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TDSSPPAKGTFTVEMLSRAKRGVTAVFVAHGLLFASWAAHIPQVKAGLGLDDAALGTALFGAPLGSVLAT LAGHWALPRWGSHRLIPVTVAGYAAAGTTVGLARSGPALFAALALWGMFQGALDVAMNTQAGTVERRAGA PMMARFHGMWSLGTLAGALIGAACVGAGIGLTAQLTVLGAVVLLVVVMLTRRLLPDAADSVAAPPEPAAG RRVTPAVAILAAVSFASFLCEGAATDWSATYLRDVVGAGPSVAAASYAAYTLTMVVTRFAAGRLHARLPS RRLLPALAVLAVAGMSVTLATADAAAGVLGFAALGVGVALLVPTAFSAAYGARGAGSAIAIVAATGWLGY LLGPPLIGHLSEWVGLSGALVTIPVMMTIVAVAIRYTPAFDTADEFHRAPAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4712 | - | - | 100% (403) | transporter, major facilitator family protein |
| M. avium 104 | MAV_1539 | - | 1e-10 | 27.55% (392) | major facilitator family protein transporter |
| M. avium 104 | MAV_4427 | - | 3e-06 | 25.88% (371) | efflux ABC transporter, permease protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1699c | - | 5e-08 | 25.46% (436) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_3420 | - | 2e-39 | 30.16% (378) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1672c | - | 5e-08 | 25.46% (436) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4138c | - | 1e-43 | 32.57% (393) | putative major facilitator superfamily protein |
| M. marinum M | MMAR_0690 | - | 4e-12 | 29.48% (346) | putative transport protein |
| M. smegmatis MC2 155 | MSMEG_3671 | - | 3e-41 | 31.40% (379) | integral membrane protein |
| M. thermoresistible (build 8) | TH_3240 | - | 3e-47 | 32.98% (373) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_0354 | - | 3e-08 | 25.31% (399) | integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_3174 | - | 1e-38 | 30.14% (365) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1699c|M.bovis_AF2122/97 --------------------------------------------------
Rv1672c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_3420|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3174|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3671|M.smegmatis_MC2_155 --------------------------------------------------
TH_3240|M.thermoresistible__bu --------------------------------------------------
MAV_4712|M.avium_104 --------------------------------------------------
MAB_4138c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0690|M.marinum_M --------------------------------------------------
MUL_0354|M.ulcerans_Agy99 MLTSGSMTTTATIAAGEAMRVSSSSSPDLPDAGDTTKFLRPRNAALRSKA
Mb1699c|M.bovis_AF2122/97 ----------------------------------MATIAASPTHNALGKA
Rv1672c|M.tuberculosis_H37Rv ----------------------------------MATIAASPTHNALGKA
Mflv_3420|M.gilvum_PYR-GCK ---------------------MDAILHRPRAARDLKGAWVGSHLMASDAR
Mvan_3174|M.vanbaalenii_PYR-1 --------------------------------------MAPEPLGSGEAR
MSMEG_3671|M.smegmatis_MC2_155 --------------------------------------MVTEQR--DPVT
TH_3240|M.thermoresistible__bu --------------------------------------MASGRVESRTRQ
MAV_4712|M.avium_104 ----------------------------------MTDSSPPAKGTFTVEM
MAB_4138c|M.abscessus_ATCC_199 ------------------------MLLAEVAVGGARSLAQRRGEDYFLTK
MMAR_0690|M.marinum_M ---------------------------------------------MTDSS
MUL_0354|M.ulcerans_Agy99 RGGSRSAARMANTKTNRKPRSARALCARAVAAPLGGARPLGERAGGRHRP
Mb1699c|M.bovis_AF2122/97 ARRLLPLLFVLYVINFVDRANISVAALAMNADLR---LSATAYGTAAGVF
Rv1672c|M.tuberculosis_H37Rv ARRLLPLLFVLYVINFVDRANISVAALAMNADLR---LSATAYGTAAGVF
Mflv_3420|M.gilvum_PYR-GCK IRRARAASAALFLTNGALFANLLPRFPEIKSDLA---MSNAGYGAAVAAF
Mvan_3174|M.vanbaalenii_PYR-1 NRRARIAVAALFLTNGALFANLLPRYPEIKADLA---MSNAAYGAAVASF
MSMEG_3671|M.smegmatis_MC2_155 TRRARVAVAALFLTNGAIFANLLPRYPEIKTDLQ---LSNATYGAAVAAF
TH_3240|M.thermoresistible__bu HQRARRAVAVLFLTNGALFANLLPRYPEIKTDLA---LSNTGYGVTIAAF
MAV_4712|M.avium_104 LSRAKRGVTAVFVAHGLLFASWAAHIPQVKAGLG---LDDAALGTALFGA
MAB_4138c|M.abscessus_ATCC_199 PLRMRVAVIGVFASFGLVVATWAVHLPTMKQATG---MSSTELGFVVLGL
MMAR_0690|M.marinum_M RRVVLAAVGFTFFIDMLVYGIVVPVLPRLAKPAG---LEFLGVGVVFACY
MUL_0354|M.ulcerans_Agy99 AREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFAAAAVGAVLAAF
: : * .
Mb1699c|M.bovis_AF2122/97 FLGYVLFQVPANAALARFGAGRTLTAVVLAWGVCSAATALVTSAHTLYLA
Rv1672c|M.tuberculosis_H37Rv FLGYVLFQVPANAALARFGAGRTLTAVVLAWGVCSAATALVTSAHTLYLA
Mflv_3420|M.gilvum_PYR-GCK SAGALLAGPAAGALIRRFQSARVAVVTTVALASLIVTAAVAPTPLVFAAT
Mvan_3174|M.vanbaalenii_PYR-1 SAGALLAGPTAAALIRRFQSSRVALATTVALAVLIVVAGLAGTPLLFAVA
MSMEG_3671|M.smegmatis_MC2_155 SAGALIAGLTAGALIRRFRSSRVGVTLTVALAVFVFAAGLAPTPILFAGA
TH_3240|M.thermoresistible__bu SAGALTAGLTAAMLIRRFRSARVAVVGTLVLAAAVLAAGLAGTAPVLGAA
MAV_4712|M.avium_104 PLGSVLATLAGHWALPRWGSHRLIPVTVAGYAAAGTTVGLARSGPALFAA
MAB_4138c|M.abscessus_ATCC_199 GVGALLGMQLSGVLVDRFGSGPIAIVGGAAMALGVNIPLAAHTVWVAGVG
MMAR_0690|M.marinum_M GLAYFVLTPVAGWLIDRRGSRSVFLSGAIILMLATLAFGYASSPVGLVTC
MUL_0354|M.ulcerans_Agy99 GVGWAVGQLVCGWLVDSLGPRATLAWTMTIAAGVLVGMAEARSVAALLVG
. : . . :
Mb1699c|M.bovis_AF2122/97 RFALGVAEGGFFPGVIAYLTVWFPCAQRARAVATFLLAIPVANTVGLPLS
Rv1672c|M.tuberculosis_H37Rv RFALGVAEGGFFPGVIAYLTVWFPCAQRARAVATFLLAIPVANTVGLPLS
Mflv_3420|M.gilvum_PYR-GCK LLFAGASD-----AITDVAQNVNALRVQRNYGRSIINSLHAIWAAGAITG
Mvan_3174|M.vanbaalenii_PYR-1 LFAAGACD-----AVTDVAQNVNGLRLQRNYGRSIINSLHAVWAVGAIVG
MSMEG_3671|M.smegmatis_MC2_155 LFLAGACD-----SIVDVAQNAHGLRVQREYGRSIINSLHAVWAIGAVLG
TH_3240|M.thermoresistible__bu LFVAGAAD-----AVTDVAQNAHGLRVQRAYGRSIINSFHAVWSVGALFG
MAV_4712|M.avium_104 LALWGMFQG-----ALDVAMNTQAGTVERRAGAPMMARFHGMWSLGTLAG
MAB_4138c|M.abscessus_ATCC_199 AVLCGVTVG-----ITDVAMNAAAVDVERFYGRPIMASFHGVFSVGNVVG
MMAR_0690|M.marinum_M RVLQGGAAAAT--WVAGYATLVEIFPREQRGRAVGLASIG--TALGALLG
MUL_0354|M.ulcerans_Agy99 AMITGVVYDAP--RPVMGAAIAELIPEPSRRAKLDAWRFGWIVSIGRAIT
* : : *
Mb1699c|M.bovis_AF2122/97 GLIVGHVHMAG-LPGWRAMFVIEALPALLLAPLLRRLLPDNPQRASWLTP
Rv1672c|M.tuberculosis_H37Rv GLIVGHVHMAG-LPGWRAMFVIEALPALLLAPLLRRLLPDNPQRASWLTP
Mflv_3420|M.gilvum_PYR-GCK GLMGAGAIALG-VPRAIHLVVAAVLFCAIVCAAYPYLLKGP---------
Mvan_3174|M.vanbaalenii_PYR-1 GLMGAGAIALQ-IPRPIHLAAAAVLFCGVVLAAYPSLLHGP---------
MSMEG_3671|M.smegmatis_MC2_155 GLTGAATIAMH-IPRGVHLAAIAVVFSIVALAAFRFLLPGD---------
TH_3240|M.thermoresistible__bu GLMGGTAVALN-IPRSVHLAVAAVLFSVVVLVGYRFLLPGE---------
MAV_4712|M.avium_104 ALIGAACVGAG-IGLTAQLTVLGAVVLLVVVMLTRRLLPDA---------
MAB_4138c|M.abscessus_ATCC_199 AGIGSAAFALH-LKVWATVLGVTVLCLALLTCSASVLLRGKLR-------
MMAR_0690|M.marinum_M PALGGLAYEAS-GPHAPFLGAAGLSALAVAALAASLPQAAG---------
MUL_0354|M.ulcerans_Agy99 GGVGGLLAAWSGVPVLFWINAVACALLALVAARCIPATAHRP--------
. : :
Mb1699c|M.bovis_AF2122/97 EERAELSARLTEDTPAPTGRSSGAGWDLVLFAVVYGGLYFALYALQFFLP
Rv1672c|M.tuberculosis_H37Rv EERAELSARLTEDTPAPTGRSSGAGWDLVLFAVVYGGLYFALYALQFFLP
Mflv_3420|M.gilvum_PYR-GCK ----------DHDDHPSARDGGTARVGPMVYLTLLALVALAMAGATVEDA
Mvan_3174|M.vanbaalenii_PYR-1 ----------DHDDHPSTRNTDGSGVRAVVLLTLLALVGIAVAGATVEDA
MSMEG_3671|M.smegmatis_MC2_155 ----------DHDDHPAAHAPAGLRAGPRTYLILLALVVIAIAGATVEDA
TH_3240|M.thermoresistible__bu ----------DHDDRAHGVRNPGPRSGLRVYAILAALVGIAVAGAVIEDA
MAV_4712|M.avium_104 --------------ADSVAAPPEPAAGRRVTPAVAILAAVSFASFLCEGA
MAB_4138c|M.abscessus_ATCC_199 ---------AGEVEAPDTVPYTMPPPVSYRRGQVVVLGLLAFLLMLSEGS
MMAR_0690|M.marinum_M ----------GQASGPGMWSGERAFPGLAVPWLVAGLAVGLALGAVEATL
MUL_0354|M.ulcerans_Agy99 ----------PVAPAVHVRAAHNSYRRAFSDGRLVLLFASSLATLTAVRG
:
Mb1699c|M.bovis_AF2122/97 QLVASLAHGTATLTAATLAALPYGVAALAMLAWSHRSIDRSGAQAGHIT-
Rv1672c|M.tuberculosis_H37Rv QLVASLAHGTATLTAATLAALPYGVAALAMLAWSHRSIDRSGAQAGHIT-
Mflv_3420|M.gilvum_PYR-GCK GSSWATLYLRDELGAPGAVAAFGYVALVGFLFVGRLIGDRLVDRYGDRA-
Mvan_3174|M.vanbaalenii_PYR-1 GSSWATLYLRDSLGAPGAVAVMGYIALVGFMFIGRMTGDRLVDRFGERA-
MSMEG_3671|M.smegmatis_MC2_155 GSSWATLYLRDTLHTPPAVAAFGYIALVGFMFIGRMIGDRLVDRFGETA-
TH_3240|M.thermoresistible__bu GSTWAILYLRDNLTAPPAVAVSGYLALAGGMLIGRMTGDRLVDRFGERA-
MAV_4712|M.avium_104 ATDWSATYLRDVVGAGPSVAAASYAAYTLTMVVTRFAAGRLHARLPSRR-
MAB_4138c|M.abscessus_ATCC_199 ATDWSSLHAQEHLGASHSEGAFAFGVFMLAMTVGRFTVDKLVERVGRVR-
MMAR_0690|M.marinum_M PIDLVARFDASGVTVGLLFALTTVAFIVTSQYAGRLSDAGRRAPVLAAG-
MUL_0354|M.ulcerans_Agy99 LYATVPMLMADSGLGAGEFGWAQVANAAAGIGLTPVITPWLGRKVAARIN
.
Mb1699c|M.bovis_AF2122/97 -----LPTTAAGSAALGAALSPMSPIVTLSWLTIAVAGI-LAAMPAFWSR
Rv1672c|M.tuberculosis_H37Rv -----LPTTAAGSAALGAALSPMSPIVTLSWLTIAVAGI-LAAMPAFWSR
Mflv_3420|M.gilvum_PYR-GCK -----VARAGGMITAVGMGIALAFPTVPGTIVGFAAAGLGVATVIPAAMR
Mvan_3174|M.vanbaalenii_PYR-1 -----VARSGGLITAAGMGAALAFPSVPGTIAGFAAAGLGVATVIPAAMR
MSMEG_3671|M.smegmatis_MC2_155 -----VVRAGGLIAAVGMGAALAFPSTAGSIAGFAAAGFGVATLIPAAMH
TH_3240|M.thermoresistible__bu -----VVRTGALLIAAGMGGALAVPTVPGTIGGFAAAGLGVATLIPAAMH
MAV_4712|M.avium_104 -----LLPALAVLAVAGMSVTLATADAAAGVLGFAALGVGVALLVPTAFS
MAB_4138c|M.abscessus_ATCC_199 -----VLRGGCALAAVGMLTVIAAPVLPLTLAGWVAVGLGLAGGVPQVFT
MMAR_0690|M.marinum_M -----WVTLGVALAVMGVPSAVGIQAAALVLLGAGLGAMIATIMPALADA
MUL_0354|M.ulcerans_Agy99 PRLDILAIAGGWTALTMAGAALAHTTFGFAIAVAASAAGEIAWFVIAVGT
. :
Mb1699c|M.bovis_AF2122/97 CTAALAGPRVAVAIATVNAVASLASFAGPYATGHLKDATGTYHLALLTVA
Rv1672c|M.tuberculosis_H37Rv CTAALAGPRVAVAIATVNAVASLASFAGPYATGHLKDATGTYHLALLTVA
Mflv_3420|M.gilvum_PYR-GCK TADELPGLRPGTGLTMLTWLMRIGFLGAPLIVGVVADAVS-LRAGLLSVP
Mvan_3174|M.vanbaalenii_PYR-1 AADELPGLRAGTGLTVLTWLMRVGFLGAPLIVGVVADATS-LRAGLLTVP
MSMEG_3671|M.smegmatis_MC2_155 AADQLPGLRPGTGLTAVTWLMRVGFFGAPLLVGVVADAAG-LRAGLLVVP
TH_3240|M.thermoresistible__bu GADQLPGIRAGTGLMAVTWLMRVGFLASPPVVGAIADATS-LRVGLLGVP
MAV_4712|M.avium_104 AAYGARG--AGSAIAIVAATGWLGYLLGPPLIGHLSEWVG-LSGALVTIP
MAB_4138c|M.abscessus_ATCC_199 VAGNIDEQHEGRVLSRVVGTGYVAVLGGPALIGWVADALS-LNTALVLPI
MMAR_0690|M.marinum_M MESAGGAQRPGTAAAAYNLAFSAGTVAGGPLAGWMADLRS-FQDAAMLIA
MUL_0354|M.ulcerans_Agy99 VHRIAPPASGGRYHGIWSMTLAIASVVAPIVSSCSLTHGGHRLVALVTVT
. . . . . . . :
Mb1699c|M.bovis_AF2122/97 AVLAAAAACSLLLRHAGRTVCANDSEIMLHPSPATPFV
Rv1672c|M.tuberculosis_H37Rv AVLAAAAACSLLLRHAGRTVCANDSEIMLHPSPATPFV
Mflv_3420|M.gilvum_PYR-GCK IAGIAIIALAAALLTARRRR------------------
Mvan_3174|M.vanbaalenii_PYR-1 VAGAALVVLAGVLGSRCRG-------------------
MSMEG_3671|M.smegmatis_MC2_155 AAGVLAIVLAGALRPHRVSVGDAGQLDREHT-------
TH_3240|M.thermoresistible__bu LAGLVAAVLAGVLSGRRRTPRW----------------
MAV_4712|M.avium_104 VMMTIVAVAIRYTPAFDTADEFHRAPAG----------
MAB_4138c|M.abscessus_ATCC_199 FAVVICGCAAGALAVTPPSKSVKPPR------------
MMAR_0690|M.marinum_M VVTLTCGVLAALVHAAVVRRAVSDA-------------
MUL_0354|M.ulcerans_Agy99 VGLAGAALCLPLNRSGDVGVRDSQYTAVAAAA------