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AGAGRDVAERLYVRLVPGALTSWIVTAAGIVWPVGRACASGCLLLALGAGVLWWITDRRPRSRRWPCAVS AGLVTVGVVGAGFGMAIALRTEALASHPISAAFGTSAAVTVTPSESALSLGSDRLMFRATIQRLRDDEIS GRVVVFARAFEFEEMGELMVGRPVRFTARISGPARHDLTVAVLNSAGAVKAGRAGALQRAAHQVCGRFAA AARRVLPADQAAMLPALVLGDTSTVSTETGRAFRSAGMTHLTAVSGANVTIVCGAVRCGAVLFSARWVGP RAAVALAGIALVAFVVVVQPTASVLRAALMASIALAAMLSSRRRQAIPALSTTVLVLLVAAPHLAVDMGF ALSVVATAALVVVAPGWSDGLVVRGWPKVLADGLAVATAAQVVTAPLVAAISGRFSVVAVVANLAVAAVI APITVLGSAAAVLVIPWPAGAQLLIRFTGPQVWWVLHVARWAADVPGATVAVPAGLAGVLIVGGVTVLVV ALWRFRWIRLAMISALLATQGSGVVD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3679 | comEC | - | 100% (517) | membrane metal-binding protein ComEC |
| M. ulcerans Agy99 | MUL_0354 | - | 1e-04 | 27.10% (155) | integral membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2437c | - | 0.0 | 71.83% (497) | hypothetical protein Mb2437c |
| M. gilvum PYR-GCK | Mflv_2663 | - | 1e-138 | 56.49% (485) | ComEC/Rec2-related protein |
| M. tuberculosis H37Rv | Rv2414c | - | 0.0 | 70.87% (515) | hypothetical protein Rv2414c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1627 | - | 1e-112 | 45.91% (501) | hypothetical protein MAB_1627 |
| M. marinum M | MMAR_3735 | comEC | 0.0 | 97.09% (515) | membrane metal-binding protein ComEC |
| M. avium 104 | MAV_1768 | - | 1e-176 | 69.08% (498) | competence protein |
| M. smegmatis MC2 155 | MSMEG_4573 | - | 1e-141 | 55.40% (500) | competence protein |
| M. thermoresistible (build 8) | TH_1460 | - | 1e-138 | 62.50% (424) | competence protein |
| M. vanbaalenii PYR-1 | Mvan_3914 | - | 1e-140 | 56.73% (483) | ComEC/Rec2-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3679|M.ulcerans_Agy99 MAGAGRDVAERLYVRLVPGALTSWIVTAAGIVWPVGRACASGCLLLALGA
MMAR_3735|M.marinum_M MAGAGRDVAERLDVRLVPGALTSWIVTAAGIVWPVGRACASGCLLLALGA
Mb2437c|M.bovis_AF2122/97 -MGFG---ASRLDVRLVPAALVSWIVTAAGIVWPIGNVCALCCVVVALGG
Rv2414c|M.tuberculosis_H37Rv -MGFG---ASRLDVRLVPAALVSWIVTAAGIVWPIGNVCALCCVVVALGG
MAV_1768|M.avium_104 -------------MRLVPSALTCWAVTAGGIWWPIGRELAWCCVGLLAIA
MSMEG_4573|M.smegmatis_MC2_155 ----MTDEPELLDLRLVPAALTAWLVTAAGIVWYIAGSVLVVIVVTLLAA
TH_1460|M.thermoresistible__bu --------------------------------------------------
Mflv_2663|M.gilvum_PYR-GCK ---------MAVDLRLVPAALTSWLVTAAGILWLWAGALAVLAVAVGVTA
Mvan_3914|M.vanbaalenii_PYR-1 -----------MDLRLVPAALTSWAVTAAGIVWLRAGAVAATLTAVAAAA
MAB_1627|M.abscessus_ATCC_1997 -MTSAGADEPVLDLRLVPPALAAWAATATGILWPTG-----YFTAAALGI
MUL_3679|M.ulcerans_Agy99 GVLWWITDRRPRSRRWPCAVSAGLVTVGVVGAGFGMAIALRTEALASHPI
MMAR_3735|M.marinum_M GVLWWITDRRPRSRRWPRAVSAGLVTVGVVGAGFGMAIALRTEALARHPI
Mb2437c|M.bovis_AF2122/97 GALWWCVARRSWHAPRLGSISAGLVAVGMVGAGYGLAVALRSEAVDRHPI
Rv2414c|M.tuberculosis_H37Rv GALWWCVARRSWHAPRLGSISAGLVAVGMVGAGYGLAVALRSEAVDRHPI
MAV_1768|M.avium_104 GALRWRAARRHR-RPRLSSVSAGLAAIGVVGAGFGFAVALRADAVDHHPI
MSMEG_4573|M.smegmatis_MC2_155 AVTRWAGPA---------RTGAVVIAVAVTGVGFAVAIGLRVNQVREHPV
TH_1460|M.thermoresistible__bu ---------------------------------MAVAITLRTDHLDRHPL
Mflv_2663|M.gilvum_PYR-GCK AVGWWAARR-TAAEAPRRGRAAATVAVALIGAGFAVAVTARVDAAGDHPI
Mvan_3914|M.vanbaalenii_PYR-1 LIGWWAARRRLRGGADRRALGSAVVAVAVVGSGFAVAVSLRVDAAAEHAI
MAB_1627|M.abscessus_ATCC_1997 GAIWVRLSRRRWNG----AVAAAVASILIAGMGFSVAAAIRHHGVQNHPL
..* * . *.:
MUL_3679|M.ulcerans_Agy99 SAAFGTSAAVTVTPSESALSLGS---DRLMFRATIQRLRD--DEISGRVV
MMAR_3735|M.marinum_M SAAFGTSAAVTVTPSESALSLGS---DRLMFRATIQRLRD--DEISGRVV
Mb2437c|M.bovis_AF2122/97 TVAFGTSALVTVTPSESPVSLGR---GRLMFRATVQRLRD--DETSGRVV
Rv2414c|M.tuberculosis_H37Rv TVAFGTSALVTVTPSESPVSLGR---GRLMFRATVQRLRD--DETSGRVV
MAV_1768|M.avium_104 AADFGASAPVTVTPSESPVSLGSGTQGRLMFRATLQQLRS--DQMSGRVV
MSMEG_4573|M.smegmatis_MC2_155 VDRYGGAATVRVVVSEVPRPTRG---NRLMFRAALTELDG--APVSGRVM
TH_1460|M.thermoresistible__bu TDRYGTVAGVVVTPTEIPRPLGG---GRLMFRGTLRSADG--QRMSGRVV
Mflv_2663|M.gilvum_PYR-GCK TGRVGSVVEVTVTPADTPRVLAG---GRTMIRGTLVRLDG--APSSGDVV
Mvan_3914|M.vanbaalenii_PYR-1 TGYFGSDTSVVVTPSETPRVLDG---GRTMIRGALVALAG--APSSGDVL
MAB_1627|M.abscessus_ATCC_1997 RSRVGQIVTAQLRVTDDPRSVTG---GRAMMRADLVGLGDPVQGMTGAVL
* . . : :: . .* *:*. : . :* *:
MUL_3679|M.ulcerans_Agy99 VFARAFEFEEMGELMVGRPVRFTARISGPARHDLTVAVLNSAGAVKAGRA
MMAR_3735|M.marinum_M VFARASEFEETGELMVGRPVRFTARISGPARHDLTVAVLNSAGAVKAGRA
Mb2437c|M.bovis_AF2122/97 VFARALDF---GELMVGQPVQFRARISRPARHDLTVAVFNATGRPTVGRA
Rv2414c|M.tuberculosis_H37Rv VFARALDF---GELMVGQPVQFRARISRPARHDLTVAVFNATGRPTVGRA
MAV_1768|M.avium_104 VFARGPDF---GGLMVGQPVRFTARIGRPTRRDLTVAVLTASGRPTLGSA
MSMEG_4573|M.smegmatis_MC2_155 VFASG-RFG---ALTPGSPVGFRATLSRPMRADLTVAALSARGDPTIGEA
TH_1460|M.thermoresistible__bu VFASAARYG---ELIAGQPAGFTARIGRPARRDLTVATLSATGSPVPGDA
Mflv_2663|M.gilvum_PYR-GCK VFAAAGDYA---RLSAGQSAAFRARVSRPTRRDLTVAVLSAQGRPVAGDA
Mvan_3914|M.vanbaalenii_PYR-1 VFASGAGYA---NLTAGQPAAFRARVSRPKRRDLTVAVLSAHGEPVPGEA
MAB_1627|M.abscessus_ATCC_1997 VFGSSSLLG---RVAVGDTVRARAAVARPGRRDLTVATLTVVAEPSIFGH
**. . : * .. * :. * * *****.:. .
MUL_3679|M.ulcerans_Agy99 GALQRAAHQVCGRFAAAARRVLPADQAAMLPALVLGDTSTVSTETGRAFR
MMAR_3735|M.marinum_M GALQRAAHQVRGRFAAAARRVLPADQAAMLPALVLGDTSTVSTETGRAFR
Mb2437c|M.bovis_AF2122/97 GPVHRAAHIVRHRFAAAVREVLPADQATMLPALVLGDTSTVTALTSREFR
Rv2414c|M.tuberculosis_H37Rv GPVHRAAHIVRHRFAAAVREVLPADQATMLPALVLGDTSTVTALTSREFR
MAV_1768|M.avium_104 SAVQRAAHEVRRRFAAAVRDTLPADQAALLPALVLGDTSAVPTPTGRDFR
MSMEG_4573|M.smegmatis_MC2_155 PAVQRGAQRIRTSFAETARLVLPADQAAILPGLVLGDTSTVSTQTTAEFR
TH_1460|M.thermoresistible__bu PALLRAAHRVRAGFAESARAVLPAEQAAMLPALVLGDTSAVSGRVTAEFR
Mflv_2663|M.gilvum_PYR-GCK APIHRAAHGLRTEFADAARLALAADPAAMLPALVLGDTTAVPARIAGEFR
Mvan_3914|M.vanbaalenii_PYR-1 APIHRAAHRLRARFAESARLALPPDQAATLPALVLGDTSALSAQTTAEFR
MAB_1627|M.abscessus_ATCC_1997 SPIHGVANGIRDRFVDVSRNALPAGEAALLPGLVLGDTSALDAQTVAMFR
.: *: : *. * .*.. *: **.******::: **
MUL_3679|M.ulcerans_Agy99 SAGMTHLTAVSGANVTIVCGAVRCGAVLFSARWVGPRAAVALAGIALVAF
MMAR_3735|M.marinum_M SAGMTHLTAVSGANVTIVCG-----AVLFSARWVGPRAAVALAGIALVAF
Mb2437c|M.bovis_AF2122/97 AAGLTHLTAVSGANVTIVCA-----AALVSARLIGPRAAVVCAAVALVAF
Rv2414c|M.tuberculosis_H37Rv AAGLTHLTAVSGANVTIVCA-----AALVSARLIGPRAAVVCAAVALVAF
MAV_1768|M.avium_104 AAGMTHLMAVSGANVTIVCA-----AVLFSARLIGPRAAVLLAALALVAF
MSMEG_4573|M.smegmatis_MC2_155 SSGLTHLTAVSGANVTIVCG-----ALLLSAAVVGPRIAVGLALVGLIAF
TH_1460|M.thermoresistible__bu AAGLTHLTAVSGANVTIVCG-----AVLLSAAVVGPRCAVAAAAVALVAF
Mflv_2663|M.gilvum_PYR-GCK ASGLAHLTAVSGANVTIVCG-----AVLLSAVLIGPRAAVGLAAITLLAF
Mvan_3914|M.vanbaalenii_PYR-1 RSGLAHLTAVSGANVTIVCG-----AVLLSAVLIGPRAAVALAALTLVGF
MAB_1627|M.abscessus_ATCC_1997 TSGLTHLMAVSGANVSIVCG-----AVLLLGRLIGLRTSVVLAGLVLVGF
:*::** *******:***. * *. . :* * :* * : *:.*
MUL_3679|M.ulcerans_Agy99 VVVVQPTASVLRAALMASIALAAMLSSRRRQAIPALSTTVLVLLVAAPHL
