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VPQRLSAWRFVTTFGVISMLADIVYEGARSITGPLLASLGASALVVGVVTGIGEAAALALRLVSGPLTDR TRKFWAWTISGYALTVVTVPFLGVSSVLWIAATLVIAERVGKAVRSPAKDTLLSHATAVTGRGKGFAVHE AMDQIGAITGPLLVAGMLALTHVNYLPTFAILALPGGATLLLLFWLRRRVPHPERYEHDDYIRGAADRPH KLSLPLSFWLYSGFTAITMIGFATFGVLSFHMVQRGVLPVPAVPIVYAAAMAADAVAALLSGWAYDRVGP KSLAALPIVGATVPMLAFTDSLPGIVLGALLWGAAVGIQESTLRAVVADLVPPPRRATAYGVYAAVLGTA TAIGGALTGYLYGVSIPMLIAVVGVIQLVALITAAPTLLRHAGQV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4615 | - | - | 100% (395) | major facilitator transporter |
| M. abscessus ATCC 19977 | MAB_3449c | - | 9e-15 | 24.54% (383) | putative transporter |
| M. abscessus ATCC 19977 | MAB_0450c | - | 2e-12 | 27.86% (402) | ABC transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2288 | - | 1e-148 | 68.25% (378) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_2221 | - | 8e-09 | 27.10% (155) | EmrB/QacA family drug resistance transporter |
| M. tuberculosis H37Rv | Rv2265 | - | 1e-148 | 68.25% (378) | integral membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0136 | - | 2e-24 | 26.45% (397) | intergral membrane protein |
| M. avium 104 | MAV_3974 | - | 5e-12 | 24.86% (366) | permease of the major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_6390 | - | 6e-09 | 23.73% (375) | transporter, major facilitator family protein |
| M. thermoresistible (build 8) | TH_2968 | - | 7e-05 | 29.50% (139) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_4961 | - | 4e-25 | 26.45% (397) | intergral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_2778 | - | 1e-149 | 70.45% (379) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2288|M.bovis_AF2122/97 MGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLL
Rv2265|M.tuberculosis_H37Rv MGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLL
MAB_4615|M.abscessus_ATCC_1997 --------------MPQRLSAWRFVTTFGVISMLADIVYEGARSITGPLL
Mvan_2778|M.vanbaalenii_PYR-1 ----------MTGTPGVGLSAWRFVTTFGVVSLLADIVYEGARSITGPLL
MMAR_0136|M.marinum_M -----------MTSGSAPQWLTRNLRVLSLVSLLQDAASELLYPLLPIYL
MUL_4961|M.ulcerans_Agy99 -----------MTSGSAPQWLTRNLRVLSLVSLLQDAASELLYPLLPIYL
MAV_3974|M.avium_104 ---------------------------------MVALGYGVISPALPTFA
Mflv_2221|M.gilvum_PYR-GCK -------MFDTVTSRAAGTTNPWPALWALLIGFFMILVDATIVAVANPAI
TH_2968|M.thermoresistible__bu -------VRRDAPSGTPVRRPFLLVTALAVVVLTVAVLQTAVVPVLG-IM
MSMEG_6390|M.smegmatis_MC2_155 ---------MRRYLAATFSALTIRDYRRYALGQTISVSGTWMQKLTQAWL
Mb2288|M.bovis_AF2122/97 AS-LGATGLVVGVVTGVGEAAALGLRLVSGPLADRSRRF----WAWTIAG
Rv2265|M.tuberculosis_H37Rv AS-LGATGLVVGVVTGVGEAAALGLRLVSGPLADRSRRF----WAWTIAG
MAB_4615|M.abscessus_ATCC_1997 AS-LGASALVVGVVTGIGEAAALALRLVSGPLTDRTRKF----WAWTISG
Mvan_2778|M.vanbaalenii_PYR-1 AS-LGATAVVVGVVTGVGEAAALILRMVSGPLADRTGRF----WTWTIGG
MMAR_0136|M.marinum_M TTVLGAPPSVVGAVEGAAEGAASLTKVVSGPLGDRFAR-----RPLIASG
MUL_4961|M.ulcerans_Agy99 ATVLGAPPSVVGAVEGAAEGAASLTKIVSGPLGDRFAR-----RPLIASG
MAV_3974|M.avium_104 RS-FGVSIKAVTFLVTVFSLSRLCFAPISGLLTERLGE-----RRIYIGG
Mflv_2221|M.gilvum_PYR-GCK MASLNAGYDAVIWVTSAYLLAYAVPLLVSGRLGDRYGP-----KNVYMVG
TH_2968|M.thermoresistible__bu AEQLHTSATAVSWAVTANLLAAAAATPLLGRLADLYSK-----RRVLLAV
MSMEG_6390|M.smegmatis_MC2_155 VLELTDSPLLLGVTVAGQQLPTLLFTTLAGVLADRYSKRTILLWTALGGM
