For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VDRSEEPGGKIDASALTRVSETALLTLYGRAYQGRHQQAILNDPMAIRLVDSIEFDFEKFGRKGQEMALR SLAFDRAALAYLSAQPRATVVALAEGLQTTFWRLTDALPDAEFHWLTVDFQPIIDLRRRLLPADPRITCL AQSALDYSWMDQVDTGDGVFITAEGLLMYLEPEESMGLIKQCANRFAGGQMVFDLPPVVVKKFAKKGLRS SKRYRVPPMPFSLTPNQLQDLARTVPGIRAVHDLPMPAGRGFLFEKVFPAFWQFKPTKQIRGAYTLLELG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6661 | - | - | 100% (280) | O-methyltransferase, putative |
| M. smegmatis MC2 155 | MSMEG_5173 | - | 8e-86 | 59.55% (267) | O-methyltransferase, putative |
| M. smegmatis MC2 155 | MSMEG_6473 | - | 1e-24 | 33.52% (182) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 1e-81 | 57.58% (264) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_5259 | - | 1e-117 | 78.57% (266) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 7e-83 | 58.33% (264) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1295c | - | 4e-69 | 48.03% (279) | O-methyltransferase OMT |
| M. marinum M | MMAR_2733 | omt | 1e-103 | 65.80% (269) | O-methyltransferase Omt |
| M. avium 104 | MAV_2991 | - | 1e-24 | 34.09% (220) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. thermoresistible (build 8) | TH_0783 | omt | 1e-119 | 75.28% (271) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_3020 | omt | 1e-100 | 64.55% (268) | O-methyltransferase Omt |
| M. vanbaalenii PYR-1 | Mvan_0979 | - | 1e-119 | 75.82% (273) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1184c|M.bovis_AF2122/97 -------MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDTIIDDPMA
Rv1153c|M.tuberculosis_H37Rv -------MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPMA
Mflv_5259|M.gilvum_PYR-GCK ------------------MLAGVSETALLTLNGRAYQARHPNAILDDPMA
Mvan_0979|M.vanbaalenii_PYR-1 --------MDQDGKIDAGALAGVSETALLTLNGRAYQARHPNAIIDDPMA
MSMEG_6661|M.smegmatis_MC2_155 ----MDRSEEPGGKIDASALTRVSETALLTLYGRAYQGRHQQAILNDPMA
TH_0783|M.thermoresistible__bu ------VHESNPDKLDASTLSGVSETALMTLYGRAEQARHPQPIIDDPMA
MMAR_2733|M.marinum_M -------MGHSDNDANARMLGGVSETALLTLNGRAHQAAKPNPIIDDPMA
MUL_3020|M.ulcerans_Agy99 -------MGHSDNNVNAGMLGGVSETALLTLNGRAHQAAKPNPIIDDPMA
MAB_1295c|M.abscessus_ATCC_199 MTESDALRPSGSSRISGDSLEGVSATTLWTLHNRGTEAKRPDSVIRDPLA
MAV_2991|M.avium_104 ------MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAA
*. * * ** *. :. :.:: *. *
Mb1184c|M.bovis_AF2122/97 VALVESIDFGFAKFGP------TGQGFALRARAFDMAAQHYLDQHPAATV
Rv1153c|M.tuberculosis_H37Rv VALVESIDFDFAKFGP------TGQGFALRARAFDMAAQHYLDQHPAATV
Mflv_5259|M.gilvum_PYR-GCK IRVVDSIDFDFDKFGRR-----KGQEMALRSLAFDRAATAYLAKHPKATV
Mvan_0979|M.vanbaalenii_PYR-1 IRLVDAIDFDFDKFGRR-----KGQEMALRSLAFDRAATRYLSRHPAATV
MSMEG_6661|M.smegmatis_MC2_155 IRLVDSIEFDFEKFGR------KGQEMALRSLAFDRAALAYLSAQPRATV
TH_0783|M.thermoresistible__bu VRLVDRIDFDFTKFGR------RGQEMALRSLAFDRAALRYLSDHPRATV
MMAR_2733|M.marinum_M IKLVESIDFDFEKFGR------RGQEMALRSLAVDRCEIAYLTKHPGATV
MUL_3020|M.ulcerans_Agy99 IKLVESNDFDFEKFGR------RGQEMALRSLAVDRCEIAYLTKHPGATV
MAB_1295c|M.abscessus_ATCC_199 AELFDAIEYDYRKFGR------PSQTHALRALAFDTQARVYLATHPRAAI
MAV_2991|M.avium_104 AEAVDRIRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDAVV
.: :.: :: ***: .* :* :* *.:
Mb1184c|M.bovis_AF2122/97 VALAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVC
Rv1153c|M.tuberculosis_H37Rv VALAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVC
Mflv_5259|M.gilvum_PYR-GCK VALAEGLQTSFWRLDAALPTAEFRWLTVDFEPIIELRRRLLPESARITTL
Mvan_0979|M.vanbaalenii_PYR-1 VALAEGLQTSFWRLDAAIPDSRFRWVSIDLEPVIALRRRLLPDSPRITTL
MSMEG_6661|M.smegmatis_MC2_155 VALAEGLQTTFWRLTDALPDAEFHWLTVDFQPIIDLRRRLLPADPRITCL
TH_0783|M.thermoresistible__bu VALAEGLQTTFWRVTDAIPDARFRWLTIDLPPIIELRERLLPAEPRIVTL
MMAR_2733|M.marinum_M VALAEGFQTGFWRVSNALPDTQFRWVSLDLEPVMELRRRLLPDSARVTNL
MUL_3020|M.ulcerans_Agy99 VAHAEGFQTGFWRVSNALPDTQFRWVSLDLEPVMELRRRLLPDSARVTNL
MAB_1295c|M.abscessus_ATCC_199 VALAEGMQTSFWRLGGADATAQFTWYSVDLPPVMELRNQLLPNDERIVKL
MAV_2991|M.avium_104 LHLGCGLDGRAFRVSVPPS---LSWFDVDQPSVIGLRRRLYDDTENYRMI
: . *:: :*: . . : * :* .:: ** :* .
Mb1184c|M.bovis_AF2122/97 AQSALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQ
Rv1153c|M.tuberculosis_H37Rv AQSALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQ
Mflv_5259|M.gilvum_PYR-GCK AQSALDYSWMDAVDTTHGVFITAEGLLMYLQPEESMGLITECAARFPGAQ
Mvan_0979|M.vanbaalenii_PYR-1 AQSALDYSWMDAVDTTDGVFITAEGLLMYLQPDEAMDLITACASRFPGGQ
MSMEG_6661|M.smegmatis_MC2_155 AQSALDYSWMDQVDTGDGVFITAEGLLMYLEPEESMGLIKQCANRFAGGQ
TH_0783|M.thermoresistible__bu AQSALDFSWMDRVDTDHGVLITAEGLLMYLQPDEAMTLIERCAARFPGGQ
MMAR_2733|M.marinum_M AQSALDYTWMDKVDSRAGVFITAEGLLMYLQPNQAMELISQCAKRFAGGQ
MUL_3020|M.ulcerans_Agy99 AQSALDYTWMDKVDSCAAVFITAEGLLMYPQPNQAMELISQCAKRFAGGQ
MAB_1295c|M.abscessus_ATCC_199 AQSALDLSWMDQVDASGGAFITAEGLLMYLQPEESLGLIEACAKRFPGGQ
MAV_2991|M.avium_104 GSSVTELQWLDEVPAGRPTLMVAEGLLMYLREDEVRRLLQRLIDRFPGGE
..*. : *:* * . .::.******* . :: *: *.*.:
Mb1184c|M.bovis_AF2122/97 MLFDLPPRWFAGWSRLGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVA
Rv1153c|M.tuberculosis_H37Rv MLFDLPPRWFAGWSRLGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVA
Mflv_5259|M.gilvum_PYR-GCK MIFDLPPVMVKKFAPKGVRSSSRYRVPPMPFSLSAAELADLVHTVPGVRA
Mvan_0979|M.vanbaalenii_PYR-1 MIFDLPPTMVKKIAPKGMRSSARYRVPPMPFSLSPAQLAELVHTVPGVTA
MSMEG_6661|M.smegmatis_MC2_155 MVFDLPPVVVKKFAKKGLRSSKRYRVPPMPFSLTPNQLQDLARTVPGIRA
TH_0783|M.thermoresistible__bu MLFDLPPVLLKKLAPKGLRASRRYRVPPMPFSLSPAQLARLADTVPGVRA
MMAR_2733|M.marinum_M MFFDLPPTIVKRVAPKGMRASRRYRVPPMPFSLSVNQLARLVDSVPGIRA
MUL_3020|M.ulcerans_Agy99 MFFDLPPTIVKRVAPKGMRASRRYRVPPMPFSLSVNQLARLVDTVPGIRA
MAB_1295c|M.abscessus_ATCC_199 MMFDSIPHWFSRRTLQGFKLSDRYVAPPMPFALTPDEGEALIS-IPGVVT
MAV_2991|M.avium_104 MHFDTLSALAPLLSKVFTRG---------IITWGIRDARRIADWNPRLRF
* ** . : : :: : : * :
Mb1184c|M.bovis_AF2122/97 VRDLRVPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG
Rv1153c|M.tuberculosis_H37Rv VRDLRVPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG
Mflv_5259|M.gilvum_PYR-GCK VHDLPMPQGRGFFFEKVFPAFWGLKATKNYRGAYTLLEFG-----
Mvan_0979|M.vanbaalenii_PYR-1 VHDLPMPRGRGFLFERVFPAFWQFKPTRNYRGAYTLLEFG-----
MSMEG_6661|M.smegmatis_MC2_155 VHDLPMPAGRGFLFEKVFPAFWQFKPTKQIRGAYTLLELG-----
TH_0783|M.thermoresistible__bu VHDLPMPEGRGFFFRAVFPRFWQARPTRQWRGAYTLLEFG-----
MMAR_2733|M.marinum_M VHDVPMPEGRGLFFKTLYPALWRFPPIKPFRGAYVLLEFG-----
MUL_3020|M.ulcerans_Agy99 VHDVPMPEGRGLFFRTLYPALWRFPPIKPFRGAYVLLEFD-----
MAB_1295c|M.abscessus_ATCC_199 AIDIPLHRGRG-IWKFVNSKRLDRGFLRRTRPSMTLLQFG-----
MAV_2991|M.avium_104 LEQSPALAGYQRIPSTVVRSIYRLTWLTGGRGYDVLNRFEY----
: * * .* .: