTDVM
TH_1338|M.thermoresistible__bu YRSATEAIAGMNAVAGWSGAPRPVPARELLPERALLGDQTAIAALESEVM
Mb1226c|M.bovis_AF2122/97 RRSHLEALITQRTLSRLRSTQRVAFFADVKMVALISQNPDAASEFITSTL
Rv1194c|M.tuberculosis_H37Rv RRSHLEALITQRTLSRLRSTQRVAFFADVKMVALISQNPDAASEFITSTL
MLBr_01052|M.leprae_Br4923 RRSHLEALTAQRTLARLKSHQQVAFFADVQLVSLITQNPEDAKEFITSTL
*: :
MSMEG_1456|M.smegmatis_MC2_155 LGPLRSSPDLLETLEAYLSEGGNINATARTLNVHRNTMLAKLDRISRMLG
Mvan_1323|M.vanbaalenii_PYR-1 LGPLRSAPDLLDFLIGYLAHGGNVNATARALNVHRNTMLTKLDRVSRATG
Mflv_0356|M.gilvum_PYR-GCK AHDAGAEPSNISVLREYLRLAGNKSALAERLHMSRPALYKRLRGIEDALG
MAB_4347|M.abscessus_ATCC_1997 ENRARHGDDLFQLLREFLNTGGNKTELAKRLHLSRPTLYTKLAIVQRLLG
MMAR_3335|M.marinum_M RPLADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLKRITDFTG
MUL_1307|M.ulcerans_Agy99 RPLADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLKRITDFTG
MAV_2195|M.avium_104 GPLADAGPTLIETLDAFLDSGGAIEACARKLFVHPNTVRYRLKRITDFTG
TH_1338|M.thermoresistible__bu RPLADAGPTLTETLDAFLESGGAIEACARRLFVHPNTVRYRLRRIAEITG
Mb1226c|M.bovis_AF2122/97 GDLESASPDLQTALLTFINEQCNASRAAKRLHTHRNTFLRRLESAQRLLP
Rv1194c|M.tuberculosis_H37Rv GDLESASPDLQTALLTFINEQCNASRAAKRLHTHRNTFLRRLESAQRLLP
MLBr_01052|M.leprae_Br4923 GDFESASPALQQTLLTFINEQCNASRAAKRLFTHRNTLLRRIESAEKLLP
* :: *. * :. ::
MSMEG_1456|M.smegmatis_MC2_155 MDVRDPEHQFTVWLAIRLDLLDEVHSAVEREASFR---------------
Mvan_1323|M.vanbaalenii_PYR-1 LDIRLPDNQFTVWLAIRLDMLTEVHAAVDREAKFR---------------
Mflv_0356|M.gilvum_PYR-GCK VDLDDGES--MTSLHVAVMVLDSLTGSG----------------------
MAB_4347|M.abscessus_ATCC_1997 VDLDDAES--RTSLHTAMLVLDHVNP------------------------
MMAR_3335|M.marinum_M RDPTQPRDAYVLRVAATVGQLNYPTPPSGAANNTITPVPLPVR---RGTE
MUL_1307|M.ulcerans_Agy99 RDPTQPRDAYVLRVAATVGQLNYPTPPSGAANNTITPVPLPVR---RGTE
MAV_2195|M.avium_104 RDPMQPRDAYVLRVAATVGQLNYPTHPPSAAGAAMPAVPLPVNGAARGQS
TH_1338|M.thermoresistible__bu RDPAVPRDAYVLRVAVSVSRLTRQSYQSSTVNPDLGSTAGWRGQAAGGHR
Mb1226c|M.bovis_AF2122/97 RPLDHTSVHVAVALEALQWRGNKAHALSSPGRRSNSVPA-----------
Rv1194c|M.tuberculosis_H37Rv RPLDHTSVHVAVALEALQWRGNKAHALSSPGRRSNSVPA-----------
MLBr_01052|M.leprae_Br4923 RPLDHTSVHIAVALEALQWRGDQTNTSGPRAGRNDGVPA-----------
:
MSMEG_1456|M.smegmatis_MC2_155 --
Mvan_1323|M.vanbaalenii_PYR-1 --
Mflv_0356|M.gilvum_PYR-GCK --
MAB_4347|M.abscessus_ATCC_1997 --
MMAR_3335|M.marinum_M GP
MUL_1307|M.ulcerans_Agy99 GP
MAV_2195|M.avium_104 GG
TH_1338|M.thermoresistible__bu AM
Mb1226c|M.bovis_AF2122/97 --
Rv1194c|M.tuberculosis_H37Rv --
MLBr_01052|M.leprae_Br4923 --