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TVGSAVRQLIAVGSVIAAGAIAVAPAVVADTVLTVGGTGSALVGDQGPWRLPYTHGAPEVNIVYPSSPVF MDWSVAHGAGSLHAAIVSTPEGKTAVGISQGGLVLAEVKRRLMALPESDRPASGELVFIGVGDPSNPQGG LLRHFPEGFRLPGFGVTVVETPETPWNTIYVTREYDGFADFPDRVHNLVAVANALVGIVYVHAQPGYASV DLEAVPDRDVTVTTNTLGGVTTSYLVRTERLPLLQPARDLGVPEKIVKHLEAALKPVVDAGYVRNDPPRT PALTAASAPEPVAASVEPEPEPERKRHLRVASPGRIAVGGPAKGRHARVVEAELRDPRDDERPDVRTQAS TPESAAHAGAKSDPPGDSPSDNSGADAERGDE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5759 | - | - | 100% (383) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 1e-52 | 41.18% (289) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_5350 | - | 1e-30 | 32.03% (281) | PPE family protein, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3852 | - | 7e-31 | 35.22% (301) | hypothetical protein Mb3852 |
| M. gilvum PYR-GCK | Mflv_4518 | - | 1e-31 | 29.46% (404) | hypothetical protein Mflv_4518 |
| M. tuberculosis H37Rv | Rv3822 | - | 1e-30 | 34.88% (301) | hypothetical protein Rv3822 |
| M. leprae Br4923 | MLBr_01232 | - | 3e-26 | 30.56% (252) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 3e-29 | 37.91% (211) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_2235 | - | 2e-29 | 36.47% (266) | PE-PGRS family protein, PE16 |
| M. avium 104 | MAV_1760 | - | 5e-26 | 34.12% (211) | hypothetical protein MAV_1760 |
| M. thermoresistible (build 8) | TH_3724 | - | 1e-34 | 37.75% (302) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 7e-23 | 34.27% (248) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_2535 | - | 2e-35 | 37.34% (308) | hypothetical protein Mvan_2535 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3852|M.bovis_AF2122/97 ------------------------MKCPGVSDCVATVRHDNVFAIAAGLR
Rv3822|M.tuberculosis_H37Rv ------------------------MKCPGVSDCVATVRHDNVFAIAAGLR
MAB_0936c|M.abscessus_ATCC_199 -----------------------------MRNLLAGTAVLVVACVTGCFG
MAV_1760|M.avium_104 -----------------------------MKQLLAGVTALLSVSTAGYFG
MLBr_01232|M.leprae_Br4923 -----------------------------MKRLLATTLAALTVGTVSGFG
Mflv_4518|M.gilvum_PYR-GCK ------------------------------------MRKTGVVCGTVFAS
Mvan_2535|M.vanbaalenii_PYR-1 -----------------------------MRRTTGKVRRSAVTCAAAAVT
MMAR_2235|M.marinum_M --MSFVVTAPETVVAAASQLTGIGSAIEAANAAAAALTTRLLPAAADEVS
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
TH_3724|M.thermoresistible__bu ----------------------------VVAVGALTWGGXGVASPAGQPE
MSMEG_5759|M.smegmatis_MC2_155 -------------------------------MTVGSAVRQLIAVGSVIAA
Mb3852|M.bovis_AF2122/97 WSAAVPPLHKGDAVTKLLVGAIAGGMLAYAAILGDGIASADTALIVPGTA
Rv3822|M.tuberculosis_H37Rv WSAAVPPLHKGDAVTKLLVGAIAGGMLACAAILGDGIASADTALIVPGTA
MAB_0936c|M.abscessus_ATCC_199 IPSAVA--DDPQVPGPPIPGIAPDGTVKAAPSAPDRTAYALGGAHVLGIP
MAV_1760|M.avium_104 IGTAAA--DGGPIGGPPTPG-APG----------DQTAYALGGAHVLGIP
MLBr_01232|M.leprae_Br4923 STVASS--EPGEPWLPPSPVPVRE-------NSPAKIVYALGGARPPTFD
Mflv_4518|M.gilvum_PYR-GCK AALALSSSSLGQAAN---------------------TALVIGGISTPSMA
Mvan_2535|M.vanbaalenii_PYR-1 AGLAMATATPGWGVS---------------------TALVIGGIGTPTLH
MMAR_2235|M.marinum_M AGIAALMSTHAQEYQLLGGQLATYHDQLVQALDRTAGWYADAETGNAALL
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKAL
TH_3724|M.thermoresistible__bu RAAALRLTATADAIIMPG----------------TKIGYIPSQDEFTAYA
MSMEG_5759|M.smegmatis_MC2_155 GAIAVAPAVVADTVLTVG----------------GTGSALVGDQGPWRLP
*
Mb3852|M.bovis_AF2122/97 PSPYGPLRS-----------------------------------------
Rv3822|M.tuberculosis_H37Rv PSPYGPLRS-----------------------------------------
MAB_0936c|M.abscessus_ATCC_199 YDEYIRMTG-----------------------------------------
MAV_1760|M.avium_104 YDQYIRMEG-----------------------------------------
MLBr_01232|M.leprae_Br4923 WDYYTIRAG-----------------------------------------
Mflv_4518|M.gilvum_PYR-GCK DALMSPLLG-----------------------------------------
Mvan_2535|M.vanbaalenii_PYR-1 DVVMSELLG-----------------------------------------
MMAR_2235|M.marinum_M RNVQQELLTGLTAPGRAWSGAGAASAGASGVDALMSSALLSGGRSVLVVG
MUL_0967|M.ulcerans_Agy99 AGLTEPVAN-LFAP--VLSGPESVAASAT---ALLSGAPLKPVEAALILS
TH_3724|M.thermoresistible__bu TAVIGATAG-----------------------------------------
MSMEG_5759|M.smegmatis_MC2_155 YTHGAPEVN-----------------------------------------
Mb3852|M.bovis_AF2122/97 --LYHFNPAMQPQIGANYYTPTATRHVVSYPGS------FWPVTGLNSPT
Rv3822|M.tuberculosis_H37Rv --LYHFNPAMQPQIGANYYNPTATRHVVSYPGS------FWPVTGLNSPT
MAB_0936c|M.abscessus_ATCC_199 --KDWFPNMKRENVWYPAGQVQGHTLERFFPGIGPIGEKILPGLGLDGPS
MAV_1760|M.avium_104 --ADWFPGQQRQIVRYPAGQVQGHVLERLFPGIGKLDES-FPGLGMDGPS
MLBr_01232|M.leprae_Br4923 --DEFFPDVNRKLIDYPARAPFRYVPTFLVPGP------------RDEVT
Mflv_4518|M.gilvum_PYR-GCK --GKFKDQ-QRVSVKWPAQAGPMTGKGDLTLGAS---------IAQGATN
Mvan_2535|M.vanbaalenii_PYR-1 --GALRDYDQRRAVSWPAQARPYTGAADMTLGDS---------IEIGTAN
MMAR_2235|M.marinum_M STGTPRPSYRFMREVYDLFVAPHY-FGDSLFGVQTP-AQFQPFTGIPNLT
MUL_0967|M.ulcerans_Agy99 ESGVPTPSASYISDVYTKYVEPNFPSATAPQGVSTP-NGLYPFTGIKDLS
TH_3724|M.thermoresistible__bu ---------------APGAVDYLGVPGEFWPATG-----------LDSLT
MSMEG_5759|M.smegmatis_MC2_155 -------------IVYPSSP----------------------------VF
Mb3852|M.bovis_AF2122/97 VGSSVSAGTNNLDAAIR------STDGPIFVAGLSQGTLVLDREQARLAN
Rv3822|M.tuberculosis_H37Rv VGSSVSAGTNNLDAAIR------STDGPIFVAGLSQGTLVLDREQARLAN
MAB_0936c|M.abscessus_ATCC_199 IGESIDIGEPNLENAIR------SGG-PGTAMGLSEGALVLNAVKNALAT
MAV_1760|M.avium_104 VGESVAEGIDNLDAAIR------TTGRPGTAIGLSEGAFVVDGEQARLAN
MLBr_01232|M.leprae_Br4923 IGEAIAVATKNLNQAIH------RGTEPAAVVGLSQGSLALDTEQEQLAT
Mflv_4518|M.gilvum_PYR-GCK LNAQIDAALAQLK-----------SGEKVTVVGLSAGSLVVNEILRELD-
Mvan_2535|M.vanbaalenii_PYR-1 LNADIDAALGRLERDADG---NLLEGERVTVVGLSAGSLVVTEVLREWQS
MMAR_2235|M.marinum_M FDESAATGASYLHAAITQQLAD---GNRVVVAGFSQGASVATLEMRHLQS
MUL_0967|M.ulcerans_Agy99 LDISLARGATILNDAILQQLAALPAGSSVAVLGYSQSAVLSSRVMPKLLA
TH_3724|M.thermoresistible__bu FDASVAXGQAMLTPMVDG---AIESDTPIVVFGHSQSAVIATKEKQRLLA
MSMEG_5759|M.smegmatis_MC2_155 MDWSVAHGAGSLHAAIVS------TPEGKTAVGISQGGLVLAEVKRRLMA
.. . * . * * .
Mb3852|M.bovis_AF2122/97 DPTAPP--PGQLTFIKAGDP-------NNLLWRAFRPGTHVPIIDYTVP-
Rv3822|M.tuberculosis_H37Rv DPTAPP--PGQLTFIKAGDP-------NNLLWRAFRPGTHVPIIDYTVP-
MAB_0936c|M.abscessus_ATCC_199 DPTAPE--PESLTFATFGDPIAKSPFSESFLTQNFAPGSVVPFMDYPVP-
MAV_1760|M.avium_104 DPTAPP--PNTLNFATFGDPIGRHAFGQSFLTAMFGVGSVVPALDYTMP-
MLBr_01232|M.leprae_Br4923 DPTAPP--PDQLTFNTFGDPSGYHGFGKSVLASIFRPGDYIPLIDYTMP-
Mflv_4518|M.gilvum_PYR-GCK ESADAPG-KDKITFVVVADS--------SRQKVISRTR-YNANLDYTYQ-
Mvan_2535|M.vanbaalenii_PYR-1 DGEENPE-ADEINFVVVADS--------SRQQIIDDTERYNPVYDYTYR-
MMAR_2235|M.marinum_M LPIDSRPSPEDLSFVLLGNPN-----NPNGGILARFPGLYIQSVGLTFNG
MUL_0967|M.ulcerans_Agy99 EGVTS----SQVNFVLLGNPM-----NPNGGVLARFPDLTLPSLGFTFYG
TH_3724|M.thermoresistible__bu EYPDPDT-APDVTFVMVANPN-----RPNGGLLARFPGLYIPILGVTFNG
MSMEG_5759|M.smegmatis_MC2_155 LPESDRPASGELVFIGVGDPSN----PQGGLLRHFPEGFRLPGFGVTVV-
: * .:. . . .
Mb3852|M.bovis_AF2122/97 ---APVESQYDTINIVGQYDIFSDPPNRPGNLLADLNAIAAGGYYGHSA-
Rv3822|M.tuberculosis_H37Rv ---APAESQYDTINIVGQYDIFSDPPNRPGNLLADLNAIAAGGYYGHSA-
MAB_0936c|M.abscessus_ATCC_199 ---ARVDSQYHTDQFISAYDSIADWPDRPDNLFALANAIAG-LATGHTA-
MAV_1760|M.avium_104 ---PPYESQYDTNRFVAAYDSIADFPDRPDNMFALANTLMG-LATGHTA-
MLBr_01232|M.leprae_Br4923 ---QRMDSQYDSNRVVAAYDGLSEFPDRADNLLAQLNCFAG-GAISHTP-
Mflv_4518|M.gilvum_PYR-GCK ---TAPETKYDIIVVTGEYDGMADFPDR-LNLLAIVNAVAG-GIFVHIP-
Mvan_2535|M.vanbaalenii_PYR-1 ---RAPQTPYDTVEVTGEYDGLADFPDRWWNLTAVANALAG-AAVRHIL-
MMAR_2235|M.marinum_M ---ATPVTEYPTTVYTTQYDGFADFPQYPLNVVADVNALLG-ISYSHSL-
MUL_0967|M.ulcerans_Agy99 ---ATPDNAFPTVSYTLEYDGFADFPRYPINLLADINAVMG-IPFVHAD-
TH_3724|M.thermoresistible__bu ATPAPADGPFDSYDVAREFDGWADFPRYPLNLVATANAILGIYYLHGGY-
MSMEG_5759|M.smegmatis_MC2_155 ---ETPETPWNTIYVTREYDGFADFPDRVHNLVAVANALVGIVYVHAQPG
: :* :: * *: * * . .
Mb3852|M.bovis_AF2122/97 TAFSDPARVAPRDITTTTNSLGATTTTYFIRTDQLPLVRALVDMAGLPPQ
Rv3822|M.tuberculosis_H37Rv TAFSDPARVAPRDITTTTNSLGATTTTYFIRTDQLPLVRALVDMAGLPPQ
MAB_0936c|M.abscessus_ATCC_199 VAFTNPKMVPARNIVTETNSRGGTTTTYFIPEQHLPLVMGFKYLG-VPEE
MAV_1760|M.avium_104 VAFTNPSMVPPQNIRTTINSRGAKDTTIMIPEKHLPLVMPLKYIG-IDEN
MLBr_01232|M.leprae_Br4923 SGFFNPEDVPPQNIRTTVNSRGAKTTTYLIPVNHLPLTLPLRYLG-WSDA
Mflv_4518|M.gilvum_PYR-GCK VMYADLSKVPARNISVEMNSEGGTTTHYLVPAEKLPLVRLFPSLANREAE
Mvan_2535|M.vanbaalenii_PYR-1 AMFADLSQVPDENVTVTQNLLGGTTTRYLVPAQRLPLVLLNPSLAPREAE
MMAR_2235|M.marinum_M YYGLTPDQVAAG-VVLPVSSPDVNTTYILIPNEHLPLLQPLRGI--VPDS
MUL_0967|M.ulcerans_Agy99 YQDLTQAQLDSA-VQLPTEGP-TQSTYYMIPTEHLPLLAPLRFIPYVGDP
TH_3724|M.thermoresistible__bu YELLTENPDILDDPERTIVQQYGDTTYYLIRTEQLPLLRPLRDLG-VPEE
MSMEG_5759|M.smegmatis_MC2_155 YASVDLEAVPDRDVTVTTNTLGGVTTSYLVRTERLPLLQPARDLG-VPEK
* :: .:*** :
Mb3852|M.bovis_AF2122/97 AAGTVDAALRPIIDRAYQ-------------------PGPAPAVNPRDLV
Rv3822|M.tuberculosis_H37Rv AAGTVDAALRPIIDRAYQ-------------------PGPAPAVNPRDLV
MAB_0936c|M.abscessus_ATCC_199 TLNRLDAILQPRVDAGYS-------------------RNDDPATAP----
MAV_1760|M.avium_104 TLNKLDAILTPRVNAGYS-------------------RNDDPATAP----
MLBr_01232|M.leprae_Br4923 LVDQIDAVLQPKIDAAYA-------------------YNDNPLNKP----
Mflv_4518|M.gilvum_PYR-GCK LKAKIDAAYSRNDVVAVSAPKAAV-FAAAPAPAAPTAVVQTPSAAQVPGS
Mvan_2535|M.vanbaalenii_PYR-1 LKATVDRGYSRNDPVRT---------------ALRTLTNEVP--DDVEDT
MMAR_2235|M.marinum_M VLDGIEPGLRDVVELGYDR------TGYADVPTPASLFPANVNPNVVAGA
MUL_0967|M.ulcerans_Agy99 LAELLEPNLRVLVNFGYGDPAYGYDTGPANVPTPFGLFPP-VSPLTVAEH
TH_3724|M.thermoresistible__bu FVDALEPYVRRIVDLGYDRN--------------TPYGEPAPVRVLPPLT
MSMEG_5759|M.smegmatis_MC2_155 IVKHLEAALKPVVDAGYVR------------------NDPPRTPALTAAS
::
Mb3852|M.bovis_AF2122/97 QGIRGIPAIAPAIAIPIGSTTGASAATSTAAATAAATNALRGANVGPGAN
Rv3822|M.tuberculosis_H37Rv QGIRGIPAIAPAIAIPIGSTTGASAATSTAAATAAATNALRGANVGPGAN
MAB_0936c|M.abscessus_ATCC_199 IAVDPRRGFDPAEVTAPASQATFGGGSDPISQITSGALAVLGNGTRPTPP
MAV_1760|M.avium_104 VQVDPVHGFDPAEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAGEADH
MLBr_01232|M.leprae_Br4923 ISVDPVNGMDPIAGIDAELR-------DSILNVFAQLRSILPPPPG----
Mflv_4518|M.gilvum_PYR-GCK VAASLRTAKADAAVEDAVVSEDAAVEDAVVSEEAAVSEEVDVKGADSADA
Mvan_2535|M.vanbaalenii_PYR-1 VTPQDTQDEVEASEGDGAAPTGTSADHAEVSEATAEDRDVTAD-----DA
MMAR_2235|M.marinum_M FVEGAVRGIDNGLAGMGLPPLPDLPAAPLLPEIWSNAPPIPGWPASVPSA
MUL_0967|M.ulcerans_Agy99 LAAGTQQGIVNSGAALQAQGPPSIPLSDIAHTLTAN-PPWAGTPALPPST
TH_3724|M.thermoresistible__bu PAPGPATQHNAGQGITVASATSTPDKRTPVVEAPVEEPPVQTGRSTLKRE
MSMEG_5759|M.smegmatis_MC2_155 APEPVAASVEPEPEPERKRHLRVASPGRIAVGGPAKGRHARVVEAELRDP
Mb3852|M.bovis_AF2122/97 KALS-----------------------------------------MVRGL
Rv3822|M.tuberculosis_H37Rv KALS-----------------------------------------MVRGL
MAB_0936c|M.abscessus_ATCC_199 N-------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_4518|M.gilvum_PYR-GCK DIEE-----------------------------------------TDTAD
Mvan_2535|M.vanbaalenii_PYR-1 EAPG-----------------------------------------DETRS
MMAR_2235|M.marinum_M IAVPPQLGGAIAGPLDHLYRTLDSVINGQINPAITSGIYQYGADLSAEAA
MUL_0967|M.ulcerans_Agy99 SPAS----------------SIEDFI------------------LAVQAA
TH_3724|M.thermoresistible__bu KPVSAR-----------------------------------HLVRNSLRA
MSMEG_5759|M.smegmatis_MC2_155 RDDE----------------------------------------RPDVRT
Mb3852|M.bovis_AF2122/97 LPKGKKH-------------------------------------------
Rv3822|M.tuberculosis_H37Rv LPKGKKH-------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_4518|M.gilvum_PYR-GCK QADIDSGAEKEAAQEDSDAGAQSGDDADKDGSVSSDSGASTDRSPSKPSA
Mvan_2535|M.vanbaalenii_PYR-1 TEDVDR----EATEPDS----ESDDTVTQNDAEPRESAADTAAEDSGPSD
MMAR_2235|M.marinum_M RHGASSELLNAIYVGRQVLPILIEGPGVILTADTYYSINAIKDLAAGNLS
MUL_0967|M.ulcerans_Agy99 NSSISRGFVKTLSTAYATLLPTTDIASELVFTLPSYNLNLFLDGVIQAIN
TH_3724|M.thermoresistible__bu VPGLRRGEPAATPTPDVTPDVTPDAPAGQPEPAEPNESAAPPAAAEADDA
MSMEG_5759|M.smegmatis_MC2_155 QASTPESAAHAGAKSDPPGDSPSDNSGADAERGDE---------------
Mb3852|M.bovis_AF2122/97 --------------------------------------
Rv3822|M.tuberculosis_H37Rv --------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------
MAV_1760|M.avium_104 --------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------
Mflv_4518|M.gilvum_PYR-GCK TSDS----------------------------------
Mvan_2535|M.vanbaalenii_PYR-1 --------------------------------------
MMAR_2235|M.marinum_M GFNQNLQLIPATNAMLLTFGATIPIAAGVSAYIGRDFP
MUL_0967|M.ulcerans_Agy99 GQ---------------------PIGD-----------
TH_3724|M.thermoresistible__bu SE------------------------------------
MSMEG_5759|M.smegmatis_MC2_155 --------------------------------------