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QTAIGRAVPFARGRGIGGSSTINAMVFARGHRDSYSRWRDNGAAGWSFDELLPYFKRSESTCGKDPSLRG QDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAADISGGLEVGFGFTDLNIVDGKRQSAADAYLLPALDRP NLEFHSGATVHRLRIRGSRCTGVEYTTAEGRQVTAAAREIILCAGAIGSPHLLLASGIGPPNHLRSFRVD VALELPGVGANLQDHPIVPLVYRAARPVPAGRYNHGELLGLIRRHATGGPPEIQIFGVDSADVPGLGGAD GYVLGVSVMQPVSRGRVGLSGPTIQEPPAIDPNYLSDDRDMGLMIEGLRIGRKIGMSQALDPWRAEELAP GDDAVDDAALRSYIQRSVASYFHPVGTCAMGTGPESVVDNQLRLHGIDNLRVIDASVMPSLPSNNTAATV YAIAERGADLVRLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4980 | - | - | 100% (435) | choline dehydrogenase |
| M. avium 104 | MAV_4474 | - | 7e-48 | 34.33% (434) | FAD dependent oxidoreductase, putative |
| M. avium 104 | MAV_4925 | - | 1e-33 | 29.37% (504) | glucose-methanol-choline |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 8e-66 | 36.03% (458) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1255 | - | 1e-56 | 33.48% (454) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 8e-66 | 36.03% (458) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 3e-58 | 34.00% (450) | GMC-type oxidoreductase |
| M. marinum M | MMAR_4427 | - | 8e-68 | 35.23% (440) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3444 | - | 1e-136 | 56.68% (434) | choline dehydrogenase |
| M. thermoresistible (build 8) | TH_3275 | - | 1e-60 | 33.82% (479) | PUTATIVE putative oxidoreductase, GMC family protein |
| M. ulcerans Agy99 | MUL_4004 | - | 3e-64 | 35.37% (458) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1606 | - | 1e-66 | 35.84% (438) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1310|M.bovis_AF2122/97 -----------------------MDTQSDYVVVGTGSAGAVVASRLSTDP
Rv1279|M.tuberculosis_H37Rv -----------------------MDTQSDYVVVGTGSAGAVVASRLSTDP
MUL_4004|M.ulcerans_Agy99 -----------------------MDIECDYVVVGTGSAGAAVVNRLSADS
MAB_0250|M.abscessus_ATCC_1997 ---------------------MVEDLAADFVIVGAGSAGAPLATRLSERT
MAV_4980|M.avium_104 --------------------------------------------------
MSMEG_3444|M.smegmatis_MC2_155 ---------------------MASEPGYDFVIVGAGTAGCVLAARLSAQE
MMAR_4427|M.marinum_M ------------------MCSDPIAARYDFVVCGSGSAGSVVARRLSENS
Mvan_1606|M.vanbaalenii_PYR-1 MGDHGHTDLAERIRLNQNRLRQNLRPQYDFIVCGAGSAGSVIARRLAENP
TH_3275|M.thermoresistible__bu ---------------MGVVMMGRRSNLHDYIVVGAGSSGCTVAGRLAEGK
Mflv_1255|M.gilvum_PYR-GCK ----------------------MAVTGYDYIVVGAGSAGCVLANRLSADP
Mb1310|M.bovis_AF2122/97 ATTVVALEAGPRDKNRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIY
Rv1279|M.tuberculosis_H37Rv ATTVVALEAGPRDKNRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIY
MUL_4004|M.ulcerans_Agy99 GTSVVALEAGPSDKNRFIGIPAAFPKLFRSEVDWDYTTEPEPQLGGREIY
MAB_0250|M.abscessus_ATCC_1997 NDQVLVLEAGPKDKDMGIHIPAAFSKLFRSDVDWDYLTEPQPQLNNRQIY
MAV_4980|M.avium_104 ---------------------------------------MQTAI-GRAVP
MSMEG_3444|M.smegmatis_MC2_155 DVRVLLIEAGSATLPPASAAPPQWQTLLGSSADWGGPTAVQDTL-GRAIH
MMAR_4427|M.marinum_M NVAVLLLEAGGTDDVAEVMDPAQWPVNLGSARDWGFASAPSAHLNGRSIP
Mvan_1606|M.vanbaalenii_PYR-1 DVSVLLLEAGGDDDDESVVRADQWPLNLGTSRDWNFVAEASPHVNGRSLP
TH_3275|M.thermoresistible__bu RHSVLVLEAGGSDLSP-FIRIPAGLMRVNPRNYWHFRLEPDPTRNGAVDT
Mflv_1255|M.gilvum_PYR-GCK AIRVLLLEAGRGDRNLWLHIPKGAGKLFDSERHMWHYETTPFGPDAHVEQ
Mb1310|M.bovis_AF2122/97 WPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAG-PRWSYADVLGYFRRI
Rv1279|M.tuberculosis_H37Rv WPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAG-PRWSYADVLGYFRRI
MUL_4004|M.ulcerans_Agy99 WPRDKVLGGSSSMNAMMWVRGFAADYDEWARLAG-SHWSYGELLGYFRQI
MAB_0250|M.abscessus_ATCC_1997 WPRGKTLGGSSSMNAMMWVRGFAADYDDWAQVAG-EQWSFANIAPYFKRI
MAV_4980|M.avium_104 FARGRGIGGSSTINAMVFARGHRDSYSRWRDNGA-AGWSFDELLPYFKRS
MSMEG_3444|M.smegmatis_MC2_155 VARGRGFGGSSAINAMMFARGHRESYDDWP-----EGWRFDDLLPYFMRS
MMAR_4427|M.marinum_M LSMGKVLGGGSSINVMAWARGHRNDWAHFAAEAGDPSWGYESVLDVYRRI
Mvan_1606|M.vanbaalenii_PYR-1 MNMGKVLGGGSSINVMMWSRGHRSDWDFFAAEASDPGWGYDAVLDIYRRI
TH_3275|M.thermoresistible__bu WAAGRVVGGGSSVNAMLWVRGNRADFDTWAKLG-AQGWDYESLLPAMRSL
Mflv_1255|M.gilvum_PYR-GCK WMRGKVIGGSSAVNGMIYNRGHRADYDALEQMGN-KGWGWDEILPIFKGF
.: .**.*::* * : ** .: * : :
Mb1310|M.bovis_AF2122/97 ENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARP
Rv1279|M.tuberculosis_H37Rv ENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARP
MUL_4004|M.ulcerans_Agy99 EDVTAAWHFVNGDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQP
MAB_0250|M.abscessus_ATCC_1997 EAVEG----ATESDEGTDGALKISKQRSPRSSTAAWLEAVKEAGFDVERA
MAV_4980|M.avium_104 ESTCGK----DPSLRGQDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAAD
MSMEG_3444|M.smegmatis_MC2_155 EASRGG----NPALRGKNGPLRVGPASPVNPLLAAALDAAVECGYAAAED
MMAR_4427|M.marinum_M EDWHGRC---DGDRRGVGGPVFVQTAPDPNPIATAVVDGAGAIGIPVYDS
Mvan_1606|M.vanbaalenii_PYR-1 EDWHGSP---DPDYRGSGGEVFVQPAPDPNPVAPAAVDAAAAVGIPTFDH
TH_3275|M.thermoresistible__bu ETWEGG----ADRYRGGTGPQHVSRIRLHHPLVQKWLTGAAQTGMPILAD
Mflv_1255|M.gilvum_PYR-GCK EDHEFG----PSATRGTGGPLHISVPRDPDPLCEDMIEAATGAGMWRVRD
* * * : . : .. *
Mb1310|M.bovis_AF2122/97 -NSPRPEGFC---ETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATAT
Rv1279|M.tuberculosis_H37Rv -NSPRPEGFC---ETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATAT
MUL_4004|M.ulcerans_Agy99 -NSAEPEGFC---ETIVTQRRGSRWSTVDAYLRPAMGRRNLSILTGATAT
MAB_0250|M.abscessus_ATCC_1997 -NTPEPKGFS---ETMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQAR
MAV_4980|M.avium_104 ISGGLEVGFG---FTDLNIVDGKRQSAADAYLLPALDRPNLEFHSGATVH
MSMEG_3444|M.smegmatis_MC2_155 ISSGDETGFG---AADLTIDGRRRQTAADAYLVPAMDRPNLDVISDAVVH
MMAR_4427|M.marinum_M NNGIMMEGPGGASLLDLQLRNRLRESVFRSYVHPYLQQRNLTVLTGATVR
Mvan_1606|M.vanbaalenii_PYR-1 PNGKMMEGCGGAAISDMRVRDGLRESVFRSYTYPYLDRPNLTVLTGAVVT
TH_3275|M.thermoresistible__bu YNGESQFGAA---WSQLSQKNGLRHSAAQAFLAPARRRGEVDVESHAVVD
Mflv_1255|M.gilvum_PYR-GCK INESDGERIG---YATSTIRGGRRVSAATAFLKPVLHRPNLTVRTGATVR
. * :. .: * : :: . : * .
Mb1310|M.bovis_AF2122/97 RVVIDGDRAVGVEYQS--DGQTRIVYARREVVLCAGAVNSPQLLMLSGIG
Rv1279|M.tuberculosis_H37Rv RVVIDGDRAVGVEYQS--DGQTRIVYARREVVLCAGAVNSPQLLMLSGIG
MUL_4004|M.ulcerans_Agy99 RIVIHGTRATGVEYQR--EGQHCTVHARREVVLCGGAVNSPQLLMLSGIG
MAB_0250|M.abscessus_ATCC_1997 RVLFDGIRAVGVEYVR--DGITHTVHARREVILSGGAINSPQLLMLSGIG
MAV_4980|M.avium_104 RLRIRGSRCTGVEYT--TAEGRQVTAAAREIILCAGAIGSPHLLLASGIG
MSMEG_3444|M.smegmatis_MC2_155 RLVISEGRCTGVEFHRSSSPSSTCVRSVGEIVLAAGAIGSAQLLMVSGVG
MMAR_4427|M.marinum_M RLTFSGSRVTGVEFS--HANAIRTVSATQEVVVSLGAVNTPKVLMQSGIG
Mvan_1606|M.vanbaalenii_PYR-1 RVPVHMQRATGVEFE--MAGTTHRIDAGVETVLCLGAIHTPKVLMHSGIG
TH_3275|M.thermoresistible__bu KVIIENGRAVGVEYVR--RGTRKVAYAAKEVILSAGALCSPLILLRSGIG
Mflv_1255|M.gilvum_PYR-GCK RVLFDGERADGVEIAT--GAGTEQVRAAREVVLSLGSLNSPKLLQLSGIG
:: . * *** : * ::. *:: :. :* **:*
Mb1310|M.bovis_AF2122/97 DRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQL-
Rv1279|M.tuberculosis_H37Rv DRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQL-
MUL_4004|M.ulcerans_Agy99 DRSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDSLAAAEKPMQL-
MAB_0250|M.abscessus_ATCC_1997 EATRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSDSLFGAEKPLQL-
MAV_4980|M.avium_104 PPNHLRSFRVDVALELPGVGANLQDHPIVPLVYRAAR-----PVPAG---
MSMEG_3444|M.smegmatis_MC2_155 PEAHLRDVGVDVVHHLPGVGANFQDHPLSGVIYTAAQ-----PIPTP---
MMAR_4427|M.marinum_M DANDLRGFGIPVVTHLRGVGHNYQDHPRIDCVWESHE-----ALAP----
Mvan_1606|M.vanbaalenii_PYR-1 DAAELHRLGIAPVQHLPGVGANLQDHPGFGCVWEYRD-----PLPP----
TH_3275|M.thermoresistible__bu PAEELRDHGIDVIADLPGVGRNLQEHPAITMTFTVTDRTLNQELTPL---
Mflv_1255|M.gilvum_PYR-GCK PSDVLGAAGVPVLVERDNVGRRMREHRCATLRYRLKEDLGYNKLLATNVG
* : . ** . :* : .
Mb1310|M.bovis_AF2122/97 -----ISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFYDE
Rv1279|M.tuberculosis_H37Rv -----ISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFYDE
MUL_4004|M.ulcerans_Agy99 -----INYLLRRRGMLTSNVGEAYGFVRSRPGLDLPDLELIFAPAPFYDE
MAB_0250|M.abscessus_ATCC_1997 -----ANYFLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELIFAPAPFFDE
MAV_4980|M.avium_104 ----------------RYNHGELLGLIRRHATGGPPEIQIFGVDSADVPG
MSMEG_3444|M.smegmatis_MC2_155 ----------------EHNHGEVMGLIR-TASAGAPDLQILMVDSTEVTG
MMAR_4427|M.marinum_M ----------------RNNGAEVTVFWKSHPKLATPDLQICVAEFPLSSP
Mvan_1606|M.vanbaalenii_PYR-1 ----------------RNTASEATYFWKSDPQLPTPDLQTCQVEVPLTSA
TH_3275|M.thermoresistible__bu ----------------SILKGAFDFVLRRRGPATAPLSHAMLFGPPLEPE
Mflv_1255|M.gilvum_PYR-GCK QALTGMKYLATRKGPLAAPSFDVVGFVKDRPDSERPLGQVMMGPWTLPPY
. : * . .
Mb1310|M.bovis_AF2122/97 ---------------------------------ALVP-PAGHGVVFGPIL
Rv1279|M.tuberculosis_H37Rv ---------------------------------ALVP-PAGHGVVFGPIL
MUL_4004|M.ulcerans_Agy99 ---------------------------------GLPAHPPGHGVVFGPIL
MAB_0250|M.abscessus_ATCC_1997 ---------------------------------GIGV-ATEHAIVMGPIL
MAV_4980|M.avium_104 -------------------------------LGGA------DGYVLGVSV
MSMEG_3444|M.smegmatis_MC2_155 -------------------------------LDIP------NAYLFGVSA
MMAR_4427|M.marinum_M -------------------------------ENAARYGLPAHGWTMCVGV
Mvan_1606|M.vanbaalenii_PYR-1 -------------------------------ENAARFGVPQAGWTMFAGV
TH_3275|M.thermoresistible__bu GWPQYHVLMAPLGTEQEKPHATQEEAEQNRYDKQNVSLSRNSIVSAFMSP
Mflv_1255|M.gilvum_PYR-GCK N------------------------------TGEPVVIEREPGISCLGMV
Mb1310|M.bovis_AF2122/97 VAPQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQ
Rv1279|M.tuberculosis_H37Rv VAPQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQ
MUL_4004|M.ulcerans_Agy99 VAPQSRGQITLRSADPHAKPIIEARYLSDPGGVDRAAMMEGLRICARIAQ
MAB_0250|M.abscessus_ATCC_1997 LKPESSGEITLTSPDPLAKPRIDPRYLSDPAGRDRAAMMFGLRTTARIAE
MAV_4980|M.avium_104 MQPVSRGRVGLSGPTIQEPPAIDPNYLSDD--RDMGLMIEGLRIGRKIGM
MSMEG_3444|M.smegmatis_MC2_155 MQPHSRGRVRLTGPTVNAAPLVDPNYLIDE--RDWKTMLEGFRIAREIGA
MMAR_4427|M.marinum_M VRPQSRGRVRLTGAHPGAPVLIEAEMLAHP--DDMKAAAAGVQLCREIGN
Mvan_1606|M.vanbaalenii_PYR-1 VRPASRGRVWLSSAQPSDPVHIDTGMLSDP--ADVAAAVAAVELCREIGN
TH_3275|M.thermoresistible__bu LHPRGRGTVRLGSPDVDATPVIEHPMLADE--RDVVDLTAAGRKVREIFQ
Mflv_1255|M.gilvum_PYR-GCK LRPTSQGYVEITSADPGAALRITPNYLTTE--HDRTATAALVRRMRSIFE
: * . * : : .. : * * . *
Mb1310|M.bovis_AF2122/97 ARPLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSD--
Rv1279|M.tuberculosis_H37Rv ARPLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSD--
MUL_4004|M.ulcerans_Agy99 APALRGLLGPVARPHNSSELDEATLELALTTCSHTLYHPLGTCRMGSD--
MAB_0250|M.abscessus_ATCC_1997 TPSMRAVLGKILRPRNPSDDLEETLVAALENNSHTLYHPVGTCRMGAD--
MAV_4980|M.avium_104 SQALDPWRAEELAPGDDA-VDDAALRSYIQRSVASYFHPVGTCAMGTG--
MSMEG_3444|M.smegmatis_MC2_155 AAAMAPWCGGELAPGPAV-ADDESLRRFICDSLSSYYHSSGTCAMGDS--
MMAR_4427|M.marinum_M SAPLRPFAKREVMPGG---LAGAELERFVRDGASTYWHQSGTAKMGRD--
Mvan_1606|M.vanbaalenii_PYR-1 AAPLRPFTKREVMPGN---LRGPALEEFVRNAASTYWHPTGTAKMGRD--
TH_3275|M.thermoresistible__bu SPAMRPHVIAENAPSRGV-ETDDEWAEFIRNHCFGGSHWVGTARMGADSD
Mflv_1255|M.gilvum_PYR-GCK QSPIAERISHETYPGPRVDSDEELVDAALEGG-YCGYHAVGTCAMGPD--
.: * : * **. ** .
Mb1310|M.bovis_AF2122/97 EASVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS
Rv1279|M.tuberculosis_H37Rv EASVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS
MUL_4004|M.ulcerans_Agy99 EASVVDRQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGAKAADLIRN
MAB_0250|M.abscessus_ATCC_1997 DASVVTPDLTVRGVQGLRVVDASVIPSLIRGHTHAPSVLLGEKAADLILS
MAV_4980|M.avium_104 PESVVDNQLRLHGIDNLRVIDASVMPSLPSNNTAATVYAIAERGADLVRL
MSMEG_3444|M.smegmatis_MC2_155 DESVVDTALRVHGLAGLRVADASVMPSLPSNNPMATVYGIAERAADLIGG
MMAR_4427|M.marinum_M DMSVVDAKLKVHGMENLRVADSSIMPRITTGNTMAPCVVIGERAAEIVKA
Mvan_1606|M.vanbaalenii_PYR-1 DMSVVDGALRVYGVAGLRVADGSIMPRVSTGNTMAPCVVIGERAAALLGA
TH_3275|M.thermoresistible__bu PDAVVDPQLRVRGVSGLRVADASVMPTLTSGNTNAPCVLIGEKAAELIRG
Mflv_1255|M.gilvum_PYR-GCK DDDVVDSHLRVRGVDGLRVVDCSVMPTIVAGNLNGPIMAMAWRAADFILH
** * : *: .*** * *::* .: .. :. :.* ::
Mb1310|M.bovis_AF2122/97 -------
Rv1279|M.tuberculosis_H37Rv -------
MUL_4004|M.ulcerans_Agy99 -------
MAB_0250|M.abscessus_ATCC_1997 PQP----
MAV_4980|M.avium_104 G------
MSMEG_3444|M.smegmatis_MC2_155 -------
MMAR_4427|M.marinum_M DHGL---
Mvan_1606|M.vanbaalenii_PYR-1 THGLRAA
TH_3275|M.thermoresistible__bu R------
Mflv_1255|M.gilvum_PYR-GCK GR-----