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ASEPGYDFVIVGAGTAGCVLAARLSAQEDVRVLLIEAGSATLPPASAAPPQWQTLLGSSADWGGPTAVQD TLGRAIHVARGRGFGGSSAINAMMFARGHRESYDDWPEGWRFDDLLPYFMRSEASRGGNPALRGKNGPLR VGPASPVNPLLAAALDAAVECGYAAAEDISSGDETGFGAADLTIDGRRRQTAADAYLVPAMDRPNLDVIS DAVVHRLVISEGRCTGVEFHRSSSPSSTCVRSVGEIVLAAGAIGSAQLLMVSGVGPEAHLRDVGVDVVHH LPGVGANFQDHPLSGVIYTAAQPIPTPEHNHGEVMGLIRTASAGAPDLQILMVDSTEVTGLDIPNAYLFG VSAMQPHSRGRVRLTGPTVNAAPLVDPNYLIDERDWKTMLEGFRIAREIGAAAAMAPWCGGELAPGPAVA DDESLRRFICDSLSSYYHSSGTCAMGDSDESVVDTALRVHGLAGLRVADASVMPSLPSNNPMATVYGIAE RAADLIGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3444 | - | - | 100% (499) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5305 | - | e-123 | 49.20% (498) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0281 | - | 4e-78 | 37.20% (508) | choline dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 1e-70 | 36.07% (524) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3085 | - | 1e-67 | 34.67% (525) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 1e-70 | 36.07% (524) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 1e-73 | 35.67% (527) | GMC-type oxidoreductase |
| M. marinum M | MMAR_4427 | - | 5e-79 | 36.83% (524) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 1e-136 | 56.68% (434) | choline dehydrogenase |
| M. thermoresistible (build 8) | TH_4204 | - | 2e-68 | 33.83% (532) | PUTATIVE glucose-methanol-choline oxidoreductase |
| M. ulcerans Agy99 | MUL_4004 | - | 1e-69 | 34.48% (525) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0327 | - | 2e-80 | 37.74% (514) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1310|M.bovis_AF2122/97 ---------MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDK
Rv1279|M.tuberculosis_H37Rv ---------MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDK
MUL_4004|M.ulcerans_Agy99 ---------MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDK
MAB_0250|M.abscessus_ATCC_1997 -------MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDK
MSMEG_3444|M.smegmatis_MC2_155 -------MASEPGYDFVIVGAGTAGCVLAARLSAQEDVRVLLIEAGSATL
MAV_4980|M.avium_104 --------------------------------------------------
MMAR_4427|M.marinum_M MCSDPIAAR----YDFVVCGSGSAGSVVARRLSENSNVAVLLLEAGGTDD
Mvan_0327|M.vanbaalenii_PYR-1 MGDMPIVTSPARSYDFIVCGAGTAGSVVARRLAENPAVSVLLVEAGGTDQ
Mflv_3085|M.gilvum_PYR-GCK -------MADAGVFDYVIAGGGTAGCVLAARLSEDPDVTVCLLEAGPSDV
TH_4204|M.thermoresistible__bu ----------MSSYDYIIAGSGSAGCVLANRLSADPKVSVLLIEAGGFDR
