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MPAPSPLLRPRDSDALRAELRRVALLGDVPVMFGGEVHGDTLVITEYHGVRTAGLRGLEVRSNSGLGGAS MVAGRPLSVADYRNATGITHDYDGPVLSEGIRSVLAVPVLVDGRARAMLYGAYRSGAPFGGRVTELVIES ARALSEEFRIRDEVDRRLRLRDTQSANSGEGAVDAESVREVHAELRRLAVDAPAGLQQRLRVLADKLSGP ADDPATVAPLTGRELDVLAQVALGCTNAEAAQRLSLKTETVKSYLRSAATKLGTRTRYEAVSRARRLHLI P
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1565 | - | - | 100% (281) | response regulator receiver protein |
| M. vanbaalenii PYR-1 | Mvan_1929 | - | 6e-08 | 37.61% (117) | regulatory protein, LuxR |
| M. vanbaalenii PYR-1 | Mvan_3973 | - | 7e-07 | 27.48% (222) | putative GAF sensor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3157c | devR | 5e-06 | 33.98% (103) | two component transcriptional regulatory protein DevR |
| M. gilvum PYR-GCK | Mflv_4865 | - | 1e-121 | 79.58% (284) | response regulator receiver protein |
| M. tuberculosis H37Rv | Rv3133c | devR | 5e-06 | 33.98% (103) | two component transcriptional regulatory protein DevR |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1522 | - | 2e-08 | 41.41% (99) | putative two-component system response regulator LuxR |
| M. marinum M | MMAR_0133 | - | 4e-12 | 31.43% (140) | two-component sensor histidine kinase |
| M. avium 104 | MAV_5280 | - | 5e-06 | 28.47% (137) | two-component system response regulator |
| M. smegmatis MC2 155 | MSMEG_5651 | - | 2e-96 | 63.31% (278) | transcriptional regulator, LuxR family protein |
| M. thermoresistible (build 8) | TH_4501 | - | 1e-07 | 26.89% (212) | PUTATIVE conserved hypothetical regulatory protein |
| M. ulcerans Agy99 | MUL_2876 | - | 1e-06 | 32.19% (146) | putative regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1565|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4865|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 --------------------------------------------------
TH_4501|M.thermoresistible__bu -----------MTIAG-----DVPDSGSDETLAG--HPGWASRPAAESDA
MUL_2876|M.ulcerans_Agy99 MGFSPRRAIPERTVGGVIDVVDMPDPPAFPTLADDEHPGWASRPIRESDA
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MMAR_0133|M.marinum_M --------------------------------------------------
Mvan_1565|M.vanbaalenii_PYR-1 ----------------MPAPSPLLRPRDSDALRAELRRVALLGDVPVMFG
Mflv_4865|M.gilvum_PYR-GCK ----------------MSAASPLLRPRDGDALRAELRRVAALGGVPVLFG
MSMEG_5651|M.smegmatis_MC2_155 ------------------MRSPLLRPRDADAVRAALRQMATITELPLTFG
TH_4501|M.thermoresistible__bu ARRYRETFADWGVDPTDDPMSVVSEAIDTRANEVRNALETCGDEEAIAAL
MUL_2876|M.ulcerans_Agy99 TRHYREAFGDCNVDPTDDPMAVVAEAIDVNAAAVRHALESQGDVHAVNAL
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MMAR_0133|M.marinum_M -------------------MLALLDRTAALRHGADVVHRRLGADLAAGAN
Mvan_1565|M.vanbaalenii_PYR-1 GEVHGDTLVITEYHGVRTAGLRGLEVRSNSGLGGASMVAGRPLSVADYRN
Mflv_4865|M.gilvum_PYR-GCK GEIHEDTLLISEYYGLRTAGLRGLAVRSSSGLGGASMVAGRPLAVADYRN
MSMEG_5651|M.smegmatis_MC2_155 GEVHSGTLLLTEFFGTRTSAMRGLAVRPSAGLGGATMVARRPISVADYRH
TH_4501|M.thermoresistible__bu ESVLDLCSLERELIEDGAQRRTFALLQVQEGLSKLRAVDDVATIVDRAPR
MUL_2876|M.ulcerans_Agy99 ETLLDLSSLEREMIEDGAARRTLALLQVQEALSKLRAVDDVAMIVDRAPR
Mb3157c|M.bovis_AF2122/97 -------------------------------MVKVFLVDDHEVVRRGLVD
Rv3133c|M.tuberculosis_H37Rv -------------------------------MVKVFLVDDHEVVRRGLVD
MAB_1522|M.abscessus_ATCC_1997 -------------------------MTD--TEVGVLLVDDQELVRTGLRR
MAV_5280|M.avium_104 -------------------------MTDPAPEITVLLVDDQDLVRSGLRR
MMAR_0133|M.marinum_M RIAEDDTMEVVAVVGGRTEELNGLVIGPQEGLGGQAAVLRRTVAVHDYCM
*
Mvan_1565|M.vanbaalenii_PYR-1 ATGITHDYDG------------------PVLSEGIRSVLAVPVLVDG--R
Mflv_4865|M.gilvum_PYR-GCK ASSITHDYDG------------------PVLSEGIRSVLAVPVLVDG--R
MSMEG_5651|M.smegmatis_MC2_155 ASAITHDYDG------------------PVLSEGIRSVLAVPVVVDG--Q
TH_4501|M.thermoresistible__bu ELVESCGFDRAVLFRVHEGRMFMESAYFGEDRAGAEKMVAFAQSVAPPLD
MUL_2876|M.ulcerans_Agy99 ELVESCGFDRAVLFRVHEGRLVMESAYFGEDREGAEKMVAFAQSVAPLLD
Mb3157c|M.bovis_AF2122/97 LLGADPELD-----------------VVGEAGSVAEAMARVPAARP---D
Rv3133c|M.tuberculosis_H37Rv LLGADPELD-----------------VVGEAGSVAEAMARVPAARP---D
MAB_1522|M.abscessus_ATCC_1997 ILRRKDGFA-----------------IVGECADGSEVAAAVSRARP---D
MAV_5280|M.avium_104 ILRRKDGFV-----------------IVAECADGDEVPAAVAAHRP---D
MMAR_0133|M.marinum_M SRDITHDFDH------------------AVRAEGLRAAMVAPIVRAH--R
. .
Mvan_1565|M.vanbaalenii_PYR-1 ARAMLYGAYRSGAPFGGRVTELVIESARALSEEFRIRDEVDRRLRLRDT-
Mflv_4865|M.gilvum_PYR-GCK ARAMLYGAYRTGAPFGGRAADLVVESARRLSEEFRIRDEVDRRLRMRDA-
MSMEG_5651|M.smegmatis_MC2_155 ARAVLYGSYRQSAPIGDRAAAAMVASARQLSEELRVRDEVDRRMRMREA-
TH_4501|M.thermoresistible__bu HMLLETQMIRRHAPAIVRDARNDPRVNRPIVEFSMTRSYVAAPVMPTGKV
MUL_2876|M.ulcerans_Agy99 HMLIETQMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSYVAAPVMPTGKM
Mb3157c|M.bovis_AF2122/97 VAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAG--
Rv3133c|M.tuberculosis_H37Rv VAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAG--
MAB_1522|M.abscessus_ATCC_1997 VVIMDLRMKQMSGIEAIRLLHAAQ-GPPALALTTFDDDELLSGALRAG--
MAV_5280|M.avium_104 VVVMDLRMRRVDGIEATRRLGGR---PPVLALTTFNEDELLSGALRAG--
MMAR_0133|M.marinum_M LYGLLYAARRSPVAWTDRDRAELLSLARQAAVAMEVADSAREMAEVAAFG
: * .
Mvan_1565|M.vanbaalenii_PYR-1 ----------------------------QSANSGEGAVDAESVREVHAEL
Mflv_4865|M.gilvum_PYR-GCK ----------------------------QAAG---GQVSDEQIREVHAEL
MSMEG_5651|M.smegmatis_MC2_155 ----------------------------QLAQFGADVASAEQIREVHADL
TH_4501|M.thermoresistible__bu IGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRRLQAEV
MUL_2876|M.ulcerans_Agy99 IGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRRQHAEV
Mb3157c|M.bovis_AF2122/97 ----------------------------ASGYVVKDIKGMELARAVKDVG
Rv3133c|M.tuberculosis_H37Rv ----------------------------ASGYVVKDIKGMELARAVKDVG
MAB_1522|M.abscessus_ATCC_1997 ----------------------------AAGFILKDSPAEELVRAVHAVA
MAV_5280|M.avium_104 ----------------------------AAGFVLKDSSAEELIRAVRAVA
MMAR_0133|M.marinum_M ----------------ERQRLAIRLHDSVGATLFSLRVALMSAQEETEPG
. :
Mvan_1565|M.vanbaalenii_PYR-1 R---------RLAVDAPAGLQQRLRVLADKLSGPADDPAT---VAPLTGR
Mflv_4865|M.gilvum_PYR-GCK R---------LLAVTAPPPLQNRLRALADTLSGTGTEPGAGPDAATLAPR
MSMEG_5651|M.smegmatis_MC2_155 R---------RMAARASRPLATQLGELADRLARALSGDAP--AATPLTAR
TH_4501|M.thermoresistible__bu RNALASADEAARALQDADLDLRKIEPQERSPAARSLAEVHTRVMAMLTRR
MUL_2876|M.ulcerans_Agy99 RSALASADEAARALQDADLDLRKIEPVERSPAARSLAEVQTRVMAMLTRR
Mb3157c|M.bovis_AF2122/97 A---------GRSLLDNRAAAALMAKLRGAAE-------KQDPLSGLTDQ
Rv3133c|M.tuberculosis_H37Rv A---------GRSLLDNRAAAALMAKLRGAAE-------KQDPLSGLTDQ
MAB_1522|M.abscessus_ATCC_1997 R---------GEAYLDPAVTSRVLNAYRRAPAA-----VSGDAQDKLTAR
MAV_5280|M.avium_104 R---------GEGYLDPAVTSRVLTTYRKAAPG-----PHGAAIAELTTR
MMAR_0133|M.marinum_M RREELLSDALVLTERATSELRAQTLSLHDLPEDKALAVTLEGDCRDFATR
:: :
Mvan_1565|M.vanbaalenii_PYR-1 ELDVLAQVALGCTNAEAAQRLSLKTETVKSYLRSAATKLGTRTRYEAVSR
Mflv_4865|M.gilvum_PYR-GCK ELDVLAQVALGCTNAEAAQRLSLKPETVKSYLRSAATKLGTRTRYESVSK
MSMEG_5651|M.smegmatis_MC2_155 EIDVLSQIALGCTNAEAAQRLSLKPETVKSYLRSASSKLGAHSRHEAVSK
TH_4501|M.thermoresistible__bu EIEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLHATNRAEAASA
MUL_2876|M.ulcerans_Agy99 EVEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLHATNRAEAASA
Mb3157c|M.bovis_AF2122/97 ERTLLGLLSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVF
Rv3133c|M.tuberculosis_H37Rv ERTLLGLLSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVF
MAB_1522|M.abscessus_ATCC_1997 ELDVLALIASGATNSEIAEQLVISEVTVKSHIGRIFVKLDLRDRAAAIVY
MAV_5280|M.avium_104 ERDVLTLIGKGLSNSEIADELCISGVTVKSHIGRIFGKLDLRDRAAAIVY
MMAR_0133|M.marinum_M TGTAAELVVLGDLPLLDSARTDALRRTAREALLNVEKHAGAHSVVVSLYR
: * : . *.:. : : :
Mvan_1565|M.vanbaalenii_PYR-1 ARRLHLIP------------------------------------------
Mflv_4865|M.gilvum_PYR-GCK ARRLHLIP------------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 ARRLRQIP------------------------------------------
TH_4501|M.thermoresistible__bu YVRLASVPEVG---------------------------------------
MUL_2876|M.ulcerans_Agy99 YVRLASVSEVG---------------------------------------
Mb3157c|M.bovis_AF2122/97 ATELKRSRPPGDGP------------------------------------
Rv3133c|M.tuberculosis_H37Rv ATELKRSRPPGDGP------------------------------------
MAB_1522|M.abscessus_ATCC_1997 AYDHGIVTPK----------------------------------------
MAV_5280|M.avium_104 AYDNGIVAPR----------------------------------------
MMAR_0133|M.marinum_M AEDGVGLTVADDGTAPDIASEHRRGLGLRATVERIERVGGWLSCTANEEG
Mvan_1565|M.vanbaalenii_PYR-1 -------------------
Mflv_4865|M.gilvum_PYR-GCK -------------------
MSMEG_5651|M.smegmatis_MC2_155 -------------------
TH_4501|M.thermoresistible__bu -------------------
MUL_2876|M.ulcerans_Agy99 -------------------
Mb3157c|M.bovis_AF2122/97 -------------------
Rv3133c|M.tuberculosis_H37Rv -------------------
MAB_1522|M.abscessus_ATCC_1997 -------------------
MAV_5280|M.avium_104 -------------------
MMAR_0133|M.marinum_M GGTVQAWVPAARAFRPVGP