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SYDVIVVGGGTSGRVVAARLSEDPEIEVLLLEKDASVPGMPPRAGGSSATDATVFARGHHASYTDWNQFG GYGWGFADLLPYFMRSETATHGDPALRGDRGPLLVGPADRLSPLMLAFRRAAVERGFSAADDISGGLETG FGPVDLVDGPRESAADPYLAPALGRDNLTVITAATVQRVLMDRNRAVGVEYRCNSKLVTVTAAREVVLAA GAVCSPQLLMLSGIGPARHLRELDADVLVDLPGIGANLQNHPLAGIVYLAAQPLPVSDHRAEMMGLLHTG SPGGAPDLQIRCTDTAGATGAVFGVETCFIGVSPMHPHSRGTVRLAGLTAEVPPVVNPHHLEDERDMKTM LDGLDVARQIGASPELRPWLAEELAPGAHITDEDRLREYIRTTGGNWFHPVGTCALGESKMSVVDSRLRV RGTDGLRVIDASVMPSLPSNNIVATVYAIAERSAEMVRDELAQRHW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5305 | - | - | 100% (467) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3444 | - | e-123 | 49.50% (497) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0281 | - | 8e-66 | 34.76% (515) | choline dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 1e-61 | 35.29% (527) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3085 | - | 3e-59 | 34.44% (514) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 1e-61 | 35.29% (527) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 7e-57 | 33.14% (522) | GMC-type oxidoreductase |
| M. marinum M | MMAR_4427 | - | 2e-60 | 33.40% (512) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 1e-116 | 51.80% (417) | choline dehydrogenase |
| M. thermoresistible (build 8) | TH_3275 | - | 9e-63 | 32.16% (541) | PUTATIVE putative oxidoreductase, GMC family protein |
| M. ulcerans Agy99 | MUL_4004 | - | 9e-58 | 31.94% (526) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1606 | - | 5e-62 | 34.25% (511) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1310|M.bovis_AF2122/97 -----------------------MDTQSDYVVVGTGSAGAVVASRLSTDP
Rv1279|M.tuberculosis_H37Rv -----------------------MDTQSDYVVVGTGSAGAVVASRLSTDP
MUL_4004|M.ulcerans_Agy99 -----------------------MDIECDYVVVGTGSAGAAVVNRLSADS
MAB_0250|M.abscessus_ATCC_1997 ---------------------MVEDLAADFVIVGAGSAGAPLATRLSERT
MSMEG_5305|M.smegmatis_MC2_155 -------------------------MSYDVIVVGGGTSGRVVAARLSEDP
MAV_4980|M.avium_104 ---------------------------------MQTAIGRAVPFARGRG-
MMAR_4427|M.marinum_M ------------------MCSDPIAARYDFVVCGSGSAGSVVARRLSENS
Mvan_1606|M.vanbaalenii_PYR-1 MGDHGHTDLAERIRLNQNRLRQNLRPQYDFIVCGAGSAGSVIARRLAENP
TH_3275|M.thermoresistible__bu ---------------MGVVMMGRRSNLHDYIVVGAGSSGCTVAGRLAEGK
Mflv_3085|M.gilvum_PYR-GCK ---------------------MADAGVFDYVIAGGGTAGCVLAARLSEDP
: * : .
Mb1310|M.bovis_AF2122/97 ATTVVALEAGPRDK-NRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREI
Rv1279|M.tuberculosis_H37Rv ATTVVALEAGPRDK-NRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREI
MUL_4004|M.ulcerans_Agy99 GTSVVALEAGPSDK-NRFIGIPAAFPKLFRSEVDWDYTTEPEPQLGGREI
MAB_0250|M.abscessus_ATCC_1997 NDQVLVLEAGPKDK-DMGIHIPAAFSKLFRSDVDWDYLTEPQPQLNNRQI
MSMEG_5305|M.smegmatis_MC2_155 EIEVLLLEK--------------------------------------DAS
MAV_4980|M.avium_104 --------------------------------------------------
MMAR_4427|M.marinum_M NVAVLLLEAGGTDD-VAEVMDPAQWPVNLGSARDWGFASAPSAHLNGRSI
Mvan_1606|M.vanbaalenii_PYR-1 DVSVLLLEAGGDDD-DESVVRADQWPLNLGTSRDWNFVAEASPHVNGRSL
TH_3275|M.thermoresistible__bu RHSVLVLEAGGSD--LSPFIRIPAGLMRVNPRNYWHFRLEPDPTRNGAVD
Mflv_3085|M.gilvum_PYR-GCK DVTVCLLEAGPSDVGDDAILVLSDWMRLLDSGYDWDYPIEPQ-ERGNSFM
Mb1310|M.bovis_AF2122/97 YWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARA-GPRWSYADVLGYFRR
Rv1279|M.tuberculosis_H37Rv YWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARA-GPRWSYADVLGYFRR
MUL_4004|M.ulcerans_Agy99 YWPRDKVLGGSSSMNAMMWVRGFAADYDEWARLA-GSHWSYGELLGYFRQ
MAB_0250|M.abscessus_ATCC_1997 YWPRGKTLGGSSSMNAMMWVRGFAADYDDWAQVA-GEQWSFANIAPYFKR
MSMEG_5305|M.smegmatis_MC2_155 VPGMPPRAGGSSATDATVFARGHHASYTDWNQFG-GYGWGFADLLPYFMR
MAV_4980|M.avium_104 -------IGGSSTINAMVFARGHRDSYSRWRDNG-AAGWSFDELLPYFKR
MMAR_4427|M.marinum_M PLSMGKVLGGGSSINVMAWARGHRNDWAHFAAEAGDPSWGYESVLDVYRR
Mvan_1606|M.vanbaalenii_PYR-1 PMNMGKVLGGGSSINVMMWSRGHRSDWDFFAAEASDPGWGYDAVLDIYRR
TH_3275|M.thermoresistible__bu TWAAGRVVGGGSSVNAMLWVRGNRADFDTWAKLG-AQGWDYESLLPAMRS
Mflv_3085|M.gilvum_PYR-GCK RHARAKVLGGCSSHNSCIAFHPPAEALDEWAAMG-ATGWSAAEVLPLVQR
** *: : : : . *. :
Mb1310|M.bovis_AF2122/97 IENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAAR
Rv1279|M.tuberculosis_H37Rv IENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAAR
MUL_4004|M.ulcerans_Agy99 IEDVTAAWHFVNGDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQ
MAB_0250|M.abscessus_ATCC_1997 IEAVEG----ATESDEGTDGALKISKQRSPRSSTAAWLEAVKEAGFDVER
MSMEG_5305|M.smegmatis_MC2_155 SETATH----GDPALRGDRGPLLVGPADRLSPLMLAFRRAAVERGFSAAD
MAV_4980|M.avium_104 SESTCG----KDPSLRGQDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAA
MMAR_4427|M.marinum_M IEDWHGR---CDGDRRGVGGPVFVQTAPDPNPIATAVVDGAGAIGIPVYD
Mvan_1606|M.vanbaalenii_PYR-1 IEDWHGS---PDPDYRGSGGEVFVQPAPDPNPVAPAAVDAAAAVGIPTFD
TH_3275|M.thermoresistible__bu LETWEGG---ADR-YRGGTGPQHVSRIRLHHPLVQKWLTGAAQTGMPILA
Mflv_3085|M.gilvum_PYR-GCK -----------------LTETVRLRDVPPDDPCGAAVLEAAARIGIPTVS
: . .. *
Mb1310|M.bovis_AF2122/97 PNSP----RPEGFCETVVTQRRGARFSTADAYLKPAM-RRKNLRVLTGAT
Rv1279|M.tuberculosis_H37Rv PNSP----RPEGFCETVVTQRRGARFSTADAYLKPAM-RRKNLRVLTGAT
MUL_4004|M.ulcerans_Agy99 PNSA----EPEGFCETIVTQRRGSRWSTVDAYLRPAM-GRRNLSILTGAT
MAB_0250|M.abscessus_ATCC_1997 ANTP----EPKGFSETMVCQHGGRRWSTADGYLKPGL-RRRNLNVVTDAQ
MSMEG_5305|M.smegmatis_MC2_155 DISG---GLETGFGPVDL--VDGPRESAADPYLAPAL-GRDNLTVITAAT
MAV_4980|M.avium_104 DISG---GLEVGFGFTDLNIVDGKRQSAADAYLLPAL-DRPNLEFHSGAT
MMAR_4427|M.marinum_M SNNGIMMEGPGGASLLDLQLRNRLRESVFRSYVHPYL-QQRNLTVLTGAT
Mvan_1606|M.vanbaalenii_PYR-1 HPNGKMMEGCGGAAISDMRVRDGLRESVFRSYTYPYL-DRPNLTVLTGAV
TH_3275|M.thermoresistible__bu DYNG---ESQFGAAWSQLSQKNGLRHSAAQAFLAPAR-RRGEVDVESHAV
Mflv_3085|M.gilvum_PYR-GCK FNRGQ-TVRNGAGWFQINATPEGARLSTSHAFLHPILGTRRNLEVRTDSW
. * *. : * : :: . : :
Mb1310|M.bovis_AF2122/97 ATRVVIDGD-RAVGVEYQSDGQT--RIVYARREVVLCAGAVNSPQLLMLS
Rv1279|M.tuberculosis_H37Rv ATRVVIDGD-RAVGVEYQSDGQT--RIVYARREVVLCAGAVNSPQLLMLS
MUL_4004|M.ulcerans_Agy99 ATRIVIHGT-RATGVEYQREGQH--CTVHARREVVLCGGAVNSPQLLMLS
MAB_0250|M.abscessus_ATCC_1997 ARRVLFDGI-RAVGVEYVRDGIT--HTVHARREVILSGGAINSPQLLMLS
MSMEG_5305|M.smegmatis_MC2_155 VQRVLMDRN-RAVGVEYRCNSKL--VTVTAAREVVLAAGAVCSPQLLMLS
MAV_4980|M.avium_104 VHRLRIRGS-RCTGVEYTTAEGR--QVTAAAREIILCAGAIGSPHLLLAS
MMAR_4427|M.marinum_M VRRLTFSGS-RVTGVEFSHANAI--RTVSATQEVVVSLGAVNTPKVLMQS
Mvan_1606|M.vanbaalenii_PYR-1 VTRVPVHMQ-RATGVEFEMAGTT--HRIDAGVETVLCLGAIHTPKVLMHS
TH_3275|M.thermoresistible__bu VDKVIIENG-RAVGVEYVRRGTR--KVAYAAKEVILSAGALCSPLILLRS
Mflv_3085|M.gilvum_PYR-GCK VSEILFDDASRATGVRYQRADLTGYDTVAARREVILTAGAIDTPKLLMLS
. .: . * .**.: * * :: **: :* :*: *
Mb1310|M.bovis_AF2122/97 GIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKD----SLFAA
Rv1279|M.tuberculosis_H37Rv GIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKD----SLFAA
MUL_4004|M.ulcerans_Agy99 GIGDRSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGD----SLAAA
MAB_0250|M.abscessus_ATCC_1997 GIGEATRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSD----SLFGA
MSMEG_5305|M.smegmatis_MC2_155 GIGPARHLRELDADVLVDLPGIGANLQNHPLAGIVYLAAQP----LPVSD
MAV_4980|M.avium_104 GIGPPNHLRSFRVDVALELPGVGANLQDHPIVPLVYRAARP----VPAGR
MMAR_4427|M.marinum_M GIGDANDLRGFGIPVVTHLRGVGHNYQDHPRIDCVWESHE-----ALAPR
Mvan_1606|M.vanbaalenii_PYR-1 GIGDAAELHRLGIAPVQHLPGVGANLQDHPGFGCVWEYRD-----PLPPR
TH_3275|M.thermoresistible__bu GIGPAEELRDHGIDVIADLPGVGRNLQEHPAITMTFTVTDRTLNQELTPL
Mflv_3085|M.gilvum_PYR-GCK GIGPTAHLREVGIDVRVDSPGVGANLDDHVEGLVFWEASRP--MVTASTQ
*** * . :* * :* :
Mb1310|M.bovis_AF2122/97 EKPGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFYD
Rv1279|M.tuberculosis_H37Rv EKPGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFYD
MUL_4004|M.ulcerans_Agy99 EKPMQLINYLLRRRGMLTSNVGEAYGFVRSRPGLDLPDLELIFAPAPFYD
MAB_0250|M.abscessus_ATCC_1997 EKPLQLANYFLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELIFAPAPFFD
MSMEG_5305|M.smegmatis_MC2_155 H-RAEMMGLLHTGSPGGAPDLQIRCTDTAGATGAVFGVETCFIG------
MAV_4980|M.avium_104 YNHGELLGLIRRHATGGPPEIQIFGVDSADVPG-LGGADGYVLG------
MMAR_4427|M.marinum_M NNGAEVTVFWKSHPKLATPDLQICVAEFPLSSPENAARYGLPAHGW----
Mvan_1606|M.vanbaalenii_PYR-1 NTASEATYFWKSDPQLPTPDLQTCQVEVPLTSAENAARFGVPQAGW----
TH_3275|M.thermoresistible__bu SILKGAFDFVLRRRGPATAPLSHAMLFGPPLEPEGWPQYHVLMAPLGTEQ
Mflv_3085|M.gilvum_PYR-GCK WWEIGLFTTVDEIPEGVRAQPDLMMHYGSVPFDMNTLRHGYPTTDNG---
.
Mb1310|M.bovis_AF2122/97 EALVP-----------------PAGHGVVFGPILVAPQSRGQITLRSADP
Rv1279|M.tuberculosis_H37Rv EALVP-----------------PAGHGVVFGPILVAPQSRGQITLRSADP
MUL_4004|M.ulcerans_Agy99 EGLPAH----------------PPGHGVVFGPILVAPQSRGQITLRSADP
MAB_0250|M.abscessus_ATCC_1997 EGIGV-----------------ATEHAIVMGPILLKPESSGEITLTSPDP
MSMEG_5305|M.smegmatis_MC2_155 -------------------------------VSPMHPHSRGTVRLAGLTA
MAV_4980|M.avium_104 -------------------------------VSVMQPVSRGRVGLSGPTI
MMAR_4427|M.marinum_M ----------------------------TMCVGVVRPQSRGRVRLTGAHP
Mvan_1606|M.vanbaalenii_PYR-1 ----------------------------TMFAGVVRPASRGRVWLSSAQP
TH_3275|M.thermoresistible__bu EKPHATQEEAEQNRYDKQNVSLSRNSIVSAFMSPLHPRGRGTVRLGSPDV
Mflv_3085|M.gilvum_PYR-GCK ---------------------------FCLTPNVTQGRSRGTVRLRSRDF
. * : * .
Mb1310|M.bovis_AF2122/97 HAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRN
Rv1279|M.tuberculosis_H37Rv HAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRN
MUL_4004|M.ulcerans_Agy99 HAKPIIEARYLSDPGGVDRAAMMEGLRICARIAQAPALRGLLGPVARPHN
MAB_0250|M.abscessus_ATCC_1997 LAKPRIDPRYLSDPAGRDRAAMMFGLRTTARIAETPSMRAVLGKILRPRN
MSMEG_5305|M.smegmatis_MC2_155 EVPPVVNPHHLEDE--RDMKTMLDGLDVARQIGASPELRPWLAEELAPGA
MAV_4980|M.avium_104 QEPPAIDPNYLSDD--RDMGLMIEGLRIGRKIGMSQALDPWRAEELAPGD
MMAR_4427|M.marinum_M GAPVLIEAEMLAHP--DDMKAAAAGVQLCREIGNSAPLRPFAKREVMP--
Mvan_1606|M.vanbaalenii_PYR-1 SDPVHIDTGMLSDP--ADVAAAVAAVELCREIGNAAPLRPFTKREVMP--
TH_3275|M.thermoresistible__bu DATPVIEHPMLADE--RDVVDLTAAGRKVREIFQSPAMRPHVIAENAPSR
Mflv_3085|M.gilvum_PYR-GCK RDRARVDPRYFTDPDSYDERIMLAGIKLARAIAAQAPLTPWVARELAPGP
:: : . * . * : *
Mb1310|M.bovis_AF2122/97 STELDEATLELALATCSHTLYHPMGTCRMGSDE--ASVVDPQLRVRGVDG
Rv1279|M.tuberculosis_H37Rv STELDEATLELALATCSHTLYHPMGTCRMGSDE--ASVVDPQLRVRGVDG
MUL_4004|M.ulcerans_Agy99 SSELDEATLELALTTCSHTLYHPLGTCRMGSDE--ASVVDRQLRVRGVDG
MAB_0250|M.abscessus_ATCC_1997 PSDDLEETLVAALENNSHTLYHPVGTCRMGADD--ASVVTPDLTVRGVQG
MSMEG_5305|M.smegmatis_MC2_155 -HITDEDRLREYIRTTGGNWFHPVGTCALGESK--MSVVDSRLRVRGTDG
MAV_4980|M.avium_104 -DAVDDAALRSYIQRSVASYFHPVGTCAMGTGP--ESVVDNQLRLHGIDN
MMAR_4427|M.marinum_M -GGLAGAELERFVRDGASTYWHQSGTAKMGRDD--MSVVDAKLKVHGMEN
Mvan_1606|M.vanbaalenii_PYR-1 -GNLRGPALEEFVRNAASTYWHPTGTAKMGRDD--MSVVDGALRVYGVAG
TH_3275|M.thermoresistible__bu -GVETDDEWAEFIRNHCFGGSHWVGTARMGADSDPDAVVDPQLRVRGVSG
Mflv_3085|M.gilvum_PYR-GCK -DATTDDELLDYIHRCHNTVYHPAATARMGSPSDPMAVLDPQLRVKGVRG
: * .*. :* :*: * : * .
Mb1310|M.bovis_AF2122/97 LRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS-------
Rv1279|M.tuberculosis_H37Rv LRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS-------
MUL_4004|M.ulcerans_Agy99 LRVADASVMPSTVRGHTHAPSVLIGAKAADLIRN-------
MAB_0250|M.abscessus_ATCC_1997 LRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQP----
MSMEG_5305|M.smegmatis_MC2_155 LRVIDASVMPSLPSNNIVATVYAIAERSAEMVRDELAQRHW
MAV_4980|M.avium_104 LRVIDASVMPSLPSNNTAATVYAIAERGADLVRLG------
MMAR_4427|M.marinum_M LRVADSSIMPRITTGNTMAPCVVIGERAAEIVKADHGL---
Mvan_1606|M.vanbaalenii_PYR-1 LRVADGSIMPRVSTGNTMAPCVVIGERAAALLGATHGLRAA
TH_3275|M.thermoresistible__bu LRVADASVMPTLTSGNTNAPCVLIGEKAAELIRGR------
Mflv_3085|M.gilvum_PYR-GCK LRVVDASAMPKLPAVNPNITVMTMAEKCAELIRTG------
*** *.* :* : . :. : * ::