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PFSLYPLAVAVFAMGTSEFMLAGLVPDIAADLGVSIGSAGLLTSAFAVGMVVGAPSMAALTRRWRARVSL SAFLLTFALVHVLGAVTTSFGVLLVTRLVAAVANAGFLAVALSTAATLVPAGRQGRGLAVLLAGTTLATI AGVPGGAVLGTMLGWRATFWAIALLCLPAVVGIATALPAGAGRAGWPVAGASLCDELAQLGRKRLALAML LAALVNAGTFATFTFLAPIVTESAGLGRLWVSVVLLLFGFGSFIGVTVAGRLSDTRPGIVIGAGGPALLA GWAALALLSSQPVALLPLAFVQGALSFAVGSTLITRVLYEASAAPTMGGAYATAALNVGAAGGPVAAAAA LGNHANVVAPVWVSSVMVALALLIAVPMLKIVAPRPNPATSTPPLGGNCG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6245 | - | - | 100% (401) | chloramphenicol resistance protein |
| M. smegmatis MC2 155 | MSMEG_2028 | - | 5e-67 | 39.53% (387) | chloramphenicol resistance protein |
| M. smegmatis MC2 155 | MSMEG_5556 | - | 6e-48 | 33.06% (372) | MFS permease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0197 | - | 3e-23 | 26.78% (351) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_1840 | - | 7e-47 | 32.98% (379) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv0191 | - | 3e-23 | 26.78% (351) | integral membrane protein |
| M. leprae Br4923 | MLBr_00556 | - | 6e-09 | 21.77% (464) | putative integral membrane drug transport protein |
| M. abscessus ATCC 19977 | MAB_2983c | - | 6e-91 | 46.38% (373) | chloramphenicol resistance protein |
| M. marinum M | MMAR_0577 | - | 7e-33 | 28.65% (384) | integral membrane transport protein |
| M. avium 104 | MAV_4987 | - | 1e-23 | 26.51% (381) | sugar transporter family protein |
| M. thermoresistible (build 8) | TH_3988 | - | 2e-18 | 27.91% (258) | PUTATIVE putative MFS permease |
| M. ulcerans Agy99 | MUL_1084 | - | 7e-21 | 26.12% (402) | integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_4890 | - | 4e-46 | 33.78% (373) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6245|M.smegmatis_MC2_155 -------------------------MPFSLYPLAVAVFAMGTSEFMLAGL
MAB_2983c|M.abscessus_ATCC_199 -------------------------MTLPIYALTLAIFAQGCSEFMFAGL
Mflv_1840|M.gilvum_PYR-GCK ---MSAAVDQQSTPGASVAAPDPVVRRLAVLALALGGFGIGTTEFVAMGL
Mvan_4890|M.vanbaalenii_PYR-1 ---MTDTLHRPSGP-VSVAAPDPVVRRLAVVALALGGFGIGTTEFVAMGL
Mb0197|M.bovis_AF2122/97 -------MTAPTGTSATTTRPWTPRIATQLSVLACAAFIYVTAEILPVGA
Rv0191|M.tuberculosis_H37Rv -------MTAPTGTSATTTRPWTPRIATQLSVLACAAFIYVTAEILPVGA
MUL_1084|M.ulcerans_Agy99 -------MTSEARTATTAARPWTPRVAAQLSVLAAAAFIYVTAEILPVGA
MAV_4987|M.avium_104 -------MTAET--ANAAARTWTPRIAAQLAILAAAAFTYVTAEILPVGA
MMAR_0577|M.marinum_M ----------MPESVTAPPELGIRHATPGLLALTIATCLAITTEILPVGL
TH_3988|M.thermoresistible__bu MSESKASQDASAPAADPVDATARRTPWIAILAAALGIFVMITIEELPIGV
MLBr_00556|M.leprae_Br4923 -------------------MSTRAGRRVAISAGSLAVLLGALDTYVVVTI
: : . :
MSMEG_6245|M.smegmatis_MC2_155 VPDIAADLGVSIGSAG---LLTSAFAVGMVVGAPSMAALTRRWRARVSLS
MAB_2983c|M.abscessus_ATCC_199 ITEVGDDFGVSLAAAG---TLTSAFAVGIIVGAPLMALISGRWPRRRALV
Mflv_1840|M.gilvum_PYR-GCK LPDIARSFDVSEPVAG---HVISAYALGVVVGAPLIAAITARMARRTLLL
Mvan_4890|M.vanbaalenii_PYR-1 LPDIATGMGVSEPTAG---HVISAYALGVVVGAPVIAAVTARMARRKLLL
Mb0197|M.bovis_AF2122/97 LSAIARNLRVSVVLVG---TLLSWYALVAAVTTVPLVRWTAHWPRRRALV
Rv0191|M.tuberculosis_H37Rv LSAIARNLRVSVVLVG---TLLSWYALVAAVTTVPLVRWTAHWPRRRALV
MUL_1084|M.ulcerans_Agy99 LSAIARNLHISVVLVG---TLLSWYALVAALTTVPLVRWTAHWPRRHALM
MAV_4987|M.avium_104 LPAIARNLQVSLVLVG---TLLSWYALVAALTTIPLVRWTAHLPRRRVLV
MMAR_0577|M.marinum_M LPAIGHTFGVRDAVTG---LLVSLYAVLVALLAVPLTVVTARFPRKPLLL
TH_3988|M.thermoresistible__bu LTLIGDDLGLSSGVVG---LTVTIPGVLAGAVAVLTPTLIGRLDRRLALV
MLBr_00556|M.leprae_Br4923 MRDIMHDVGIPVNQMQRITWIVTMYLLGYIAAMPLLSRASDRFGRKLLLQ
: : . : : : : : *
MSMEG_6245|M.smegmatis_MC2_155 AFLLTFALVHVLGAVT---TSFGVLLVTRLVAAVANAGFLAVALSTAATL
MAB_2983c|M.abscessus_ATCC_199 LFLSVFIAAHIVGATA---ASFPLLLIVRVVSAVANAGFLAVALTTAMSI
Mflv_1840|M.gilvum_PYR-GCK ALMAVFTLGNLASMLA---SSYETLVGARFLAGLPHGAYFGVAALVAAHL
Mvan_4890|M.vanbaalenii_PYR-1 ALMALFTIGNLASMLA---PTYETLIAARFLAGLPHGAYFGVAALVAAHL
Mb0197|M.bovis_AF2122/97 VSLVCLTVSQLVSALA---PNFAVLAAGRVLCAVTHGLLWAVIAPIATRL
Rv0191|M.tuberculosis_H37Rv VSLVCLTVSQLVSALA---PNFAVLAAGRVLCAVTHGLLWAVIAPIATRL
MUL_1084|M.ulcerans_Agy99 VSLVCLTISQLISALA---PNFAVLAAGRALCAITHGLLWSVIAPIATRL
MAV_4987|M.avium_104 ASLTCLTASQLISALA---PNFAVLAAGRVLCAITHGLLWSVIAPIATRL
MMAR_0577|M.marinum_M TTLLGYAVSNTLVAIA---PTFAMVAAGRAVGGVTHALFFSLCIGYAPRL
TH_3988|M.thermoresistible__bu SALLLVFVSAATSAIA---PNLPVLLASRLFAGMAIGVFWALLAVVVARV
MLBr_00556|M.leprae_Br4923 VSLAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVASGALLPITLALGADL
: : : * . .:. . : :
MSMEG_6245|M.smegmatis_MC2_155 VPAGRQGRGLAVLLAGTTLATIAGVPGGAVLGTMLG-WRATFWAIALLCL
MAB_2983c|M.abscessus_ATCC_199 TGPRAKGRTTALLLSGITIACVAGVPGGAALGYFWG-WRAALWAVVLVSV
Mflv_1840|M.gilvum_PYR-GCK MGPQHRAKAVAHVLTGLTVATVLGVPVASWLGQSLG-WRAAFGLVVAVGV
Mvan_4890|M.vanbaalenii_PYR-1 MGPQNRAKAVAHVLTGLTVATVLGVPIASWLGQSLG-WRAAFGLVVGVGL