MMAR_3735|M.marinum_M VIVVQPTASVLRAALMASIALAAMLSSRRRQAIPALSTTVLVLLVAAPHL
Mb2437c|M.bovis_AF2122/97 VILVQPTASVLRAAVMGAIALVGMLSARRRQAIPALSGSVLVLLAAAPHL
Rv2414c|M.tuberculosis_H37Rv VILVQPTASVLRAAVMGAIALVGMLSARRRQAIPALSGSVLVLLAAAPHL
MAV_1768|M.avium_104 VVVVQPTASVLRAAVMGAIALAGMLTSRRRQAIPALAATVLVLLAVAPQL
MSMEG_4573|M.smegmatis_MC2_155 VIVVQPSASVLRSAVMGAVTLLAIVTHRRRQAIPALAASVLVLMAAAPEL
TH_1460|M.thermoresistible__bu VIVVLPSASVLRAAVMAAITLLAMVSHRRRQAIPALAASVLGLVVAAPEL
Mflv_2663|M.gilvum_PYR-GCK VVVVQPSPSVLRAAVMGAITLLAVLSHRRRQALPALSATVIALMVGAPEL
Mvan_3914|M.vanbaalenii_PYR-1 VVVVQPSPSVLRAAVMGAITLLAVLSHRRRQALPALAATVIALMIGVPEL
MAB_1627|M.abscessus_ATCC_1997 VILVRPSPSVLRAAVMGAIGLLGVLTARRRQAIPALAATILVLLAVSPGL
*::* *:.****:*:*.:: * .::: *****:***: ::: *: * *
MUL_3679|M.ulcerans_Agy99 AVDMGFALSVVATAALVVVAPGWSDGLVVRGWPKVLADGLAVATAAQVVT
MMAR_3735|M.marinum_M AVDMGFALSVVATAALVVVAPGWSDGLVARGWPKVLADGLAVATAAQVVT
Mb2437c|M.bovis_AF2122/97 AVDIGFALSVAATGALVVIAPVWSRRLVDRGCPKVLADALAVAAAAQLVT
Rv2414c|M.tuberculosis_H37Rv AVDIGFALSVAATGALVVIAPVWSRRLVDRGCPKVLADALAVAAAAQLVT
MAV_1768|M.avium_104 SVDVGFALSVLATAALVVLAPAWSRRLADRGWPKPLADAVAVAWAAQLVT
MSMEG_4573|M.smegmatis_MC2_155 AVDVGFALSVCATAAIVVIAPVWARRLEARGWPSTLAAAVSVAAAAQLVT
TH_1460|M.thermoresistible__bu AVDAGFALSVAATAALIVIAPAWSRRLTARGWPKPLADAVSIATAAQVVT
Mflv_2663|M.gilvum_PYR-GCK AVDVGFALSVSATAALVVIAPAWSRRLTERGWPKPPADAVSVALAAQLVT
Mvan_3914|M.vanbaalenii_PYR-1 AVDVGFALSVAATAALVVLAPAWSRRLTGRGWPKPVADAVSVAVAAQLVT
MAB_1627|M.abscessus_ATCC_1997 AVDIGFALSVVATAALVVLAPRWSMRLTARGWPKPLADALCVAVAAQLVT
:** ****** **.*::*:** *: * ** *. * .:.:* ***:**
MUL_3679|M.ulcerans_Agy99 APLVAAISGRFSVVAVVANLAVAAVIAPITVLGSAAAVLVIPWPAGAQLL
MMAR_3735|M.marinum_M APLVAAISGRFSVVAVVANLAVAAVIAPITVLGSAAAVLVIPWPAGAQLL
Mb2437c|M.bovis_AF2122/97 APLVAAISGRVSLVAVVANLAVAAVIAPITVLGSVAAVLVVPWPAGAQVL
Rv2414c|M.tuberculosis_H37Rv APLVAAISGRVSLVAVVANLAVAAVIAPITVLGSVAAVLVVPWPAGAQVL
MAV_1768|M.avium_104 APLVAAISGRFSVVAAAANLLVAAVIAPITVLGTAAAALCPIWPAGARLL
MSMEG_4573|M.smegmatis_MC2_155 APLVAGISGRFSVVAVAANLAVVGVIPPITVLGTAAAALAAVWPAGAGLL
TH_1460|M.thermoresistible__bu APLIAGISGRLSLVSIAANLAVAVVIPPITVLGTVAAALGACWPDGAQLL
Mflv_2663|M.gilvum_PYR-GCK APLVAGISGSVSLVGVLANLAVAPVIPPITVFGTAAAALCALWPSGAELL
Mvan_3914|M.vanbaalenii_PYR-1 APLVAGISGSVSVVAVLANLVVAPVIPPITVIGCAAAALCPLWPAGAELL
MAB_1627|M.abscessus_ATCC_1997 APVIAAISGSVSMASIAANVLAGLVIVPITVLGTAAAALTVVSPQVAGLL
**::*.*** .*:.. **: . ** ****:* .**.* * * :*
MUL_3679|M.ulcerans_Agy99 IRFTGPQVWWVLHVARWAADVPGATVAVPAGLAGVLIVGGVTVLVVALWR
MMAR_3735|M.marinum_M IRFTGPQVWWVLHVARWAADVPGATVAVPAGLAGVLIVGGVTVLVVALWR
Mb2437c|M.bovis_AF2122/97 IRFTGPEVWWVLRVAHWASGVPAATVPVAAGLPGVLLVGGATVFTVAQWR
Rv2414c|M.tuberculosis_H37Rv IRFTGPEVWWVLRVAHWASGVPAATVPVAAGLPGVLLVGGATVFTVAQWR
MAV_1768|M.avium_104 IRFTGPELWWVGGVAHRAAGLPGATVPVPDGTAGTLIVGGVTLLAVVAWR
MSMEG_4573|M.smegmatis_MC2_155 IRFTGPEVWWLLSVARWASGMPAATVPTPSGWAGVLLVAISGVTLTVLWR
TH_1460|M.thermoresistible__bu IRFAGPEVWWLLEVARWSAAVPGSAVPVPSGVAGVTVVAGGAVAAVLLWR
Mflv_2663|M.gilvum_PYR-GCK IRFTGPEVWWLLTVARWAARMPAATVPVPSGIAGVLTVAVLAVAVAAVWH
Mvan_3914|M.vanbaalenii_PYR-1 IRFTGPEVWWLLGVARWAAGLPIAAVPVPSGAAGVLTVAIAAVAVAATWH
MAB_1627|M.abscessus_ATCC_1997 ARFCGPELWWLLRVADYASAGGTTAIPVPAGVLGFAVVAVLLGIAVWLWR
** **::**: ** :: :::... * * *. . *:
MUL_3679|M.ulcerans_Agy99 FRWIR----------LAMISALLATQGS-------GVVD-------
MMAR_3735|M.marinum_M FRWIR----------LAMISALLATLGSGLAWSVAGLVGPS-----
Mb2437c|M.bovis_AF2122/97 LALVSRGHVQNDGGGRHMSACLVAVRAGRP------FVTPSWGERG
Rv2414c|M.tuberculosis_H37Rv WRWFRAAMCKT---MAVAVICLLAWSLSG-------LVGPS-----
MAV_1768|M.avium_104 WRRFR----------AAAAAALLIDLAWV-------LSGLT-----
MSMEG_4573|M.smegmatis_MC2_155 SRWVR----------RAVAGAAVVMLAWTVAGQVVGAVGPT-----
TH_1460|M.thermoresistible__bu RPWIR----------WATAGTVLSLVAWTVAGP--GPSG-------
Mflv_2663|M.gilvum_PYR-GCK ---------------RVVSGRRETIMR-------------------
Mvan_3914|M.vanbaalenii_PYR-1 ---------------WVVSHRRDTIVR-------------------
MAB_1627|M.abscessus_ATCC_1997 RRWFR----------GLVWTGVLCALALMISAR---VVS-------