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GRQFTPDFTPDPKLYPFASRWFDSSRGRLHYIDESDGPPILLCHGNPTWSFLYRHIIVALRDHFRCIAPD YLGFGLSEHPGTFGYKVDEHAQVVGEFVDHLGLDNYLTMGQDWGGPISMAVAVERAERVRGIVLGNTWFW PADTLTMKAFSTVMSSLPMQYAILHHNFFVERLIPAGTTHRPSSAVMEHYRGVQPTASARVGVAEMPKQI LAARPLLARLASEVPAQLGTKPALLVWGMKDFAFRPEPMLARMRAVFADHILVELPEAKHLIQEDAPDEI AAAIIARFG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3052 | - | - | 100% (290) | haloalkane dehalogenase |
| M. ulcerans Agy99 | MUL_3979 | dhaA | 3e-23 | 27.34% (278) | haloalkane dehalogenase |
| M. ulcerans Agy99 | MUL_2888 | ephB | 1e-10 | 32.41% (108) | epoxide hydrolase EphB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1864c | - | 1e-140 | 81.98% (283) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_4848 | - | 2e-15 | 38.10% (105) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1833c | - | 1e-140 | 81.98% (283) | haloalkane dehalogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2289 | - | 2e-16 | 27.90% (276) | putative hydrolase, alpha/beta hydrolase fold |
| M. marinum M | MMAR_2710 | - | 1e-172 | 98.97% (290) | haloalkane dehalogenase |
| M. avium 104 | MAV_2130 | - | 2e-28 | 31.79% (302) | haloalkane dehalogenase |
| M. smegmatis MC2 155 | MSMEG_6314 | - | 2e-18 | 28.76% (306) | haloalkane dehalogenase |
| M. thermoresistible (build 8) | TH_1615 | linB | 5e-17 | 28.72% (289) | POSSIBLE HALOALKANE DEHALOGENASE DHAA (1-CHLOROHEXANE |
| M. vanbaalenii PYR-1 | Mvan_2384 | - | 6e-20 | 27.49% (291) | haloalkane dehalogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3052|M.ulcerans_Agy99 -----MGRQFTPDFTPDP-----KLYPFASRWFDSSRG-----RLHYIDE
MMAR_2710|M.marinum_M -----MGRQFTPDFTPDP-----KLYPFASRWFDSSRG-----RLHYIDE
Mb1864c|M.bovis_AF2122/97 ---------MSIDFTPDP-----QLYPFESRWFDSSRG-----RIHYVDE
Rv1833c|M.tuberculosis_H37Rv ---------MSIDFTPDP-----QLYPFESRWFDSSRG-----RIHYVDE
MSMEG_6314|M.smegmatis_MC2_155 ---------MQTLRTPDERFAQLPEFPYAPMYCDIDDGEGGRLRVAWVED
Mvan_2384|M.vanbaalenii_PYR-1 ---------MDILRTPDERFADLPDFPFAPHYVEVDG-----LRMHYLDE
MAV_2130|M.avium_104 MPVHAEELNMHVLRTPDSRFENLEDYPFVAHYLDVTARDTRPLRMHYLDE
TH_1615|M.thermoresistible__bu ---------MPGSKPYGE-----------PRFREIKNK-----RMAYIDE
Mflv_4848|M.gilvum_PYR-GCK -------------------------MTVVHHRIDTVDG----HQVFYREA
MAB_2289|M.abscessus_ATCC_1997 --MGVAAHQQIYRPVSGHGGAMSLGLEKHRRSVDIERG-----RISYLDI
: :: : :
MUL_3052|M.ulcerans_Agy99 S--DGPPILLCHGNPTWSFLYRHIIVALRDH-FRCIAPDYLGFGLSE--H
MMAR_2710|M.marinum_M G--DGPPILLCHGNPTWSFLYRHIIVALRDH-FRCIAPDYLGFGLSE--H
Mb1864c|M.bovis_AF2122/97 G--TGPPILLCHGNPTWSFLYRDIIVALRDR-FRCVAPDYLGFGLSE--R
Rv1833c|M.tuberculosis_H37Rv G--TGPPILLCHGNPTWSFLYRDIIVALRDR-FRCVAPDYLGFGLSE--R
MSMEG_6314|M.smegmatis_MC2_155 GPAHAEPVLLLHGEPSWSFLYRKMIPILVAAGHRVICPDLVGFGRSD--K
Mvan_2384|M.vanbaalenii_PYR-1 GPADGPVVLLLHGEPSWSYLYRRMIPVLVDAGLRAVAIDLVGFGRSD--K
MAV_2130|M.avium_104 GPIDGPPIVLLHGEPTWSYLYRTMITPLTDAGNRVLAPDLIGFGRSD--K
TH_1615|M.thermoresistible__bu G--EGDAIVFQHGNPTSSYLWRNVLPHLEGL-GRLVACDLIGMGGSEKLS
Mflv_4848|M.gilvum_PYR-GCK GDPDAPVIVLLHGFPTSSFMFRNLIPELADR-YRVIAPDYLGFGYSDAPT
MAB_2289|M.abscessus_ATCC_1997 G--AGSPTVFVHGVLTNSLLWRDVVTAVAATGRRCIALDLPGHGHSP--V
. . :: ** : * ::* :: : * :. * * * *
MUL_3052|M.ulcerans_Agy99 PGTFG-YKVDEHAQVV-GEFVDHLGLDNYLTMGQDWGGPISMAVAVERAE
MMAR_2710|M.marinum_M PGTFG-YKVDEHAQVV-GEFVDHLGLDNYLTMGQDWGGPISMAVAVERAE
Mb1864c|M.bovis_AF2122/97 PSGFG-YQIDEHARVI-GEFVDHLGLDRYLSMGQDWGGPISMAVAVERAD
Rv1833c|M.tuberculosis_H37Rv PSGFG-YQIDEHARVI-GEFVDHLGLDRYLSMGQDWGGPISMAVAVERAD
MSMEG_6314|M.smegmatis_MC2_155 PTRIEDHTYARHVEWMRSLVFDALDLRKVTLVGQDWGGLIGLRLAAEHPD
Mvan_2384|M.vanbaalenii_PYR-1 PTRREDYTYQAHVDWT-WAAIEAIGLTGITLVCQDWGGLIGLRLVGEHPD
MAV_2130|M.avium_104 PSRIEDYSYQRHVDWV-VSWFEHLNLSDVTLFVQDWGSLIGLRIAAEQPD
TH_1615|M.thermoresistible__bu PSGPDRYHYGEHRDYLFALWEELELGDRVVLVLHDWGSVLGFDWANHHRD
Mflv_4848|M.gilvum_PYR-GCK VEDFD-YTFDALTDSV-AGLLTQLGIRRYAIYVQDYGAPVGWRLALRDPA
MAB_2289|M.abscessus_ATCC_1997 PADGIDVTLSGLAQLI-AEFLDSIGIDEFDLVANDTGGAVAQIMVARQPD
:* *. :. . .
MUL_3052|M.ulcerans_Agy99 RVRGIVLGNTWFWPADTL-----TMKAFSTVMSSLPMQYAILHHNFFVER
MMAR_2710|M.marinum_M RVRGIVLGNTWFWPADTL-----TMKAFSTVMSSLPMQYAILHHNFFVER
Mb1864c|M.bovis_AF2122/97 RVRGVVLGNTWFWPADTL-----AMKAFSRVMSSPPVQYAILRRNFFVER
Rv1833c|M.tuberculosis_H37Rv RVRGVVLGNTWFWPADTL-----AMKAFSRVMSSPPVQYAILRRNFFVER
MSMEG_6314|M.smegmatis_MC2_155 RFANIVVANTGLPTGDIP-----MPDIWWQFRN-----AIQKAPKVDVGR
Mvan_2384|M.vanbaalenii_PYR-1 RFARVVAANTTLPTGDQR-----PGEAFLAWQR-----FSQETPDFAVGH
MAV_2130|M.avium_104 RVGRLVVANGFLPTAQRR-----TPPAFYAWRA-----FARYSPVLPAGR
TH_1615|M.thermoresistible__bu RVQGIAHMESIVTPLTWADW-EDPARSVFQGLRTPEGERMVLEENIFVEA
Mflv_4848|M.gilvum_PYR-GCK AITAIITQNGNGYNDGFVAEGWQPAWDYQREQTPETEAALRGILTFETTR
