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DASEGPAAGHGDTERAVLLATKLHIPAIAGQLVHRTALLDALSQSCRSRLILLSAPVGWGKTTLLSQWAL GAGKDQRFGWLSLDASDNDPVWFWMYVIAALQKISPGVGTRAVELLTMGADPIQVVLPTLLNDLDAVARP IVLILDDYHMVVNRAIHEQVAFAVGRMPANLHVVLATRSDPLLPLARLRANGELVEMRSDDLRFGVGEAG QLLNDVLGLDLTEEDVRLLHRRTEGWAAGLYLAALSLAGRAQAAAFIRTFAGDNRHIVDYLMAEVLDRQS PRIRNFLLRTSVMRRFNGALCDAVLQSSDSVSVLEEMERENLFLVPLDMSRHWYRYHHLFGELLRAELHR CEPELVPGLHRRAAKWFEAEGLVDEALRHLVAAGDIAESADLIVEDWANELAGGGLSTVSGWLDLLPEGT VRGDPRLSAIRAWVALNVGLFDDARIWIEAVAAGLEGVSAAEGSARAGLSEQLVALREVYAFKIGDVTNA LDAARQAATLEVGEAPPARSAAHVTYGAALYFSGDIDEARTELQRAVELTERTGDRRHRVYALGYLALIE AESGQLADAEHLIRRATGVGPDPAGTQNFIDVAVSLAVSVVLYASGEWAAAADAAHLAVGLARKGAGILE VAKALMVRAKILNDFGDLEAAEKSRSEAGALLRRCPDNVAVHPMIGSAGQGRRVAVAAYNDEHIAEDLTS KELEVLRLLATRLSRRDIGQRLYVSLNTVKTHQRAIYRKLGVDNRNSAVARGRELGLL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4430 | - | - | 100% (759) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0529 | - | 6e-82 | 31.81% (657) | serine/threonine-protein kinase PknK |
| M. smegmatis MC2 155 | MSMEG_5288 | - | 1e-54 | 29.79% (584) | putative serine/threonine protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3107c | pknK | 2e-66 | 30.65% (646) | serine/threonine-protein kinase transcriptional regulatory |
| M. gilvum PYR-GCK | Mflv_4809 | - | 1e-63 | 30.85% (752) | regulatory protein, LuxR |
| M. tuberculosis H37Rv | Rv3080c | pknK | 2e-66 | 30.65% (646) | serine/threonine-protein kinase transcriptional regulatory |
| M. leprae Br4923 | MLBr_01753 | - | 5e-08 | 28.10% (306) | putative transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0060 | - | 1e-08 | 38.18% (110) | nitrate/nitrite response transcriptional regulatory protein |
| M. marinum M | MMAR_2576 | pknK | 2e-68 | 30.28% (644) | serine/threonine-protein kinase transcriptional regulatory |
| M. avium 104 | MAV_0872 | - | 6e-07 | 30.20% (149) | DNA-binding response regulator, LuxR family protein |
| M. thermoresistible (build 8) | TH_3225 | - | 6e-08 | 25.73% (342) | PUTATIVE regulatory protein, LuxR |
| M. ulcerans Agy99 | MUL_0351 | narL | 2e-07 | 40.22% (92) | nitrate/nitrite response regulator protein NarL |
| M. vanbaalenii PYR-1 | Mvan_1633 | - | 1e-62 | 29.01% (748) | regulatory protein, LuxR |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 MTDVDP-----HATRRDLVPNIPAELLEAGFDNVEEIGRGGFGVVYRCVQ
Rv3080c|M.tuberculosis_H37Rv MTDVDP-----HATRRDLVPNIPAELLEAGFDNVEEIGRGGFGVVYRCVQ
MMAR_2576|M.marinum_M MAEDAPYTTQAHPAQRGGISGIPGELIDAGFENVAEVGRGGFGIVYRAFQ
Mflv_4809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1633|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4430|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01753|M.leprae_Br4923 -------------------------MYSLGEMQKPVPVGADYLASCLVAR
TH_3225|M.thermoresistible__bu --------------------------------------------------
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 PSLDRAVAVKVLSTDLDRDNLERFLREQRAMGRLSGHPHIVTVLQVGVLA
Rv3080c|M.tuberculosis_H37Rv PSLDRAVAVKVLSTDLDRDNLERFLREQRAMGRLSGHPHIVTVLQVGVLA
MMAR_2576|M.marinum_M PSLDRTVAVKVLTADLDPDNLDRFLREQRAMGRLSGHPHIVTILEVGTTA
Mflv_4809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1633|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4430|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01753|M.leprae_Br4923 LRSTDVPTDLHRGCTVTLFLGDVEGLAELSETQPDEAADAIARLDCVVSE
TH_3225|M.thermoresistible__bu --------------------------------------------------
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 GGRPFIVMPYHAKNSLETLIRRHGPLDWRETLSIGVKLAGALEAAHRVGT
Rv3080c|M.tuberculosis_H37Rv GGRPFIVMPYHAKNSLETLIRRHGPLDWRETLSIGVKLAGALEAAHRVGT
MMAR_2576|M.marinum_M TGRPFLVMPYHQNDSLEALVRRNGPLDWGEVVRLGVKVAGALEAAHRVGT
Mflv_4809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1633|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4430|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01753|M.leprae_Br4923 AVAAHGGVQQVVQGVRGNFLATFARASDATACALDLQLAPIVPVRFRIAL
TH_3225|M.thermoresistible__bu --------------------------------------------------
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 LHRDVKPGNILLTDYGEPQLTDFGIARIAGGFETATGVIAGSPAFTAPEV
Rv3080c|M.tuberculosis_H37Rv LHRDVKPGNILLTDYGEPQLTDFGIARIAGGFETATGVIAGSPAFTAPEV
MMAR_2576|M.marinum_M LHRDVKPGNILISDYGEPQLTDFGIARIAGGFQTSTGVITGSPAFTAPEV
Mflv_4809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1633|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4430|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01753|M.leprae_Br4923 HTGEVQISNDDVNNVVFMMVQAAGLLDLACGGQTVLSSITGDLVVDGLPA
TH_3225|M.thermoresistible__bu --MSSRDGDVVLHGRAAEIATLRDVMSTARAGSSRVLVLHGEAGVGKTAL
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 LEGASPTPASDVYSLGATLFCVLTGHAAYERRSGERVIAQFLRITSQPIP
Rv3080c|M.tuberculosis_H37Rv LEGASPTPASDVYSLGATLFCALTGHAAYERRSGERVIAQFLRITSQPIP
MMAR_2576|M.marinum_M LEGAPPTPQSDVYSLGATLFSAITGHAAFERRRGEKVVAQFLRITSQPIP
Mflv_4809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1633|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4430|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01753|M.leprae_Br4923 DTWLVDLGSHLLRDLARPVRVMQLCHRNLRRNLHELGIRTVPGGPSLPVP
TH_3225|M.thermoresistible__bu LGQLLGDAAGMRCVQVAGVESDMELAYAGLHQLCAPLLDRLDDLPSP---
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 DLRKQGLPADVAAAIERAMAR--HPADRPATAADVGEELRDVQRRNGVSV
Rv3080c|M.tuberculosis_H37Rv DLRKQGLPADVAAAIERAMAR--HPADRPATAADVGEELRDVQRRNGVSV
MMAR_2576|M.marinum_M NLREEGLPADVASVIEKAMAR--DPADRPDSAAAFGEQLRQVQREHGVAV
Mflv_4809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1633|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4430|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01753|M.leprae_Br4923 LTTFVGRAAQIKELQELLTEKRLLTLVGPGGVGKTRLALQVVARVADEFS
TH_3225|M.thermoresistible__bu -------------------QRDVLNVAFGRGAGPAPGRFLVGLAVLNLLA
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 DEMPLPVELGVERRRSPEAHAAHRHTGGGTPTVPTPPTPATKYRPSVPTG
Rv3080c|M.tuberculosis_H37Rv DEMPLPVELGVERRRSPEAHAAHRHTGGGTPTVPTPPTPATKYRPSVPTG
MMAR_2576|M.marinum_M DEMAHPVELGAPRSDLATARSTYGHD---THATPAPPTPATKYRPQVPAR
Mflv_4809|M.gilvum_PYR-GCK ------------------------------------------MGRPRIAD
Mvan_1633|M.vanbaalenii_PYR-1 ----------------------------MVAGDWLPRIPAATIGRPRIAD
MSMEG_4430|M.smegmatis_MC2_155 -------------------MDASEGPAAGHGDTERAVLLATKLHIPAIAG
MLBr_01753|M.leprae_Br4923 GELSYFDLAPDTDHDIFPITVLDNLRRCIGDRRMLMVLDNCEYLLDVCAN
TH_3225|M.thermoresistible__bu AAGADQPLLCVIDDAQWLDRVSLQTLGFVARRLMAEPVAMVFALRDDIHE
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 SLVTRSRLTDILRAGGRRRLILIHAPSGFGKSTLAAQWREELSRDGAAVA
Rv3080c|M.tuberculosis_H37Rv SLVTRSRLTDILRAGGRRRLILIHAPSGFGKSTLAAQWREELSRDGAAVA
MMAR_2576|M.marinum_M SRVSRRRLTDALSAAGRRRLILIYAPSGYGKSTLAAQWREELVRAGVAVA
Mflv_4809|M.gilvum_PYR-GCK RVVPRPDLLKRLESSAGGDLVVLTAPAGYGKTTVTAMWDAEDRR---QFA
Mvan_1633|M.vanbaalenii_PYR-1 RVVQRPGVLRRLKAAGSGDLVVMSAPAGYGKTTAAALWDFEDDR---PFA
MSMEG_4430|M.smegmatis_MC2_155 QLVHRTALLDALSQSCRSRLILLSAPVGWGKTTLLSQWALGAGKD-QRFG
MLBr_01753|M.leprae_Br4923 VMTTLLGACPSLTILATSREPIGVAGEVIWRVSMLSPADEAVELFTERAA
TH_3225|M.thermoresistible__bu ALVGVPALAVPGLADADARTLLEHMFP--GAIDANVRDRLVAESRGNPLA
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 ------------------------------------MDVTKTEKVRVVVG
MAB_0060|M.abscessus_ATCC_1997 ------------------------------------MQVSG-ELVRVVVG
Mb3107c|M.bovis_AF2122/97 WLTIDNDDNNEVWFLSHLLESIRRVRPTLAESLGHVLEEHGDDAGRYVLT
Rv3080c|M.tuberculosis_H37Rv WLTIDNDDNNEVWFLSHLLESIRRVRPTLAESLGHVLEEHGDDAGRYVLT
MMAR_2576|M.marinum_M WLTIDDDDNNPVWFLAHLLESIRRVHPGVAESLDHVLEEHGDDGSRYLLT
Mflv_4809|M.gilvum_PYR-GCK WARIDHLDDDPGHLLLHIATAVVRLG-AGDDHLLNYLRGPGR-EPEHLLP
Mvan_1633|M.vanbaalenii_PYR-1 WVRIDHLDDDPAHLLLHVATAVVRLT-ETDRTLLRYLRGPGRPALTHLVP
MSMEG_4430|M.smegmatis_MC2_155 WLSLDASDNDPVWFWMYVIAALQKISPGVGTR-AVELLTMGADPIQVVLP
MLBr_01753|M.leprae_Br4923 LVQPGFSVTDGNRQIVTEICQRLDGMPLAIELAAARIRTLSLTEIADGLD
TH_3225|M.thermoresistible__bu LLEVPRTYAVGELAGGFVSPGAGSAPSRIEENYVHRIRALPAQTRRLLLI
MAV_0872|M.avium_104 -------------------MNVVGEAEDGSAALELIKS--HQPDVALLDY
MUL_0351|M.ulcerans_Agy99 DDHPLFREGVVRALSLSGSVNVVGEADDGAAALELIET--HLPDVALLDY
MAB_0060|M.abscessus_ATCC_1997 DDHPLFREGVVRALTASGQITVVAEAENGTGALELIRE--HRPDVALVDY
Mb3107c|M.bovis_AF2122/97 SLIDEIHENDDRIAVVIDDWHRVSDSRTQAALGFLLDNGCHHLQLIVTSW
Rv3080c|M.tuberculosis_H37Rv SLIDEIHENDDRIAVVIDDWHRVSDSRTQAALGFLLDNGCHHLQLIVTSW
MMAR_2576|M.marinum_M SIIDALHDADEPTTLIVDDWQRVSDSQTIAALSFLLEHGCHHLQIIVTSW
Mflv_4809|M.gilvum_PYR-GCK AVVRLLEEFG-PIVVILDDVHKLSTPQSISALHAFVDAAPLTTTVALLGR
Mvan_1633|M.vanbaalenii_PYR-1 VVVQILEDCG-PLVLVLDDVHKLSAADAVTALQMLIDEAPATTTPALLGR
MSMEG_4430|M.smegmatis_MC2_155 TLLNDLDAVARPIVLILDDYHMVVNRAIHEQVAFAVGRMPANLHVVLATR
MLBr_01753|M.leprae_Br4923 DRFRLLTGGARTAVRRQQTLRASMDWS--YALLTESERALFRRLSAISGT
TH_3225|M.thermoresistible__bu AAAEPIGDSALFLRAAALMGIAVDALAPAEAARVIQFGPRMRFFHPLMRS
:
MAV_0872|M.avium_104 RMPGMDGAQVAAAVRADGLATRVLLISAHDESAIVYQA------------
MUL_0351|M.ulcerans_Agy99 RMPRMDGAQVAAAVRSNGLPTRVLLISAHDESAIVYQA------------
MAB_0060|M.abscessus_ATCC_1997 RMPELDGTQVAAAVRRDELPTRVLLLSAHDDAAIVYRA------------
Mb3107c|M.bovis_AF2122/97 SRAGLPVGRLRIGDELAEIDSAALRFDTDEAAALLNDAGGLRLPRADVQA
Rv3080c|M.tuberculosis_H37Rv SRAGLPVGRLRIGDELAEIDSAALRFDTDEAAALLNDAGGLRLPRADVQA
MMAR_2576|M.marinum_M SRTGLPLSRLRLADELVEIDSAALRFDSGEATSFFDSLGGLSLTGNDVAA
Mflv_4809|M.gilvum_PYR-GCK FLLPLDIARRRLAGNLVEVDQDALRLTAEETVAALESVRGPSDD-ATVAT
Mvan_1633|M.vanbaalenii_PYR-1 HMLPVALARRRLQRSVVEVDQEALRLSVEEAAEVLGSVSGPHSD-ATVAA
MSMEG_4430|M.smegmatis_MC2_155 SDPLLPLARLRANGELVEMRSDDLRFGVGEAGQLLNDVLGLDLTEEDVRL
MLBr_01753|M.leprae_Br4923 FDLKVAYAVGHDDLEEPDQVFDRLTMLIDKSLVIVEGRQGGSRYRLLETV
TH_3225|M.thermoresistible__bu AAYRAADPRDRRAVHRALAEATDPGADPDRRAWHAANGVTGTDDAVAAEL
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 LTTSTDGWAAALRLAALSLRGGGDATQLLRGLSGASDVIHEFLSENVLDT
Rv3080c|M.tuberculosis_H37Rv LTTSTDGWAAALRLAALSLRGGGDATQLLRGLSGASDVIHEFLSENVLDT
MMAR_2576|M.marinum_M LTESTDGWAAGLQLAGLSVRGGADASTLVGKLCGTSEVIGEFLAENVLAS
Mflv_4809|M.gilvum_PYR-GCK VIDLCEGWAAGVILTAMALRDG----TAPEALAGRNNLVVEYVVEEVIDR
Mvan_1633|M.vanbaalenii_PYR-1 VVDLCEGWAAGVILTAMALRDG----TALEALTRRNNLVVDYVVEEVIDR
MSMEG_4430|M.smegmatis_MC2_155 LHRRTEGWAAGLYLAALSLAGRAQAAAFIRTFAGDNRHIVDYLMAEVLDR
MLBr_01753|M.leprae_Br4923 RQYAMKKLEESNEVDLVLARHRDHYMALGALLDTPGDIDHEQLVEQVETE
TH_3225|M.thermoresistible__bu EKSAARAQQRGGIAATATFLERAVVLTADPGLRGRRALAAAQAKRDAADS
MAV_0872|M.avium_104 LQQGAAGFVLK-----DSTRSEIVKAVLDCAQGR----------------
MUL_0351|M.ulcerans_Agy99 LQQGAAGFLLK-----DSTRTEIVKAVLDCAKGR----------------
MAB_0060|M.abscessus_ATCC_1997 LEEGAAGFLSK-----ESTRTELVGAVLDCARGR----------------
Mb3107c|M.bovis_AF2122/97 LEPELREFLLV-----ASVTERTCGGLASALAGITNGRAMLEEAEHRG-L
Rv3080c|M.tuberculosis_H37Rv LEPELREFLLV-----ASVTERTCGGLASALAGITNGRAMLEEAEHRG-L
MMAR_2576|M.marinum_M LEPEIVDFVLA-----TSIPERICADLASALAQVPRGQALLEQVAQRG-L
Mflv_4809|M.gilvum_PYR-GCK VDDDTRSFLLE-----SAMLDRFTAEHLDAVLGRVDAAWMLEQLATSGNP
Mvan_1633|M.vanbaalenii_PYR-1 LDGDTATFLVE-----SAVLDRFTAEQLDTVLGRDDSARMLEMLYGSGNP
MSMEG_4430|M.smegmatis_MC2_155 QSPRIRNFLLR-----TSVMRRFNGALCDAVLQSSDSVSVLEEMEREN-L
MLBr_01753|M.leprae_Br4923 LDNLRSAFAWSRETGDIAGALQLASSLQPIWFGRGHMYEGLAWFDSIFEH
TH_3225|M.thermoresistible__bu AAAHDLLAIAER----APLSALEWARAVHLRAQLEFARSRAGDAGGPPVG
.
MAV_0872|M.avium_104 -------------------DVVAPALVGGLAAEIRQRAEPTGPVLSAR--
MUL_0351|M.ulcerans_Agy99 -------------------DVVAPSLVGGLAGEIRQRAAPMAPVLSAR--
MAB_0060|M.abscessus_ATCC_1997 -------------------DVVAASLTAGLAGEIRKRAQPAGPSLSTR--
Mb3107c|M.bovis_AF2122/97 FLQRTEDDPNWFRFHQMFADFLHRRLERGGSHRVAELHRRASAWFAENGY
Rv3080c|M.tuberculosis_H37Rv FLQRTEDDPNWFRFHQMFADFLHRRLERGGSHRVAELHRRASAWFAENGY
MMAR_2576|M.marinum_M FLQPVDGEPGWFHYHQMFAEFLRRRLERDDPQRVAQLHRTAALWLKEHDR
Mflv_4809|M.gilvum_PYR-GCK FLISLDSQGDSFRYHHLFGDVLRARLRASEPARFRELASRAADLLEREGD
Mvan_1633|M.vanbaalenii_PYR-1 FLIAIDHHRVWYRYHHLFGDVLRGRLRDLAPARFRELATRAADLLERDGD
MSMEG_4430|M.smegmatis_MC2_155 FLVPLDMSRHWYRYHHLFGELLRAELHRCEPELVPGLHRRAAKWFEAEGL
MLBr_01753|M.leprae_Br4923 KNIEHLVAPKEVLARAVANKVMLHAILASSPPDGSDLVTQAQQALTMARE
TH_3225|M.thermoresistible__bu QTAAALLTAAQLLQDVDAPAARESYLEAFAALMYAGRLAPSGALLEAADA
: . :
MAV_0872|M.avium_104 -EREVLHR-------IARGQSIPAIAGELYVAP--------STVKTHVQR
MUL_0351|M.ulcerans_Agy99 -EREVLHR-------IAKGQSIPAIAGELYVAP--------STVKTHVQR
MAB_0060|M.abscessus_ATCC_1997 -EREVLRM-------IAAGQTVPAIARALFLAP--------STVKTHVQR
Mb3107c|M.bovis_AF2122/97 LHEAVDHA-------LAAGDPARAVDLVEQDETNLPEQSKMTTLLAIVQK
Rv3080c|M.tuberculosis_H37Rv LHEAVDHA-------LAAGDPARAVDLVEQDETNLPEQSKMTTLLAIVQK
MMAR_2576|M.marinum_M LHDAVKHA-------LAAGDPALAVDFVEDDETNLLEQSKMTTLLEIVKK
Mflv_4809|M.gilvum_PYR-GCK IDGALVHA-------LEAGDRARAAALVGREAVRLGFDGRAGVLARRLGM
Mvan_1633|M.vanbaalenii_PYR-1 IDGALLQA-------LDAGDRTRAAALVGREAVRLGFDGRAGVLARRLAM
MSMEG_4430|M.smegmatis_MC2_155 VDEALRHL-------VAAGDIAESADLIVEDWANELAGGGLSTVSGWLDL
MLBr_01753|M.leprae_Br4923 IGDSAVLARALTACGFSSGYDTEVARPYFAEAVELARTQGDKWTLSQIRL
TH_3225|M.thermoresistible__bu VQAAFARAP----------EGSRAVDAFCQGMTQRIVGGISAAAAPLRVA
MAV_0872|M.avium_104 LYEKLGVSDRAAAVAEAMRQGLLS--------------------------
MUL_0351|M.ulcerans_Agy99 LYEKLGVSDRAAAVAEAMRQGLLD--------------------------
MAB_0060|M.abscessus_ATCC_1997 LYEKLGVGDRAAAVAEAMRRGLLE--------------------------
Mb3107c|M.bovis_AF2122/97 LPTSMVVSRARLQLAIAWANILLQRPAPATGALNRFET------------
Rv3080c|M.tuberculosis_H37Rv LPTSMVVSRARLQLAIAWANILLQRPAPATGALNRFET------------
MMAR_2576|M.marinum_M LPPRLIVSRERLQLAIAWANILLQRKVPADAALNLFTK------------
Mflv_4809|M.gilvum_PYR-GCK LDARTFAEQPDAAVARAWLGVTTADAELIQRSLMLALH------------
Mvan_1633|M.vanbaalenii_PYR-1 LDARTFAEHPDAAVARAWLGVTTADAELIHRSLMLATR------------
MSMEG_4430|M.smegmatis_MC2_155 LPEGTVRGDPRLSAIRAWVALNVGLFDDARIWIEAVAA------------
MLBr_01753|M.leprae_Br4923 WGVVGFCVSGDPVALRAAAEAADDLAQEIGDRFVSLQCRLLLSIAQLWQG
TH_3225|M.thermoresistible__bu LTAMCELARSRPAEVVHWLVPAFPVLQESAGHELWDEN---------LVD
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 ALGRAELPEATQADLRAEADVLR-AVAEVFADRVERVDDLLAEAMSRPDT
Rv3080c|M.tuberculosis_H37Rv ALGRAELPEATQADLRAEADVLR-AVAEVFADRVERVDDLLAEAMSRPDT
MMAR_2576|M.marinum_M ALDHADP--ATQADLRVEADVLQ-AVADTFADRIDRVDTLVAEALSRPQT
Mflv_4809|M.gilvum_PYR-GCK SDHGGPLADGTPSVSVAVALISS-LVGVGGVAEVIRHADTVRAAG---DN
Mvan_1633|M.vanbaalenii_PYR-1 SDHGQPLSDGTPSVKVAVALISS-LVGAGGVNDVIRQADVVRAAG---DR
MSMEG_4430|M.smegmatis_MC2_155 GLEGVSAAEGSARAGLSEQLVALREVYAFKIGDVTNALDAARQAATLEVG
MLBr_01753|M.leprae_Br4923 DMDGAIVRSGEVVAGAEAAHDTVTRTFGLYVQTRALVHRDVSAALVTAGL
TH_3225|M.thermoresistible__bu ALSEAVVRQARDAGALAGLPQALVYRAGVHLLFGEFGLADTLLTEAESIT
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 LPPRVPGTAGNTAALAAICRFEFAEVYPLLDWAAPYQEMMGP-FGTVYAQ
Rv3080c|M.tuberculosis_H37Rv LPPRVPGTAGNTAALAAICRFEFAEVYPLLDWAAPYQEMMGP-FGTVYAQ
MMAR_2576|M.marinum_M FHPRVPAVAGNVSAFAALYRFQFDQVRRLLAWATPYREMMGP-FVSVYAR
Mflv_4809|M.gilvum_PYR-GCK LVNPWWGAATVMKGAAEAMRGQGGRARLLLESALPVIEDLPG-FHAA---
Mvan_1633|M.vanbaalenii_PYR-1 LVNPWWGAATVMKGAAEAMRGQVARARALLESALPVIEDLPG-FQAA---
MSMEG_4430|M.smegmatis_MC2_155 EAPPARSAAHVTYGAALYFSGDIDEARTELQRAVELTERTGDRRHRVYAL
MLBr_01753|M.leprae_Br4923 VVEAAAELSGVYQGIGYAAMVFAALAMGDVAAAVEASEACRPHLGADHGL
TH_3225|M.thermoresistible__bu AATDHRGPVRYHRLIIAAWRGDAVEAARLIEAAAADGEARGEGRLMGLTG
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 CLRGMAARNR----LDIVAALQNFRTAFEVGTAVGAHSHAARLAGSLLA-
Rv3080c|M.tuberculosis_H37Rv CLRGMAARNR----LDIVAALQNFRTAFEVGTAVGAHSHAARLAGSLLA-
MMAR_2576|M.marinum_M CYLGLAAKFA----LDIATALAEFRRAVEIAQSCGTNSNATRIAGAFLG-
Mflv_4809|M.gilvum_PYR-GCK ---ALAHLAL----LDLAAGDD--------------EAAVERCDAARTL-
Mvan_1633|M.vanbaalenii_PYR-1 ---ALAHLAL----LDLAAGDD--------------DGAVARSEEARTL-
MSMEG_4430|M.smegmatis_MC2_155 GYLALIEAES----GQLADAEHLIRRATGVGPDPAGTQNFIDVAVSLAVS
MLBr_01753|M.leprae_Br4923 VAIHLELMAA----VALARGDVIVARRLADN-SVSATTGWHQMAALTTRA
TH_3225|M.thermoresistible__bu YAAALLYNGIGRYREALAAARTTCEYEDLGFYSWCLHELVEAAARVGETD
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 ELLYETGDLAGAGRLMDESYLLGSEGGAVDYLAARYVIGARVKAAQGDHE
Rv3080c|M.tuberculosis_H37Rv ELLYETGDLAGAGRLMDESYLLGSEGGAVDYLAARYVIGARVKAAQGDHE
MMAR_2576|M.marinum_M EMLHDVGELTEAKLLLDESYRLGPEGGGVDYLVARFVAGARVNAAHGDCA
Mflv_4809|M.gilvum_PYR-GCK ADKYDLSDVVPMIVVYSTSAVMSARVGDVPAALHAVQITQTLLERLGNLS
Mvan_1633|M.vanbaalenii_PYR-1 VDKYDLCDVVPMIVVYATSAVMAARVGDEVGARRAVAVSETLLGRLGHLS
MSMEG_4430|M.smegmatis_MC2_155 VVLYASGEWAAAADAAHLAVGLARKGAGILEVAKALMVRAKILNDFGDLE
MLBr_01753|M.leprae_Br4923 RIAMAQGEPELARADIHAALACGADIQASLGISDSMELLAELISQGDNHR
TH_3225|M.thermoresistible__bu TAHRALGDIEERAGASGTPWGLGALAGARALLADGDEADRLFREALDHLS
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 GAADRLSTGGDTAVQLGLPRLAARINNERIRLGIALPAAVAADLLAPRTI
Rv3080c|M.tuberculosis_H37Rv GAADRLSTGGDTAVQLGLPRLAARINNERIRLGIALPAAVAADLLAPRTI
MMAR_2576|M.marinum_M AAAERLEAGMAVADQLHLPRLSAAINHERVRLGIGLSPSVSARLRDTRHN
Mflv_4809|M.gilvum_PYR-GCK ARTALLGHG--------LLAWTAAALQDRALLSRHLTAAERVRHREP---
Mvan_1633|M.vanbaalenii_PYR-1 ARTALLGHG--------LLAWTAAVIQDPELLGRHLGAAERACHREP---
MSMEG_4430|M.smegmatis_MC2_155 AAEK--------------SRSEAGALLRRCPDNVAVHPMIGS--------
MLBr_01753|M.leprae_Br4923 QAGRLFGAASAQREKTGEVRFKVWDAGYESAVAVLRGAMGCKDFDSAWAE
TH_3225|M.thermoresistible__bu RSRVVVHRARVHLTYGEWLRREHRRGEARRELNEAHGMFTRMGAQG----
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 PRDNGIATMTAELDEDSAVRLLSAGDS-ADRDQACQRAGALAAAIDGTRR
Rv3080c|M.tuberculosis_H37Rv PRDNGIATMTAELDEDSAVRLLSAGDS-ADRDQACQRAGALAAAIDGTRR
MMAR_2576|M.marinum_M SSDDGIVTLTYELDEASAIRLLSAGGSEQDRADAHRRARDLLTGIDATLR
Mflv_4809|M.gilvum_PYR-GCK -------DAVALVQRVERVKAMAVGGTRPLTAAELRLLPHLATHLSLQR-
Mvan_1633|M.vanbaalenii_PYR-1 -------DAVALVQRVDRVKAMAAGGTRPLTAAELRLLPHLASHLSLQR-
MSMEG_4430|M.smegmatis_MC2_155 -------------AGQGRRVAVAAYNDEHIAEDLTSKELEVLRLLATRLS
MLBr_01753|M.leprae_Br4923 GAAMPIDDAITYAQRGRGNRKRPTTGWESLTPAEHN----VIRLVSEGLD
TH_3225|M.thermoresistible__bu -------FAERSRRELIAVGEKVRRQPLTSGDELTAQEAQIAGLAADGLT
MAV_0872|M.avium_104 --------------------------------------------------
MUL_0351|M.ulcerans_Agy99 --------------------------------------------------
MAB_0060|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3107c|M.bovis_AF2122/97 PLAALQAQILHIETLAATGRESDARNELAPVATKCAELGLSRLLVDAGLA
Rv3080c|M.tuberculosis_H37Rv PLAALQAQILHIETLAATGRESDARNELAPVATKCAELGLSRLLVDAGLA
MMAR_2576|M.marinum_M PWAALRAQLLLAETLRAAGLQPDP--ESAGLAQRCNELGLVRLAVDAGLT
Mflv_4809|M.gilvum_PYR-GCK ---IAEELVIGRETAKSQATSIYRKLGVSSRGQAVSEAIRIGLLAD----
Mvan_1633|M.vanbaalenii_PYR-1 ---VAEELVIGRETVKSQATAIYRKLGVSSRGEAVAEAKRVGLIAD----
MSMEG_4430|M.smegmatis_MC2_155 RRDIGQRLYVSLNTVKTHQRAIYRKLGVDNRNSAVARGRELGLL------
MLBr_01753|M.leprae_Br4923 TKDIAARLFVSVRTVHTHLTRIYSKLGLTSRVQLVQEAARHN--------
TH_3225|M.thermoresistible__bu NQEIGAQLFLSVHTVEWHLRKVFVKLGITSRRQLRAAPRVTATW------