Mb1310|M.bovis_AF2122/97 -NRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSM
Rv1279|M.tuberculosis_H37Rv -NRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSM
MUL_4004|M.ulcerans_Agy99 -NRFIGIPAAFPKLFRSEVDWDYTTEPEPQLGGREIYWPRDKVLGGSSSM
MAB_0250|M.abscessus_ATCC_1997 -DMGIHIPAAFSKLFRSDVDWDYLTEPQPQLNNRQIYWPRGKTLGGSSSM
MSMEG_3444|M.smegmatis_MC2_155 -PPASAAPPQWQTLLGSSADWGGPTAVQDTL-GRAIHVARGRGFGGSSAI
MAV_4980|M.avium_104 --------------------------MQTAI-GRAVPFARGRGIGGSSTI
MMAR_4427|M.marinum_M -VAEVMDPAQWPVNLGSARDWGFASAPSAHLNGRSIPLSMGKVLGGGSSI
Mvan_0327|M.vanbaalenii_PYR-1 -VPSVAAADQWPLNLGSERDWGFSAVATSHLNGRAVPLSMGKVLGGGSSI
Mflv_3085|M.gilvum_PYR-GCK GDDAILVLSDWMRLLDSGYDWDYPIEPQERG-NSFMRHARAKVLGGCSSH
TH_4204|M.thermoresistible__bu -NPLFSIPKGSGKLFDSERHMWHYETTPFGPGRHTEQWMRGKVLGGSSSV
: :** *:
Mb1310|M.bovis_AF2122/97 NAMMWVRGFASDYDEWAARAG-PRWSYADVLGYFRRIENVTAAWHFVSGD
Rv1279|M.tuberculosis_H37Rv NAMMWVRGFASDYDEWAARAG-PRWSYADVLGYFRRIENVTAAWHFVSGD
MUL_4004|M.ulcerans_Agy99 NAMMWVRGFAADYDEWARLAG-SHWSYGELLGYFRQIEDVTAAWHFVNGD
MAB_0250|M.abscessus_ATCC_1997 NAMMWVRGFAADYDDWAQVAG-EQWSFANIAPYFKRIEAVEG----ATES
MSMEG_3444|M.smegmatis_MC2_155 NAMMFARGHRESYDDWP-----EGWRFDDLLPYFMRSEASRGG----NPA
MAV_4980|M.avium_104 NAMVFARGHRDSYSRWRDN-GAAGWSFDELLPYFKRSESTCGK----DPS
MMAR_4427|M.marinum_M NVMAWARGHRNDWAHFAAEAGDPSWGYESVLDVYRRIEDWHGRC---DGD
Mvan_0327|M.vanbaalenii_PYR-1 NLMVWARGHKADWDYFAFESGDEGWGYESVLDLYRRIEDFHGDP---DPD
Mflv_3085|M.gilvum_PYR-GCK NSCIAFHPPAEALDEWAAMG-ATGWSAAEVLPLVQR--------------
TH_4204|M.thermoresistible__bu NGMIYNRGNRADYDGLEQLGN-KGWGWDDILPIFKQFEDNEFGP----SP
* : * .: :
Mb1310|M.bovis_AF2122/97 DSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSP----RPEGFC
Rv1279|M.tuberculosis_H37Rv DSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSP----RPEGFC
MUL_4004|M.ulcerans_Agy99 DSGVTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQPNSA----EPEGFC
MAB_0250|M.abscessus_ATCC_1997 DEGTDGALKISKQRSPRSSTAAWLEAVKEAGFDVERANTP----EPKGFS
MSMEG_3444|M.smegmatis_MC2_155 LRGKNGPLRVGPASPVNPLLAAALDAAVECGYAAAEDISS---GDETGFG
MAV_4980|M.avium_104 LRGQDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAADISG---GLEVGFG
MMAR_4427|M.marinum_M RRGVGGPVFVQTAPDPNPIATAVVDGAGAIGIPVYDSNNGIMMEGPGGAS
Mvan_0327|M.vanbaalenii_PYR-1 YRGTGGPVYVTPAPDPNPLAPATIEAARTVGIPTFENQNGRMMEQSAGAA
Mflv_3085|M.gilvum_PYR-GCK ---LTETVRLRDVPPDDPCGAAVLEAAARIGIPTVSFNRGQTVRNGAGWF
TH_4204|M.thermoresistible__bu TRGAGGPLHISVPRDADPLCDEMIDAGTVAGLHRVEDINE---SDDERIG
