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VDFGALPPEINSARMYFGAGAAPLLGAAAAWNDIAVELSTAASAIESVITRLSSDQWLGTASLSMAAAAQ PLLAWLSYTAESSALAAAQAAASVAAFETAFAMTVPPAEVAANRARLAALMATNIFGQNVPAIAATEARY GEMWAQDASAMYGYAASCAGAVRLNPLTRPSETTNPGGIASQAVAVSHAAASVSVQQAGFENLISTVSDA VTSLSGPVTSSPHVTSLGAFIEDIIFLDIPRFVESAFHGLGATADYATMIAANLLTLQTSANTATSAGGV APAAAAGSALAQTVTSAGVGDASSVGALSVPVGWTTAAPAATGGAASDGTGWAVPDEDVPSPAGMVAGTN GAGARPGPRYGVKPRVMPKKVLV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2167 | - | - | 100% (373) | PPE family protein |
| M. ulcerans Agy99 | MUL_4621 | - | e-101 | 53.69% (393) | PPE family protein |
| M. ulcerans Agy99 | MUL_4672 | - | 6e-73 | 44.16% (385) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2792c | PPE44 | 1e-126 | 64.23% (383) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-27 | 30.33% (366) | PPE protein |
| M. tuberculosis H37Rv | Rv2770c | PPE44 | 1e-125 | 63.97% (383) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-42 | 32.85% (411) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 3e-26 | 29.62% (368) | PPE family protein |
| M. marinum M | MMAR_1947 | - | 0.0 | 98.66% (373) | PPE family protein, PPE44 |
| M. avium 104 | MAV_1347 | - | 1e-80 | 46.68% (392) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 8e-29 | 35.41% (209) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 4e-32 | 30.39% (408) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-29 | 30.27% (370) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2167|M.ulcerans_Agy99 -------------MDFGALPPEINSARMYFGAGAAPLLGAAAAWNDIAVE
MMAR_1947|M.marinum_M ---------MESQVDFGALPPEINSARMYFGAGAAPLLGAAAAWNDIAVE
Mb2792c|M.bovis_AF2122/97 -------------MDFGALPPEVNSARMYGGAGAADLLAAAAAWNGIAVE
Rv2770c|M.tuberculosis_H37Rv -------------MDFGALPPEVNSARMYGGAGAADLLAAAAAWNGIAVE
MAV_1347|M.avium_104 -----------MTFDFGALPPEVNSTRMYTGAGAAPMMAAAAAFSNLADE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
* .** :*: : *.*.. : *. : :. .
MUL_2167|M.ulcerans_Agy99 LSTAASAIESVITRLSSDQWLGTASLSMAAAAQPLLAWLSYTAESSALAA
MMAR_1947|M.marinum_M LSTAASAIESVITRLSSDQWLGTASLSMAAAAQPLLAWLSYTAESSALAA
Mb2792c|M.bovis_AF2122/97 VSTAASSVGSVITRLSTEHWMGPASLSMAAAVQPYLVWLTCTAESSALAA
Rv2770c|M.tuberculosis_H37Rv VSTAASSVGSVITRLSTEHWMGPASLSMAAAVQPYLVWLTCTAESSALAA
MAV_1347|M.avium_104 LSTTAAATQSAIANLTGEEWMGPSAAAMVTAVQPYVQWMHTTAGQLQQAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
::* : : : * .: . * *: : .
MUL_2167|M.ulcerans_Agy99 AQAAASVAAFETAFAMTVPPAEVAANRARLAALMATNIFGQNVPAIAATE
MMAR_1947|M.marinum_M AQAAASVAAFETAFAMTVPPAEVAANRARLAELMATNIFGQNVPAIAATE
Mb2792c|M.bovis_AF2122/97 AQAMASAAAFETAFALTVPPAEVVANRALLAELTATNILGQNVSAIAATE
Rv2770c|M.tuberculosis_H37Rv AQAMASAAAFETAFALTVPPAEVVANRALLAELTATNILGQNVSAIAATE
MAV_1347|M.avium_104 AQAMASAAAYETAFAMTVPPALVAANRAQLAALIASNVLGQNAAAIAATE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
.* .:. *. :*:: . : *:: * :*.:* * .* .*
MUL_2167|M.ulcerans_Agy99 ARYGEMWAQDASAMYGYAASCAGAVRLNPLTRPSETTNPGGIASQAVAVS
MMAR_1947|M.marinum_M ARYGEMWAQDASAMYGYAASCAGAVRLNPLTRPSETTNPGGIARQAAAVS
Mb2792c|M.bovis_AF2122/97 ARYGEMWAQDASAMYGYAAASAVAARLNPLTRPSHITNPAGLAHQAAAVG
Rv2770c|M.tuberculosis_H37Rv ARYGEMWAQDASAMYGYAAASAVAARLNPLTRPSHITNPAGLAHQAAAVG
MAV_1347|M.avium_104 AQYGEMWAQDAAAMYGYAASSATAGKLSPLTSPAPTNQPGGLGAQAAAVS
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
* * .** * *::* * : * ..
MUL_2167|M.ulcerans_Agy99 HAAASVSVQQAG--------------------------------------
MMAR_1947|M.marinum_M HAAASVSVQQAG--------------------------------------
Mb2792c|M.bovis_AF2122/97 QAGASASARQVG--------------------------------------
Rv2770c|M.tuberculosis_H37Rv QAGASAFARQVG--------------------------------------
MAV_1347|M.avium_104 GATATS-AQTSG--------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVN------------------------
MUL_2167|M.ulcerans_Agy99 --------------------FENLISTVSDAVTSLSGPVTSSPHVTSL-G
MMAR_1947|M.marinum_M --------------------FENLISTVSDAVMSLSAPVTSSPHVTSL-G
Mb2792c|M.bovis_AF2122/97 --------------------LSHLISDVADAVLSFASPVMSAADTG---L
Rv2770c|M.tuberculosis_H37Rv --------------------LSHLISDVADAVLSFASPVMSAADTG---L
MAV_1347|M.avium_104 --------------------LQGTVANVPNVVRTLAAPADPPGLS-----
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MLBr_01182|M.leprae_Br4923 --------------EGMEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQ
. :
MUL_2167|M.ulcerans_Agy99 AFIEDIIFLDIPRFVESAFHGLGATADYATMIAANLLTLQTSANTATSAG
MMAR_1947|M.marinum_M AFIEDIIFLDIPRFVESAFHGLGATADYATMIAANLLTLQTSANTATSAG
Mb2792c|M.bovis_AF2122/97 EAVRQFLNLDVPLFVESAFHGLGGVADFATAAIGNMTLLADAMG---TVG
Rv2770c|M.tuberculosis_H37Rv EAVRQFLNLDVPLFVESAFHGLGGVADFATAAIGNMTLLADAMG---TVG
MAV_1347|M.avium_104 -ALDNLLGNPVVNNVGNAGFNVVSWNVFNTIVSNILYNHTLDTAAAAGVA
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MLBr_01182|M.leprae_Br4923 LWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKA
MUL_2167|M.ulcerans_Agy99 GVAPAAAAGSALAQTVTS--AGVG---------DASSVGALSVPVGWTTA
MMAR_1947|M.marinum_M GVAPAAAAGSALAQTVTS--AGVG---------DASSVGALSVPVGWTTA
Mb2792c|M.bovis_AF2122/97 GAAPGGGAAAAVAHAVAP--AGVGGTALTADLGNASVVGRLSVPASWSTA
Rv2770c|M.tuberculosis_H37Rv GAAPGGGAAAAVAHAVAP--AGVGGTALTADLGNASVVGRLSVPASWSTA
MAV_1347|M.avium_104 GEVGGAVGGGALVGAAAPATAGVGAAPVLASMGSAATVGELSTPATWSAP
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
MLBr_01182|M.leprae_Br4923 AESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTA
. ..
MUL_2167|M.ulcerans_Agy99 APAATGGAASDGTGWAVPDED-----VPSPAGMVAGTNGAGARPGPRYGV
MMAR_1947|M.marinum_M APAATGGAASDGTGWAVPDED-----VPSPAGMVAGTNGAGARPGPRYGV
Mb2792c|M.bovis_AF2122/97 APATAAGAALDGTGWAVPEEDGPIAVMPPAPGMVVAANSVGADSGPRYGV
Rv2770c|M.tuberculosis_H37Rv APATAAGAALDGTGWAVPEEDGPIAVMPPAPGMVVAANSVGADSGPRYGV
MAV_1347|M.avium_104 TPEPAA-TTVGATEWASPAEEPHTAWATGMP-AVASAGRGGYGMGPRYGV
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
MLBr_01182|M.leprae_Br4923 SQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNT
MUL_2167|M.ulcerans_Agy99 KPRVMPKKVLV---------------------------------------
MMAR_1947|M.marinum_M KPRVMPKKVLV---------------------------------------
Mb2792c|M.bovis_AF2122/97 KPIVMPKHGLF---------------------------------------
Rv2770c|M.tuberculosis_H37Rv KPIVMPKHGLF---------------------------------------
MAV_1347|M.avium_104 KPKVMPTRLPV---------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
MLBr_01182|M.leprae_Br4923 ALRLQPRAFVMPRNPAAG--------------------------------
MUL_2167|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1947|M.marinum_M --------------------------------------------------
Mb2792c|M.bovis_AF2122/97 --------------------------------------------------
Rv2770c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1347|M.avium_104 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MUL_2167|M.ulcerans_Agy99 ---------------
MMAR_1947|M.marinum_M ---------------
Mb2792c|M.bovis_AF2122/97 ---------------
Rv2770c|M.tuberculosis_H37Rv ---------------
MAV_1347|M.avium_104 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------
MLBr_01182|M.leprae_Br4923 ---------------