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TTDQITVEQLLVNGRRVDGHGEVLDVINPATGQVFARCHCGDAADIDAAVENAQAAFTSGVWRDAPIHHR AKVMNKFADLLEANMEELYRLETLNNGRPITETKAQITRLPEWYRYNAALLLADRTSVVPMAGPYHSYTS RMPLGVVGILSSFNHPLMIASKSLAPALATGNSVVLKPSEQTPLTALVVGQLALEAGIPPGVLNVVPGLG PDAGARLVEHPLVKKAVFTGGTEPGRSIAVATARRFAKATLELGGKSPVVVFDDMDVDVAARGAAFGGFI GAGQTCIAGTRLIVQSTIYQQFVDALVAQAEAIRIGDPALAETQLGPVISERARQRILNYVAIGVEEGAT VATGGAAAEVAGMDGFFVKPTVLSNVTNDMRVAREEIFGPVLVVIPFEDEDDAVRIANDSDYGLGSSIWT RDVARAHRVASRFEQGIVWVNDHHRLDPCSPWGGVRESGQGREGGWESFHDFTNVRSVTIRTDSTDVDWY AGVGQERLN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6874 | - | - | 100% (500) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6491 | - | e-154 | 55.56% (477) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6297 | - | e-112 | 43.64% (472) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 6e-87 | 40.88% (455) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4389 | - | 8e-92 | 40.99% (466) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 2e-88 | 38.19% (487) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 2e-62 | 31.29% (457) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 1e-89 | 38.88% (499) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 1e-103 | 42.16% (491) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | 1e-104 | 42.13% (489) | betaine-aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3080 | - | 1e-89 | 39.96% (483) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2877 | - | 1e-101 | 42.51% (487) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0014 | - | 1e-102 | 43.25% (474) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6874|M.smegmatis_MC2_155 MT--------TDQITVEQLLVNGRRVDG-HGEVLDVINPATGQVFARCHC
MAV_1897|M.avium_104 MTDTTISNGVTEQLVHFDLVIGGESVAAESGRTYDSIDPYTALPWARVPD
Rv0223c|M.tuberculosis_H37Rv --------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPM
TH_3080|M.thermoresistible__bu -------------VHPEELFIGGEWATPSSAQRIEVISPHTEEPVAAVAA
Mflv_4389|M.gilvum_PYR-GCK ---------MTQIVDTAGVFVGGEFRR--TDRTVPVFEAATGEILGEGPS
MMAR_2875|M.marinum_M --------MTTVAVPHHAMLIGGESVD--SDRRLSLVDPGDESPVATVAC
MUL_2877|M.ulcerans_Agy99 --------MTTVAVPHHAMLIGGESVD--SDRRLSLVDPGDESPVATVAC
Mvan_0014|M.vanbaalenii_PYR-1 ----------MSDIPHYRMYIDGAWRD--AADTIEVRSPATGELVATVAY
Mb2883c|M.bovis_AF2122/97 ------------------------------MSTTQLINPATEEVLASVDH
MAB_3328|M.abscessus_ATCC_1997 -------------MSVPSSWINGRPVAT-HGDTHRVINPATGEAVADLKL
MLBr_02573|M.leprae_Br4923 -------------------------------MSIATINPATGETVKTFTP
.
MSMEG_6874|M.smegmatis_MC2_155 GDAADIDAAVENAQAAFTSGVWRDAPIHHRAKVMNKFADLLEANMEELYR
MAV_1897|M.avium_104 CGPADVDRAVAAARAALR-GPWGQLTGTARGKLLWRLGELIAREAESLAE
Rv0223c|M.tuberculosis_H37Rv AAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTK
TH_3080|M.thermoresistible__bu ACPDDVDRAVAAARAAFDTGPWPRMDPAERVAVIRGLAERYGERRSELAE
Mflv_4389|M.gilvum_PYR-GCK AAAADIDDAVAAARGE-GAAKWRAATVDERADGLKRFATALRGRAKHTST
MMAR_2875|M.marinum_M GDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIE
MUL_2877|M.ulcerans_Agy99 GDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIE
Mvan_0014|M.vanbaalenii_PYR-1 GGVTTVDDAVAAAKAADEAGVWRNTSAQQRADVLDAIADNLAARTDELTA
Mb2883c|M.bovis_AF2122/97 TDANAVDDAVQRARAAQR--RWARLAPAQRAAGLRAFAAAVQAHLDELAA
MAB_3328|M.abscessus_ATCC_1997 ATTADVDAAVAAARAAGP--AWASSTPVDRSSVLAKLAAVLSANADTLVA
MLBr_02573|M.leprae_Br4923 TTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAA
:: *: * . : * .
MSMEG_6874|M.smegmatis_MC2_155 LETLNNGRPITETKAQITRLP-EWYRYNAALLLADRTSVVPMAGP-YHSY
MAV_1897|M.avium_104 LEVRDGGKLVREMIGQMKALP-DYYIYYAGLADKLQGEVVPVDKPNFFVY
Rv0223c|M.tuberculosis_H37Rv LLAAETGQPPTIIETMHWMGSMGAMNYFAGAADKVTWTETRTGSYGQSI-
TH_3080|M.thermoresistible__bu LITAQIGAPISFAQRAQVGLPWTMMSAFCTLAENHPWQQTRAGMYGADVH
Mflv_4389|M.gilvum_PYR-GCK LVSRENGMPITLSRAVNGAFPSVLVNYYAKLIRSWTAEEVRPALIGHTV-
MMAR_2875|M.marinum_M LEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQRPAPIETFPVLS
MUL_2877|M.ulcerans_Agy99 LEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQRPAPIETFPVLS
Mvan_0014|M.vanbaalenii_PYR-1 LQVAENGATVRAAGAFLIGYAIAHLRYFAGLARTYAFQSSGPLMEAPTLA
Mb2883c|M.bovis_AF2122/97 LEVANSGHP-IVSAEWEAGHVRDVLAFYAASPERLSGRQIPVAGGVDVTF
MAB_3328|M.abscessus_ATCC_1997 DEVAQTGKPVRLASEFDVPGSIDNVEFFAGAARHLEGKATAEYSADHTSS
MLBr_02573|M.leprae_Br4923 LMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGASKA
*
MSMEG_6874|M.smegmatis_MC2_155 T---SRMPLGVVGILSSFNHPLMIASKSLAPALATGNSVVLKPSEQTPLT
MAV_1897|M.avium_104 T---RHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKPSDHTPAS
Rv0223c|M.tuberculosis_H37Rv ---VSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLT
TH_3080|M.thermoresistible__bu ---VRREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPESPLD
Mflv_4389|M.gilvum_PYR-GCK ---VRREPIGVVGAITPWNYPQALAVMKIAPALAAGCSVVLKASPETSLD
MMAR_2875|M.marinum_M QSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLS
MUL_2877|M.ulcerans_Agy99 QSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLS
Mvan_0014|M.vanbaalenii_PYR-1 AGMIVRDPVGVCAGMIPWNFPLLLAVWKLGPALAAGNTVVLKPDDQTPLT
Mb2883c|M.bovis_AF2122/97 N-----EPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLT
MAB_3328|M.abscessus_ATCC_1997 ---IRREAAGVVATITPWNYPLQMAVWKVLPALAAGCTVVIKPSELTPLT
MLBr_02573|M.leprae_Br4923 L--ARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQC
. ** : .:* * ..: :* ::* .
MSMEG_6874|M.smegmatis_MC2_155 ALVVGQLALEAGIPPGVLNVVPGLGPDAGARLVEHPLVKKAVFTGGTEPG
MAV_1897|M.avium_104 TLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKIAFTGSTATG
Rv0223c|M.tuberculosis_H37Rv ANALAEVFAEVGLPEGVLSVVPG-GIETGQALTSNPDIDMFTFTGSSAVG
TH_3080|M.thermoresistible__bu ALLLAELIADSGIPSGVVNVLPG-PAGVGERLVRHPGVDKVSFTGSTAAG
Mflv_4389|M.gilvum_PYR-GCK ALVFAEAAAEAGLPPGVLNVVPG-DAAAGAHLVTHPGVDKVAFTGSTNAG
MMAR_2875|M.marinum_M ILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAFTGSTAVG
MUL_2877|M.ulcerans_Agy99 ILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAFTGSTAVG
Mvan_0014|M.vanbaalenii_PYR-1 LLELARAADEVGLPAGVLNVVTGAGPTVGARLAEHPDVRKVAFTGSTEVG
Mb2883c|M.bovis_AF2122/97 TMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVG
MAB_3328|M.abscessus_ATCC_1997 TLTLARLAAEAGLPEGVLNVVTGRGDDVGYALASHPDVDLVTFTGSTAVG
MLBr_02573|M.leprae_Br4923 ALYLADVIARGGFPEDCFQTLLISANGVEAILRD-PRVAAATLTGSEPAG
.. *: . ...: . : * : :**. *
MSMEG_6874|M.smegmatis_MC2_155 RSIAVATARRFAKATLELGGKSPVVVFDDMDVDVAARGAAFGGFIGAGQT
MAV_1897|M.avium_104 ISVGKAAIDNMTRFTLELGGKSAQVVFDDADLDAAANGVIAGVFAATGQT
Rv0223c|M.tuberculosis_H37Rv REVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQG
TH_3080|M.thermoresistible__bu RAVAAAAAAGLKRVSLELGGKSAAVVLSDADPAAVATAVRSASLSNSGQI
Mflv_4389|M.gilvum_PYR-GCK RVIGAECGRLIRPVTLELGGKSAAVILDDADLDTTVNGLRTASFVNNGQT
MMAR_2875|M.marinum_M REIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGCFAYSGQV
MUL_2877|M.ulcerans_Agy99 REIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGCFAYSGQV
Mvan_0014|M.vanbaalenii_PYR-1 KSVMRAAADTVKKVTLELGGKGASIVLDDADLDLAVDGSLFAFLLMSGQA
Mb2883c|M.bovis_AF2122/97 KRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGVFDNAGQD
MAB_3328|M.abscessus_ATCC_1997 RKVMAAAAVHGHRTQLELGGKAPFVVFDDADMDAAIAGAVAGAIINSGQD
MLBr_02573|M.leprae_Br4923 QAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQS
: *****. . ::: . * . . . **
MSMEG_6874|M.smegmatis_MC2_155 CIAGTRLIVQSTIYQQFVDALVAQAEAIRIGDPALAETQLGPVISERARQ
MAV_1897|M.avium_104 CLAGSRLLVHESVADALVERIVARASTIKLGDPKDPATEMGPVSNQPQYE
Rv0223c|M.tuberculosis_H37Rv CVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRT
TH_3080|M.thermoresistible__bu CNALTRILMPAGRAAEFTDALAAEMESLVIGDPTDAETQIGPLVARRQQE
Mflv_4389|M.gilvum_PYR-GCK CHLSSRILVPAKRYAEFVSAIAELADSLTVGDPLDEKTEIGPLVSERQRE
MMAR_2875|M.marinum_M CESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPVIDAAQRT
MUL_2877|M.ulcerans_Agy99 CESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPVIDAAQRT
Mvan_0014|M.vanbaalenii_PYR-1 CESGTRLLVHESIHDEFVRRMVARAETLVMGDPMSLASDLGPLVSAKQKA
Mb2883c|M.bovis_AF2122/97 CCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLVSRAHRD
MAB_3328|M.abscessus_ATCC_1997 CTAATRALVARDLYDDFVAGVGEVMSKVVVGDPLDPDTDIGPLISAAHRA
MLBr_02573|M.leprae_Br4923 CIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRA
* .* : : . : :* . :::**:
MSMEG_6874|M.smegmatis_MC2_155 RILNYVAIGVEEGATVATGG--AAAEVAGMDGFFVKPTVLSNVTNDMRVA
MAV_1897|M.avium_104 KVLSHFASAREQGATVAYGG--EPAGELG--GFFVKPTVLTGVDRSMRAV
Rv0223c|M.tuberculosis_H37Rv RVEGYIAKGIEEGARLVCGG-GRPEG--LDNGFFIQPTVFADVDNKMTIA
TH_3080|M.thermoresistible__bu RVRGYIEAGCAEGARLVTGGPGLPAG--VDRGWYVQPTLFADADNSMRIA
Mflv_4389|M.gilvum_PYR-GCK RVLDYVQVGRDSGARLVAGG-SVPTG--LERGWYVAPTVFADVDNSDRLA
MMAR_2875|M.marinum_M RILNYIRGAQTDGATVALGG-EALTGGMFDKGFWVAPTILTGVHNDMAIA
MUL_2877|M.ulcerans_Agy99 RILNYIRGAQTDGATVALGG-EALTGGMFDKGFWVAPTILTGVHNDMAIA
Mvan_0014|M.vanbaalenii_PYR-1 RVEKYIALGQEEGCKLAYQG-TVPTDPALAQGHWVPPTILTGATNDMRIA
Mb2883c|M.bovis_AF2122/97 KVAGYVP----DDAPVAFRG-TAPAG----RGFWFPPTVLTPKRGD-RTV
MAB_3328|M.abscessus_ATCC_1997 KVSSIVDRAPAQGGRIVTGA-TAPDLP----GSFYRPTLIADVAETSEVY
MLBr_02573|M.leprae_Br4923 QVEQQVDAAAAAGAVIRCGG-KRPDRP----GWFYPPTVITDITKDMALY
:: . . : . * : **:::
MSMEG_6874|M.smegmatis_MC2_155 REEIFGPVLVVIPFEDEDDAVRIANDSDYGLGSSIWTRDVARAHRVASRF
MAV_1897|M.avium_104 AEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAAGVWTKDVHRAHRVAARL
Rv0223c|M.tuberculosis_H37Rv QEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQI
TH_3080|M.thermoresistible__bu REEIFGPVLTVIPYPDEDAAVAIANDSDYGLAGSVFTADTERGLAIAARI
Mflv_4389|M.gilvum_PYR-GCK QEEIFGPVITITAYADDADAVRLANDTEFGLAGTVWSQDSARATEIARAM
MMAR_2875|M.marinum_M REEVFGPVLVVIGYDGDEQAIAIANDSDYGLAASIWTSDNARGLAMAERI
MUL_2877|M.ulcerans_Agy99 REEVFGPVLVVSGYDGDEQAIAIANDSDYGLAASIWTSDNARGLAMAERI
Mvan_0014|M.vanbaalenii_PYR-1 REEIFGPVLVVLTYGDDDEAVAIANDSEYGLSAGVWSADRERALGIARRL
Mb2883c|M.bovis_AF2122/97 TDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVARAV
MAB_3328|M.abscessus_ATCC_1997 RDEIFGPVLTVRPFTDDDDALRQANDTAYGLAASAWTRDVYRAQRASREI
MLBr_02573|M.leprae_Br4923 TDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNI
:*:**** : *: ** : :**.. :: : . .
MSMEG_6874|M.smegmatis_MC2_155 EQGIVWVNDHHRLDPCSPWGGVRESGQGREGGWESFHDFTNVRSVTIRTD
MAV_1897|M.avium_104 NAGTVWVNAYRVVSPHVPFGGMGHSGIGRENGIDAVKDFTETKAVWVELS
Rv0223c|M.tuberculosis_H37Rv RTGTYGIN-WYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMG
TH_3080|M.thermoresistible__bu RTGTFGVNQGYTMDPFAPFGGVKGSGYGRELGPEGIDAYTDVKSISVAPA
Mflv_4389|M.gilvum_PYR-GCK HTGSVGVN-HYQLDIQSPFGGIKSSGLGRELGPEGLDAYLVTKSIYQADP
MMAR_2875|M.marinum_M QSGSVWINDAHQINCRLPFGGYKQSGVGRELGPDALDAYTEVKTIHLDLS
MUL_2877|M.ulcerans_Agy99 RSGSVWINDAHQINCRLLFGGYKQSGVGRELGPDTLDAYTEVKTIHLDLS
Mvan_0014|M.vanbaalenii_PYR-1 QSGTVWVNDWHMINAMYPFGGVKQSGLGRELGPDALDEYTEPKFIHVDMT
Mb2883c|M.bovis_AF2122/97 ESGNLSVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIAVG
MAB_3328|M.abscessus_ATCC_1997 RAGCVWINDHIPIISEMPHGGFGASGFGKDMSDYSLEEYLTVKHVMSDIT
MLBr_02573|M.leprae_Br4923 VAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA--
* :* ** ** *:: . : : :
MSMEG_6874|M.smegmatis_MC2_155 STDVDWYAGVGQERLN--
MAV_1897|M.avium_104 GATRDPFT-LG-------
Rv0223c|M.tuberculosis_H37Rv YTVA--------------
TH_3080|M.thermoresistible__bu STT---------------
Mflv_4389|M.gilvum_PYR-GCK FPE---------------
MMAR_2875|M.marinum_M GGREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 GGREAKPYDVLLGHPETG
Mvan_0014|M.vanbaalenii_PYR-1 DDRRKHVYPVVISAAAQG
Mb2883c|M.bovis_AF2122/97 EEM---------------
MAB_3328|M.abscessus_ATCC_1997 GTADKDWHRTIFAKR---
MLBr_02573|M.leprae_Br4923 ------------------