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MRHLRCFVVLAEELHFGRAAQRLHVAQPALSQLIQRVERELGAQLFLRTRRTVSLTEAGQTLLPEARRIL RDADRVTQAVRAVHRGETGSVTIGFVGSAADDVLPRLVAAHRRHHPGVSIRLEEGTTAQQLEWLRDQRIT VGLGRTPIDDPAVSTVVLARESLVLAVPDSHALSGAESAELAGLAEEPFIMFPRHLGPGLYDIIHSACAA AGFTPSVVYETVRMQTIVGLVSGGLGVALVPESVRNLGRKGVRYVHLADAPPAIELSMMWRNDCESPHLQ PLRKTARHL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5654 | - | - | 100% (289) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_6125 | - | 7e-48 | 39.50% (281) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_1895 | - | 1e-47 | 40.82% (267) | HTH-type transcriptional regulator AlsR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 8e-16 | 29.39% (245) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_1346 | - | 6e-51 | 43.97% (282) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 8e-16 | 29.39% (245) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02041 | oxyR | 4e-26 | 30.71% (241) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3208c | - | 2e-35 | 36.26% (273) | LysR family transcriptional regulator |
| M. marinum M | MMAR_2756 | oxyR | 4e-29 | 31.00% (271) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_1538 | - | 7e-35 | 31.67% (281) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 3e-24 | 29.30% (273) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 2e-28 | 31.00% (271) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_1027 | - | 2e-49 | 38.79% (281) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1346|M.gilvum_PYR-GCK ---------------MKLRHLRYFRAVAEELHFGRAAQRLLIAQPPLSQQ
Mvan_1027|M.vanbaalenii_PYR-1 --------------MFSLARLSCFVAVAEELHFGRAAERLHMTQPPLSRQ
MSMEG_5654|M.smegmatis_MC2_155 -----------------MRHLRCFVVLAEELHFGRAAQRLHVAQPALSQL
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MLBr_02041|M.leprae_Br4923 --------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQA
Mb0121|M.bovis_AF2122/97 ---------------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSA
Rv0117|M.tuberculosis_H37Rv ---------------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSA
MAB_3208c|M.abscessus_ATCC_199 ---------------MELRQLEYFLAVAEHANFTRAAEALHVAQPWVSAQ
MAV_1538|M.avium_104 ---------------MAVGDYEWFITLAELQHVTAAAEQLHVAQPTLTRM
TH_3504|M.thermoresistible__bu ----------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSA
. * .:.: . ** : * ::
Mflv_1346|M.gilvum_PYR-GCK IRQLEREVGADLLRRTTRSVELTEAGRAFLERTVRILDAVDDAVDQARRI
Mvan_1027|M.vanbaalenii_PYR-1 VQQLENELGVQLIDRTTRNVTLTPAGAAFLPDARRILQLAEGAAQTVKRI
MSMEG_5654|M.smegmatis_MC2_155 IQRVERELGAQLFLRTRRTVSLTEAGQTLLPEARRILRDADRVTQAVRAV
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MLBr_02041|M.leprae_Br4923 LAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGE
Mb0121|M.bovis_AF2122/97 IAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAV
Rv0117|M.tuberculosis_H37Rv IAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAV
MAB_3208c|M.abscessus_ATCC_199 VRRLERELGNELFDRSSRVLRLTEFGKALLPLAGAALRTVGEIRSAADAM
MAV_1538|M.avium_104 LARLEQRLGVALFDRHGRRLSLNTYGRIFYEHARRAQLELDSARRAIADL
TH_3504|M.thermoresistible__bu VRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT
: :* :. *. * :. * :
Mflv_1346|M.gilvum_PYR-GCK GTGAEGRLVVGCVGSATYSLLPRLVRELRAALPAVDLRVRGEMLAPEQLA
Mvan_1027|M.vanbaalenii_PYR-1 PAGDLGTVVVGFTAASAHAVLPRLLERARERLPDVKLDLR-EMVTAAQIE
MSMEG_5654|M.smegmatis_MC2_155 HRGETGSVTIGFVGSAADDVLPRLVAAHRRHHPGVSIRLE-EGTTAQQLE
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVI-EDQTERLLT
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVI-EDQTERLLT
MLBr_02041|M.leprae_Br4923 SDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLPTLTLRVV-EDQTEHLLT
Mb0121|M.bovis_AF2122/97 RSGITGTLRLGTVPTAS-TTASLVLSAFCSAHPLAKVQVCSRLAATELYR
Rv0117|M.tuberculosis_H37Rv RSGITGTLRLGTVPTAS-TTASLVLSAFCSAHPLAKVQVCSRLAATELYR
MAB_3208c|M.abscessus_ATCC_199 AGVLCGQLAIGTVPHPS-PLLAEALAAYRRAHPAVTVTLT-EARSDQLAT
MAV_1538|M.avium_104 ADPAVGEIRLAYLSSFGSTVVPRLIARFKESSPRVTFTLE-EGAAESIAD
TH_3504|M.thermoresistible__bu EAAAQAHYVIGHTPALSGAEAYALIEPAVTAYPSTSFTLR-QLYPDALTD
. .. : * . : . .
Mflv_1346|M.gilvum_PYR-GCK ALHAKDIDLALMRPPVDDPA-LTAVSLRRDRLLVALPAGHRCADRD-EVS
Mvan_1027|M.vanbaalenii_PYR-1 GLMTGELDLGMARPPLKRPG-LVSRPLLHEQLLAALPEGHPLADMTRELT
MSMEG_5654|M.smegmatis_MC2_155 WLRDQRITVGLGRTPIDDPA-VSTVVLARESLVLAVPDSHALSGAE-SAE
MMAR_2756|M.marinum_M ALREGSLDTALIALPADYGG-LTEIPIYEEDFVLALPPGHPMADRH-GVP
MUL_2998|M.ulcerans_Agy99 ALREGSLDTALIALPADYGG-LTEIPIYEEDFVLALPPGHPMADRH-GVP
MLBr_02041|M.leprae_Br4923 ALREGALDAAMIALPVETAG-IAEIPIYDEDFVLALPPGHPLSGKR-RVP
Mb0121|M.bovis_AF2122/97 RLREFELDAVIVHPETQDSDDVDLVPLYEEQYVLLSPADMLPPGTS-TLV
Rv0117|M.tuberculosis_H37Rv RLREFELDAVIVHPETQDSDDVDLVPLYEEQYVLLSPADMLPPGTS-TLV
MAB_3208c|M.abscessus_ATCC_199 AVVERRLDMAVMAWLAQPPSQLRERILAKENIVAVVHRDDPLAGRE-SVA
MAV_1538|M.avium_104 RVRSGGVDIGVVSPRPVERT-LAWRSLFRQRLGVAVPDGHRFARGA-AVS
TH_3504|M.thermoresistible__bu AVFDGTVQLGLRRGVVPTPE-LATAVIGYHRVRVAFVDSHPLAARE-SVD
: : : : : . . .
Mflv_1346|M.gilvum_PYR-GCK LADLRDEDFISHAGGGRSRMSALLAALCADAGFSPRIRD-EVDETSTLVT
Mvan_1027|M.vanbaalenii_PYR-1 LIDLDGQDFVMYSPVQARYFNELLISTFTIAGTTPRYVQ-YVTQVHTMLV
MSMEG_5654|M.smegmatis_MC2_155 LAGLAEEPFIMFPRHLGPGLYDIIHSACAAAGFTPSVVY-ETVRMQTIVG
MMAR_2756|M.marinum_M VAALSELPLLLLDEG--HCLRDQALDVCQNAGVRAELADTRAASLATAVQ
MUL_2998|M.ulcerans_Agy99 VAALSELPLLLLDEG--HCLRDQALDVCQNAGVRAEHADTRADSLATAVQ
MLBr_02041|M.leprae_Br4923 TTALAQLPLLLLDEG--HCLRDQTLDICRKSGVQAELANTRAASLATAVQ
Mb0121|M.bovis_AF2122/97 WRDAAQLPLALLTAD---MRDRQVIDAAFADHAVSAIPQVETDSVASLFA
Rv0117|M.tuberculosis_H37Rv WRDAAQLPLALLTAD---MRDRQVIDAAFADHAVSAIPQVETDSVASLFA
MAB_3208c|M.abscessus_ATCC_199 LAELRDRALISHPQG--CEIRTALDQACLATGFTPRVVF-ETSSADMMRH
MAV_1538|M.avium_104 MVDLADEPFVTMHPG--FGMRRLLDELCAAAQFRPRVAL-QAPNLTTAAS
TH_3504|M.thermoresistible__bu ITELAREQVALWAPPGTSYYSDFLMGACRRAGFEPDYVVSRVQGAATVAA
. . .
Mflv_1346|M.gilvum_PYR-GCK LVAGGLGVALVPEP----TAALEIG-GVTYRPLAAKAGATIELLAVYRSA
Mvan_1027|M.vanbaalenii_PYR-1 LVRSGIGIALVPAS----AATLHPE-GVVFRTIGAFRERPVELDAVWRGD
MSMEG_5654|M.smegmatis_MC2_155 LVSGGLGVALVPES----VRNLGRK-GVRYVHLADAP-PAIELSMMWRND
MMAR_2756|M.marinum_M CVNGGLGVTLIPQS----AVSVEAARSRVGLAHFAAPTPGRRIGLVYRAS
MUL_2998|M.ulcerans_Agy99 CVNGGLGVTLIPQS----AVSVEAARSRVGLTHFAAPTPGRRIGLVYRAS
MLBr_02041|M.leprae_Br4923 CVTGGLGVTLLPQS----AAPVESVRSKLGLAQFAAPCPGRRIGLAFRSA
Mb0121|M.bovis_AF2122/97 QVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNAL
Rv0117|M.tuberculosis_H37Rv QVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNAL
MAB_3208c|M.abscessus_ATCC_199 LVVRDLGVAVTPRLP-------REQLGRLRQIDLSDRAMSGRLSLLWRGK
MAV_1538|M.avium_104 LVAAGLGISLVPIDG-------SSYPSGVSVKPLADADAYRDVGMIWDSG
TH_3504|M.thermoresistible__bu PLTTG-GIAFVTAAA-------GPTMNGRVQVVDLTPPLLVPVQALWQRH
: . :. . . :
Mflv_1346|M.gilvum_PYR-GCK DASPLTAKVV-DVLRATV----------------
Mvan_1027|M.vanbaalenii_PYR-1 STNPALLRVLKDVLPQQEWTT-------------
MSMEG_5654|M.smegmatis_MC2_155 CESPHLQPLRKTARHL------------------
MMAR_2756|M.marinum_M SGRDEAYRQLAAIMGESISNEQQVRLVN------
MUL_2998|M.ulcerans_Agy99 SGRDEAYRQLAAIMGESISNEQQVRLVN------
MLBr_02041|M.leprae_Br4923 SGRSASYRQIAKIIGELISTEHHVRLVA------
Mb0121|M.bovis_AF2122/97 GPGSPVARALITCAQALALNEFFDTQLRGITRRR
Rv0117|M.tuberculosis_H37Rv GPGSPVARALITCAQALALNEFFDTQLRGITRRR
MAB_3208c|M.abscessus_ATCC_199 GATLEAVAFAACIDELCRKDANLVS---------
MAV_1538|M.avium_104 RPLPRSARDFIAGAAAVGHGGW------------
TH_3504|M.thermoresistible__bu TLSAIRDRILEGLG--------------------