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TTGTTGTTGTFPRDELHGTPTRDIINPATGAVITTVPEHGAAEVDAAVARARAAFENGPWPRLARSERAR LLLGIADAIEADSERLYTLEARNNGRPITETRAQLSRVPEWFRYNAGLLAAQRTAVLPGDGPYVTYQQRR PLGVCGIITPFNHPMLILARSLSAALANGNTVVVKPSEMTPLTTLALAEIIAAAAIPEGVVNVVTGGRPA GERLTEHPDVAKITLTGGTEAGRSASIATAARFARITAELGGKTPIAVFDDVDPRIAAEGAAFAAFVAAG QSCVAGSRFLVQRGIYDAFVDALSARADAIRLGDPELATTQMGPLISARQRDKVRALIDAGLAEGARLAA GGAIPDLPAPFDGGFYLRPTVLADATIDMTVSRQEIFGPVAVIVPFDTEADAVAMANDNRYGLGAGVWTV DVGRAHRVAAGIDAGMVWVNDHHRLEPSLPWGGIKESGSGKDAGTESFDDFSWIKTVVVRTAAEPVDWYG GEPQSRLN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6491 | - | - | 100% (499) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6874 | - | e-154 | 55.56% (477) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6297 | - | e-107 | 42.98% (470) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 1e-87 | 40.77% (466) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3083 | - | 6e-95 | 39.58% (480) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv2858c | aldC | 1e-87 | 40.77% (466) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 2e-62 | 32.89% (456) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 1e-88 | 41.16% (481) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 1e-87 | 38.72% (483) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | 1e-101 | 43.50% (469) | betaine-aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3080 | - | 3e-91 | 40.47% (467) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2877 | - | 4e-86 | 38.51% (483) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0014 | - | 4e-95 | 41.24% (468) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2883c|M.bovis_AF2122/97 ------------------------------MSTTQLINPATEEVLASVDH
Rv2858c|M.tuberculosis_H37Rv ------------------------------MSTTQLINPATEEVLASVDH
MSMEG_6491|M.smegmatis_MC2_155 --------MTTGTTGTTGTFPRDELHG---TPTRDIINPATGAVITTVPE
MMAR_2875|M.marinum_M --------MTTVAVPHHAMLIGGESVD--SDRRLSLVDPGDESPVATVAC
MUL_2877|M.ulcerans_Agy99 --------MTTVAVPHHAMLIGGESVD--SDRRLSLVDPGDESPVATVAC
Mvan_0014|M.vanbaalenii_PYR-1 ----------MSDIPHYRMYIDGAWRD--AADTIEVRSPATGELVATVAY
TH_3080|M.thermoresistible__bu -------------VHPEELFIGGEWATPSSAQRIEVISPHTEEPVAAVAA
Mflv_3083|M.gilvum_PYR-GCK MDG------------DPDLCIGGAWRHACDGGTRDIINPANGAVAAVVDE
MAV_1897|M.avium_104 MTDTTISNGVTEQLVHFDLVIGGESVAAESGRTYDSIDPYTALPWARVPD
MAB_3328|M.abscessus_ATCC_1997 -------------MSVPSSWINGRPVAT-HGDTHRVINPATGEAVADLKL
MLBr_02573|M.leprae_Br4923 -------------------------------MSIATINPATGETVKTFTP
.* .
Mb2883c|M.bovis_AF2122/97 TDANAVDDAVQRARAAQRR--WARLAPAQRAAGLRAFAAAVQAHLDELAA
Rv2858c|M.tuberculosis_H37Rv TDANAVDDAVQRARAAQRR--WARLAPAQRAAGLRAFAAAVQAHLDELAA
MSMEG_6491|M.smegmatis_MC2_155 HGAAEVDAAVARARAAFENGPWPRLARSERARLLLGIADAIEADSERLYT
MMAR_2875|M.marinum_M GDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIE
MUL_2877|M.ulcerans_Agy99 GDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIE
Mvan_0014|M.vanbaalenii_PYR-1 GGVTTVDDAVAAAKAADEAGVWRNTSAQQRADVLDAIADNLAARTDELTA
TH_3080|M.thermoresistible__bu ACPDDVDRAVAAARAAFDTGPWPRMDPAERVAVIRGLAERYGERRSELAE
Mflv_3083|M.gilvum_PYR-GCK ATPQDALDAVAAARAAFDQGGWRATAVAERSALLQRIADLLQRDKEDLAR
MAV_1897|M.avium_104 CGPADVDRAVAAARAALR-GPWGQLTGTARGKLLWRLGELIAREAESLAE
MAB_3328|M.abscessus_ATCC_1997 ATTADVDAAVAAARAAGP--AWASSTPVDRSSVLAKLAAVLSANADTLVA
MLBr_02573|M.leprae_Br4923 TTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAA
. *: * * : * .