: : . : * * :
Mb2288|M.bovis_AF2122/97 YTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHAASVTG
Rv2265|M.tuberculosis_H37Rv YTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHAASVTG
MAB_4615|M.abscessus_ATCC_1997 YALTVVTVPFLGVSSVLWIAATLVIAERVGKAVRSPAKDTLLSHATAVTG
Mvan_2778|M.vanbaalenii_PYR-1 YFLTVVTVPFLGAVGVLWAAAALIIAERVGKAVRSPAKDTLLSHATAVTG
MMAR_0136|M.marinum_M YGMAALGKLIVAAAGAWPGVLAGRVVDRLGKGLRGAPRDALLVDGVEPAQ
MUL_4961|M.ulcerans_Agy99 YGMAALGKLIVAAAGAWPGVLAGRVVDRLGKGLRGAPRDALLVDGVDPAQ
MAV_3974|M.avium_104 LLIVAVSTAACAFSQAYWQLMLCRVFSGVGSTMFYVSALGLMIHISPADA
Mflv_2221|M.gilvum_PYR-GCK LTVFTVASLWCGLSDSIGMLIAARVVQGVGAALLTPQTMTVITRTFPAHR
TH_2968|M.thermoresistible__bu LVVVLAGSVLAATTASLPLLITARVLQGASFALY-PISIAILRDELPPDR
MSMEG_6390|M.smegmatis_MC2_155 LPALVLGVLVWIDVVNIWIVLAAAVAQGFADAVDKPARLTFVNDIATPET
: . . : .:
Mb2288|M.bovis_AF2122/97 RGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALA
Rv2265|M.tuberculosis_H37Rv RGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALA
MAB_4615|M.abscessus_ATCC_1997 RGKGFAVHEAMDQIGAITGPLLVAGMLALTHVNYLPTFAILALPGGATLL
Mvan_2778|M.vanbaalenii_PYR-1 RGRGFAVHEAMDQIGAVAGPLAVAAMLVVFGGDYAPTLALLAVPGVGVLA
MMAR_0136|M.marinum_M RGRAFGFHRTMDTLGAVIGPLLGLAGYELFDHQIGPVLYLAVIPAVLSVL
MUL_4961|M.ulcerans_Agy99 RGRAFGFHRTMDTLGAVIGPLLGLAGYELFDHQIGPVLYLAVIPAMLSVL
MAV_3974|M.avium_104 RGRIAGLFTTSFMVGAVGGP--AVGGLAAGWGLTAPFVVYGVAMLGVALV
Mflv_2221|M.gilvum_PYR-GCK RGVAMSVWGATAGVATLVGPLAGGVLVDSLGWQWIFIVNVPVGIVGLVMA
TH_2968|M.thermoresistible__bu LGRAMAVMSGTLGFGGGAGLVVTGLLMTDGAVYQRVFWLCTAFTLAVIVI
MSMEG_6390|M.smegmatis_MC2_155 LANAVTLNSIIQNSGKIAGPAVAGVLISAVGVSASFFLNAASYLPVVIAL
. . . *
Mb2288|M.bovis_AF2122/97 LLLWLQRRVPRPESY-----------------------------------
Rv2265|M.tuberculosis_H37Rv LLLWLQRRVPRPESY-----------------------------------
MAB_4615|M.abscessus_ATCC_1997 LLFWLRRRVPHPERY-----------------------------------
Mvan_2778|M.vanbaalenii_PYR-1 LLAWLRVRVPEPARYEV---------------------------------
MMAR_0136|M.marinum_M LITWVR----EPPRN-----------------------------------
MUL_4961|M.ulcerans_Agy99 LIAWVR----EPPRN-----------------------------------
MAV_3974|M.avium_104 LFLGLRNSALAAPPP-----------------------------------
Mflv_2221|M.gilvum_PYR-GCK LRLVPALPNPVRQGFDVPG-VVLSGVGLFLIVFALQEGQSHGWALWIWAT
TH_2968|M.thermoresistible__bu AVLIVPVRHRRATGTLDWFGAAGLALGLSLGLLAITQGSHWGWTSPSTLG
MSMEG_6390|M.smegmatis_MC2_155 LLIRPHAPVITGNVS-----------------------------------
Mb2288|M.bovis_AF2122/97 -----------EDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTF
Rv2265|M.tuberculosis_H37Rv -----------EDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTF
MAB_4615|M.abscessus_ATCC_1997 -----------EHDDYIRGAADRPHKLSLPLSFWLYSGFTAITMIGFATF
Mvan_2778|M.vanbaalenii_PYR-1 -----------EAAPSTKPVARVSFLRSLPRSFWTYAGFSAATMLGFTTF
MMAR_0136|M.marinum_M -------------LAKAKPASILDGTRRLSRRYWAVVSFLVLFSIANFPD
MUL_4961|M.ulcerans_Agy99 -------------LAKAKPASILDGTRRLPRRYWAVVSFLVLFSIANFPD
MAV_3974|M.avium_104 --------------PTRSTVTMREALRVRAYQSALLSNFATGWSAFGLRM
Mflv_2221|M.gilvum_PYR-GCK VLAGVAVMAAFVYWQSINTAGALIPLVIFRDRNFSMSNLGVATIGFVATG
TH_2968|M.thermoresistible__bu AAAASVVILVGWWCWEQRAAHPLVSTRMLSRRPMLLTNLATIFVGMGLYF
MSMEG_6390|M.smegmatis_MC2_155 --------------AKGHLGETLRYVSARPHIAAALVLMAVSGLLAFNWN
: .
