For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TLNQLRAFVEAHRLGSFTAAADALAVAQASVSELVRRLEEELDAQLFVRGSRRLALTAAGQELLPYAEQA VHAADGGVHAVRSLGSLGGGTATFGMPRNADYYLLSSLVQTFHMRYPAVRVRLVGQNSAETAAAIQAGEI EAGMLILPIDDEDLTVRPLLRDEVFYVTADPARAAEPVTIQQFSEADLVLYDAHYGWKDPTRRQLAERAQ LAGLRLEPMIEIEHVEAALKLAAGKVGDTIASGAVIDSDAFPAALHTAPFAEPLYDVIALAQHRARPLSN ATREFARLAEDTIRELHIPSALSGPDEVAPLIARRGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5657 | - | - | 100% (318) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_5654 | - | 7e-20 | 29.15% (247) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_3840 | - | 3e-18 | 26.60% (312) | LysR-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2303c | - | 6e-07 | 23.11% (264) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1346 | - | 1e-18 | 29.46% (241) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2282c | - | 6e-07 | 23.11% (264) | LysR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02041 | oxyR | 3e-21 | 28.20% (305) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2238 | - | 9e-22 | 30.59% (304) | LysR family transcriptional regulator |
| M. marinum M | MMAR_2756 | oxyR | 1e-21 | 27.82% (266) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_2838 | - | 2e-19 | 26.49% (302) | hydrogen peroxide-inducible genes activator |
| M. thermoresistible (build 8) | TH_3504 | - | 2e-12 | 26.69% (236) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 8e-22 | 27.44% (266) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_4734 | - | 6e-15 | 32.29% (192) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1346|M.gilvum_PYR-GCK ---------------MKLRHLRYFRAVAEELHFGRAAQRLLIAQPPLSQQ
Mvan_4734|M.vanbaalenii_PYR-1 ---------------MELRQLEAFVAVAGELHFGRAAEKLHIGQPTLSEL
MLBr_02041|M.leprae_Br4923 --------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQA
MAV_2838|M.avium_104 --------MPDKTYQPTIAGLRAFVAVAEKRQFSGAATALGVSQSTLSQA
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
Mb2303c|M.bovis_AF2122/97 --------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRR
Rv2282c|M.tuberculosis_H37Rv --------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRR
MAB_2238|M.abscessus_ATCC_1997 ---------------MEIHQLRYLLAVADTSSFTKAAAALHVAQPGVSAQ
MSMEG_5657|M.smegmatis_MC2_155 ---------------MTLNQLRAFVEAHRLGSFTAAADALAVAQASVSEL
TH_3504|M.thermoresistible__bu ----------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSA
: : : : ** * : * :*
Mflv_1346|M.gilvum_PYR-GCK IRQLEREVGADLLRRTTRSVELTEAGRAFLERTVRILDAVDDAVDQARRI
Mvan_4734|M.vanbaalenii_PYR-1 IRRLEREVGTPLLTRTTRRVALTQAGVELFGRAKVILDDVEGAAAAVRRL
MLBr_02041|M.leprae_Br4923 LAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGE
MAV_2838|M.avium_104 LAALEAGLGTQLVERSTRRVFLTPQGAELLPHAQAVVEAADAFTAAAAGS
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
Mb2303c|M.bovis_AF2122/97 LASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSL
Rv2282c|M.tuberculosis_H37Rv LASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSL
MAB_2238|M.abscessus_ATCC_1997 IRLLERELGQDLFDRSGRQVRLTDAGKAVIPYARAALAAVDGVREAADEI
MSMEG_5657|M.smegmatis_MC2_155 VRRLEEELDAQLFVRGSRRLALTAAGQELLPYAEQAVHAADGGVHAVRSL
TH_3504|M.thermoresistible__bu VRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT
: :* :. * * * :* * . :
Mflv_1346|M.gilvum_PYR-GCK GTGAEGRLVVGCVGSATYSLLPRLVRELRAALP----AVDLRVRGEMLAP
Mvan_4734|M.vanbaalenii_PYR-1 ADGEAGTVRLGITPPVAPVLAPHLSQALHSAAP----DVQLVVQ-RMWLP
MLBr_02041|M.leprae_Br4923 SDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLP----TLTLRVV-EDQTE
MAV_2838|M.avium_104 ADPLRAGMRLGLIPTVAPYVLPTVLAGIAERRP----GLTLRVT-EDQTE
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLP----TLTVRVI-EDQTE
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLP----TLTVRVI-EDQTE
Mb2303c|M.bovis_AF2122/97 RTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSE
Rv2282c|M.tuberculosis_H37Rv RTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSE
MAB_2238|M.abscessus_ATCC_1997 GGLIRGHIAFGTVTSHGADLS-SLLSAFHRDHP----AISITLT-EAGCE
MSMEG_5657|M.smegmatis_MC2_155 GSLGGGTATFGMPRNADYYLLSSLVQTFHMRYP----AVRVRLV-GQNSA
TH_3504|M.thermoresistible__bu EAAAQAHYVIGHTPALSGAEAYALIEPAVTAYP----STSFTLR-QLYPD
. :
Mflv_1346|M.gilvum_PYR-GCK EQLAALHAKDIDLALMRPPVDDP-ALTAVSLRRDRLLVALPAGHRCADRD
Mvan_4734|M.vanbaalenii_PYR-1 DLQRAIGDGELDVAITCGPVADPPGILSEVFCAEPVMVGLRADHHLAGRD
MLBr_02041|M.leprae_Br4923 HLLTALREGALDAAMIALPVETA-GIAEIPIYDEDFVLALPPGHPLSGKR
MAV_2838|M.avium_104 RLLAVLREGALDAALIALPAETA-GVTAIPIYDEDFVLALPPGHPLAGKR
MMAR_2756|M.marinum_M RLLTALREGSLDTALIALPADYG-GLTEIPIYEEDFVLALPPGHPMADRH
MUL_2998|M.ulcerans_Agy99 RLLTALREGSLDTALIALPADYG-GLTEIPIYEEDFVLALPPGHPMADRH
Mb2303c|M.bovis_AF2122/97 HAIAAVRDGIADLGFIENPCPPT-GLGSVVVARDELVVVVPPGHKWARRS
Rv2282c|M.tuberculosis_H37Rv HAIAAVRDGIADLGFIENPCPPT-GLGSVVVARDELVVVVPPGHKWARRS
MAB_2238|M.abscessus_ATCC_1997 ELVAGLREGRLDGAIVALGAQRLAGLGLQVIDDQPLVAAVAADDLLATRR
MSMEG_5657|M.smegmatis_MC2_155 ETAAAIQAGEIEAGMLILPIDDE-DLTVRPLLRDEVFYVTADPARAAEPV
TH_3504|M.thermoresistible__bu ALTDAVFDGTVQLGLRRGVVPTP-ELATAVIGYHRVRVAFVDSHPLAARE
: : .: : . . . :
Mflv_1346|M.gilvum_PYR-GCK EVSLADLRDEDFISHAGGGRSRMSALLAALCADAGFSP------------
Mvan_4734|M.vanbaalenii_PYR-1 AVELRNLSTETIGVHSEALFPAWSLALRQVLDDTGIRPPAVEFTDTDLAA
MLBr_02041|M.leprae_Br4923 RVPTTALAQLPLLLLDEG--HCLRDQTLDICRKSGVQAELAN--------
MAV_2838|M.avium_104 RVPATALADLPLLLLDEG--HCLRDQALDVCHKAGVRAELAN--------
MMAR_2756|M.marinum_M GVPVAALSELPLLLLDEG--HCLRDQALDVCQNAGVRAELAD--------
MUL_2998|M.ulcerans_Agy99 GVPVAALSELPLLLLDEG--HCLRDQALDVCQNAGVRAEHAD--------
Mb2303c|M.bovis_AF2122/97 RVVSARELAQTPLVTREPNSGIRDSLTAALRDTLGEDMQQAP--------
Rv2282c|M.tuberculosis_H37Rv RVVSARELAQTPLVTREPNSGIRDSLTAALRDTLGEDMQQAP--------
MAB_2238|M.abscessus_ATCC_1997 TITLQRLCEHTLICLPTG--SGVRSILESECRSLGLSPNVAF--------
MSMEG_5657|M.smegmatis_MC2_155 TIQQFSEADLVLYDAHYGWKDPTRRQLAERAQLAGLRLEPMI--------
TH_3504|M.thermoresistible__bu SVDITELAREQVALWAPPGTSYYSDFLMGACRRAGFEPDYVVS-------
: *
Mflv_1346|M.gilvum_PYR-GCK ---RIRDEVDETSTLVTLVAGGLGVALVPEPTAALEIGG--VTYRPLAAK
Mvan_4734|M.vanbaalenii_PYR-1 YRWPIQSEVDWVLTTAAVAGDSAGVVLRPTSPAHFVPYT--LQWCPIRAT
MLBr_02041|M.leprae_Br4923 ------TRAASLATAVQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAAP
MAV_2838|M.avium_104 ------TRAASLATAVQCVTGGLGVTLIPQSAVPVEASRSRLGLAQFAAP
MMAR_2756|M.marinum_M ------TRAASLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLAHFAAP
MUL_2998|M.ulcerans_Agy99 ------TRADSLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLTHFAAP
Mb2303c|M.bovis_AF2122/97 ----PVLELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFG--RLLAVDIP
Rv2282c|M.tuberculosis_H37Rv ----PVLELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFG--RLLAVDIP
MAB_2238|M.abscessus_ATCC_1997 -------EASSPRALVSLVEQGLGIAVVPAPYVRNRAGVLALDIRPALRG
MSMEG_5657|M.smegmatis_MC2_155 -------EIEHVEAALKLAAGKVGDTIASGAVIDSDAFPAALHTAPFAEP
TH_3504|M.thermoresistible__bu -------RVQGAATVAAPLTTG-GIAFVTAAAGPTMNGR--VQVVDLTPP
. : * . .
Mflv_1346|M.gilvum_PYR-GCK AGATIELLAVYRSADASPLTAKVVDVLRATV-------------------
Mvan_4734|M.vanbaalenii_PYR-1 TVAVGRFVRLALSVDVPPGWVSQPDHLRHGAGSLLED-------------
MLBr_02041|M.leprae_Br4923 CPGRRIGLAFRSASGRSASYRQIAKIIGELISTEHHVRLVA---------
MAV_2838|M.avium_104 RPGRRIGLVFRSSSGRDDSYRELAGLIGELISSQHQVRLVK---------
MMAR_2756|M.marinum_M TPGRRIGLVYRASSGRDEAYRQLAAIMGESISNEQQVRLVN---------
MUL_2998|M.ulcerans_Agy99 TPGRRIGLVYRASSGRDEAYRQLAAIMGESISNEQQVRLVN---------
Mb2303c|M.bovis_AF2122/97 ALNLRRQLRAIWVGGRTPPAGAIRDLLSHITSRST---------------
Rv2282c|M.tuberculosis_H37Rv ALNLRRQLRAIWVGGRTPPAGAIRDLLSHITSRST---------------
MAB_2238|M.abscessus_ATCC_1997 ----RLALAWRLDGPVGPAARAFLERARAVL-------------------
MSMEG_5657|M.smegmatis_MC2_155 -LYDVIALAQHRARPLSNATREFARLAEDTIRELHIPSALSGPDEVAPLI
TH_3504|M.thermoresistible__bu LLVPVQALWQR------HTLSAIRDRILEGLG------------------
:
Mflv_1346|M.gilvum_PYR-GCK -----
Mvan_4734|M.vanbaalenii_PYR-1 -----
MLBr_02041|M.leprae_Br4923 -----
MAV_2838|M.avium_104 -----
MMAR_2756|M.marinum_M -----
MUL_2998|M.ulcerans_Agy99 -----
Mb2303c|M.bovis_AF2122/97 -----
Rv2282c|M.tuberculosis_H37Rv -----
MAB_2238|M.abscessus_ATCC_1997 -----
MSMEG_5657|M.smegmatis_MC2_155 ARRGR
TH_3504|M.thermoresistible__bu -----