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VELRQLEAFVAVAGELHFGRAAEKLHIGQPTLSELIRRLEREVGTPLLTRTTRRVALTQAGVELFGRAKV ILDDVEGAAAAVRRLADGEAGTVRLGITPPVAPVLAPHLSQALHSAAPDVQLVVQRMWLPDLQRAIGDGE LDVAITCGPVADPPGILSEVFCAEPVMVGLRADHHLAGRDAVELRNLSTETIGVHSEALFPAWSLALRQV LDDTGIRPPAVEFTDTDLAAYRWPIQSEVDWVLTTAAVAGDSAGVVLRPTSPAHFVPYTLQWCPIRATTV AVGRFVRLALSVDVPPGWVSQPDHLRHGAGSLLED
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4734 | - | - | 100% (315) | LysR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1027 | - | 1e-28 | 41.14% (175) | LysR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3362 | - | 2e-25 | 37.67% (223) | LysR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 7e-18 | 41.78% (146) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_1346 | - | 3e-32 | 34.20% (307) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 7e-18 | 41.78% (146) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02663 | oxyS | 2e-19 | 41.10% (146) | putative LysR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3308 | - | 3e-26 | 31.11% (270) | LysR family transcriptional regulator |
| M. marinum M | MMAR_2756 | oxyR | 9e-20 | 35.48% (186) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_2838 | - | 2e-19 | 34.46% (177) | hydrogen peroxide-inducible genes activator |
| M. smegmatis MC2 155 | MSMEG_1895 | - | 6e-34 | 35.34% (283) | HTH-type transcriptional regulator AlsR |
| M. thermoresistible (build 8) | TH_3504 | - | 4e-20 | 27.94% (272) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 6e-20 | 35.48% (186) | hydrogen peroxide-inducible genes activator, OxyR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1346|M.gilvum_PYR-GCK ---------------MKLRHLRYFRAVAEELHFGRAAQRLLIAQPPLSQQ
MSMEG_1895|M.smegmatis_MC2_155 ---------------MELRHLRYFRAVGEELHFGRAAERLHMAQPPLSQQ
Mvan_4734|M.vanbaalenii_PYR-1 ---------------MELRQLEAFVAVAGELHFGRAAEKLHIGQPTLSEL
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MAV_2838|M.avium_104 --------MPDKTYQPTIAGLRAFVAVAEKRQFSGAATALGVSQSTLSQA
Mb0121|M.bovis_AF2122/97 ---------------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSA
Rv0117|M.tuberculosis_H37Rv ---------------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSA
MLBr_02663|M.leprae_Br4923 ---------------MLFRQLEYFVAVAQERHFARAAERCYVSQPALSSA
TH_3504|M.thermoresistible__bu ----------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSA
MAB_3308|M.abscessus_ATCC_1997 ---------------MELRQLEHFVAVAGEMSFSRAVQRAHVVQSALSTS
: * * **. * *. : * .**
Mflv_1346|M.gilvum_PYR-GCK IRQLEREVGADLLRRTTRSVELTEAGRAFLERTVRILDAVDDAVDQARRI
MSMEG_1895|M.smegmatis_MC2_155 IRQLERELGCTLLTRTTRSVELTPAGHTYLRRAVEILDAVDAANTEAQRI
Mvan_4734|M.vanbaalenii_PYR-1 IRRLEREVGTPLLTRTTRRVALTQAGVELFGRAKVILDDVEGAAAAVRRL
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MAV_2838|M.avium_104 LAALEAGLGTQLVERSTRRVFLTPQGAELLPHAQAVVEAADAFTAAAAGS
Mb0121|M.bovis_AF2122/97 IAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAV
Rv0117|M.tuberculosis_H37Rv IAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAV
MLBr_02663|M.leprae_Br4923 IAKLERELNVTLINRGHSFEGLTPEGERLVVWAKRILAEHDAFKAEVHAV
TH_3504|M.thermoresistible__bu VRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT
MAB_3308|M.abscessus_ATCC_1997 VGKLEKELGVELFDRTRQQIRLTPAGELFHTHATRVIQAARYAKDSIGNF
: ** :. *. * ** * :
Mflv_1346|M.gilvum_PYR-GCK GTGAEGRLVVGCVGSATYSLLPRLVRELRAALPAVDLRVRG-EMLAPEQL
MSMEG_1895|M.smegmatis_MC2_155 ASGIQGRIAIGCVGSATYSLLPQLVRALGESLPGIEVTVRG-EMLAPAQI
Mvan_4734|M.vanbaalenii_PYR-1 ADGEAGTVRLGITPPVAPVLAPHLSQALHSAAPDVQLVVQ--RMWLPDLQ
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVI--EDQTERLL
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVI--EDQTERLL
MAV_2838|M.avium_104 ADPLRAGMRLGLIPTVAPYVLPTVLAGIAERRPGLTLRVT--EDQTERLL
Mb0121|M.bovis_AF2122/97 RSGITGTLRLGTVPTAS-TTASLVLSAFCSAHPLAKVQVCS-RLAATELY
Rv0117|M.tuberculosis_H37Rv RSGITGTLRLGTVPTAS-TTASLVLSAFCSAHPLAKVQVCS-RLAATELY
MLBr_02663|M.leprae_Br4923 RSGITGTLRLGTVPTAS-TTASLVLSAFCSEHPLIKVQICS-RLPVTELH
TH_3504|M.thermoresistible__bu EAAAQAHYVIGHTPALSGAEAYALIEPAVTAYPSTSFTLR--QLYPDALT
MAB_3308|M.abscessus_ATCC_1997 RGELTGTVDLGALITFGPLDVPKMLGQFHREYPLVQIRLRQSQSGSNAYL
. .* . : * . : .
Mflv_1346|M.gilvum_PYR-GCK AALHAKDIDLALMR-PPVDDPALTAVSLRRDRLLVALPAGHRCADRDEVS
MSMEG_1895|M.smegmatis_MC2_155 EALLSGGIDLALLR-PPVRQEAVLTHTVRRDGLVVALPADHALAIRDAVT
Mvan_4734|M.vanbaalenii_PYR-1 RAIGDGELDVAITCGPVADPPGILSEVFCAEPVMVGLRADHHLAGRDAVE
MMAR_2756|M.marinum_M TALREGSLDTALIA-LPADYGGLTEIPIYEEDFVLALPPGHPMADRHGVP
MUL_2998|M.ulcerans_Agy99 TALREGSLDTALIA-LPADYGGLTEIPIYEEDFVLALPPGHPMADRHGVP
MAV_2838|M.avium_104 AVLREGALDAALIA-LPAETAGVTAIPIYDEDFVLALPPGHPLAGKRRVP
Mb0121|M.bovis_AF2122/97 RRLREFELDAVIVHPETQDSDDVDLVPLYEEQYVLLSPADMLPPGTSTLV
Rv0117|M.tuberculosis_H37Rv RRLREFELDAVIVHPETQDSDDVDLVPLYEEQYVLLSPADMLPPGTSTLV
MLBr_02663|M.leprae_Br4923 RRLGDFELDAVIVHSAPDDTHAVDLVPLYHEHYVLVSPADMLPPGASVLA
TH_3504|M.thermoresistible__bu DAVFDGTVQLGLRR-GVVPTPELATAVIGYHRVRVAFVDSHPLAARESVD
MAB_3308|M.abscessus_ATCC_1997 SAIADGTLDLALVSAPDRFPAGIQMRLLCQEPMMFVCRPDHRLAQRRHVT
: :: : : . . . . . :
Mflv_1346|M.gilvum_PYR-GCK LADLRDEDFISHAGGG-RSRMSALLAALCADAGFSP--------------
MSMEG_1895|M.smegmatis_MC2_155 VADLRDEDFVVHTGHG-RSVMSNLVATVCADAGFLP--------------
Mvan_4734|M.vanbaalenii_PYR-1 LRNLSTETIGVHSEAL-FPAWSLALRQVLDDTGIRPPAVEFTDTDLAAYR
MMAR_2756|M.marinum_M VAALSELPLLLLDEG---HCLRDQALDVCQNAGVRA--------------
MUL_2998|M.ulcerans_Agy99 VAALSELPLLLLDEG---HCLRDQALDVCQNAGVRA--------------
MAV_2838|M.avium_104 ATALADLPLLLLDEG---HCLRDQALDVCHKAGVRA--------------
Mb0121|M.bovis_AF2122/97 WRDAAQLPLALLTADM-RDRQVIDAAFADHAVSAIP--------------
Rv0117|M.tuberculosis_H37Rv WRDAAQLPLALLTADM-RDRQVIDAAFADHAVSAIP--------------
MLBr_02663|M.leprae_Br4923 WPEASQLPLALLTPDM-RDRQLIDRAFAGHAITATP--------------
TH_3504|M.thermoresistible__bu ITELAREQVALWAPPG-TSYYSDFLMGACRRAGFEP--------------
MAB_3308|M.abscessus_ATCC_1997 VTELVDEHLIGFPPQFSLRRIVEDAFTAAGVTAFTP--------------
. .
Mflv_1346|M.gilvum_PYR-GCK -RIRDEVDETSTLVTLVAGGLGVALVPEPTAALEIGG------VTYRPLA
MSMEG_1895|M.smegmatis_MC2_155 -RIRQEVSETSTLVTLVAAGLGVAIVPDPTTALDIAG------VRYVPLR
Mvan_4734|M.vanbaalenii_PYR-1 WPIQSEVDWVLTTAAVAGDSAGVVLRPTSPAHFVPYT------LQWCPIR
MMAR_2756|M.marinum_M ELADTRAASLATAVQCVNGGLGVTLIPQSAVSVEAARS----RVGLAHFA
MUL_2998|M.ulcerans_Agy99 EHADTRADSLATAVQCVNGGLGVTLIPQSAVSVEAARS----RVGLTHFA
MAV_2838|M.avium_104 ELANTRAASLATAVQCVTGGLGVTLIPQSAVPVEASRS----RLGLAQFA
Mb0121|M.bovis_AF2122/97 ---QVETDSVASLFAQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELV
Rv0117|M.tuberculosis_H37Rv ---QVETDSVASLFAQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELV
MLBr_02663|M.leprae_Br4923 ---QVETDSVASLFAQVATGNWACIVPHTWLWTTPIG----AEIRAVEMV
TH_3504|M.thermoresistible__bu DYVVSRVQGAATVAAPLTTG-GIAFVTAAAGPTMNGR------VQVVDLT
MAB_3308|M.abscessus_ATCC_1997 ---HEVALEYAIAASLVHHGLGTIFMPASEAAQFPHLR--------ALAV
. . : . .
Mflv_1346|M.gilvum_PYR-GCK AKAGATIELLAVYRSADASPLTAKVVDVLRATV----------------
MSMEG_1895|M.smegmatis_MC2_155 PTD-LGVDLVAAH--TGDSPLITNVLRVLRTLTEGPKSPTQAHPGT---
Mvan_4734|M.vanbaalenii_PYR-1 ATTVAVGRFVRLALSVDVPPGWVSQPDHLRHGAGSLLED----------
MMAR_2756|M.marinum_M APTPGRRIGLVYRASSGRDEAYRQLAAIMGESISNEQQVRLVN------
MUL_2998|M.ulcerans_Agy99 APTPGRRIGLVYRASSGRDEAYRQLAAIMGESISNEQQVRLVN------
MAV_2838|M.avium_104 APRPGRRIGLVFRSSSGRDDSYRELAGLIGELISSQHQVRLVK------
Mb0121|M.bovis_AF2122/97 DPVLKAQIALATNALGPGSPVARALITCAQALALNEFFDTQLRGITRRR
Rv0117|M.tuberculosis_H37Rv DPVLKAQIALATNALGPGSPVARALITCAQALALNEFFDTQLRGITRRR
MLBr_02663|M.leprae_Br4923 DPVLKADVALATNSAGPGSPVARALVASAKQLALNEFFEAQLAGITRRR
TH_3504|M.thermoresistible__bu PPLLVPVQALWQRHTLSAIR--DRILEGLG-------------------
MAB_3308|M.abscessus_ATCC_1997 RPAIIWKIYLASAEQSQLGPASAQLAEHLVASAHAQTNSPKT-------
: