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MVVVRRWLVPLIALVSVLLGIGTAANPVSAAEEAVLIPGASPFKPINPFYPIIAATYRYIGINLHDDADA QLVDYSQNPFSTDRALLDGVERADVAVREIDGQVVVIGESMGSMVASRLAADLAHSPDPPSPDDIRFVLI ASPEEGVAQYFKEGTRIPLLNYTVSRVAQSPYPTTVVFGEYDGWADPPDRPWNLVAVANAAMGLIYVHGP AMWDVDLSDVPPENITVDGTVTRYFVPTEHLPLTRPFRDLGVPDCLVDAADHILRPIIDAGYRRHDQPGD SRPYLYDGRIRRDVPPVVPLQQGGDDGGGGADEENENAAQHPQADGDGRLDRDDLDVSESAEDPDVSEAA QDPDVSESAADRDGRAVTHDPDVPESGEDPDARESTNDSADDSAQRQEAGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0761 | - | - | 100% (401) | hypothetical protein Mvan_0761 |
| M. vanbaalenii PYR-1 | Mvan_2535 | - | 9e-30 | 33.04% (345) | hypothetical protein Mvan_2535 |
| M. vanbaalenii PYR-1 | Mvan_0276 | - | 2e-29 | 39.11% (202) | hypothetical protein Mvan_0276 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3569 | PPE63 | 7e-40 | 36.11% (288) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_3371 | - | 2e-30 | 32.80% (311) | hypothetical protein Mflv_3371 |
| M. tuberculosis H37Rv | Rv3539 | PPE63 | 7e-40 | 36.11% (288) | PPE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 5e-26 | 33.79% (219) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 3e-27 | 35.87% (223) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_4939 | - | 4e-30 | 38.55% (166) | PE-PGRS family protein |
| M. avium 104 | MAV_1760 | - | 6e-25 | 31.56% (244) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_5350 | - | 1e-107 | 48.91% (413) | PPE family protein, putative |
| M. thermoresistible (build 8) | TH_3724 | - | 3e-29 | 37.85% (214) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 1e-15 | 26.06% (376) | PE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0761|M.vanbaalenii_PYR-1 MVVVRRWLVPLIALVSVLLGIGTAANPVSAAEEAVLIPGASPFKPIN---
MSMEG_5350|M.smegmatis_MC2_155 MISWRKQLVPLIAAASLVLASGTVVDVASRAEEAILIPGATVLKPIN---
Mb3569|M.bovis_AF2122/97 ---MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFE
Rv3539|M.tuberculosis_H37Rv ---MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFE
MMAR_4939|M.marinum_M ----MSYVVAAPDFLSTAAEDLAAMGSAVSTATAAAARSTTLLLAAGADE
MAB_0936c|M.abscessus_ATCC_199 ---MRNLLAGTAVLVVACVTGCFGIPSAVADDPQVPGPPIPGIAPDGTVK
MAV_1760|M.avium_104 ---MKQLLAGVTALLSVSTAGYFGIGTAAADGGPIGGPPTPG-APG----
MLBr_01232|M.leprae_Br4923 ---MKRLLATTLAALTVGTVSGFGSTVASSEPGEPWLPPSPVPVRE----
Mflv_3371|M.gilvum_PYR-GCK ---MRRSIRKRAGLACGAVFASAAMAVSTATGASAVTTAVAIGGLGTP--
TH_3724|M.thermoresistible__bu VVAVGALTWGGXGVASPAGQPERAAALRLTATADAIIMPGTKIGYIP---
MUL_0967|M.ulcerans_Agy99 --MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAE
Mvan_0761|M.vanbaalenii_PYR-1 -------------PFYPIIAATYRY-------------------------
MSMEG_5350|M.smegmatis_MC2_155 -------------PFYPLIALNYPK-------------------------
Mb3569|M.bovis_AF2122/97 SVCSGLADRWWQGPSSRMMAAQAAR-HTGWLAAAATQAEGAASQAQTMAL
Rv3539|M.tuberculosis_H37Rv SVCSGLADRWWQGPSSRMMAAQAAR-HTGWLAAAATQAEGAASQAQTMAL
MMAR_4939|M.marinum_M VSTHIAALFSTHGLQYQLASAQAAEFHERFVLTLAADAN-----------
MAB_0936c|M.abscessus_ATCC_199 AAP-----SAPDRTAYALGGAHVLG------------------------I
MAV_1760|M.avium_104 -----------DQTAYALGGAHVLG------------------------I
MLBr_01232|M.leprae_Br4923 --------NSPAKIVYALGGARPPT------------------------F
Mflv_3371|M.gilvum_PYR-GCK --------DMHEIVINPLLGGKLAR-------------------------
TH_3724|M.thermoresistible__bu -----------SQDEFTAYATAVIG-------------------------
MUL_0967|M.ulcerans_Agy99 VSEAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVK
.