Mb0197|M.bovis_AF2122/97 VPPSHAGRATTSIYIGTSLALVVGSPLTAAMSLMWG-WRLAAVCVTGAAA
Rv0191|M.tuberculosis_H37Rv VPPSHAGRATTSIYIGTSLALVVGSPLTAAMSLMWG-WRLAAVCVTGAAA
MUL_1084|M.ulcerans_Agy99 VPPSHAGRATTSIYIGTSLALVIGSPLTAALSLMWG-WRLAAVCVTVAAA
MAV_4987|M.avium_104 VPPSHAGRATMSIYVGTSLALVVGSPLTAALSLMWG-WRLAVVCVTVAAA
MMAR_0577|M.marinum_M VGLADVGRALALVGGGVSAGIVVGVPLLTSVGTAVG-WRGAFAVLAVLAA
TH_3988|M.thermoresistible__bu AHPDDLPKALTLAFGGVSVAVVLGVPFAAWIGAMVG-WRWAFVLVGALGL
MLBr_00556|M.leprae_Br4923 WAQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLFSDWRYVFWINIPLTA
. . : * : . ** .
MSMEG_6245|M.smegmatis_MC2_155 PAVVGIATALPAGAGRAGWPVAGASL-----------------CDELAQL
MAB_2983c|M.abscessus_ATCC_199 PALAAIMYALPVGRPVTGLPDG---------------------IGELRTL
Mflv_1840|M.gilvum_PYR-GCK LTLTALALWLPVQLRLMRSTSP---------------------LTELGAL
Mvan_4890|M.vanbaalenii_PYR-1 VTLTALWCWLPFQLKFMRATSP---------------------LTELGAL
Mb0197|M.bovis_AF2122/97 AVALAARLALPEMVLRADQLEHVG--------------------RRARHH
Rv0191|M.tuberculosis_H37Rv AVALAARLALPEMVLRADQLEHVG--------------------RRARHH
MUL_1084|M.ulcerans_Agy99 VVTVAARLLLPEMVLSADQLQHVG--------------------PRSRHH
MAV_4987|M.avium_104 VVTVAARLMLPEMVLTEHQLAHVG--------------------PRSRHH
MMAR_0577|M.marinum_M VLLLVVAKLLPPVSSESAPPPAG------------------------TAK
TH_3988|M.thermoresistible__bu MVAVALTVLLPPVPVAERTTLGQLG----------------------AAW
MLBr_00556|M.leprae_Br4923 IAMLMIQVSLSAHDRGDELEKVDVVGGVLLAIALGLVVIGLYNPQPDSKQ
*.
MSMEG_6245|M.smegmatis_MC2_155 GRKRLALAMLLAALVNAGTFATFT-------------FLAPIVTESAGLG
MAB_2983c|M.abscessus_ATCC_199 RNRRLQITLAAGVLCNAATFCAFT-------------YLAPVSVQVTSLS
Mflv_1840|M.gilvum_PYR-GCK RRPQVWLALAVGMIGFGGMFAVYT-------------YIATTMTDVAGMP
Mvan_4890|M.vanbaalenii_PYR-1 RRPQVWLALLVGMIGFGGMFAVYT-------------YITTTMTDVAGMP
Mb0197|M.bovis_AF2122/97 RNPRLVKVSVLTMIAVTGHFVSYT-------------YIVVIIRDVVGVR
Rv0191|M.tuberculosis_H37Rv RNPRLVKVSVLTMIAVTGHFVSYT-------------YIVVIIRDVVGVR
MUL_1084|M.ulcerans_Agy99 RNRALIIVSLITMVGVTGHFVSYT-------------YIVVIIRQVVGVR
MAV_4987|M.avium_104 RNGRLITVSLLAMVAVTGHFVSYT-------------FIVEIIRNVVGVR
MMAR_0577|M.marinum_M GRRRLAAVVSSNALTYTGQFTLYT-------------FISAVLLAAG-AR
TH_3988|M.thermoresistible__bu SIPAARTGVLVTLVMVTAHFTAYT-------------YASPVLQDRIHIT
MLBr_00556|M.leprae_Br4923 VLPSYGVPVLVGGIVATVAFAVWERCARTRLIDPAGVHIRPFLSALGASV
: * : .
MSMEG_6245|M.smegmatis_MC2_155 RLWVSVVLLLFGFGSFIGVTVAGRLSDTRPGIVIGAGGPALLAGWAALAL
MAB_2983c|M.abscessus_ATCC_199 PAWTPALLALFGCGSFVGVHATGRLADSHANLVAGGGGVLLLAGWIAFAG
Mflv_1840|M.gilvum_PYR-GCK RALVPVALMVFGLGMFFGNLVGGRLADRSVVRALYLSMGALCAMLTLFVA
Mvan_4890|M.vanbaalenii_PYR-1 RGLVPLALMMFGLGMVLGNLVGGRLADGSVVRALYLSLGALCGALALFVV
Mb0197|M.bovis_AF2122/97 GPNLAWLLAAYGVAGLVSVPLVARPLDRWPKGAVIVGMTGLTAAFTLLTA
Rv0191|M.tuberculosis_H37Rv GPNLAWLLAAYGVAGLVSVPLVARPLDRWPKGAVIVGMTGLTAAFTLLTA
MUL_1084|M.ulcerans_Agy99 GPSLAWLLAAYGVAGVVAVALVARPLDRRPKGTIIFCVAGLTFAFVLLTA
MAV_4987|M.avium_104 GPTLAWVLAAYGLAGLLSVPLVARPLDHRPKSAVILCMTGLTAAFAVLTA
MMAR_0577|M.marinum_M PAFIGPLLLMCGVCSLAGLWYVGATLDRNPRQTTVIIIVVVIGALLGLGA
TH_3988|M.thermoresistible__bu ESGVGPMLFVFGIAGFLGNFAAGPLLRRSMRATYVVLPIGVMVGVXXXGP
MLBr_00556|M.leprae_Br4923 AAGAALMVTLVNVELFGQGVLGMDQTQAAGLLVWFLIALPIGAVLGGWGA
: . . . :
MSMEG_6245|M.smegmatis_MC2_155 LSSQPVALLPLAFVQ--------GALSFAVGSTLITRVLYEASAAPTMGG
MAB_2983c|M.abscessus_ATCC_199 TAAHDWLFVTLVFAL--------GALSFGVGSTLFSQGLYAASDAPMLGS
Mflv_1840|M.gilvum_PYR-GCK ASHNPWTALLALFGI--------GLTGSAVGPALQTRLMDVAHDAQTLAA
Mvan_4890|M.vanbaalenii_PYR-1 ASHNPWTALLVLFLI--------GLTGSAVGPALQTRLMDVAHDAQTLAA
Mb0197|M.bovis_AF2122/97 LAFGERHTAATALLG-TGAIVLWGALATAVSPMLQSAAMRSGGDDPDGAS
Rv0191|M.tuberculosis_H37Rv LAFGERHTAATALLG-TGAIVLWGALATAVSPMLQSAAMRSGGDDPDGAS
MUL_1084|M.ulcerans_Agy99 LAFGGHLAPMTALVVGTGAIVLWGAAVTAVSPMLQSAAMRSGADDPDGAS
MAV_4987|M.avium_104 LAFGGPTGATTALIG-TAAIVLWGAMATAVSPMMQSAAMRNGADDPDGAS
MMAR_0577|M.marinum_M SFPALLPVVLAAAVW--------NGAFGGIPSIYQAGAVRAQAATPEMAG
TH_3988|M.thermoresistible__bu NSRWRPDGTRM---------------------------------------
MLBr_00556|M.leprae_Br4923 TKAGDRTMTFVGLLITAGG--YWLISHWPVDLLNYRRSIFGLFSVPTMYA
MSMEG_6245|M.smegmatis_MC2_155 AYATAALNVGAAGGPVAAAAALGNHANVVAPVWVSSVMVALALLIAVPML
MAB_2983c|M.abscessus_ATCC_199 SLTTAAFNVGTVIGPSLGGASIHTPLGYRGPLWVSVMLAALALVVTLCGL
Mflv_1840|M.gilvum_PYR-GCK ALNHSALNIGNATGAWVGGLVIAAGYGYTAPAGAGAVLALAGLVVLTVSV
Mvan_4890|M.vanbaalenii_PYR-1 ALNHSALNIGNATGAWVGGLVIAAGLGYTAPAAAGAVLALAGLAVLTVSV