Mb2288|M.bovis_AF2122/97 GLLSFHMVSHGV--------LAAAMVPVVYAAAMAADALTALA--SGFSY
Rv2265|M.tuberculosis_H37Rv GLLSFHMVSHGV--------LAAAMVPVVYAAAMAADALTALA--SGFSY
MAB_4615|M.abscessus_ATCC_1997 GVLSFHMVQRGV--------LPVPAVPIVYAAAMAADAVAALL--SGWAY
Mvan_2778|M.vanbaalenii_PYR-1 GVLSFHQVERGV--------VHVAVVPVIYAAAMVADALAALA--TGWVY
MMAR_0136|M.marinum_M ALLLLRLKQIG---------FSVVGVIMAYVGYNAVYALASFP--AGALA
MUL_4961|M.ulcerans_Agy99 ALLLLRLKQIG---------FSVVGVIMAYVGYNAVYALASFP--VGALA
MAV_3974|M.avium_104 ALVPLFVSDVMG--------RGIGTIGVVLAAFAGGNALAVVP--SGYLS
Mflv_2221|M.gilvum_PYR-GCK MILPLMFFAQAV--------CGLTPTRAALLTAPMAVATGVLAPFVGKLV
TH_2968|M.thermoresistible__bu AFLGITLFVQVPRDQAGFGFSATVLQASVVYLLPGACTGFVVALVSGRFI
MSMEG_6390|M.smegmatis_MC2_155 VLLPTLARDTFG--------GDARVVGFAFTSMGVGAVFGGLA--LAGVL
.: . . .
Mb2288|M.bovis_AF2122/97 DRYGAKTLAVLPILSILVVLFAF--TDNVTM----VVIGTLVWGAAVGIQ
Rv2265|M.tuberculosis_H37Rv DRYGAKTLAVLPILSILVVLFAF--TDNVTM----VVIGTLVWGAAVGIQ
MAB_4615|M.abscessus_ATCC_1997 DRVGPKSLAALPIVGATVPMLAF--TDSLPG----IVLGALLWGAAVGIQ
Mvan_2778|M.vanbaalenii_PYR-1 DKVGAVVLGALPVMAGLVPALAF--NDHLVP----VVAGALVWGAAVGIQ
MMAR_0136|M.marinum_M DRLGRPVVYAFGLVFFAVGYLGLGITTDTAT----AWALIAAYGLFTACY
MUL_4961|M.ulcerans_Agy99 DRLGRPVVYAFGLVLFAVGYLGLGITTDTAT----AWALIAAYGLFTACY
MAV_3974|M.avium_104 DRMGRRTLLIVGLVTSGAATVWLGFVASLPV----FLVAAGVVGVVTGIY
Mflv_2221|M.gilvum_PYR-GCK DRAHPRSVVGFGFSLMAIGVTWLSIEMTPTTPIWRLLLPLTAMGAAMAFI
TH_2968|M.thermoresistible__bu DRYGARPVLMVGALAGIGGFVFIAVAHTHTWQ---VIAAAVLTNAYISLG
MSMEG_6390|M.smegmatis_MC2_155 RGTSKWLILNGCVLGAALALTGLMPTVTIAY------ALLFVVGAASVTF
: : .
Mb2288|M.bovis_AF2122/97 ESTLRGVVADLVASPRRA----------SAYGVFAAGLGAATAGGGALIG
Rv2265|M.tuberculosis_H37Rv ESTLRGVVADLVASPRRA----------SAYGVFAAGLGAATAGGGALIG
MAB_4615|M.abscessus_ATCC_1997 ESTLRAVVADLVPPPRRA----------TAYGVYAAVLGTATAIGGALTG
Mvan_2778|M.vanbaalenii_PYR-1 ESTLRAVVADLVEPARRA----------TAYGIYAAVLGCAAAAGGALTG
MMAR_0136|M.marinum_M DGVGKAWISAIVSAELQS----------SAQGVFQGLSGFAVLAAGLWAG
MUL_4961|M.ulcerans_Agy99 DGVGKAWISAIVSAELQS----------SAQGVFQGLSGFAVLAAGLWAG
MAV_3974|M.avium_104 MSPLQAAVADILGNEARAGLPVATVQMMSDLGAIVGSMAVGWAAEQIGYG
Mflv_2221|M.gilvum_PYR-GCK WSPLAATATRNLPPHLAG-AGSGVYNTTRQVGSVLGSAGMAALMSSELST
TH_2968|M.thermoresistible__bu YGALPALVVGEAPPGATG-----IATGMNAIARTIGSSVAAALVAVAVAG
MSMEG_6390|M.smegmatis_MC2_155 RSTATTLLQLYSDPGVRG----------RIISLLVLATNGTTPVGGPMIG
. . .
Mb2288|M.bovis_AF2122/97 -------------------------WLYDIS--IGTLVVV--------VI
Rv2265|M.tuberculosis_H37Rv -------------------------WLYDIS--IGTLVVV--------VI
MAB_4615|M.abscessus_ATCC_1997 -------------------------YLYGVS--IPMLIAV--------VG
Mvan_2778|M.vanbaalenii_PYR-1 -------------------------YLYGQS--VPLLVGV--------VI
MMAR_0136|M.marinum_M -------------------------FLWGVDGRLPLLISG--------GA
MUL_4961|M.ulcerans_Agy99 -------------------------FLWGVDGRLPLLISG--------GA
MAV_3974|M.avium_104 -------------------------WGFFISGVVLLIAAVGWVMAPETRT
Mflv_2221|M.gilvum_PYR-GCK KIPGADAVPQSEGEVAALPQFLREPFALAMSQSMLLPAFVALFGVIAALF
TH_2968|M.thermoresistible__bu --------------------------STTAAPSEAGFTAIFAGGAVTALF
MSMEG_6390|M.smegmatis_MC2_155 ------------------------WICTHANPRVACLVGG-------LGT
Mb2288|M.bovis_AF2122/97 ALELMALVMMFAIRLPRVAPS-----------------------------
Rv2265|M.tuberculosis_H37Rv ALELMALVMMFAIRLPRVAPS-----------------------------
MAB_4615|M.abscessus_ATCC_1997 VIQLVALITAAPTLLRHAGQV-----------------------------
Mvan_2778|M.vanbaalenii_PYR-1 GVQAIALAVLPVVR--RVAR------------------------------
MMAR_0136|M.marinum_M GAVFALALLAAAAGTRRRAR------------------------------
MUL_4961|M.ulcerans_Agy99 GAVFALALLAAAAGTRRRAR------------------------------
MAV_3974|M.avium_104 ATELEADLMAASRTSSRCEQQL----------------------------
Mflv_2221|M.gilvum_PYR-GCK LFDLLGDRDAAAPPAPDVEPLEPFDPDHPLDWADGEDDYVEYEVSREEFD
TH_2968|M.thermoresistible__bu AMLLIGLSRTGRPAFETVEARQESRAMN-HEWG-----------------
MSMEG_6390|M.smegmatis_MC2_155 VAAALAHWAYLRKAGTRKDPIPL---------------------------
Mb2288|M.bovis_AF2122/97 --------------------------------------------------
Rv2265|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4615|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2778|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0136|M.marinum_M --------------------------------------------------
MUL_4961|M.ulcerans_Agy99 --------------------------------------------------
MAV_3974|M.avium_104 --------------------------------------------------
Mflv_2221|M.gilvum_PYR-GCK RLATDGTADGAAYNITEDFTEDITDVLDTVVEAPPAPADSTPSQQWRDLV
TH_2968|M.thermoresistible__bu --------------------------------------------------
MSMEG_6390|M.smegmatis_MC2_155 --------------------------------------------------
Mb2288|M.bovis_AF2122/97 -------------------------------
Rv2265|M.tuberculosis_H37Rv -------------------------------
MAB_4615|M.abscessus_ATCC_1997 -------------------------------
Mvan_2778|M.vanbaalenii_PYR-1 -------------------------------
MMAR_0136|M.marinum_M -------------------------------
MUL_4961|M.ulcerans_Agy99 -------------------------------
MAV_3974|M.avium_104 -------------------------------
Mflv_2221|M.gilvum_PYR-GCK DQLLDVSSPPGAPRNGVGSADAEHPGGGPRV
TH_2968|M.thermoresistible__bu -------------------------------
MSMEG_6390|M.smegmatis_MC2_155 -------------------------------