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VIDFGALPPEINSARIYTGPGPGSLSAAAANWASLAAELQTAAGYYQSVVSGLTSGGWLGPASLSMASAF WPYVTWTSMVATQAREAASQATLAVGAYETALAMTVPPPVVAANRVQLATLTATNFFGQNSPAIAATEAA YSEMWAQDALAMYDYAANSASACALTVLNSPPEVVNPVGAATQTTAVTHATAASGAQAAAVTGTDQLSLA GLVSAVPTMLGGLASPTSALTAATSSLLPELGTTPIYALPSYFMAAGTPLYAMSSILGMAQTAQGLANGA AAAVQGAAAGAASSGASALGSLGSGVVGGLGNAASLGPLSVPANWTSVIPTLNGGAISGLPNAGLDAANA APTVLGAAPRGALAGAPRSPGPRYGVVPTIMSRPPSDGYA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4672 | - | - | 100% (390) | PPE family protein |
| M. ulcerans Agy99 | MUL_1701 | - | 6e-76 | 43.39% (401) | PPE family protein |
| M. ulcerans Agy99 | MUL_3072 | - | 1e-74 | 44.67% (394) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1817 | PPE26 | 1e-80 | 45.07% (406) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-33 | 30.42% (401) | PPE protein |
| M. tuberculosis H37Rv | Rv1789 | PPE26 | 1e-80 | 45.07% (406) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-46 | 33.83% (399) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-31 | 29.59% (392) | PPE family protein |
| M. marinum M | MMAR_4501 | - | 0.0 | 96.92% (390) | PPE family protein |
| M. avium 104 | MAV_2928 | - | 6e-77 | 45.05% (424) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-35 | 31.52% (422) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 4e-35 | 32.91% (398) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-36 | 32.23% (394) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4672|M.ulcerans_Agy99 ------------MIDFGALPPEINSARIYTGPGPGSLSAAAANWASLAAE
MMAR_4501|M.marinum_M ------------MIDFGALPPEINSARIYAGPGPGSLSAAAAGWASLAAE
Mb1817|M.bovis_AF2122/97 -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
Rv1789|M.tuberculosis_H37Rv -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
MAV_2928|M.avium_104 ------------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
* .** :* : ***...: :*. * :: *
MUL_4672|M.ulcerans_Agy99 LQTAAGYYQSVVSGLTSGGWLGPASLSMASAFWPYVTWTSMVATQAREAA
MMAR_4501|M.marinum_M LQAAAGYYQSVVSGLTSGGWLGPASLSMASAFWPYVTWTSMVATQAGEAA
Mb1817|M.bovis_AF2122/97 LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
Rv1789|M.tuberculosis_H37Rv LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
MAV_2928|M.avium_104 LGIAASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
** : : : : * .: ** * :: . ..
MUL_4672|M.ulcerans_Agy99 SQATLAVGAYETALAMTVPPPVVAANRVQLATLTATNFFGQNSPAIAATE
MMAR_4501|M.marinum_M SQATLAVAAYETALAMTVPPPVVAANRVQLATLTATNFFGQNSPAIAATE
Mb1817|M.bovis_AF2122/97 TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
Rv1789|M.tuberculosis_H37Rv TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
MAV_2928|M.avium_104 SQGRAAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* *. *. *:: . : *:. * :*.:* *: .** *
MUL_4672|M.ulcerans_Agy99 AAYSEMWAQDALAMYDYAANSASAC-ALTVLNSPPEVVNPVGAATQ-TTA
MMAR_4501|M.marinum_M AAYSEMWAQDALAMYDYAANSASAC-ALTVLNSPPEVVNPAGAAAQ-TTA
Mb1817|M.bovis_AF2122/97 AQYGEMWAQDSAAMYAYAGSSASAS-AVTPFSTPPQIANPTAQGTQ-AAA
Rv1789|M.tuberculosis_H37Rv AQYGEMWAQDSAAMYAYAGSSASAS-AVTPFSTPPQIANPTAQGTQ-AAA
MAV_2928|M.avium_104 AQYMEMWAQDAAAMYGYAAASQTAS-TLSPFAAPPNTTAPEGESDQ-AAA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
* * .** * : .* * . : : ..* .
MUL_4672|M.ulcerans_Agy99 VTHATAAS---GAQAAAVTGTDQLSLAGLVS-------------AVPTML
MMAR_4501|M.marinum_M VTQATVAS---GAQAAAVAGTDQLSLAGLVS-------------AVPTML
Mb1817|M.bovis_AF2122/97 VATAAG-----TAQSTL-TEMITGLPNALQS-------------LTSPLL
Rv1789|M.tuberculosis_H37Rv VATAAG-----TAQSTL-TEMITGLPNALQS-------------LTSPLL
MAV_2928|M.avium_104 VSQAMAQPAGSTAQTAANTSSQLATPQALSAGT------SQAATQASSSS
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEAT------------VVPQVD
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFD-VSNIIADIIRLYG------EVLRFLFEPIF
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALD-LSNIIADLIRAYG------ELLRFLFEPIF
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLD-LSSIISDLLNQYL------QGVPGG-QAIL
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPD-PNDPIEMLLKNS-------QHFLGMYRALK
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
:
MUL_4672|M.ulcerans_Agy99 GGLA----------SPTSALTAATSSLLPELGTTPIYALPS---------
MMAR_4501|M.marinum_M GGLA----------SPTSALTAATSSLLPELGTTPIYALPS---------
Mb1817|M.bovis_AF2122/97 QSSN----------GPLSWLWQILFGTPN--FPTSISALLTDLQP-----
Rv1789|M.tuberculosis_H37Rv QSSN----------GPLSWLWQILFGTPN--FPTSISALLTDLQP-----
MAV_2928|M.avium_104 ASQT----------GPFTWLTSALQNLQQSGLPTPTNNYLG-LSPT----
MLBr_01182|M.leprae_Br4923 QQVN----------VDVATPQTAVPDSSSAAAPQLWGGFAQHLSPIN---
Mflv_0325|M.gilvum_PYR-GCK NFLR-------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 DFLR-------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 DFLK-------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_4783|M.abscessus_ATCC_1997 GLIT-------DPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MUL_4672|M.ulcerans_Agy99 -------------YFMAAGTPLYAMSSILGMAQTAQGLAN------GAAA
MMAR_4501|M.marinum_M -------------YFMAAGTPLYAMSSILGMAQTAQGLAN------GAAA
Mb1817|M.bovis_AF2122/97 ---------YASFFYNTEGLPYFSIGMGNNFIQAAKTLG-----LIGSAA
Rv1789|M.tuberculosis_H37Rv ---------YASFFYNTEGLPYFSIGMGNNFIQSAKTLG-----LIGSAA
MAV_2928|M.avium_104 --------FYTVMLKQTSGLGYFSNGITAFWSQLAQQLVSGPGGSTAGAG
MLBr_01182|M.leprae_Br4923 --------DTLSMINNHAGMANAGLSLVNGMGSAMKSLAP---TTTKAAE
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT--LAIVAGVGQ---HLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT--LAIVLGVGA---YLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGITGLVLLIDH---VLNNPVDVPAEDEA
MAB_4783|M.abscessus_ATCC_1997 -TFAVMGTPIYAAIMGPAAGISIPLAITLAS------LSQMPEAPPVDAP
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
. *
MUL_4672|M.ulcerans_Agy99 AVQGAAAGAASSGASALGSLGSG--VVGGLGNAASLGPLS----------
MMAR_4501|M.marinum_M AVQGAAAGAASSGASALGSLGSG--VVGGLGNAASLGPLS----------
Mb1817|M.bovis_AF2122/97 PAAVAAAGDAAKGLPGLGGMLGGGPVAAGLGNAASVGKLS----------
Rv1789|M.tuberculosis_H37Rv PAAVAAAGDAAKGLPGLGGMLGGGPVAAGLGNAASVGKLS----------
MAV_2928|M.avium_104 GAWYPTPQFASLGLGNLGSVGGASHVSAISAGAGRAGALS----------
MLBr_01182|M.leprae_Br4923 SAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLR----------
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSP-----P
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTA-----P
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAG-----T
MAB_4783|M.abscessus_ATCC_1997 AETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSPATPGSA-----P
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
. .
MUL_4672|M.ulcerans_Agy99 VPANWTSVIP-TLNGGAISGLPNAGLDAANAAPT-----VLGAAPRGALA
MMAR_4501|M.marinum_M VPASWTSVIP-TLNGGAISGLPNAGLDAANAAPT-----VLGAAPRGALA
Mb1817|M.bovis_AF2122/97 VPPVWSGPLPGSVTPGAAPLPVSTVSAAPEAAPG----SLLGGLPLAGAG
Rv1789|M.tuberculosis_H37Rv VPPVWSGPLPGSVTPGAAPLPVSTVSAAPEAAPG----SLLGGLPLAGAG
MAV_2928|M.avium_104 VPQQWA-TLTSAVSP-AVSEEGSAVQAAAGGAPGGAANGLLRGMPVGALG
MLBr_01182|M.leprae_Br4923 VPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGG
Mflv_0325|M.gilvum_PYR-GCK APGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGI
Mvan_0415|M.vanbaalenii_PYR-1 APGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGV
MSMEG_0619|M.smegmatis_MC2_155 TVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGV
MAB_4783|M.abscessus_ATCC_1997 AP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQ-PAPGVARRSAGARRAASIVEPAGSAAAAA
. . .
MUL_4672|M.ulcerans_Agy99 --GAPRSPGPRYGVVPTIMSRPPSDGYA----------------------
MMAR_4501|M.marinum_M --GAPRSPGPRYGVVPTIMSRPPSGGYA----------------------
Mb1817|M.bovis_AF2122/97 --GAGAG--PRYGFRPTVMARPPFAG------------------------
Rv1789|M.tuberculosis_H37Rv --GAGAG--PRYGFRPTVMARPPFAG------------------------
MAV_2928|M.avium_104 RRGAAAGYVNKYGFRYSVLTRPPSAG------------------------
MLBr_01182|M.leprae_Br4923 SGTGGVNTALRLQPRAFVMPRNPAAG------------------------
Mflv_0325|M.gilvum_PYR-GCK AASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTAST
Mvan_0415|M.vanbaalenii_PYR-1 AASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATE
MSMEG_0619|M.smegmatis_MC2_155 AASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASE
MAB_4783|M.abscessus_ATCC_1997 LACNPATGKSRRRRRRTIDDRGYRHEYATMDDHTPTGP--QDPVTAVASG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHGHRHEHQQPASMS-----------AATAPSA
: : :
MUL_4672|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4501|M.marinum_M --------------------------------------------------
Mb1817|M.bovis_AF2122/97 --------------------------------------------------
Rv1789|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2928|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK RGAGPMGFAGTVSRG-DEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATD
Mvan_0415|M.vanbaalenii_PYR-1 RGAGPMGFAGTVSRD-AAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEP
MSMEG_0619|M.smegmatis_MC2_155 RGSDAMGFTGTVTRH-DVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENP
MAB_4783|M.abscessus_ATCC_1997 TGAGRLGFAGVHTATTAVEATGLSTLDGDAEN--RTIPMLPGTWDVTDDD
TH_3113|M.thermoresistible__bu AGIRVLGGAGRISRT-RGSVPHAEITPGDPTE--PSSPTDRAHRPAEPN-
MUL_4672|M.ulcerans_Agy99 -------------------
MMAR_4501|M.marinum_M -------------------
Mb1817|M.bovis_AF2122/97 -------------------
Rv1789|M.tuberculosis_H37Rv -------------------
MAV_2928|M.avium_104 -------------------
MLBr_01182|M.leprae_Br4923 -------------------
Mflv_0325|M.gilvum_PYR-GCK DRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 D------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 AP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 R------------------
TH_3113|M.thermoresistible__bu -------------------