Mb0197|M.bovis_AF2122/97 GLYVTAFQIGIMAGALLGGLLYERSLAMMLTASAGLMGVALFGMTVSQHL
Rv0191|M.tuberculosis_H37Rv GLYVTAFQIGIMAGALLGGLLYERSLAMMLTASAGLMGVALFGMTVSQHL
MUL_1084|M.ulcerans_Agy99 GLYVTAFQVGIMAGSLIGGLLYERSVAMMLTASAGLMGVALVGMTSARRV
MAV_4987|M.avium_104 GLYVTAFQVGIMAGSLLGGLLYERSVILMLSASGVLMAVALVGIAANRRM
MMAR_0577|M.marinum_M AWVNATANLGIAAGAAIGAGLLP-TIGLAGLPWVAAALIAISLAVTLATG
TH_3988|M.thermoresistible__bu --------------------------------------------------
MLBr_00556|M.leprae_Br4923 DLLVAGLGLGLVIGPLSSATLRVVPTAQHGIASAAVVVARMTGMLIGVAA
MSMEG_6245|M.smegmatis_MC2_155 KIVAPRPNPATSTPPLGGNCG-----------------------------
MAB_2983c|M.abscessus_ATCC_199 QARRRTRRAVTSARSS----------------------------------
Mflv_1840|M.gilvum_PYR-GCK VLQKR---------------------------------------------
Mvan_4890|M.vanbaalenii_PYR-1 LLQKRG--------------------------------------------
Mb0197|M.bovis_AF2122/97 FENPTLSPGDG---------------------------------------
Rv0191|M.tuberculosis_H37Rv FENPTLSPGDG---------------------------------------
MUL_1084|M.ulcerans_Agy99 FEAPVAVAGATSHNQ-----------------------------------
MAV_4987|M.avium_104 LDVAPTSSRDS---------------------------------------
MMAR_0577|M.marinum_M RGPTH---------------------------------------------
TH_3988|M.thermoresistible__bu --------------------------------------------------
MLBr_00556|M.leprae_Br4923 LTAWGLYRFNQILAGLSTAVPPDATLIERAAAVADQAKRAYTMMYSDIFM
MSMEG_6245|M.smegmatis_MC2_155 ------------------------------
MAB_2983c|M.abscessus_ATCC_199 ------------------------------
Mflv_1840|M.gilvum_PYR-GCK ------------------------------
Mvan_4890|M.vanbaalenii_PYR-1 ------------------------------
Mb0197|M.bovis_AF2122/97 ------------------------------
Rv0191|M.tuberculosis_H37Rv ------------------------------
MUL_1084|M.ulcerans_Agy99 ------------------------------
MAV_4987|M.avium_104 ------------------------------
MMAR_0577|M.marinum_M ------------------------------
TH_3988|M.thermoresistible__bu ------------------------------
MLBr_00556|M.leprae_Br4923 ITAIVCVIGALLGLLISSRKEHASEPKVPE