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SAASPLLRPRDGDALRAELRRVAALGGVPVLFGGEIHEDTLLISEYYGLRTAGLRGLAVRSSSGLGGASM VAGRPLAVADYRNASSITHDYDGPVLSEGIRSVLAVPVLVDGRARAMLYGAYRTGAPFGGRAADLVVESA RRLSEEFRIRDEVDRRLRMRDAQAAGGQVSDEQIREVHAELRLLAVTAPPPLQNRLRALADTLSGTGTEP GAGPDAATLAPRELDVLAQVALGCTNAEAAQRLSLKPETVKSYLRSAATKLGTRTRYESVSKARRLHLIP *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4865 | - | - | 100% (281) | response regulator receiver protein |
| M. gilvum PYR-GCK | Mflv_0730 | - | 1e-06 | 38.24% (68) | two component LuxR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3579 | - | 5e-05 | 40.35% (57) | two component LuxR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0914c | - | 2e-06 | 28.26% (138) | LuxR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0890c | - | 2e-06 | 28.26% (138) | LuxR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1522 | - | 1e-06 | 33.66% (101) | putative two-component system response regulator LuxR |
| M. marinum M | MMAR_0133 | - | 3e-12 | 32.46% (114) | two-component sensor histidine kinase |
| M. avium 104 | MAV_4201 | - | 2e-05 | 32.43% (74) | transcriptional regulator, LuxR family protein |
| M. smegmatis MC2 155 | MSMEG_5651 | - | 9e-98 | 66.43% (280) | transcriptional regulator, LuxR family protein |
| M. thermoresistible (build 8) | TH_3563 | - | 4e-07 | 41.67% (60) | PUTATIVE DNA-binding response regulator, LuxR family protein |
| M. ulcerans Agy99 | MUL_2876 | - | 9e-06 | 31.51% (146) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1565 | - | 1e-120 | 79.58% (284) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0914c|M.bovis_AF2122/97 MRALLAQNRLVTLCGTGGVGKTRLAIQIASASELRDGLCFVDLAPITESG
Rv0890c|M.tuberculosis_H37Rv MRALLAQNRLVTLCGTGGVGKTRLAIQIASASELRDGLCFVDLAPITESG
Mflv_4865|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1565|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3563|M.thermoresistible__bu --------------------------------------------------
MAV_4201|M.avium_104 --------------------------------------------------
MMAR_0133|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
Mb0914c|M.bovis_AF2122/97 IVAATAARAVGLPDQPGRSTMDSLRRFIGNRRMLMVLDNCEHLLDACAAL
Rv0890c|M.tuberculosis_H37Rv IVAATAARAVGLPDQPGRSTMDSLRRFIGNRRMLMVLDNCEHLLDACAAL
Mflv_4865|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1565|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3563|M.thermoresistible__bu --------------------------------------------------
MAV_4201|M.avium_104 ----------------------------------MMLMAQAVLPTRAELL
MMAR_0133|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
Mb0914c|M.bovis_AF2122/97 VVELLGACPELTILATSREPIGMAGEITWRVPSMSITDEAVELFADRASR
Rv0890c|M.tuberculosis_H37Rv VVELLGACPELTILATSREPIGMAGEITWRVPSMSITDEAVELFADRASR
Mflv_4865|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1565|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3563|M.thermoresistible__bu --------------------------------------------------
MAV_4201|M.avium_104 AALSVAIDLGLGQPAEHMLRAALIATRLCDRLGLSRQQRDCVYYTTLVMW
MMAR_0133|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
Mb0914c|M.bovis_AF2122/97 VQPGFTIANHNAAAVGEICRRLDGIPLAIEFAAARVRSMSPLEIADGLDD
Rv0890c|M.tuberculosis_H37Rv VQPGFTIANHNAAAVGEICRRLDGIPLAIEFAAARVRSMSPLEIADGLDD
Mflv_4865|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1565|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3563|M.thermoresistible__bu --------------------------------------------------
MAV_4201|M.avium_104 VGCHADSHEYARWFGDDIAVRHDSYLVDWSGIPYLRFLASNVGRGQPLAH
MMAR_0133|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 ---------------------------------------------MGFSP
Mb0914c|M.bovis_AF2122/97 CFRLLAGGVRGAVQRQQTLRASIDWSHALLTETEQILFRRLAPFVGGFDL
Rv0890c|M.tuberculosis_H37Rv CFRLLAGGVRGAVQRQQTLRASIDWSHALLTETEQILFRRLAPFVGGFDL
Mflv_4865|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1565|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3563|M.thermoresistible__bu --------------------------------------------------
MAV_4201|M.avium_104 RLSVMATLFANARGHISRLIHSHCASAALLADRIGLGPNVQAALAYTFER
MMAR_0133|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 RRAIPERTVGGVIDVVDMPDPPAFPTLADDEHPGWASRPIRESDATRHYR
Mb0914c|M.bovis_AF2122/97 AAVRAVAAGSDLDPFSVLDQLTLLVDKSLVVADDCQGRTRYRLLETVRRY
Rv0890c|M.tuberculosis_H37Rv AAVRAVAAGSDLDPFSVLDQLTLLVDKSLVVADDCQGRTRYRLLETVRRY
Mflv_4865|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1565|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3563|M.thermoresistible__bu --------------------------------------------------
MAV_4201|M.avium_104 YDGGGLPTGARGEDIPIQMRIAQLADMVEVHHRSYG----------VAGA
MMAR_0133|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 EAFGDCNVDPTDDPMAVVAEAIDVN----------------------AAA
Mb0914c|M.bovis_AF2122/97 ALEKLGDSGEADVHARHRDYYTALAASLNTPADNDHQRLVARAETEIDNL
Rv0890c|M.tuberculosis_H37Rv ALEKLGDSGEADVHARHRDYYTALAASLNTPADNDHQRLVARAETEIDNL
Mflv_4865|M.gilvum_PYR-GCK ---------------------MSAASPLLRPRDGDALRAELRRVAALGGV
Mvan_1565|M.vanbaalenii_PYR-1 ---------------------MPAPSPLLRPRDSDALRAELRRVALLGDV
MSMEG_5651|M.smegmatis_MC2_155 -----------------------MRSPLLRPRDADAVRAALRQMATITEL
MAB_1522|M.abscessus_ATCC_1997 --------------------MTDTEVGVLLVDDQELVRTGLRRILRRKDG
TH_3563|M.thermoresistible__bu -------------------MGEPQQPTVMVVDDHPIWREAVARDLAEAGL
MAV_4201|M.avium_104 VAMVGARRGGQFDPGIADVFLRDADAILAGPQTGDAWAAALREAPDRHRV
MMAR_0133|M.marinum_M -------------------MLALLDRTAALRHGADVVHRRLGADLAAGAN
MUL_2876|M.ulcerans_Agy99 VRHALESQGDVHAVNALETLLDLSSLEREMIEDGAARRTLALLQVQEALS
Mb0914c|M.bovis_AF2122/97 RAAFAWSRENGHITEALQLASSLQPIWFGRAHLREGLSWFNSILEDQRFH
Rv0890c|M.tuberculosis_H37Rv RAAFAWSRENGHITEALQLASSLQPIWFGRAHLREGLSWFNSILEDQRFH
Mflv_4865|M.gilvum_PYR-GCK ------------------------PVLFG---------------------
Mvan_1565|M.vanbaalenii_PYR-1 ------------------------PVMFG---------------------
MSMEG_5651|M.smegmatis_MC2_155 ------------------------PLTFG---------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3563|M.thermoresistible__bu --------------------------------------------------
MAV_4201|M.avium_104 DE-----------------------------------------------Q
MMAR_0133|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 KLR-----------------------------------------------
Mb0914c|M.bovis_AF2122/97 RLAVSTAVRARALADKAMLSTWLATSPVGATDIIAPAQQALAMAREVG-D
Rv0890c|M.tuberculosis_H37Rv RLAVSTAVRARALADKAMLSTWLATSPVGATDIIAPAQQALAMAREVG-D
Mflv_4865|M.gilvum_PYR-GCK ---------GEIHEDTLLISEYYGLRTAGLRGLAVRSSSGLGGASMVAGR
Mvan_1565|M.vanbaalenii_PYR-1 ---------GEVHGDTLVITEYHGVRTAGLRGLEVRSNSGLGGASMVAGR
MSMEG_5651|M.smegmatis_MC2_155 ---------GEVHSGTLLLTEFFGTRTSAMRGLAVRPSAGLGGATMVARR
MAB_1522|M.abscessus_ATCC_1997 ---------FAIVGECADGSEVAAAVSRARPDVVIMDLRMKQMSGIEAIR
TH_3563|M.thermoresistible__bu ----------SVVATADGVAAARRRAAAVRPDVVLMDMRLPDGDGARATA
MAV_4201|M.avium_104 SLDAALVALGDFVDLKCPFTLGHSRAVARLAGQAARAAGLDADAVALTRR
MMAR_0133|M.marinum_M ---------RIAEDDTMEVVAVVGGRTEELNGLVIGPQEGLGGQAAVLRR
MUL_2876|M.ulcerans_Agy99 -----AVDDVAMIVDRAPRELVESCGFDRAVLFRVHEGRLVMESAYFGED
Mb0914c|M.bovis_AF2122/97 PAALVR-ALTACGCSSGYNAEAAAPYFAEATDLARAIDDKWTLCQILYWR
Rv0890c|M.tuberculosis_H37Rv PAALVR-ALTACGCSSGYNAEAAAPYFAEATDLARAIDDKWTLCQILYWR
Mflv_4865|M.gilvum_PYR-GCK PLAVAD-YRNASSITHDYDGPVLSEGIRSVLAVPVLVDG-----------
Mvan_1565|M.vanbaalenii_PYR-1 PLSVAD-YRNATGITHDYDGPVLSEGIRSVLAVPVLVDG-----------
MSMEG_5651|M.smegmatis_MC2_155 PISVAD-YRHASAITHDYDGPVLSEGIRSVLAVPVVVDG-----------
MAB_1522|M.abscessus_ATCC_1997 LLHAAQ-GPPALALTTFDDDELLSGALRAGAAGFILKDS-----------
TH_3563|M.thermoresistible__bu EVRAVSPDSRVLVLSASEERDDVLEAVKAGATGYLVKSA-----------
MAV_4201|M.avium_104 AGHVHDLGRIGVSNQIWSRPGPLSGSQFERVRLHPYLTVR----------
MMAR_0133|M.marinum_M TVAVHD-YCMSRDITHDFDHAVRAEGLRAAMVAPIVRAHRLYG-------
MUL_2876|M.ulcerans_Agy99 REGAEKMVAFAQSVAPLLDHMLIETQMIRRHAPAIVRDAR----------
Mb0914c|M.bovis_AF2122/97 GVGTCISGDPNALRAAAEECRDLADTIGDRFVSRHCSLWLSLAQMWAGNL
Rv0890c|M.tuberculosis_H37Rv GVGTCISGDPNALRAAAEECRDLADTIGDRFVSRHCSLWLSLAQMWAGNL
Mflv_4865|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1565|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3563|M.thermoresistible__bu --------------------------------------------------
MAV_4201|M.avium_104 --------------------------------------------------
MMAR_0133|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
Mb0914c|M.bovis_AF2122/97 TEALELSREITAEAEASNDVPTKVLGLYTQAQVLAYCGASAAHAIAGACI
Rv0890c|M.tuberculosis_H37Rv TEALELSREITAEAEASNDVPTKVLGLYTQAQVLAYCGASAAHAIAGACI
Mflv_4865|M.gilvum_PYR-GCK -----------------------------RARAMLYGAYRTGAPFGGRAA
Mvan_1565|M.vanbaalenii_PYR-1 -----------------------------RARAMLYGAYRSGAPFGGRVT
MSMEG_5651|M.smegmatis_MC2_155 -----------------------------QARAVLYGSYRQSAPIGDRAA
MAB_1522|M.abscessus_ATCC_1997 -----------------------------PAEELVRAVHAVAR--GEAYL
TH_3563|M.thermoresistible__bu -----------------------------SKTELVDAVHATAQ--GRAVF
MAV_4201|M.avium_104 -----------------------ILDQVPGLRRLAEVAGNHHECLDGSGY
MMAR_0133|M.marinum_M -----------LLYAARRSPVAWTDRDRAELLSLARQAAVAMEVADSARE
MUL_2876|M.ulcerans_Agy99 -------------------------NDPRVNRPIVDFSLTHSYVAAPVMP
:
Mb0914c|M.bovis_AF2122/97 AAATELGGVYQGIGYAAMTYAALAAGDVTAALEASDAARPILRAQPDQVT
Rv0890c|M.tuberculosis_H37Rv AAATELGGVYQGIGYAAMTYAALAAGDVTAALEASDAARPILRAQPDQVT
Mflv_4865|M.gilvum_PYR-GCK DLVVES------------------ARRLSEEFRIRDEVDRRLRMR-----
Mvan_1565|M.vanbaalenii_PYR-1 ELVIES------------------ARALSEEFRIRDEVDRRLRLR-----
MSMEG_5651|M.smegmatis_MC2_155 AAMVAS------------------ARQLSEELRVRDEVDRRMRMR-----
MAB_1522|M.abscessus_ATCC_1997 DPAVTS--------------------------------------------
TH_3563|M.thermoresistible__bu TPGLAG--------------------------------------------
MAV_4201|M.avium_104 PRGLAG-----------------SALGMPDRILAAAVCYQSGREP-----
MMAR_0133|M.marinum_M MAEVAAFGERQRLAIRLHDSVGATLFSLRVALMSAQEETEPGRREELLSD
MUL_2876|M.ulcerans_Agy99 TGKMIG-------------------FLHADRLYSGRIVDEIDRDT-----
Mb0914c|M.bovis_AF2122/97 MHQVLMAQLALAGGDAIAARQFANDAVDATNGWHRMVALTIRARVATARG
Rv0890c|M.tuberculosis_H37Rv MHQVLMAQLALAGGDAIAARQFANDAVDATNGWHRMVALTIRARVATARG
Mflv_4865|M.gilvum_PYR-GCK -----DAQAAG---GQVSDEQIR---------------------------
Mvan_1565|M.vanbaalenii_PYR-1 -----DTQSANSGEGAVDAESVR---------------------------
MSMEG_5651|M.smegmatis_MC2_155 -----EAQLAQFGADVASAEQIR---------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3563|M.thermoresistible__bu --------------------------------------------------
MAV_4201|M.avium_104 ------RPYREQLSEAEAARRLRG--------------------------
MMAR_0133|M.marinum_M ALVLTERATSELRAQTLSLHDLPEDK------------------------
MUL_2876|M.ulcerans_Agy99 -VWAFAEGFGYAYERTVLLERMR---------------------------
Mb0914c|M.bovis_AF2122/97 EPELARDDAHAALACGAELHIYQGMPDAMELLAGLAGEVGSHSEGVRLLG
Rv0890c|M.tuberculosis_H37Rv EPELARDDAHAALACGAELHIYQGMPDAMELLAGLAGEVGSHSEGVRLLG
Mflv_4865|M.gilvum_PYR-GCK ----------------------------------------EVHAELRLLA
Mvan_1565|M.vanbaalenii_PYR-1 ----------------------------------------EVHAELRRLA
MSMEG_5651|M.smegmatis_MC2_155 ----------------------------------------EVHADLRRMA
MAB_1522|M.abscessus_ATCC_1997 ----------------------------------------RVLNAYRRAP
TH_3563|M.thermoresistible__bu ----------------------------------------LVLGEYRRIS
MAV_4201|M.avium_104 ---------------------------------------RVRCGELDPVA
MMAR_0133|M.marinum_M ------------------------------------ALAVTLEGDCRDFA
MUL_2876|M.ulcerans_Agy99 ----------------------------------------RQHAEVRSAL
Mb0914c|M.bovis_AF2122/97 AAAALRQQTRQVRFKIWDAGYQASVTALREAMGDEDFDRAWAEGAALSTD
Rv0890c|M.tuberculosis_H37Rv AAAALRQQTRQVRFKIWDAGYQASVTALREAMGDEDFDRAWAEGAALSTD
Mflv_4865|M.gilvum_PYR-GCK VTAPPPLQNRLR--------------------------------------
Mvan_1565|M.vanbaalenii_PYR-1 VDAPAGLQQRLR--------------------------------------
MSMEG_5651|M.smegmatis_MC2_155 ARASRPLATQLG--------------------------------------
MAB_1522|M.abscessus_ATCC_1997 AAVSGDAQDKLT--------------------------------------
TH_3563|M.thermoresistible__bu RQPGAGPDAPRL--------------------------------------
MAV_4201|M.avium_104 AEAVLHAAGQPVG-------------------------------------
MMAR_0133|M.marinum_M TRTGTAAELVVLG-------------------------------------
MUL_2876|M.ulcerans_Agy99 ASADEAARALQDADLDLR------------------------------KI
Mb0914c|M.bovis_AF2122/97 EAIAYAQRGRGERKRPARGWGSLTPTERDVVRLVSEGLSNKDIAKRLFVS
Rv0890c|M.tuberculosis_H37Rv EAIAYAQRGRGERKRPARGWGSLTPTERDVVRLVSEGLSNKDIAKRLFVS
Mflv_4865|M.gilvum_PYR-GCK -ALADTLSGTGTEPGAGPDAATLAPRELDVLAQVALGCTNAEAAQRLSLK
Mvan_1565|M.vanbaalenii_PYR-1 -VLADKLSGPADDPAT---VAPLTGRELDVLAQVALGCTNAEAAQRLSLK
MSMEG_5651|M.smegmatis_MC2_155 -ELADRLARALSGDAP--AATPLTAREIDVLSQIALGCTNAEAAQRLSLK
MAB_1522|M.abscessus_ATCC_1997 ------------------------ARELDVLALIASGATNSEIAEQLVIS
TH_3563|M.thermoresistible__bu -----------------------TERETEILRYVAKGLTAKQIAAQLSLS
MAV_4201|M.avium_104 -------------PRPNPRPDGLTPREIEVLGHVARGASNKEIAAALVIS
MMAR_0133|M.marinum_M -DLPLLDSARTDALRRTAREALLNVEKHAGAHSVVVSLYRAEDGVGLTVA
MUL_2876|M.ulcerans_Agy99 EPVERSPAARSLAEVQTRVMAMLTRREVEVLRLMAAGRTNQQIADELVIS
: : . : . * :
Mb0914c|M.bovis_AF2122/97 PRTVQTHLTHVYAK-LGLASRVQLVDEAARRGSPS---------------
Rv0890c|M.tuberculosis_H37Rv PRTVQTHLTHVYAK-LGLPSRVQLVDEAARRGSPS---------------
Mflv_4865|M.gilvum_PYR-GCK PETVKSYLRSAATK-LGTRTRYESVSKARRLHLIP---------------
Mvan_1565|M.vanbaalenii_PYR-1 TETVKSYLRSAATK-LGTRTRYEAVSRARRLHLIP---------------
MSMEG_5651|M.smegmatis_MC2_155 PETVKSYLRSASSK-LGAHSRHEAVSKARRLRQIP---------------
MAB_1522|M.abscessus_ATCC_1997 EVTVKSHIGRIFVK-LDLRDRAAAIVYAYDHGIVTPK-------------
TH_3563|M.thermoresistible__bu HRTVENHVQATFRK-LQVANRVELARYAIEHGLDE---------------
MAV_4201|M.avium_104 EKTARNHVERTYAK-IGVSNRIGASMYALQHGLVPAAPPHS---------
MMAR_0133|M.marinum_M DDGTAPDIASEHRRGLGLRATVERIERVGGWLSCTANEEGGGTVQAWVPA
MUL_2876|M.ulcerans_Agy99 AGTVKSHVKRVLRK-LHATNRAEAASAYVRLASVSEVG------------
. : : :
Mb0914c|M.bovis_AF2122/97 ---------
Rv0890c|M.tuberculosis_H37Rv ---------
Mflv_4865|M.gilvum_PYR-GCK ---------
Mvan_1565|M.vanbaalenii_PYR-1 ---------
MSMEG_5651|M.smegmatis_MC2_155 ---------
MAB_1522|M.abscessus_ATCC_1997 ---------
TH_3563|M.thermoresistible__bu ---------
MAV_4201|M.avium_104 ---------
MMAR_0133|M.marinum_M ARAFRPVGP
MUL_2876|M.ulcerans_Agy99 ---------