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MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDKDMGIHIPAAFSKLFRSDVDWDYLTEPQ PQLNNRQIYWPRGKTLGGSSSMNAMMWVRGFAADYDDWAQVAGEQWSFANIAPYFKRIEAVEGATESDEG TDGALKISKQRSPRSSTAAWLEAVKEAGFDVERANTPEPKGFSETMVCQHGGRRWSTADGYLKPGLRRRN LNVVTDAQARRVLFDGIRAVGVEYVRDGITHTVHARREVILSGGAINSPQLLMLSGIGEATRLGELGIPV VHDAPQVGQNLLDHLCCPVGYAVKSDSLFGAEKPLQLANYFLRHRGMLTSNVGEAYGFLRSHPNLTLPDL ELIFAPAPFFDEGIGVATEHAIVMGPILLKPESSGEITLTSPDPLAKPRIDPRYLSDPAGRDRAAMMFGL RTTARIAETPSMRAVLGKILRPRNPSDDLEETLVAALENNSHTLYHPVGTCRMGADDASVVTPDLTVRGV QGLRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0250 | - | - | 100% (529) | GMC-type oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0816 | - | 5e-37 | 29.16% (535) | glucose-methanol-choline oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3830c | - | 4e-34 | 28.81% (531) | dehydrogenase (glucose-methanol-choline oxidoreductase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 0.0 | 63.95% (527) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1255 | - | 3e-83 | 38.23% (531) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 0.0 | 63.95% (527) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4141 | - | 0.0 | 62.36% (526) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 4e-58 | 34.00% (450) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3375 | - | 6e-79 | 35.97% (556) | alcohol dehydrogenase |
| M. thermoresistible (build 8) | TH_4204 | - | 9e-80 | 37.01% (535) | PUTATIVE glucose-methanol-choline oxidoreductase |
| M. ulcerans Agy99 | MUL_4004 | - | 0.0 | 62.17% (526) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2938 | - | 9e-79 | 35.97% (556) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1310|M.bovis_AF2122/97 -----MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFI
Rv1279|M.tuberculosis_H37Rv -----MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFI
MMAR_4141|M.marinum_M -----MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDKNRFI
MUL_4004|M.ulcerans_Agy99 -----MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDKNRFI
MAB_0250|M.abscessus_ATCC_1997 ---MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDKDMGI
MSMEG_3375|M.smegmatis_MC2_155 ------MAEFDYVIVGAGSAGCLLANRLSANPDHRVLLIEAGGKDNWFWI
Mvan_2938|M.vanbaalenii_PYR-1 MPEMSPVAEFDFIIVGAGSAGCLLANRLSANPDHRVLLIEAGGKDDWFWI
Mflv_1255|M.gilvum_PYR-GCK ----MAVTGYDYIVVGAGSAGCVLANRLSADPAIRVLLLEAGRGDRNLWL
TH_4204|M.thermoresistible__bu ------MSSYDYIIAGSGSAGCVLANRLSADPKVSVLLIEAGGFDRNPLF
MAV_4980|M.avium_104 --------------------------------------------------
Mb1310|M.bovis_AF2122/97 GVPAAFSKLFRS-EIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMM
Rv1279|M.tuberculosis_H37Rv GVPAAFSKLFRS-EIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMM
MMAR_4141|M.marinum_M GIPAAFPKLFRS-EVDWDYTTEPEPQLGGREIYWPRGKVLGGSSSMNAMM
MUL_4004|M.ulcerans_Agy99 GIPAAFPKLFRS-EVDWDYTTEPEPQLGGREIYWPRDKVLGGSSSMNAMM
MAB_0250|M.abscessus_ATCC_1997 HIPAAFSKLFRS-DVDWDYLTEPQPQLNNRQIYWPRGKTLGGSSSMNAMM
MSMEG_3375|M.smegmatis_MC2_155 KVPVGYLFTIANPRTDWCFNTEPDPGLAGRSIIYARGRVIGGCSSINAMI
Mvan_2938|M.vanbaalenii_PYR-1 KVPVGYLYTIANPRTDWCFTTEPDPGLAGRSIIYARGRVIGGCSSINAMI
Mflv_1255|M.gilvum_PYR-GCK HIPKGAGKLFDSERHMWHYETTP-FGPDAHVEQWMRGKVIGGSSAVNGMI
TH_4204|M.thermoresistible__bu SIPKGSGKLFDSERHMWHYETTP-FGPGRHTEQWMRGKVLGGSSSVNGMI
MAV_4980|M.avium_104 -----------------------MQTAIGRAVPFARGRGIGGSSTINAMV
: : *.: :**.*::*.*:
Mb1310|M.bovis_AF2122/97 WVRGFASDYDEWAARAGPR-WSYA------DVLGYFRRIENVTAAWHFVS
Rv1279|M.tuberculosis_H37Rv WVRGFASDYDEWAARAGPR-WSYA------DVLGYFRRIENVTAAWHFVS
MMAR_4141|M.marinum_M WVRGFAADYDEWARLAGSH-WSYG------ELLGYFRQIEDVTAAWHFVN
MUL_4004|M.ulcerans_Agy99 WVRGFAADYDEWARLAGSH-WSYG------ELLGYFRQIEDVTAAWHFVN
MAB_0250|M.abscessus_ATCC_1997 WVRGFAADYDDWAQVAGEQ-WSFA------NIAPYFKRIEAVEG----AT
MSMEG_3375|M.smegmatis_MC2_155 HMRGQASDYELWARATGDDRWLWGGPDRPGQTLAIYKELENYFGG----A
Mvan_2938|M.vanbaalenii_PYR-1 HMRGQASDYELWARATGDERWLWGGPDRAGETLEIYKELEDYFGG----A
Mflv_1255|M.gilvum_PYR-GCK YNRGHRADYDALEQM-GNKGWGWD------EILPIFKGFEDHEFG----P
TH_4204|M.thermoresistible__bu YNRGNRADYDGLEQL-GNKGWGWD------DILPIFKQFEDNEFG----P
MAV_4980|M.avium_104 FARGHRDSYSRWRDNGAAG-WSFD------ELLPYFKRSESTCGK----D
** .*. . * : : :: *
Mb1310|M.bovis_AF2122/97 GDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARP-NSPRPEGFCE
Rv1279|M.tuberculosis_H37Rv GDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARP-NSPRPEGFCE
MMAR_4141|M.marinum_M GDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFPPVQP-NSAEPEGFCE
MUL_4004|M.ulcerans_Agy99 GDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQP-NSAEPEGFCE
MAB_0250|M.abscessus_ATCC_1997 ESDEGTDGALKISKQRSPRSSTAAWLEAVKEAGFDVERA-NTPEPKGFSE
MSMEG_3375|M.smegmatis_MC2_155 DEWHGADGEIRVERPRVRWKILDAWQAAAAQFGITPIEEFNRGDNSGSAY
Mvan_2938|M.vanbaalenii_PYR-1 DEWHGADGEIRVERPRVRWKILDAWQNAAAQLGIEPIDEFNRGDNSGSAY
Mflv_1255|M.gilvum_PYR-GCK SATRGTGGPLHISVPRDPDPLCEDMIEAATGAGMWRVRDINESDGERIGY
TH_4204|M.thermoresistible__bu SPTRGAGGPLHISVPRDADPLCDEMIDAGTVAGLHRVEDINESDDERIGY
MAV_4980|M.avium_104 PSLRGQDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAADISGGLEVGFGF
* * : : * * .
Mb1310|M.bovis_AF2122/97 TVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVID---------
Rv1279|M.tuberculosis_H37Rv TVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVID---------
MMAR_4141|M.marinum_M TIVTQRRGSRWSTVDAYLRPAMGRRNLSILTGATATRIVIH---------
MUL_4004|M.ulcerans_Agy99 TIVTQRRGSRWSTVDAYLRPAMGRRNLSILTGATATRIVIH---------
MAB_0250|M.abscessus_ATCC_1997 TMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQARRVLFD---------
MSMEG_3375|M.smegmatis_MC2_155 FHVNQRRGRRWSMADAFLHPVAHRRNLTVYTQTRALRLLMDDQVSEEQRR
Mvan_2938|M.vanbaalenii_PYR-1 FHVNQRRGRRWSMADAFLHPVTHRPNLTVYAQTQALQLLTDDQVHEDQRR
Mflv_1255|M.gilvum_PYR-GCK ATSTIRGGRRVSAATAFLKPVLHRPNLTVRTGATVRRVLFD---------
TH_4204|M.thermoresistible__bu ATATIKNGRRVSAARAFLKPALRRANLSVRTRAVAQRILLA---------
MAV_4980|M.avium_104 TDLNIVDGKRQSAADAYLLPALDRPNLEFHSGATVHRLRIR---------
* * * . .:* * * ** . : : . ::
Mb1310|M.bovis_AF2122/97 ------GDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGD
Rv1279|M.tuberculosis_H37Rv ------GDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGD
MMAR_4141|M.marinum_M ------GTRATGIEYQREGQHCTVHARREVVLCGGAVNSPQLLMLSGIGD
MUL_4004|M.ulcerans_Agy99 ------GTRATGVEYQREGQHCTVHARREVVLCGGAVNSPQLLMLSGIGD
MAB_0250|M.abscessus_ATCC_1997 ------GIRAVGVEYVRDGITHTVHARREVILSGGAINSPQLLMLSGIGE
MSMEG_3375|M.smegmatis_MC2_155 GAWTTAQHRVTGVRLLKDGQIVDVRARREVILSAGAIGSPHLMQVSGLGP
Mvan_2938|M.vanbaalenii_PYR-1 GAWTTAQRRVTGLRLLKEGQIVDVRARREVILSAGAIGSPHLMQVSGLGP
Mflv_1255|M.gilvum_PYR-GCK ------GERADGVEIATGAGTEQVRAAREVVLSLGSLNSPKLLQLSGIGP
TH_4204|M.thermoresistible__bu ------GGRAVGLEIASRGRTGKVYATREVIIAMGSLNTPKLLQLSGIGP
MAV_4980|M.avium_104 ------GSRCTGVEYTTAEGRQVTAAAREIILCAGAIGSPHLLLASGIGP
* *:. . * **:::. *::.:*:*: **:*
Mb1310|M.bovis_AF2122/97 RDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDS------LFAAEK
Rv1279|M.tuberculosis_H37Rv RDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDS------LFAAEK
MMAR_4141|M.marinum_M RSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDS------LAAAEK
MUL_4004|M.ulcerans_Agy99 RSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDS------LAAAEK
MAB_0250|M.abscessus_ATCC_1997 ATRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSDS------LFGAEK
MSMEG_3375|M.smegmatis_MC2_155 AGLLAEHQVPVAVDLPGVGENLQDHLQLRTVFRVRGARTVNTLYRNWITR
Mvan_2938|M.vanbaalenii_PYR-1 AGLLTQHQVPVVVDLPGVGENLQDHLQLRTVYRVRGARTVNTLYRNWITR
Mflv_1255|M.gilvum_PYR-GCK SDVLGAAGVPVLVERDNVGRRMREHRCATLRYRLKEDLGYNKLLATNVGQ
TH_4204|M.thermoresistible__bu REVLDAAGVPVYLDRANVGRRMREHRCATLRFDLREDLGYNRLLATGTGQ
MAV_4980|M.avium_104 PNHLRSFRVDVALELPGVGANLQDHPIVPLVYRAARPVP-----------
* : . . ** .: :* :
Mb1310|M.bovis_AF2122/97 PGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELI-FAPAPFYDE
Rv1279|M.tuberculosis_H37Rv PGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELI-FAPAPFYDE
MMAR_4141|M.marinum_M PMQLINYLLRRRGMLTSNVGEAYGFVRSRPGLDLPDLELI-FAPAPFYDE
MUL_4004|M.ulcerans_Agy99 PMQLINYLLRRRGMLTSNVGEAYGFVRSRPGLDLPDLELI-FAPAPFYDE
MAB_0250|M.abscessus_ATCC_1997 PLQLANYFLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELI-FAPAPFFDE
MSMEG_3375|M.smegmatis_MC2_155 AGMGIQYLLLRSGPMTMPPSTLGAFAKSDPTLASPDLEWH-VQPLSLPKF
Mvan_2938|M.vanbaalenii_PYR-1 AGMGIQYLLLRSGPMTMPPSTLGAFAKSDPALASPDLEWH-VQPLSLPKF
Mflv_1255|M.gilvum_PYR-GCK ALTGMKYLATRKGPLAAPSFDVVGFVKDRPDSERPLGQVM-MGPWTLPPY
TH_4204|M.thermoresistible__bu ALTGAKYLATRKGPLAAPSFDVVGFVKTQPGLDRPDGQIM-LGPWTIPPY
MAV_4980|M.avium_104 -------------AGRYNHGELLGLIRRHATGGPPEIQIFGVDSADVPGL
.: : . * : . . .
Mb1310|M.bovis_AF2122/97 A----LVP-PAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSD
Rv1279|M.tuberculosis_H37Rv A----LVP-PAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSD
MMAR_4141|M.marinum_M G----LPAHPPGHGVVFGPILVAPQSRGQITLRSADPHAKPIIEARYLSD
MUL_4004|M.ulcerans_Agy99 G----LPAHPPGHGVVFGPILVAPQSRGQITLRSADPHAKPIIEARYLSD
MAB_0250|M.abscessus_ATCC_1997 G----IGV-ATEHAIVMGPILLKPESSGEITLTSPDPLAKPRIDPRYLSD
MSMEG_3375|M.smegmatis_MC2_155 G---EPLHP--FAAITPSVCNLRPTSRGHVRMATADPLADPKILCNYLST
Mvan_2938|M.vanbaalenii_PYR-1 G---EPLHP--FGAITPSVCNLRPTSRGYVRIADADPLSHPKIFCNYLST
Mflv_1255|M.gilvum_PYR-GCK N-TGEPVVIEREPGISCLGMVLRPTSQGYVEITSADPGAALRITPNYLTT
TH_4204|M.thermoresistible__bu NQSGEPVVIPRQAGVSALGMALRPTSEGTVEITAVDPAAPLRIDPNYLGS
MAV_4980|M.avium_104 G---------GADGYVLGVSVMQPVSRGRVGLSGPTIQEPPAIDPNYLSD
. : * * * : : * .**
Mb1310|M.bovis_AF2122/97 LGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELAL
Rv1279|M.tuberculosis_H37Rv LGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELAL
MMAR_4141|M.marinum_M PGGVDRAAMMEGLRICARIAQAPALRGLLGPVARPHNSSELDEATLELAL
MUL_4004|M.ulcerans_Agy99 PGGVDRAAMMEGLRICARIAQAPALRGLLGPVARPHNSSELDEATLELAL
MAB_0250|M.abscessus_ATCC_1997 PAGRDRAAMMFGLRTTARIAETPSMRAVLGKILRPRNPSDDLEETLVAAL
MSMEG_3375|M.smegmatis_MC2_155 DD--DRQKAVRGLRMTRQIMSAPALARYSPEEMLP-GPQLASDDDLQQAA
Mvan_2938|M.vanbaalenii_PYR-1 DA--DRDAAVRGLRMTRQIMAAPSLARYCPEEMLP-GPQLVSDDDLQAAA
Mflv_1255|M.gilvum_PYR-GCK EH--DRTATAALVRRMRSIFEQSPIAERISHETYP-GPRVDSDEELVDAA
TH_4204|M.thermoresistible__bu DA--DRETTANLLRRMRSVFEQSPIAERISHETFP-GPHIRSDDELVDAA
MAV_4980|M.avium_104 DR--DMGLMIEGLRIGRKIGMSQALDPWRAEELAP-GDDAVDDAALRSYI
* :* : .: * . : *
Mb1310|M.bovis_AF2122/97 ATCSHTLYHPMGTCRMGSDEAS--------VVDPQLRVRGVDGLRVADAS
Rv1279|M.tuberculosis_H37Rv ATCSHTLYHPMGTCRMGSDEAS--------VVDPQLRVRGVDGLRVADAS
MMAR_4141|M.marinum_M TTCSHTLYHPLGTCRMGSDEAS--------VVDPQLRVRGVDGLRVADAS
MUL_4004|M.ulcerans_Agy99 TTCSHTLYHPLGTCRMGSDEAS--------VVDRQLRVRGVDGLRVADAS
MAB_0250|M.abscessus_ATCC_1997 ENNSHTLYHPVGTCRMGADDAS--------VVTPDLTVRGVQGLRVVDAS
MSMEG_3375|M.smegmatis_MC2_155 RELGTTIFHPVGTCAMGAFDTHGLPTSATTVLDTDLRVFRVAGLRVADAS
Mvan_2938|M.vanbaalenii_PYR-1 RELGTTIFHPVGTCAMGAFDARGLPRSAATVLDTDCRVFRVAGLRVADAS
Mflv_1255|M.gilvum_PYR-GCK LEGGYCGYHAVGTCAMGPDDDD--------VVDSHLRVRGVDGLRVVDCS
TH_4204|M.thermoresistible__bu LDGGYCGYHAIGTCAMGPSDDD--------VVDPQLRVRGVDGLRVVDCS
MAV_4980|M.avium_104 QRSVASYFHPVGTCAMGTGPES--------VVDNQLRLHGIDNLRVIDAS
:*.:*** **. *: . : : .*** *.*
Mb1310|M.bovis_AF2122/97 VMPSTVRGHTHAPSVLIGEKAADLIRS---
Rv1279|M.tuberculosis_H37Rv VMPSTVRGHTHAPSVLIGEKAADLIRS---
MMAR_4141|M.marinum_M VMPSTVRGHTHAPSVLIGAKAADLIRN---
MUL_4004|M.ulcerans_Agy99 VMPSTVRGHTHAPSVLIGAKAADLIRN---
MAB_0250|M.abscessus_ATCC_1997 VIPSLIRGHTHAPSVLLGEKAADLILSPQP
MSMEG_3375|M.smegmatis_MC2_155 AMPNITSGNTNAPVMLIAERAARAILG---
Mvan_2938|M.vanbaalenii_PYR-1 AMPTITSGNTNAPVMLIAERAARAILK---
Mflv_1255|M.gilvum_PYR-GCK VMPTIVAGNLNGPIMAMAWRAADFILHGR-
TH_4204|M.thermoresistible__bu VLPVMVAGNLNGPIMAVAWRAADLIRQDL-
MAV_4980|M.avium_104 VMPSLPSNNTAATVYAIAERGADLVRLG--
.:* .: .. :. :.* :