Mvan_0761|M.vanbaalenii_PYR-1 --------IGINLHDDADAQLVDYSQN-----------------------
MSMEG_5350|M.smegmatis_MC2_155 --------IGIHFHEDGQPLLIDYSQD-----------------------
Mb3569|M.bovis_AF2122/97 AYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWA
Rv3539|M.tuberculosis_H37Rv AYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWA
MMAR_4939|M.marinum_M TYLTTEIANAQRCLAGAINAPATALLGHPLLGADPTASASTAATPAGGAS
MAB_0936c|M.abscessus_ATCC_199 PYDEYIRMTGKDWFPNMKRENVWYPAG-----------------------
MAV_1760|M.avium_104 PYDQYIRMEGADWFPGQQRQIVRYPAG-----------------------
MLBr_01232|M.leprae_Br4923 DWDYYTIRAGDEFFPDVNRKLIDYPAR-----------------------
Mflv_3371|M.gilvum_PYR-GCK ---ENDILDGVEWPAEAKRPGTGQTLG-----------------------
TH_3724|M.thermoresistible__bu ATAGAPGAVDYLGVPGEFWPATG---------------------------
MUL_0967|M.ulcerans_Agy99 ALAGLTEPVANLFAPVLSGPESVAASATALLSGAPLKPVEAALILSESGV
Mvan_0761|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5350|M.smegmatis_MC2_155 --------------------------------------------------
Mb3569|M.bovis_AF2122/97 QDVVAMLNYHAVASAVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPS
Rv3539|M.tuberculosis_H37Rv QDVVAMLNYHAVASAVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPS
MMAR_4939|M.marinum_M MAPAAAGTRITVP---GAGPLYYPRFLTELP-YLG---------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK --------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 PTPSAS--------------------------------------------
Mvan_0761|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5350|M.smegmatis_MC2_155 --------------------------------------------------
Mb3569|M.bovis_AF2122/97 STTTRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEV
Rv3539|M.tuberculosis_H37Rv STTTRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEV
MMAR_4939|M.marinum_M -QALLLGIPGPS---SASIL--------QGYDLINHAIGENWFPDTIASV
MAB_0936c|M.abscessus_ATCC_199 --------------------------------QVQGHTLERFFPGIGPIG
MAV_1760|M.avium_104 --------------------------------QVQGHVLERLFPGIGKLD
MLBr_01232|M.leprae_Br4923 --------------------------------APFRYVPTFLVPGP----
Mflv_3371|M.gilvum_PYR-GCK --------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
MUL_0967|M.ulcerans_Agy99 -----------------------------YISDVYTKYVEPNFPSATAPQ
Mvan_0761|M.vanbaalenii_PYR-1 ---------------PFSTDRALLDGVERADVAVR--EIDGQ----VVVI
MSMEG_5350|M.smegmatis_MC2_155 ---------------ALNSDKALLDGVQQTMIAVQ--QTDGK----IVII
Mb3569|M.bovis_AF2122/97 VSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQ---PVTVA
Rv3539|M.tuberculosis_H37Rv VSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQ---PVTVA
MMAR_4939|M.marinum_M INYPASIGILSGSLAAPDTNTAVAIGARMLHEQIMSAVTNGSG-LPVHVA
MAB_0936c|M.abscessus_ATCC_199 EKILPGL-----GLDGPSIGESIDIGEPNLENAIR---SGG----PGTAM
MAV_1760|M.avium_104 ES-FPGL-----GMDGPSVGESVAEGIDNLDAAIR---TTGR---PGTAI
MLBr_01232|M.leprae_Br4923 -------------RDEVTIGEAIAVATKNLNQAIH---RGTE---PAAVV
Mflv_3371|M.gilvum_PYR-GCK ----------------QSITVGITNLGTHFDAAFARLEAGEQ----FTVV
TH_3724|M.thermoresistible__bu -------------LDSLTFDASVAXGQAMLTPMVDGAIESDT---PIVVF
MUL_0967|M.ulcerans_Agy99 GVSTPNGLYPFTGIKDLSLDISLARGATILNDAILQQLAALPAGSSVAVL
.: .
Mvan_0761|M.vanbaalenii_PYR-1 GESMGSMVASRL-AADLAHSPDPPSPDDIRFVLIASP-------EEGVAQ
MSMEG_5350|M.smegmatis_MC2_155 GESMGSMVAARV-AKELAASPNP-RLDDVRVVLIAPP-------EVGVAE
Mb3569|M.bovis_AF2122/97 GLSMGSMVIDRE-LAYLAIDPNAPPSSALTFVELAGP------ERGLAQT
Rv3539|M.tuberculosis_H37Rv GLSMGSMVIDRE-LAYLAIDPNAPPSSALTFVELAGP------ERGLAQT
MMAR_4939|M.marinum_M TLSQGTIVANRE-LAYLATDPNAPPAHALEFALFGSP------ELGLAHI
MAB_0936c|M.abscessus_ATCC_199 GLSEGALVLNAV-KNALATDPTAPEPESLTFATFGDPIAKSPFSESFLTQ
MAV_1760|M.avium_104 GLSEGAFVVDGE-QARLANDPTAPPPNTLNFATFGDPIGRHAFGQSFLTA
MLBr_01232|M.leprae_Br4923 GLSQGSLALDTE-QEQLATDPTAPPPDQLTFNTFGDPSGYHGFGKSVLAS
Mflv_3371|M.gilvum_PYR-GCK GFSAGSLVVNDF-MRELANDPDAPTKDQVKFILVADS--------SRQKL
TH_3724|M.thermoresistible__bu GHSQSAVIATKEKQRLLAEYPDPDTAPDVTFVMVANPN-----RPNGGLL
MUL_0967|M.ulcerans_Agy99 GYSQSAVLSSRVMPKLLA---EGVTSSQVNFVLLGNP-----MNPNGGVL
* .:. ** : . .. .
Mvan_0761|M.vanbaalenii_PYR-1 YFKEGTRIPLLNYTVS----RVAQSPYPTTVVFGEYDGWADPPDRPWNLV
MSMEG_5350|M.smegmatis_MC2_155 YFKEGTFIPILNYRVK----RVALSPYPTTIVIGEYDGWADPPDRPWNLL
Mb3569|M.bovis_AF2122/97 YLPVGTTIPIAGYTVG----NAPESQYNTSVVYSQYDIWADPPDRPWNLL
Rv3539|M.tuberculosis_H37Rv YLPVGTTIPIAGYTVG----NAPESQYNTSVVYSQYDIWADPPDRPWNLL
MMAR_4939|M.marinum_M YLPDGLTVPLINYTVH----GLSNTQYDVSVVNGQYDFWGNPPDRPWNLP
MAB_0936c|M.abscessus_ATCC_199 NFAPGSVVPFMDYPVP----ARVDSQYHTDQFISAYDSIADWPDRPDNLF
MAV_1760|M.avium_104 MFGVGSVVPALDYTMP----PPYESQYDTNRFVAAYDSIADFPDRPDNMF
MLBr_01232|M.leprae_Br4923 IFRPGDYIPLIDYTMP----QRMDSQYDSNRVVAAYDGLSEFPDRADNLL
Mflv_3371|M.gilvum_PYR-GCK LNETSKYNPQYDYTYR----PAPQTMYDIDVVTGEYDGAADLPDRWWNFL
TH_3724|M.thermoresistible__bu ARFPGLYIPILGVTFNGATPAPADGPFDSYDVAREFDGWADFPRYPLNLV
MUL_0967|M.ulcerans_Agy99 ARFPDLTLPSLGFTFYG---ATPDNAFPTVSYTLEYDGFADFPRYPINLL
. * . : :* .: * *:
Mvan_0761|M.vanbaalenii_PYR-1 AVANAAMGLIYVHG-PAMWDVDLSDVPPENITVD------GTVTRYFVPT
MSMEG_5350|M.smegmatis_MC2_155 ATANALLGIVYVHG-VPSFTTDPNDVPPENVKTIPGNADHGPITTMLVPT
Mb3569|M.bovis_AF2122/97 AGANALMGAAYFHD-LTAY-AAPQ--QGIEIAAVTSSLG-GTTTTYMIPS