.: : . : . *
Mb1310|M.bovis_AF2122/97 ETVVTQRRGARFSTADAYLKPAMR-RKNLRVLTGATATRVVIDGD-RAVG
Rv1279|M.tuberculosis_H37Rv ETVVTQRRGARFSTADAYLKPAMR-RKNLRVLTGATATRVVIDGD-RAVG
MUL_4004|M.ulcerans_Agy99 ETIVTQRRGSRWSTVDAYLRPAMG-RRNLSILTGATATRIVIHGT-RATG
MAB_0250|M.abscessus_ATCC_1997 ETMVCQHGGRRWSTADGYLKPGLR-RRNLNVVTDAQARRVLFDGI-RAVG
MSMEG_3444|M.smegmatis_MC2_155 AADLTIDGRRRQTAADAYLVPAMD-RPNLDVISDAVVHRLVISEG-RCTG
MAV_4980|M.avium_104 FTDLNIVDGKRQSAADAYLLPALD-RPNLEFHSGATVHRLRIRGS-RCTG
MMAR_4427|M.marinum_M LLDLQLRNRLRESVFRSYVHPYLQ-QRNLTVLTGATVRRLTFSGS-RVTG
Mvan_0327|M.vanbaalenii_PYR-1 ISDIRARGGRRQSVFTSYVTPVLH-RPNLDVLTCALVTRVSFDGD-RATG
Mflv_3085|M.gilvum_PYR-GCK QINATPEG-ARLSTSHAFLHPILGTRRNLEVRTDSWVSEILFDDASRATG
TH_4204|M.thermoresistible__bu YATATIKNGRRVSAARAFLKPALR-RANLSVRTRAVAQRILLAGG-RAVG
* :. .:: * : : ** . : : . .: : * .*
Mb1310|M.bovis_AF2122/97 VEYQ--SDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDID
Rv1279|M.tuberculosis_H37Rv VEYQ--SDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDID
MUL_4004|M.ulcerans_Agy99 VEYQ--REGQHCTVHARREVVLCGGAVNSPQLLMLSGIGDRSHLADHGIE
MAB_0250|M.abscessus_ATCC_1997 VEYV--RDGITHTVHARREVILSGGAINSPQLLMLSGIGEATRLGELGIP
MSMEG_3444|M.smegmatis_MC2_155 VEFHRSSSPSSTCVRSVGEIVLAAGAIGSAQLLMVSGVGPEAHLRDVGVD
MAV_4980|M.avium_104 VEYT--TAEGRQVTAAAREIILCAGAIGSPHLLLASGIGPPNHLRSFRVD
MMAR_4427|M.marinum_M VEFS--HANAIRTVSATQEVVVSLGAVNTPKVLMQSGIGDANDLRGFGIP
Mvan_0327|M.vanbaalenii_PYR-1 VELV--LDGQSRRIAVNTEVILSLGAINTPKVLLHSGIGDETELRRVGIP
Mflv_3085|M.gilvum_PYR-GCK VRYQRADLTGYDTVAARREVILTAGAIDTPKLLMLSGIGPTAHLREVGID
TH_4204|M.thermoresistible__bu LEIAS--RGRTGKVYATREVIIAMGSLNTPKLLQLSGIGPREVLDAAGVP
:. *::: *::.:.::* **:* * :
Mb1310|M.bovis_AF2122/97 TVYHAPEVGCNLLDHLVTVLGFDVEKDS------LFAAEKPGQLISYLLR
Rv1279|M.tuberculosis_H37Rv TVYHAPEVGCNLLDHLVTVLGFDVEKDS------LFAAEKPGQLISYLLR
MUL_4004|M.ulcerans_Agy99 TVYHAPEVGQNLLDHLITPLGFDVAGDS------LAAAEKPMQLINYLLR
MAB_0250|M.abscessus_ATCC_1997 VVHDAPQVGQNLLDHLCCPVGYAVKSDS------LFGAEKPLQLANYFLR
MSMEG_3444|M.smegmatis_MC2_155 VVHHLPGVGANFQDHPLSGV--------------IYTAAQPIPTP-----
MAV_4980|M.avium_104 VALELPGVGANLQDHPIVPL--------------VYRAARPVPAG-----
MMAR_4427|M.marinum_M VVTHLRGVGHNYQDHPRIDC--------------VWESHEALAP------
Mvan_0327|M.vanbaalenii_PYR-1 LHTHLSGVGRNLQDHPGFDC--------------VWEYSEPLAP------
Mflv_3085|M.gilvum_PYR-GCK VRVDSPGVGANLDDHVEGLV--------------FWEASRPMVTA-----
TH_4204|M.thermoresistible__bu VYLDRANVGRRMREHRCATLRFDLREDLGYNRLLATGTGQALTGAKYLAT
. ** . :* ..