MAB_2289|M.abscessus_ATCC_1997 RIRTLALTN-CDTEGHVPPKLFKPVVALARPPLMALIGPRLFARRKVLRA
. : :
MUL_3052|M.ulcerans_Agy99 LIPAGTTH--RPSSAVMEHYRGVQPTA-SARVGVAEMPKQILAARPLLAR
MMAR_2710|M.marinum_M LIPAGTTH--RPSSAVMEHYRGVQPTA-SARVGVAEMPKQILAARPLLAR
Mb1864c|M.bovis_AF2122/97 LIPAGTEH--RPSSAVMAHYRAVQPNA-AARRGVAEMPKQILAARPLLAR
Rv1833c|M.tuberculosis_H37Rv LIPAGTEH--RPSSAVMAHYRAVQPNA-AARRGVAEMPKQILAARPLLAR
MSMEG_6314|M.smegmatis_MC2_155 FVASGCRR--PLSDGVIAAYDAPFPDD-SYCAGPRAMPGLVPTSPDDPAA
Mvan_2384|M.vanbaalenii_PYR-1 IVNGGCVS--TLAPEVIAAYDAPFPDD-SYKAGARQFPTLVPTSPDDPAA
MAV_2130|M.avium_104 IVSVGTVR--RVSSKVRAGYDAPFPDK-TYQAGARAFPQLVPTSPADPAI
TH_1615|M.thermoresistible__bu MLPRGVHR--TLSDEEMAHYREPFRDRGEGRRPTLTWPRNVPIDGEPADV
Mflv_4848|M.gilvum_PYR-GCK MQYTAGVP--DPSVVSPDTWHHDFALLSRPGNDRIQLKLFLDYSTNPKIY
MAB_2289|M.abscessus_ATCC_1997 LLGAGYRKPGRLPDSIVESYGQPVFGT----AESSRFLSKMLRAMHTRDL
: . . : :
MUL_3052|M.ulcerans_Agy99 LASEVPAQLG----TKPALLVWGMKDFAFR-PEPMLARMRAVFADHILVE
MMAR_2710|M.marinum_M LASEVPAQLG----TKPALLVWGMKDFAFR-PEPMLARMRAVFADHVLVE
Mb1864c|M.bovis_AF2122/97 LAREVPATLG----TKPTLLIWGMKDVAFR-PKTIIPRLSATFPDHVLVE
Rv1833c|M.tuberculosis_H37Rv LAREVPATLG----TKPTLLIWGMKDVAFR-PKTIIPRLSATFPDHVLVE
MSMEG_6314|M.smegmatis_MC2_155 EANRAAWKVLRAS-KTPMLVAFSDGDPITGGMAPIFKKEMRGAHGIEHPV
Mvan_2384|M.vanbaalenii_PYR-1 PANRAAWEVLRTF-DRPFLCAFSDSDPITRGADAPLRKFIPGAQGRPEVT
MAV_2130|M.avium_104 PANRKAWEALGRW-EKPFLAIFGARDPILGHADSPLIKHIPGAAGQPHAR
TH_1615|M.thermoresistible__bu AAIVADYAVWLAEGDVPKLFVNAEPGAIVRGRVRDFVRSWPNQTEIT---
Mflv_4848|M.gilvum_PYR-GCK PALHDYLRAS----GVPLLAVWGDKDPFFG---PDGARAFAKDAVDSEIH
MAB_2289|M.abscessus_ATCC_1997 EAARAGLVTF----TKPTLIAWGLGDYFFPLKYGQRLAELFGGPVTFETV
* * * . .
MUL_3052|M.ulcerans_Agy99 LPEAKHLIQEDAPDEIAAAIIARFG------------
MMAR_2710|M.marinum_M LPEAKHFIQEDAPDEIAAAIIARFG------------
Mb1864c|M.bovis_AF2122/97 LPNAKHFIQEDAPDRIAAAIIERFG------------
Rv1833c|M.tuberculosis_H37Rv LPNAKHFIQEDAPDRIAAAIIERFG------------
MSMEG_6314|M.smegmatis_MC2_155 ISGAGHFLQEDAGEDLASAVVEFLRDR----------
Mvan_2384|M.vanbaalenii_PYR-1 IAGGGHFLQEDKGPELAAVVVDFIAANPV--------
MAV_2130|M.avium_104 IN-ASHFIQEDRGPELAERILSWQQALL---------
TH_1615|M.thermoresistible__bu -VAGRHYIQEDSPDEIGAAIADFVRKLRG--------
Mflv_4848|M.gilvum_PYR-GCK LIDGGHFLLESELTRVANLIRDFLERRL---------
MAB_2289|M.abscessus_ATCC_1997 PDGRLYFPDEDADRLLPLLYRHWHSAGRQESSTEVGS
: *. :