Mb2883c|M.bovis_AF2122/97 LEVANSGHPIVSAE-WEAGHVRDVLAFYAASPERLSGRQIP--VAG---G
Rv2858c|M.tuberculosis_H37Rv LEVANSGHPIVSAE-WEAGHVRDVLAFYAASPERLSGRQIP--VAG---G
MSMEG_6491|M.smegmatis_MC2_155 LEARNNGRPITETR-AQLSRVPEWFRYNAGLLAAQRTAVLP--GDGP--Y
MMAR_2875|M.marinum_M LEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQRPAPIETFPVLS
MUL_2877|M.ulcerans_Agy99 LEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQRPAPIETFPVLS
Mvan_0014|M.vanbaalenii_PYR-1 LQVAENGATVRAAGAFLIGYAIAHLRYFAGLARTYAFQSSGPLMEAPTLA
TH_3080|M.thermoresistible__bu LITAQIGAPISFAQRAQVGLPWTMMSAFCTLAENHPWQQTRAGMYG---A
Mflv_3083|M.gilvum_PYR-GCK LETVDTGKTLAESR-IDIDDVTSVFRYYANLVASEAERVVDVGDPA---V
MAV_1897|M.avium_104 LEVRDGGKLVREMI-GQMKALPDYYIYYAGLADKLQGEVVPVDKPN---F
MAB_3328|M.abscessus_ATCC_1997 DEVAQTGKPVRLASEFDVPGSIDNVEFFAGAARHLEGKATAEYSAD---H
MLBr_02573|M.leprae_Br4923 LMTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPAEAAAVG-AS
* : .
Mb2883c|M.bovis_AF2122/97 VDVTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLT
Rv2858c|M.tuberculosis_H37Rv VDVTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLT
MSMEG_6491|M.smegmatis_MC2_155 VTYQQRRPLGVCGIITPFNHPMLILARSLSAALANGNTVVVKPSEMTPLT
MMAR_2875|M.marinum_M QSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLS
MUL_2877|M.ulcerans_Agy99 QSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLS
Mvan_0014|M.vanbaalenii_PYR-1 AGMIVRDPVGVCAGMIPWNFPLLLAVWKLGPALAAGNTVVLKPDDQTPLT
TH_3080|M.thermoresistible__bu DVHVRREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPESPLD
Mflv_3083|M.gilvum_PYR-GCK ISRVIREPIGVCVLIAPWNYPLLQMSWKVAPALAAGCTMVAKPSEVTPLS
MAV_1897|M.avium_104 FVYTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKPSDHTPAS
MAB_3328|M.abscessus_ATCC_1997 TSSIRREAAGVVATITPWNYPLQMAVWKVLPALAAGCTVVIKPSELTPLT
MLBr_02573|M.leprae_Br4923 KALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQC
. ** : *:* * ..: * : * *
Mb2883c|M.bovis_AF2122/97 TMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVG
Rv2858c|M.tuberculosis_H37Rv TMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVG
MSMEG_6491|M.smegmatis_MC2_155 TLALAEIIAAAAIPEGVVNVVTG-GRPAGERLTEHPDVAKITLTGGTEAG
MMAR_2875|M.marinum_M ILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAFTGSTAVG
MUL_2877|M.ulcerans_Agy99 ILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAFTGSTAVG
Mvan_0014|M.vanbaalenii_PYR-1 LLELARAADEVGLPAGVLNVVTGAGPTVGARLAEHPDVRKVAFTGSTEVG
TH_3080|M.thermoresistible__bu ALLLAELIADSGIPSGVVNVLPGPAG-VGERLVRHPGVDKVSFTGSTAAG
Mflv_3083|M.gilvum_PYR-GCK TIAFAKLLDEAGVPPGVVNLIQGSGATLGPALTDNPQVDFISFTGGLATG
MAV_1897|M.avium_104 TLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKIAFTGSTATG
MAB_3328|M.abscessus_ATCC_1997 TLTLARLAAEAGLPEGVLNVVTGRGDDVGYALASHPDVDLVTFTGSTAVG
MLBr_02573|M.leprae_Br4923 ALYLADVIARGGFPEDCFQTLLISANGVEAILRD-PRVAAATLTGSEPAG
: :. .. . .: : . : * : :**. .*
Mb2883c|M.bovis_AF2122/97 KRVMAGAAAQVKRVTLELGGKSANIVFHDC-------DLERAATTAPAGV
Rv2858c|M.tuberculosis_H37Rv KRVMAGAAAQVKRVTLELGGKSANIVFHDC-------DLERAATTAPAGV
MSMEG_6491|M.smegmatis_MC2_155 RSASIATAARFARITAELGGKTPIAVFDDV-------DPRIAAEGAAFAA
MMAR_2875|M.marinum_M REIMRLASGTVKQVTLELGGKGPTIVLDDA-------DLEMAVEGVLYGC
MUL_2877|M.ulcerans_Agy99 REIMRLASGTVKQVTLELGGKGPTIVLDDA-------DLEMAVEGVLYGC
Mvan_0014|M.vanbaalenii_PYR-1 KSVMRAAADTVKKVTLELGGKGASIVLDDA-------DLDLAVDGSLFAF
TH_3080|M.thermoresistible__bu RAVAAAAAAGLKRVSLELGGKSAAVVLSDA-------DPAAVATAVRSAS
Mflv_3083|M.gilvum_PYR-GCK RTIARTAAEHVTKVALELGGKNPHLVFADIRDAGRESGWDAAVDHVLTGV
MAV_1897|M.avium_104 ISVGKAAIDNMTRFTLELGGKSAQVVFDDA-------DLDAAANGVIAGV
MAB_3328|M.abscessus_ATCC_1997 RKVMAAAAVHGHRTQLELGGKAPFVVFDDA-------DMDAAIAGAVAGA
MLBr_02573|M.leprae_Br4923 QAVGAIAGNEIKPTVLELGGSDPFIVMPSA-------DLDAAVATAVTGR
: ****. . *: . . . .
Mb2883c|M.bovis_AF2122/97 FDNAGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPL
Rv2858c|M.tuberculosis_H37Rv FDNAGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPL
MSMEG_6491|M.smegmatis_MC2_155 FVAAGQSCVAGSRFLVQRGIYDAFVDALSARADAIRLGDPELATTQMGPL
MMAR_2875|M.marinum_M FAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPV
MUL_2877|M.ulcerans_Agy99 FAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPV
Mvan_0014|M.vanbaalenii_PYR-1 LLMSGQACESGTRLLVHESIHDEFVRRMVARAETLVMGDPMSLASDLGPL
TH_3080|M.thermoresistible__bu LSNSGQICNALTRILMPAGRAAEFTDALAAEMESLVIGDPTDAETQIGPL
Mflv_3083|M.gilvum_PYR-GCK FLHSGQVCSAGTRLIIEESIADEFVAALAARAATIRMGDGLDPASETGPL
MAV_1897|M.avium_104 FAATGQTCLAGSRLLVHESVADALVERIVARASTIKLGDPKDPATEMGPV
MAB_3328|M.abscessus_ATCC_1997 IINSGQDCTAATRALVARDLYDDFVAGVGEVMSKVVVGDPLDPDTDIGPL
MLBr_02573|M.leprae_Br4923 VQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPL
. ** * : .* : : . : :* :: **:
Mb2883c|M.bovis_AF2122/97 VSRAHRDKVAGYVP----DDAPVAFRG-----TAPAGRGFWFPPTVLTPK
Rv2858c|M.tuberculosis_H37Rv VSRAHRDKVAGYVP----DDAPVAFRG-----TAPAGRGFWFPPTVLTPK
MSMEG_6491|M.smegmatis_MC2_155 ISARQRDKVRALIDAGLAEGARLAAGGAIPDLPAPFDGGFYLRPTVLADA
MMAR_2875|M.marinum_M IDAAQRTRILNYIRGAQTDGATVALGGEAL-TGGMFDKGFWVAPTILTGV
MUL_2877|M.ulcerans_Agy99 IDAAQRTRILNYIRGAQTDGATVALGGEAL-TGGMFDKGFWVAPTILTGV
Mvan_0014|M.vanbaalenii_PYR-1 VSAKQKARVEKYIALGQEEGCKLAYQGTVP-TDPALAQGHWVPPTILTGA
TH_3080|M.thermoresistible__bu VARRQQERVRGYIEAGCAEGARLVTGGPGL-PAG-VDRGWYVQPTLFADA
Mflv_3083|M.gilvum_PYR-GCK VSAQHRDKVESYVRLGISEGAQLIAGGCRP-EDPVLAGGYFYRPTIFDRC
MAV_1897|M.avium_104 SNQPQYEKVLSHFASAREQGATVAYGG----EPAGELGGFFVKPTVLTGV
MAB_3328|M.abscessus_ATCC_1997 ISAAHRAKVSSIVDRAPAQGGRIVTGA-----TAPDLPGSFYRPTLIADV
MLBr_02573|M.leprae_Br4923 ATESGRAQVEQQVDAAAAAGAVIRCGG-----KRPDRPGWFYPPTVITDI
:: . . : . * : **::
Mb2883c|M.bovis_AF2122/97 RGDRTVT-DEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRA
Rv2858c|M.tuberculosis_H37Rv RGDRTVT-DEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRA
MSMEG_6491|M.smegmatis_MC2_155 TIDMTVSRQEIFGPVAVIVPFDTEADAVAMANDNRYGLGAGVWTVDVGRA
MMAR_2875|M.marinum_M HNDMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDYGLAASIWTSDNARG
MUL_2877|M.ulcerans_Agy99 HNDMAIAREEVFGPVLVVSGYDGDEQAIAIANDSDYGLAASIWTSDNARG
Mvan_0014|M.vanbaalenii_PYR-1 TNDMRIAREEIFGPVLVVLTYGDDDEAVAIANDSEYGLSAGVWSADRERA
TH_3080|M.thermoresistible__bu DNSMRIAREEIFGPVLTVIPYPDEDAAVAIANDSDYGLAGSVFTADTERG
Mflv_3083|M.gilvum_PYR-GCK DRSMRIVQEETFGPILTVERFTDEAEAVTLGNDTEYGLAAGVRTTDTARG
MAV_1897|M.avium_104 DRSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAAGVWTKDVHRA
MAB_3328|M.abscessus_ATCC_1997 AETSEVYRDEIFGPVLTVRPFTDDDDALRQANDTAYGLAASAWTRDVYRA
MLBr_02573|M.leprae_Br4923 TKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQ
:* ***: : *: .* . :**... : : .
Mb2883c|M.bovis_AF2122/97 LRVARAVESGNLSVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETK
Rv2858c|M.tuberculosis_H37Rv LRVARAVESGNLSVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETK
MSMEG_6491|M.smegmatis_MC2_155 HRVAAGIDAGMVWVNDHHRLEPSLPWGGIKESGSGKDAGTESFDDFSWIK
MMAR_2875|M.marinum_M LAMAERIQSGSVWINDAHQINCRLPFGGYKQSGVGRELGPDALDAYTEVK
MUL_2877|M.ulcerans_Agy99 LAMAERIRSGSVWINDAHQINCRLLFGGYKQSGVGRELGPDTLDAYTEVK
Mvan_0014|M.vanbaalenii_PYR-1 LGIARRLQSGTVWVNDWHMINAMYPFGGVKQSGLGRELGPDALDEYTEPK
TH_3080|M.thermoresistible__bu LAIAARIRTGTFGVNQGYTMDPFAPFGGVKGSGYGRELGPEGIDAYTDVK
Mflv_3083|M.gilvum_PYR-GCK ERVVRALRHGTVWLNDFGYYTAAAEWGGFGRSGNGRELGPTGLAEYQEIK
MAV_1897|M.avium_104 HRVAARLNAGTVWVNAYRVVSPHVPFGGMGHSGIGRENGIDAVKDFTETK
MAB_3328|M.abscessus_ATCC_1997 QRASREIRAGCVWINDHIPIISEMPHGGFGASGFGKDMSDYSLEEYLTVK
MLBr_02573|M.leprae_Br4923 RHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIK
: * . :* ** ** *:: . : *
Mb2883c|M.bovis_AF2122/97 NVFIAVGEEM---------------
Rv2858c|M.tuberculosis_H37Rv NVFIAVGEEM---------------
MSMEG_6491|M.smegmatis_MC2_155 TVVVRTAAEPVDWYGGEPQSRLN--
MMAR_2875|M.marinum_M TIHLDLSGGREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 TIHLDLSGGREAKPYDVLLGHPETG
Mvan_0014|M.vanbaalenii_PYR-1 FIHVDMTDDRRKHVYPVVISAAAQG
TH_3080|M.thermoresistible__bu SISVAPASTT---------------
Mflv_3083|M.gilvum_PYR-GCK HIWHNTAPAAAGWFTG---------
MAV_1897|M.avium_104 AVWVELSGATRDPFTLG--------
MAB_3328|M.abscessus_ATCC_1997 HVMSDITGTADKDWHRTIFAKR---
MLBr_02573|M.leprae_Br4923 TVWIA--------------------
: