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MRSPLLRPRDADAVRAALRQMATITELPLTFGGEVHSGTLLLTEFFGTRTSAMRGLAVRPSAGLGGATMV ARRPISVADYRHASAITHDYDGPVLSEGIRSVLAVPVVVDGQARAVLYGSYRQSAPIGDRAAAAMVASAR QLSEELRVRDEVDRRMRMREAQLAQFGADVASAEQIREVHADLRRMAARASRPLATQLGELADRLARALS GDAPAATPLTAREIDVLSQIALGCTNAEAAQRLSLKPETVKSYLRSASSKLGAHSRHEAVSKARRLRQIP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5651 | - | - | 100% (280) | transcriptional regulator, LuxR family protein |
| M. smegmatis MC2 155 | MSMEG_4430 | - | 3e-09 | 32.76% (174) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0473 | - | 5e-08 | 26.91% (249) | transcriptional regulator, LuxR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0867c | narL | 1e-06 | 37.80% (82) | nitrate/nitrite response transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_4865 | - | 8e-98 | 66.43% (280) | response regulator receiver protein |
| M. tuberculosis H37Rv | Rv0844c | narL | 1e-06 | 37.80% (82) | nitrate/nitrite response transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1522 | - | 2e-08 | 37.25% (102) | putative two-component system response regulator LuxR |
| M. marinum M | MMAR_0133 | - | 7e-16 | 28.22% (287) | two-component sensor histidine kinase |
| M. avium 104 | MAV_4109 | - | 7e-07 | 32.17% (143) | two component transcriptional regulatory protein devr |
| M. thermoresistible (build 8) | TH_4501 | - | 6e-12 | 30.14% (209) | PUTATIVE conserved hypothetical regulatory protein |
| M. ulcerans Agy99 | MUL_2876 | - | 3e-10 | 28.40% (257) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1565 | - | 2e-96 | 63.31% (278) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4865|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1565|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4109|M.avium_104 --------------------------------------------------
Mb0867c|M.bovis_AF2122/97 --------------------------------------------------
Rv0844c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4501|M.thermoresistible__bu -----------MTIAG-----DVPDSGSDETLAG--HPGWASRPAAESDA
MUL_2876|M.ulcerans_Agy99 MGFSPRRAIPERTVGGVIDVVDMPDPPAFPTLADDEHPGWASRPIRESDA
MMAR_0133|M.marinum_M --------------------------------------------------
Mflv_4865|M.gilvum_PYR-GCK ----------------MSAASPLLRPRDGDALRAELRRVAALGGVPVLFG
Mvan_1565|M.vanbaalenii_PYR-1 ----------------MPAPSPLLRPRDSDALRAELRRVALLGDVPVMFG
MSMEG_5651|M.smegmatis_MC2_155 ------------------MRSPLLRPRDADAVRAALRQMATITELPLTFG
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4109|M.avium_104 --------------------------------------------------
Mb0867c|M.bovis_AF2122/97 --------------------------------------------------
Rv0844c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4501|M.thermoresistible__bu ARRYRETFADWGVDPTDDPMSVVSEAIDTRANEVRNALETCGDEEAIAAL
MUL_2876|M.ulcerans_Agy99 TRHYREAFGDCNVDPTDDPMAVVAEAIDVNAAAVRHALESQGDVHAVNAL
MMAR_0133|M.marinum_M -------------------MLALLDRTAALRHGADVVHRRLGADLAAGAN
Mflv_4865|M.gilvum_PYR-GCK GEIHEDTLLISEYYGLRTAGLRGLAVRSSSGLGGASMVAGRPLAVADYRN
Mvan_1565|M.vanbaalenii_PYR-1 GEVHGDTLVITEYHGVRTAGLRGLEVRSNSGLGGASMVAGRPLSVADYRN
MSMEG_5651|M.smegmatis_MC2_155 GEVHSGTLLLTEFFGTRTSAMRGLAVRPSAGLGGATMVARRPISVADYRH
MAB_1522|M.abscessus_ATCC_1997 ---------------------------MTDTEVGVLLVDDQELVRTGLRR
MAV_4109|M.avium_104 -------------------------------MVKVFLVDDHEVVRRGLCD
Mb0867c|M.bovis_AF2122/97 ------------------------MSNPQPEKVRVVVGDDHPLFREGVVR
Rv0844c|M.tuberculosis_H37Rv ------------------------MSNPQPEKVRVVVGDDHPLFREGVVR
TH_4501|M.thermoresistible__bu ESVLDLCSLERELIEDGAQRRTFALLQVQEGLSKLRAVDDVATIVDRAPR
MUL_2876|M.ulcerans_Agy99 ETLLDLSSLEREMIEDGAARRTLALLQVQEALSKLRAVDDVAMIVDRAPR
MMAR_0133|M.marinum_M RIAEDDTMEVVAVVGGRTEELNGLVIGPQEGLGGQAAVLRRTVAVHDYCM
Mflv_4865|M.gilvum_PYR-GCK ASSITHDYDG---------------PVLSEGIRSVLAVPVLVDGRARAML
Mvan_1565|M.vanbaalenii_PYR-1 ATGITHDYDG---------------PVLSEGIRSVLAVPVLVDGRARAML
MSMEG_5651|M.smegmatis_MC2_155 ASAITHDYDG---------------PVLSEGIRSVLAVPVVVDGQARAVL
MAB_1522|M.abscessus_ATCC_1997 ILRRKDGFA-----------------IVGECADGSEVAAAVSRARP---D
MAV_4109|M.avium_104 LLSSDPDLR-----------------IVGEAGTVAEAKARIPAARP---D
Mb0867c|M.bovis_AF2122/97 ALSLSGSVN-----------------VVGEADDGAAALELIKAHLP---D
Rv0844c|M.tuberculosis_H37Rv ALSLSGSVN-----------------VVGEADDGAAALELIKAHLP---D
TH_4501|M.thermoresistible__bu ELVESCGFDRAVLFRVHEGRMFMESAYFGEDRAGAEKMVAFAQSVAPPLD
MUL_2876|M.ulcerans_Agy99 ELVESCGFDRAVLFRVHEGRLVMESAYFGEDREGAEKMVAFAQSVAPLLD
MMAR_0133|M.marinum_M SRDITHDFDH---------------AVRAEGLRAAMVAPIVRAHRLYGLL
. .* .
Mflv_4865|M.gilvum_PYR-GCK YGAYRTGAPFGGRAADLVVESARRLSEEFRIRDEVDRRLRMRDAQAAG--
Mvan_1565|M.vanbaalenii_PYR-1 YGAYRSGAPFGGRVTELVIESARALSEEFRIRDEVDRRLRLRDTQSANSG
MSMEG_5651|M.smegmatis_MC2_155 YGSYRQSAPIGDRAAAAMVASARQLSEELRVRDEVDRRMRMREAQLAQFG
MAB_1522|M.abscessus_ATCC_1997 VVIMDLRMKQMSGIEAIR-LLHAAQGPPALALTTFDDDELLSGALRAG-A
MAV_4109|M.avium_104 VAVLDVRLPDGNGIELCRDLLSEHPDLRCLMLTSFTSDEAMLEAILAG-A
Mb0867c|M.bovis_AF2122/97 VALLDYRMPGMDGAQVPAAVRSYELPTRVLLISAHDEPAIVYQALQQG-A
Rv0844c|M.tuberculosis_H37Rv VALLDYRMPGMDGAQVAAAVRSYELPTRVLLISAHDEPAIVYQALQQG-A
TH_4501|M.thermoresistible__bu HMLLETQMIRRHAPAIVRDARNDPRVNRPIVEFSMTRSYVAAPVMPTGKV
MUL_2876|M.ulcerans_Agy99 HMLIETQMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSYVAAPVMPTGKM
MMAR_0133|M.marinum_M YAARRSPVAWTDRDRAELLSLARQAAVAMEVADSAREMAEVAAFGERQRL
Mflv_4865|M.gilvum_PYR-GCK -GQVSDE-------------------------------------------
Mvan_1565|M.vanbaalenii_PYR-1 EGAVDAE-------------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 ADVASAE-------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 AGFILKD-------------------------------------------
MAV_4109|M.avium_104 SGFVIKD-------------------------------------------
Mb0867c|M.bovis_AF2122/97 AGFLLKD-------------------------------------------
Rv0844c|M.tuberculosis_H37Rv AGFLLKD-------------------------------------------
TH_4501|M.thermoresistible__bu IGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRRLQAEV
MUL_2876|M.ulcerans_Agy99 IGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRRQHAEV
MMAR_0133|M.marinum_M AIRLHDSVG--------------------------ATLFSLRVALMSAQE
.
Mflv_4865|M.gilvum_PYR-GCK -----QIREVHAELRLLAVTAPPPLQNRLRALADTLSGTGTEPGAGPDAA
Mvan_1565|M.vanbaalenii_PYR-1 -----SVREVHAELRRLAVDAPAGLQQRLRVLADKLSGPADDPAT---VA
MSMEG_5651|M.smegmatis_MC2_155 -----QIREVHADLRRMAARASRPLATQLGELADRLARALSGDAP--AAT
MAB_1522|M.abscessus_ATCC_1997 ----SPAEELVRAVHAVARGEAYLDPAVTSRVLNAYRRAP-AAVSGDAQD
MAV_4109|M.avium_104 ----IKGMELARAIKDVGAGKSLLDNRAAAALMAKLRGS---AAQADPLS
Mb0867c|M.bovis_AF2122/97 ----STRTEIVKAVLDCAKGRDVVAPSLVGGLAGEIRQR-----AAPVAP
Rv0844c|M.tuberculosis_H37Rv ----STRTEIVKAVLDCAKGRDVVAPSLVGGLAGEIRQR-----AAPVAP
TH_4501|M.thermoresistible__bu RNALASADEAARALQDADLDLRKIEPQERSPAARSLAEV-----HTRVMA
MUL_2876|M.ulcerans_Agy99 RSALASADEAARALQDADLDLRKIEPVERSPAARSLAEV-----QTRVMA
MMAR_0133|M.marinum_M ETEPGRREELLSDALVLTERATSELRAQTLSLHDLPEDKALAVTLEGDCR
*
Mflv_4865|M.gilvum_PYR-GCK TLAPRELDVLAQVALGCTNAEAAQRLSLKPETVKSYLRSAATKLGTRTRY
Mvan_1565|M.vanbaalenii_PYR-1 PLTGRELDVLAQVALGCTNAEAAQRLSLKTETVKSYLRSAATKLGTRTRY
MSMEG_5651|M.smegmatis_MC2_155 PLTAREIDVLSQIALGCTNAEAAQRLSLKPETVKSYLRSASSKLGAHSRH
MAB_1522|M.abscessus_ATCC_1997 KLTARELDVLALIASGATNSEIAEQLVISEVTVKSHIGRIFVKLDLRDRA
MAV_4109|M.avium_104 GLTEQERTLLGLLSEGLTNRQIAARMFLAEKTVKNYVSRLLAKLGMERRT
Mb0867c|M.bovis_AF2122/97 VLSAREREVLNRIACGQSIPAIAAELYVAPSTVKTHVQRLYEKLGVSDRA
Rv0844c|M.tuberculosis_H37Rv VLSAREREVLNRIACGQSIPAIAAELYVAPSTVKTHVQRLYEKLGVSDRA
TH_4501|M.thermoresistible__bu MLTRREIEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLHATNRA
MUL_2876|M.ulcerans_Agy99 MLTRREVEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLHATNRA
MMAR_0133|M.marinum_M DFATRTGTAAELVVLGDLPLLDSARTDALRRTAREALLNVEKHAGAHSVV
:: : : * : . *.: : :
Mflv_4865|M.gilvum_PYR-GCK ESVSKARRLHLIP-------------------------------------
Mvan_1565|M.vanbaalenii_PYR-1 EAVSRARRLHLIP-------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 EAVSKARRLRQIP-------------------------------------
MAB_1522|M.abscessus_ATCC_1997 AAIVYAYDHGIVTPK-----------------------------------
MAV_4109|M.avium_104 QAAVFASKLNQQAGRPPTPPDWPG--------------------------
Mb0867c|M.bovis_AF2122/97 AAVAEAMRQRLLD-------------------------------------
Rv0844c|M.tuberculosis_H37Rv AAVAEAMRQRLLD-------------------------------------
TH_4501|M.thermoresistible__bu EAASAYVRLASVPEVG----------------------------------
MUL_2876|M.ulcerans_Agy99 EAASAYVRLASVSEVG----------------------------------
MMAR_0133|M.marinum_M VSLYRAEDGVGLTVADDGTAPDIASEHRRGLGLRATVERIERVGGWLSCT
:
Mflv_4865|M.gilvum_PYR-GCK ------------------------
Mvan_1565|M.vanbaalenii_PYR-1 ------------------------
MSMEG_5651|M.smegmatis_MC2_155 ------------------------
MAB_1522|M.abscessus_ATCC_1997 ------------------------
MAV_4109|M.avium_104 ------------------------
Mb0867c|M.bovis_AF2122/97 ------------------------
Rv0844c|M.tuberculosis_H37Rv ------------------------
TH_4501|M.thermoresistible__bu ------------------------
MUL_2876|M.ulcerans_Agy99 ------------------------
MMAR_0133|M.marinum_M ANEEGGGTVQAWVPAARAFRPVGP