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ISWRKQLVPLIAAASLVLASGTVVDVASRAEEAILIPGATVLKPINPFYPLIALNYPKIGIHFHEDGQPL LIDYSQDALNSDKALLDGVQQTMIAVQQTDGKIVIIGESMGSMVAARVAKELAASPNPRLDDVRVVLIAP PEVGVAEYFKEGTFIPILNYRVKRVALSPYPTTIVIGEYDGWADPPDRPWNLLATANALLGIVYVHGVPS FTTDPNDVPPENVKTIPGNADHGPITTMLVPTKNLPLTQFLRDIGVPDQWVDAIDNILRPIIDSAYVRND KPGDSRPYLYNGEIRRNVETPQEVETPEADVAGGVETTDVDTTSTETKDVGTHNAVDGDSKLGIKESDTK GVTTNDTKNDAKVVIKDVSKDVDTEVVTKDDETTATDTDTDTDTEARAGDDIEKKKSPRETRRERRHEHR DAIRDGLDNVKSQVESGLKDLAKGLKGPRAKQKKVKNENETQSESASESDSE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5350 | - | - | 100% (473) | PPE family protein, putative |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 1e-40 | 32.71% (425) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_5759 | - | 1e-30 | 32.03% (281) | PE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3569 | PPE63 | 3e-33 | 33.69% (282) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_3371 | - | 3e-25 | 29.94% (314) | hypothetical protein Mflv_3371 |
| M. tuberculosis H37Rv | Rv3539 | PPE63 | 3e-33 | 33.69% (282) | PPE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 7e-25 | 32.27% (220) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 1e-22 | 32.00% (225) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_4939 | - | 3e-28 | 35.58% (208) | PE-PGRS family protein |
| M. avium 104 | MAV_1760 | - | 2e-21 | 30.37% (214) | hypothetical protein MAV_1760 |
| M. thermoresistible (build 8) | TH_3724 | - | 2e-25 | 35.71% (224) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 3e-11 | 27.37% (285) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_0761 | - | 1e-107 | 48.91% (413) | hypothetical protein Mvan_0761 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3569|M.bovis_AF2122/97 ---MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFE
Rv3539|M.tuberculosis_H37Rv ---MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFE
MMAR_4939|M.marinum_M ----MSYVVAAPDFLSTAAEDLAAMGSAVSTATAAAARSTTLLLAAGADE
MAB_0936c|M.abscessus_ATCC_199 ---MRNLLAGTAVLVVACVTGCFGIPSAVADDPQVPGPPIPGIAPDGTVK
MAV_1760|M.avium_104 ---MKQLLAGVTALLSVSTAGYFGIGTAAADGGPIGGPPTPG-APG----
MLBr_01232|M.leprae_Br4923 ---MKRLLATTLAALTVGTVSGFGSTVASSEPGEPWLPPSPVPVRE----
MSMEG_5350|M.smegmatis_MC2_155 MISWRKQLVPLIAAASLVLASGTVVDVASRAEEAILIPGATVLKPIN---
Mvan_0761|M.vanbaalenii_PYR-1 MVVVRRWLVPLIALVSVLLGIGTAANPVSAAEEAVLIPGASPFKPIN---
Mflv_3371|M.gilvum_PYR-GCK ---MRRSIRKRAGLACGAVFASAAMAVSTATGASAVTTAVAIGGLGTP--
TH_3724|M.thermoresistible__bu ------VVAVGALTWGGXGVASPAGQPERAAALRLTATADAIIMPGTKIG
MUL_1034|M.ulcerans_Agy99 ----MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALTSGLLAAAQDE
:
Mb3569|M.bovis_AF2122/97 SVCSGLADRWWQGPSSRMMAAQAAR-HTGWLAAAATQAEGAASQAQTMAL
Rv3539|M.tuberculosis_H37Rv SVCSGLADRWWQGPSSRMMAAQAAR-HTGWLAAAATQAEGAASQAQTMAL
MMAR_4939|M.marinum_M VSTHIAALFSTHGLQYQLASAQAAEFHERFVLTLAADAN-----------
MAB_0936c|M.abscessus_ATCC_199 AAP-----SAPDRTAYALGGAHVLG------------------------I
MAV_1760|M.avium_104 -----------DQTAYALGGAHVLG------------------------I
MLBr_01232|M.leprae_Br4923 --------NSPAKIVYALGGARPPT------------------------F
MSMEG_5350|M.smegmatis_MC2_155 -------------PFYPLIALNYPK-------------------------
Mvan_0761|M.vanbaalenii_PYR-1 -------------PFYPIIAATYRY-------------------------
Mflv_3371|M.gilvum_PYR-GCK --------DMHEIVINPLLGGKLAR-------------------------
TH_3724|M.thermoresistible__bu --------YIPSQDEFTAYATAVIG-------------------------
MUL_1034|M.ulcerans_Agy99 VSAAIAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAG-----------A
Mb3569|M.bovis_AF2122/97 AYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWA
Rv3539|M.tuberculosis_H37Rv AYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWA
MMAR_4939|M.marinum_M TYLTTEIANAQRCLAGAINAPATALLGHPLLGADPTASASTAATPAGGAS
MAB_0936c|M.abscessus_ATCC_199 PYDEYIRMTGKDWFPNMKRENVWYPAG-----------------------
MAV_1760|M.avium_104 PYDQYIRMEGADWFPGQQRQIVRYPAG-----------------------
MLBr_01232|M.leprae_Br4923 DWDYYTIRAGDEFFPDVNRKLIDYPAR-----------------------
MSMEG_5350|M.smegmatis_MC2_155 --------IGIHFHEDGQPLLIDYSQD-----------------------
Mvan_0761|M.vanbaalenii_PYR-1 --------IGINLHDDADAQLVDYSQN-----------------------
Mflv_3371|M.gilvum_PYR-GCK ---ENDILDGVEWPAEAKRPGTGQTLG-----------------------
TH_3724|M.thermoresistible__bu ATAGAPGAVDYLGVPGEFWPATG---------------------------
MUL_1034|M.ulcerans_Agy99 AYAQAEAANASLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTA
Mb3569|M.bovis_AF2122/97 QDVVAMLNYHAVASAVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPS
Rv3539|M.tuberculosis_H37Rv QDVVAMLNYHAVASAVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPS
MMAR_4939|M.marinum_M MAPAAAGTRITVP---GAGPLYYPRFLTELP-YLG---------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MSMEG_5350|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0761|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK --------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
MUL_1034|M.ulcerans_Agy99 VSSTLMADPVVALIMGGTSVPLPGP-------------------------
Mb3569|M.bovis_AF2122/97 STTTRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEV
Rv3539|M.tuberculosis_H37Rv STTTRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEV
MMAR_4939|M.marinum_M -QALLLGIPGPS---SASIL--------QGYDLINHAIGENWFPDTIASV
MAB_0936c|M.abscessus_ATCC_199 --------------------------------QVQGHTLERFFPGIGPIG
MAV_1760|M.avium_104 --------------------------------QVQGHVLERLFPGIGKLD
MLBr_01232|M.leprae_Br4923 --------------------------------APFRYVPTFLVPGP----
MSMEG_5350|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0761|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK --------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
MUL_1034|M.ulcerans_Agy99 ----------------------------GYVSDINNNYIQPLFSGAIPQA
Mb3569|M.bovis_AF2122/97 VSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQ--PVTVAG
Rv3539|M.tuberculosis_H37Rv VSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQ--PVTVAG
MMAR_4939|M.marinum_M INYPASIGILSGSLAAPDTNTAVAIGARMLHEQIMSAVTNGSGLPVHVAT
MAB_0936c|M.abscessus_ATCC_199 EKILPGL-----GLDGPSIGESIDIGEPNLENAIR---SGG---PGTAMG
MAV_1760|M.avium_104 ES-FPGL-----GMDGPSVGESVAEGIDNLDAAIR---TTGR--PGTAIG
MLBr_01232|M.leprae_Br4923 -------------RDEVTIGEAIAVATKNLNQAIH---RGTE--PAAVVG
MSMEG_5350|M.smegmatis_MC2_155 ---------------ALNSDKALLDGVQQTMIAVQ--QTDGK---IVIIG
Mvan_0761|M.vanbaalenii_PYR-1 ---------------PFSTDRALLDGVERADVAVR--EIDGQ---VVVIG
Mflv_3371|M.gilvum_PYR-GCK ----------------QSITVGITNLGTHFDAAFARLEAGEQ---FTVVG
TH_3724|M.thermoresistible__bu -------------LDSLTFDASVAXGQAMLTPMVDGAIESDT--PIVVFG
MUL_1034|M.ulcerans_Agy99 LFTPEQFWPVTPGLGNLTFNQSVAQGVTLLNDAINTQLALGN--KVVAFG
.: .
Mb3569|M.bovis_AF2122/97 LSMGSMVIDRE-LAYLAIDPNAPPSSALTFVELAGP------ERGLAQTY
Rv3539|M.tuberculosis_H37Rv LSMGSMVIDRE-LAYLAIDPNAPPSSALTFVELAGP------ERGLAQTY
MMAR_4939|M.marinum_M LSQGTIVANRE-LAYLATDPNAPPAHALEFALFGSP------ELGLAHIY
MAB_0936c|M.abscessus_ATCC_199 LSEGALVLNAV-KNALATDPTAPEPESLTFATFGDPIAKSPFSESFLTQN
MAV_1760|M.avium_104 LSEGAFVVDGE-QARLANDPTAPPPNTLNFATFGDPIGRHAFGQSFLTAM
MLBr_01232|M.leprae_Br4923 LSQGSLALDTE-QEQLATDPTAPPPDQLTFNTFGDPSGYHGFGKSVLASI
MSMEG_5350|M.smegmatis_MC2_155 ESMGSMVAARV-AKELAASPNP-RLDDVRVVLIAPP-------EVGVAEY
Mvan_0761|M.vanbaalenii_PYR-1 ESMGSMVASRL-AADLAHSPDPPSPDDIRFVLIASP-------EEGVAQY
Mflv_3371|M.gilvum_PYR-GCK FSAGSLVVNDF-MRELANDPDAPTKDQVKFILVADS--------SRQKLL
TH_3724|M.thermoresistible__bu HSQSAVIATKEKQRLLAEYPDPDTAPDVTFVMVANPNR----PNGGLLAR
MUL_1034|M.ulcerans_Agy99 YSQSATIVNNEILALMAMGTGAPDPGDLSFIMVGAPNN----PDGGLLAR
* .: :* . . : . .. .
Mb3569|M.bovis_AF2122/97 LPVGTTIPIAGYTVG----NAPESQYNTSVVYSQYDIWADPPDRPWNLLA
Rv3539|M.tuberculosis_H37Rv LPVGTTIPIAGYTVG----NAPESQYNTSVVYSQYDIWADPPDRPWNLLA
MMAR_4939|M.marinum_M LPDGLTVPLINYTVH----GLSNTQYDVSVVNGQYDFWGNPPDRPWNLPA
MAB_0936c|M.abscessus_ATCC_199 FAPGSVVPFMDYPVP----ARVDSQYHTDQFISAYDSIADWPDRPDNLFA
MAV_1760|M.avium_104 FGVGSVVPALDYTMP----PPYESQYDTNRFVAAYDSIADFPDRPDNMFA
MLBr_01232|M.leprae_Br4923 FRPGDYIPLIDYTMP----QRMDSQYDSNRVVAAYDGLSEFPDRADNLLA
MSMEG_5350|M.smegmatis_MC2_155 FKEGTFIPILNYRVK----RVALSPYPTTIVIGEYDGWADPPDRPWNLLA
Mvan_0761|M.vanbaalenii_PYR-1 FKEGTRIPLLNYTVS----RVAQSPYPTTVVFGEYDGWADPPDRPWNLVA
Mflv_3371|M.gilvum_PYR-GCK NETSKYNPQYDYTYR----PAPQTMYDIDVVTGEYDGAADLPDRWWNFLA
TH_3724|M.thermoresistible__bu FP-GLYIPILGVTFNGATPAPADGPFDSYDVAREFDGWADFPRYPLNLVA
MUL_1034|M.ulcerans_Agy99 FP-GFYIPFLDVSFNG--ATPAANPYPTSIFTAQYDGIAHAPQYRLNILS
. * . : . :* .. * *: :
Mb3569|M.bovis_AF2122/97 GANALMGAAYFHD-LTAY-AAPQ--QGIEIAAVTSSLG-GTTTTYMIPSP
Rv3539|M.tuberculosis_H37Rv GANALMGAAYFHD-LTAY-AAPQ--QGIEIAAVTSSLG-GTTTTYMIPSP
MMAR_4939|M.marinum_M WVNSLFGAAYYHN-TSSF-ASLS--DAVEVSSVTTSLG-GTITTYLIPSP
MAB_0936c|M.abscessus_ATCC_199 LANAIAGLATGHT-AVAF-TNPKMVPARNIVTETNSRG-GTTTTYFIPEQ
MAV_1760|M.avium_104 LANTLMGLATGHT-AVAF-TNPSMVPPQNIRTTINSRG-AKDTTIMIPEK
MLBr_01232|M.leprae_Br4923 QLNCFAGGAISHT-PSGF-FNPEDVPPQNIRTTVNSRG-AKTTTYLIPVN
MSMEG_5350|M.smegmatis_MC2_155 TANALLGIVYVHG-VPSFTTDPNDVPPENVKTIPGNADHGPITTMLVPTK
Mvan_0761|M.vanbaalenii_PYR-1 VANAAMGLIYVHG-PAMWDVDLSDVPPENITVD------GTVTRYFVPTE
Mflv_3371|M.gilvum_PYR-GCK LANAIAGGLFVHV-PMMFSDYEAVTPEENITRVTNTLG-GTTTTYLVPTK
TH_3724|M.thermoresistible__bu TANAILGIYYLHGGYYELLTENPDILDDPERTIVQQYG--DTTYYLIRTE
MUL_1034|M.ulcerans_Agy99 DINAIMGYFYVHG------NYPDLMSGQAIQLPTSPGYTGNTDYYMYLTQ
* * * :
Mb3569|M.bovis_AF2122/97 TLPLLLPLKQIGVP-DWIVGGLNNVLKPLVDAGYSQYAPT---AGPYFSH
Rv3539|M.tuberculosis_H37Rv TLPLLLPLKQIGVP-DWIVGGLNNVLKPLVDAGYSQYAPT---AGPYFSH
MMAR_4939|M.marinum_M TLPMLLPLEQIGVP-APIVAGLNSVLAPIVNDGYSSLTPN---AGPYFSQ
MAB_0936c|M.abscessus_ATCC_199 HLPLVMGFKYLGVP-EETLNRLDAILQPRVDAGYSRNDDP---ATAPIAV
MAV_1760|M.avium_104 HLPLVMPLKYIGID-ENTLNKLDAILTPRVNAGYSRNDDP---ATAPVQV
MLBr_01232|M.leprae_Br4923 HLPLTLPLRYLGWS-DALVDQIDAVLQPKIDAAYAYNDNP---LNKPISV
MSMEG_5350|M.smegmatis_MC2_155 NLPLTQFLRDIGVP-DQWVDAIDNILRPIIDSAYVRNDKPG-DSRPYLYN
Mvan_0761|M.vanbaalenii_PYR-1 HLPLTRPFRDLGVP-DCLVDAADHILRPIIDAGYRRHDQPG-DSRPYLYD
Mflv_3371|M.gilvum_PYR-GCK TLPLVQLLP--------FLKSQEASLKAKIDAGYSRNDDRL-AAAAAATS
TH_3724|M.thermoresistible__bu QLPLLRPLRDLGVP-EEFVDALEPYVRRIVDLGYDRNTPYG-EPAPVRVL
MUL_1034|M.ulcerans_Agy99 DLPLVQPIRDIPYAGPPLADLIQPQLRVLVDLGYSDYGPGLSYADVPTPA
**: : : : :: .*
Mb3569|M.bovis_AF2122/97 GNLVW---------------------------------------------
Rv3539|M.tuberculosis_H37Rv GNLVW---------------------------------------------
MMAR_4939|M.marinum_M GALVGLPSAADVLGSWPWPALGSVTAHIC---------------------
MAB_0936c|M.abscessus_ATCC_199 DPRRGFDPAEVTAPASQATFGGGSDPISQITSGALAVLGNGTRPTPPN--
MAV_1760|M.avium_104 DPVHGFDPAEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAGEADH---
MLBr_01232|M.leprae_Br4923 DPVNGMDPIAGIDAELR-------DSILNVFAQLRSILPPPPG-------
MSMEG_5350|M.smegmatis_MC2_155 GEIRRNVETPQEVETPEADVAGGVETTDVDTTSTETKDVGTHNAVDGDSK
Mvan_0761|M.vanbaalenii_PYR-1 GRIRRDVPPVVPLQQGGDDGGGGADE--------ENENAAQHPQADGDGR
Mflv_3371|M.gilvum_PYR-GCK TARSLAAPTVTNEATDEVADDEAVATVQKISTDSDAEQADVPAERTSSKP
TH_3724|M.thermoresistible__bu PPLTPAPGPATQHNAGQGITVASATSTPDKRTPVVEAPVEEPPVQTGRST
MUL_1034|M.ulcerans_Agy99 GLLSVPNPFAVSYYLLKGSLQAPYGAAVEIGVEAGLLGPESFPDTYPWVP
Mb3569|M.bovis_AF2122/97 --------------------------------------------------
Rv3539|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MSMEG_5350|M.smegmatis_MC2_155 LGIKESDTKGVTTNDTKNDAKVVIKDVSKDVDTEVVTKDDETTATDTDTD
Mvan_0761|M.vanbaalenii_PYR-1 LDRDDLDVS----------------ESAEDPDVSEAAQDPDVSESAADRD
Mflv_3371|M.gilvum_PYR-GCK AVDDAADD-----------DEAAANEDAEADAADAKVDAKEDAEAAVKDD
TH_3724|M.thermoresistible__bu LKRE------------------------KPVSARHLVRNSLRAVPGLRRG
MUL_1034|M.ulcerans_Agy99 ---------------------------SLNPGLNFYLGQPSVTLLSLLSG
Mb3569|M.bovis_AF2122/97 --------------------------------------------------
Rv3539|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MSMEG_5350|M.smegmatis_MC2_155 TDTEARAGDDIEKKKSPRETRRERRHEHRDAIRDGLDNVKSQVESGLKDL
Mvan_0761|M.vanbaalenii_PYR-1 GRAVTHDPDVPESGEDP---------DARESTNDSADDSAQRQEAGG---
Mflv_3371|M.gilvum_PYR-GCK ADASAGTNDDGEEGADSGSNDSAAAAGDTDSSDGSSSEGPGSSDSGSSE-
TH_3724|M.thermoresistible__bu EPAATPTPDVTPDVTPDAPAGQPEPAEPNESAAPPAAAEADDASE-----
MUL_1034|M.ulcerans_Agy99 GLGDIFHLIPPPVFP-----------------------------------
Mb3569|M.bovis_AF2122/97 -------------------------------
Rv3539|M.tuberculosis_H37Rv -------------------------------
MMAR_4939|M.marinum_M -------------------------------
MAB_0936c|M.abscessus_ATCC_199 -------------------------------
MAV_1760|M.avium_104 -------------------------------
MLBr_01232|M.leprae_Br4923 -------------------------------
MSMEG_5350|M.smegmatis_MC2_155 AKGLKGPRAKQKKVKNENETQSESASESDSE
Mvan_0761|M.vanbaalenii_PYR-1 -------------------------------
Mflv_3371|M.gilvum_PYR-GCK -------------------------------
TH_3724|M.thermoresistible__bu -------------------------------
MUL_1034|M.ulcerans_Agy99 -------------------------------