Rv3539|M.tuberculosis_H37Rv AGANALMGAAYFHD-LTAY-AAPQ--QGIEIAAVTSSLG-GTTTTYMIPS
MMAR_4939|M.marinum_M AWVNSLFGAAYYHN-TSSF-ASLS--DAVEVSSVTTSLG-GTITTYLIPS
MAB_0936c|M.abscessus_ATCC_199 ALANAIAGLATGHT-AVAF-TNPKMVPARNIVTETNSRG-GTTTTYFIPE
MAV_1760|M.avium_104 ALANTLMGLATGHT-AVAF-TNPSMVPPQNIRTTINSRG-AKDTTIMIPE
MLBr_01232|M.leprae_Br4923 AQLNCFAGGAISHT-PSGF-FNPEDVPPQNIRTTVNSRG-AKTTTYLIPV
Mflv_3371|M.gilvum_PYR-GCK ALANAIAGGLFVHV-PMMFSDYEAVTPEENITRVTNTLG-GTTTTYLVPT
TH_3724|M.thermoresistible__bu ATANAILGIYYLHGGYYELLTENPDILDDPERTIVQQYG--DTTYYLIRT
MUL_0967|M.ulcerans_Agy99 ADINAVMGIPFVHA-----DYQDLTQAQLDSAVQLPTEGPTQSTYYMIPT
* * * * * ::
Mvan_0761|M.vanbaalenii_PYR-1 EHLPLTRPFRDL-GVPDCLVDAADHILRPIIDAGYRRHDQPGDSRPYLYD
MSMEG_5350|M.smegmatis_MC2_155 KNLPLTQFLRDI-GVPDQWVDAIDNILRPIIDSAYVRNDKPGDSRPYLYN
Mb3569|M.bovis_AF2122/97 PTLPLLLPLKQI-GVPDWIVGGLNNVLKPLVDAGYSQYAPT--AGPYFSH
Rv3539|M.tuberculosis_H37Rv PTLPLLLPLKQI-GVPDWIVGGLNNVLKPLVDAGYSQYAPT--AGPYFSH
MMAR_4939|M.marinum_M PTLPMLLPLEQI-GVPAPIVAGLNSVLAPIVNDGYSSLTPN--AGPYFSQ
MAB_0936c|M.abscessus_ATCC_199 QHLPLVMGFKYL-GVPEETLNRLDAILQPRVDAGYSRNDDP--ATAPIAV
MAV_1760|M.avium_104 KHLPLVMPLKYI-GIDENTLNKLDAILTPRVNAGYSRNDDP--ATAPVQV
MLBr_01232|M.leprae_Br4923 NHLPLTLPLRYL-GWSDALVDQIDAVLQPKIDAAYAYNDNP--LNKPISV
Mflv_3371|M.gilvum_PYR-GCK KTLPLVQLLP--------FLKSQEASLKAKIDAGYSRNDDRLAAAAAATS
TH_3724|M.thermoresistible__bu EQLPLLRPLRDL-GVPEEFVDALEPYVRRIVDLGYDRNTPYGEPAPVRVL
MUL_0967|M.ulcerans_Agy99 EHLPLLAPLRFIPYVGDPLAELLEPNLRVLVNFGYGDPAYGYDTGPANVP
**: : : : :: .*
Mvan_0761|M.vanbaalenii_PYR-1 GRIRRDVPPVVPLQQGGDDGGGGADE--------ENENAAQHPQADGDGR
MSMEG_5350|M.smegmatis_MC2_155 GEIRRNVETPQEVETPEADVAGGVETTDVDTTSTETKDVGTHNAVDGDSK
Mb3569|M.bovis_AF2122/97 GNLVW---------------------------------------------
Rv3539|M.tuberculosis_H37Rv GNLVW---------------------------------------------
MMAR_4939|M.marinum_M GALVGLPSAADVLGSWPWPALGSVTAHIC---------------------
MAB_0936c|M.abscessus_ATCC_199 DPRRGFDPAEVTAPASQATFGGGSDPISQITSGALAVLGNGTRPTPPN--
MAV_1760|M.avium_104 DPVHGFDPAEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAGEADH---
MLBr_01232|M.leprae_Br4923 DPVNGMDPIAGIDAELR-------DSILNVFAQLRSILPPPPG-------
Mflv_3371|M.gilvum_PYR-GCK TARSLAAPTVTNEATDEVADDEAVATVQKISTDSDAEQADVPAERTSSKP
TH_3724|M.thermoresistible__bu PPLTPAPGPATQHNAGQGITVASATSTPDKRTPVVEAPVEEPPVQTGRST
MUL_0967|M.ulcerans_Agy99 TPFG-LFPPVSPLTVAEHLAAGTQQGIVNSGAALQAQGPPSIPLSDIAHT
Mvan_0761|M.vanbaalenii_PYR-1 LDRDDLDVS----------------ESAEDPDVSEAAQDPDVSESAADRD
MSMEG_5350|M.smegmatis_MC2_155 LGIKESDTKGVTTNDTKNDAKVVIKDVSKDVDTEVVTKDDETTATDTDTD
Mb3569|M.bovis_AF2122/97 --------------------------------------------------
Rv3539|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK AVDDAADD-----------DEAAANEDAEADAADAKVDAKEDAEAAVKDD
TH_3724|M.thermoresistible__bu LKRE------------------------KPVSARHLVRNSLRAVPGLRRG
MUL_0967|M.ulcerans_Agy99 LTANPPWAG----------TPALPPSTSPASSIEDFILAVQAANSSISRG
Mvan_0761|M.vanbaalenii_PYR-1 GRAVTHDPDVPESGEDP---------DARESTNDSADDSAQRQEAGG---
MSMEG_5350|M.smegmatis_MC2_155 TDTEARAGDDIEKKKSPRETRRERRHEHRDAIRDGLDNVKSQVESGLKDL
Mb3569|M.bovis_AF2122/97 --------------------------------------------------
Rv3539|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK ADASAGTNDDGEEGADSGSNDSAAAAGDTDSSDGSSSEGPGSSDSGSSE-
TH_3724|M.thermoresistible__bu EPAATPTPDVTPDVTPDAPAGQPEPAEPNESAAPPAAAEADDASE-----
MUL_0967|M.ulcerans_Agy99 FVKTLSTAYATLLPTTDIASELVFTLPSYNLNLFLDGVIQAINGQPIGD-
Mvan_0761|M.vanbaalenii_PYR-1 -------------------------------
MSMEG_5350|M.smegmatis_MC2_155 AKGLKGPRAKQKKVKNENETQSESASESDSE
Mb3569|M.bovis_AF2122/97 -------------------------------
Rv3539|M.tuberculosis_H37Rv -------------------------------
MMAR_4939|M.marinum_M -------------------------------
MAB_0936c|M.abscessus_ATCC_199 -------------------------------
MAV_1760|M.avium_104 -------------------------------
MLBr_01232|M.leprae_Br4923 -------------------------------
Mflv_3371|M.gilvum_PYR-GCK -------------------------------
TH_3724|M.thermoresistible__bu -------------------------------
MUL_0967|M.ulcerans_Agy99 -------------------------------