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DFGALPPEVNSARMYGGAGAADLLAAAAAWNGIAVEVSTAASSVGSVITRLSTEHWMGPASLSMAAAVQP YLVWLTCTAESSALAAAQAMASAAAFETAFALTVPPAEVVANRALLAELTATNILGQNVSAIAATEARYG EMWAQDASAMYGYAAASAVAARLNPLTRPSHITNPAGLAHQAAAVGQAGASAFARQVGLSHLISDVADAV LSFASPVMSAADTGLEAVRQFLNLDVPLFVESAFHGLGGVADFATAAIGNMTLLADAMGTVGGAAPGGGA AAAVAHAVAPAGVGGTALTADLGNASVVGRLSVPASWSTAAPATAAGAALDGTGWAVPEEDGPIAVMPPA PGMVVAANSVGADSGPRYGVKPIVMPKHGLF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2770c | PPE44 | - | 100% (382) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv2768c | PPE43 | e-123 | 60.56% (393) | PPE family protein |
| M. tuberculosis H37Rv | Rv1039c | PPE15 | e-107 | 55.84% (394) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2792c | PPE44 | 0.0 | 99.74% (382) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-29 | 29.14% (374) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-42 | 33.09% (417) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 1e-28 | 30.96% (394) | PPE family protein |
| M. marinum M | MMAR_1947 | - | 1e-127 | 64.49% (383) | PPE family protein, PPE44 |
| M. avium 104 | MAV_1347 | - | 2e-86 | 50.39% (383) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-32 | 30.24% (420) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 8e-33 | 30.42% (355) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2167 | - | 1e-125 | 63.97% (383) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-33 | 30.02% (413) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2770c|M.tuberculosis_H37Rv -------------MDFGALPPEVNSARMYGGAGAADLLAAAAAWNGIAVE
Mb2792c|M.bovis_AF2122/97 -------------MDFGALPPEVNSARMYGGAGAADLLAAAAAWNGIAVE
MMAR_1947|M.marinum_M ---------MESQVDFGALPPEINSARMYFGAGAAPLLGAAAAWNDIAVE
MUL_2167|M.ulcerans_Agy99 -------------MDFGALPPEINSARMYFGAGAAPLLGAAAAWNDIAVE
MAV_1347|M.avium_104 -----------MTFDFGALPPEVNSTRMYTGAGAAPMMAAAAAFSNLADE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: * .** :*: : *.*.. :: *. : :. .
Rv2770c|M.tuberculosis_H37Rv VSTAASSVGSVITRLSTEHWMGPASLSMAAAVQPYLVWLTCTAESSALAA
Mb2792c|M.bovis_AF2122/97 VSTAASSVGSVITRLSTEHWMGPASLSMAAAVQPYLVWLTCTAESSALAA
MMAR_1947|M.marinum_M LSTAASAIESVITRLSSDQWLGTASLSMAAAAQPLLAWLSYTAESSALAA
MUL_2167|M.ulcerans_Agy99 LSTAASAIESVITRLSSDQWLGTASLSMAAAAQPLLAWLSYTAESSALAA
MAV_1347|M.avium_104 LSTTAAATQSAIANLTGEEWMGPSAAAMVTAVQPYVQWMHTTAGQLQQAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
:::* : : : * :: . * *: : *
Rv2770c|M.tuberculosis_H37Rv AQAMASAAAFETAFALTVPPAEVVANRALLAELTATNILGQNVSAIAATE
Mb2792c|M.bovis_AF2122/97 AQAMASAAAFETAFALTVPPAEVVANRALLAELTATNILGQNVSAIAATE
MMAR_1947|M.marinum_M AQAAASVAAFETAFAMTVPPAEVAANRARLAELMATNIFGQNVPAIAATE
MUL_2167|M.ulcerans_Agy99 AQAAASVAAFETAFAMTVPPAEVAANRARLAALMATNIFGQNVPAIAATE
MAV_1347|M.avium_104 AQAMASAAAYETAFAMTVPPALVAANRAQLAALIASNVLGQNAAAIAATE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: .:. *: **:: . : *:: * :*.:* * .* .*
Rv2770c|M.tuberculosis_H37Rv ARYGEMWAQDASAMYGYAAASAVAARLNPLTRPSHI--------------
Mb2792c|M.bovis_AF2122/97 ARYGEMWAQDASAMYGYAAASAVAARLNPLTRPSHI--------------
MMAR_1947|M.marinum_M ARYGEMWAQDASAMYGYAASCAGAVRLNPLTRPSET--------------
MUL_2167|M.ulcerans_Agy99 ARYGEMWAQDASAMYGYAASCAGAVRLNPLTRPSET--------------
MAV_1347|M.avium_104 AQYGEMWAQDAAAMYGYAASSATAGKLSPLTSPAPT--------------
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPF--------------
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPL--------------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPS--------------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPF--------------
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPS--------------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
* * .** * *::* * : * ..
Rv2770c|M.tuberculosis_H37Rv TNPAGLAHQAAAVGQAGASAFARQVGLSHLISDVADAVLSFASPVMS--A
Mb2792c|M.bovis_AF2122/97 TNPAGLAHQAAAVGQAGASASARQVGLSHLISDVADAVLSFASPVMS--A
MMAR_1947|M.marinum_M TNPGGIARQAAAVSHAAASVSVQQAGFENLISTVSDAVMSLSAPVTS--S
MUL_2167|M.ulcerans_Agy99 TNPGGIASQAVAVSHAAASVSVQQAGFENLISTVSDAVTSLSGPVTS--S
MAV_1347|M.avium_104 NQPGGLGAQAAAVSGATATS-AQTSGLQGTVANVPNVVRTLAAPADP--P
MSMEG_0619|M.smegmatis_MC2_155 LLKPGVGEAGSASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVP
TH_3569|M.thermoresistible__bu LLAPGVSEAADAMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLD
Mflv_0325|M.gilvum_PYR-GCK VLLPGVGEAGRAAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLR
Mvan_0415|M.vanbaalenii_PYR-1 VLAPGVGEAGRAAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLR
MAB_0809c|M.abscessus_ATCC_199 ILHD--HDHGHDDHDHEHGHDDDHGHGDLDPTDP-EWWVHVAGEMVEHFE
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
. .
Rv2770c|M.tuberculosis_H37Rv ADTG--LEAVRQFLNLDVPLFVES-----AFHGLGGVADFATAAIGNMTL
Mb2792c|M.bovis_AF2122/97 ADTG--LEAVRQFLNLDVPLFVES-----AFHGLGGVADFATAAIGNMTL
MMAR_1947|M.marinum_M PHVTSLGAFIEDIIFLDIPRFVES-----AFHGLGATADYATMIAANLLT
MUL_2167|M.ulcerans_Agy99 PHVTSLGAFIEDIIFLDIPRFVES-----AFHGLGATADYATMIAANLLT
MAV_1347|M.avium_104 GLS-----ALDNLLGNPVVNNVGN-----AGFNVVSWNVFNTIVSNILYN
MSMEG_0619|M.smegmatis_MC2_155 GGQ-AILDFLKDPLGNLGRLLTDF-----MTNPAGALATWWPFLFGVAYQ
TH_3569|M.thermoresistible__bu QLFGPIVDFLRDPIGNLFQLIDDF-----LTNPAGALVTWWPLLFAVAYQ
Mflv_0325|M.gilvum_PYR-GCK FLFEPIFNFLRDPIGNTFALITDF-----LTNPVQALITWGPFLLAVVYQ
Mvan_0415|M.vanbaalenii_PYR-1 FLFEPIFDFLRDPLGNTIKLITDF-----LTNPAQALITWGPFLAAVAYQ
MAB_0809c|M.abscessus_ATCC_199 LLLNNLLTDPAALLTNLPMVLADV-----AFHAAQLASTIGQFAPALIQP
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGS
Rv2770c|M.tuberculosis_H37Rv LADAMG---TVGGAAPGGGAAAAVAHAVAP--AGVGGTALTADLGNASVV
Mb2792c|M.bovis_AF2122/97 LADAMG---TVGGAAPGGGAAAAVAHAVAP--AGVGGTALTADLGNASVV
MMAR_1947|M.marinum_M LQTSANTATSAGGVAPAAAAGSALAQTVTS--AGVG---------DASSV
MUL_2167|M.ulcerans_Agy99 LQTSANTATSAGGVAPAAAAGSALAQTVTS--AGVG---------DASSV
MAV_1347|M.avium_104 HTLDTAAAAGVAGEVGGAVGGGALVGAAAPATAGVGAAPVLASMGSAATV
MSMEG_0619|M.smegmatis_MC2_155 VFFNLVGWPTWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAED
TH_3569|M.thermoresistible__bu VFTNLVGWPTWAMILASPVLIPLAITLGVAGLVMIADQAQP-----PAEE
Mflv_0325|M.gilvum_PYR-GCK AVSWVGASILYPSLFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEE
Mvan_0415|M.vanbaalenii_PYR-1 AVSWVGASILYPSLLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEE
MAB_0809c|M.abscessus_ATCC_199 ALALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMA-ASAGTALA
MLBr_01182|M.leprae_Br4923 AMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASI
.:
Rv2770c|M.tuberculosis_H37Rv GRLSVPASWS------------TAAPATAAGAALDGTGWAVPEEDGPIAV
Mb2792c|M.bovis_AF2122/97 GRLSVPASWS------------TAAPATAAGAALDGTGWAVPEEDGPIAV
MMAR_1947|M.marinum_M GALSVPVGWT------------TAAPAATGGAASDGTGWAVPDED-----
MUL_2167|M.ulcerans_Agy99 GALSVPVGWT------------TAAPAATGGAASDGTGWAVPDED-----
MAV_1347|M.avium_104 GELSTPATWS------------APTPEPAA-TTVGATEWASPAEEPHTAW
MSMEG_0619|M.smegmatis_MC2_155 EAPQEVAAAPRTDQPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPA
TH_3569|M.thermoresistible__bu AAPEEDVAAP-------------------VRAEPQNPLPLTXXX------
Mflv_0325|M.gilvum_PYR-GCK PAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAA
Mvan_0415|M.vanbaalenii_PYR-1 PAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAA
MAB_0809c|M.abscessus_ATCC_199 PSPPASAAAP-------------AAPASAPAPTASGTAPAPPSPPPVGDP
MLBr_01182|M.leprae_Br4923 GSLRVPQTWTTAS--------QPVTAATRALSPARVAVATESESAPLLGG
. .
Rv2770c|M.tuberculosis_H37Rv MPPAPGMVVAANSVGADSGPRYGVKPIVMPKHGLF---------------
Mb2792c|M.bovis_AF2122/97 MPPAPGMVVAANSVGADSGPRYGVKPIVMPKHGLF---------------
MMAR_1947|M.marinum_M VPSPAGMVAGTNGAGARPGPRYGVKPRVMPKKVLV---------------
MUL_2167|M.ulcerans_Agy99 VPSPAGMVAGTNGAGARPGPRYGVKPRVMPKKVLV---------------
MAV_1347|M.avium_104 ATGMP-AVASAGRGGYGMGPRYGVKPKVMPTRLPV---------------
MSMEG_0619|M.smegmatis_MC2_155 AATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRR
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERR
Mvan_0415|M.vanbaalenii_PYR-1 TASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERR
MAB_0809c|M.abscessus_ATCC_199 GFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETAAARQ
MLBr_01182|M.leprae_Br4923 GLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG------------
Rv2770c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2792c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1947|M.marinum_M --------------------------------------------------
MUL_2167|M.ulcerans_Agy99 --------------------------------------------------
MAV_1347|M.avium_104 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 KRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGF
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK KRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGF
Mvan_0415|M.vanbaalenii_PYR-1 KRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGF
MAB_0809c|M.abscessus_ATCC_199 ARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAGTMGF
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Rv2770c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2792c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1947|M.marinum_M --------------------------------------------------
MUL_2167|M.ulcerans_Agy99 --------------------------------------------------
MAV_1347|M.avium_104 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 TGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAPSPDDPE
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHTDGRD
Mvan_0415|M.vanbaalenii_PYR-1 AGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD------E
MAB_0809c|M.abscessus_ATCC_199 AGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDPEHGRQD------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Rv2770c|M.tuberculosis_H37Rv -----------
Mb2792c|M.bovis_AF2122/97 -----------
MMAR_1947|M.marinum_M -----------
MUL_2167|M.ulcerans_Agy99 -----------
MAV_1347|M.avium_104 -----------
MSMEG_0619|M.smegmatis_MC2_155 GGPRR------
TH_3569|M.thermoresistible__bu -----------
Mflv_0325|M.gilvum_PYR-GCK GHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 RHNHHDGKDSQ
MAB_0809c|M.abscessus_ATCC_199 -----------
MLBr_01182|M.leprae_Br4923 -----------