Mb1310|M.bovis_AF2122/97 RRGMLTSNVGEAYGFVRSRPELK----LPDLELIFAPAPF--YDEALVP-
Rv1279|M.tuberculosis_H37Rv RRGMLTSNVGEAYGFVRSRPELK----LPDLELIFAPAPF--YDEALVP-
MUL_4004|M.ulcerans_Agy99 RRGMLTSNVGEAYGFVRSRPGLD----LPDLELIFAPAPF--YDEGLPAH
MAB_0250|M.abscessus_ATCC_1997 HRGMLTSNVGEAYGFLRSHPNLT----LPDLELIFAPAPF--FDEGIGV-
MSMEG_3444|M.smegmatis_MC2_155 -----EHNHGEVMGLIR-TASAG----APDLQILMVDSTE--VTGLDIP-
MAV_4980|M.avium_104 -----RYNHGELLGLIRRHATGG----PPEIQIFGVDSAD--VPGLGGA-
MMAR_4427|M.marinum_M -----RNNGAEVTVFWKSHPKLA----TPDLQICVAEFPL--SSPENAAR
Mvan_0327|M.vanbaalenii_PYR-1 -----RNNASEATYFATSAAGMD----APDLQTCQAEVPK--SSAENIAR
Mflv_3085|M.gilvum_PYR-GCK -----STQWWEIGLFTTVDEIPEGVRAQPDLMMHYGSVPF--DMNTLRHG
TH_4204|M.thermoresistible__bu RKGPLAAPSFDVVGFVKTQPGLD----RPDGQIMLGPWTIPPYNQSGEPV
: : *: .
Mb1310|M.bovis_AF2122/97 --PAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRA
Rv1279|M.tuberculosis_H37Rv --PAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRA
MUL_4004|M.ulcerans_Agy99 --PPGHGVVFGPILVAPQSRGQITLRSADPHAKPIIEARYLSDPGGVDRA
MAB_0250|M.abscessus_ATCC_1997 --ATEHAIVMGPILLKPESSGEITLTSPDPLAKPRIDPRYLSDPAGRDRA
MSMEG_3444|M.smegmatis_MC2_155 -----NAYLFGVSAMQPHSRGRVRLTGPTVNAAPLVDPNYLIDER--DWK
MAV_4980|M.avium_104 -----DGYVLGVSVMQPVSRGRVGLSGPTIQEPPAIDPNYLSDDR--DMG
MMAR_4427|M.marinum_M YGLPAHGWTMCVGVVRPQSRGRVRLTGAHPGAPVLIEAEMLAHPD--DMK
Mvan_0327|M.vanbaalenii_PYR-1 FGLPEFGWTLFAGVVRPKSRGHLALRSADPVDPIDIHANMLAHPD--DVK
Mflv_3085|M.gilvum_PYR-GCK YPTTDNGFCLTPNVTQGRSRGTVRLRSRDFRDRARVDPRYFTDPDSYDER
TH_4204|M.thermoresistible__bu VIPRQAGVSALGMALRPTSEGTVEITAVDPAAPLRIDPNYLGSDA--DRE
. * * : : . :... : *
Mb1310|M.bovis_AF2122/97 AMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALATCSHTL
Rv1279|M.tuberculosis_H37Rv AMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALATCSHTL
MUL_4004|M.ulcerans_Agy99 AMMEGLRICARIAQAPALRGLLGPVARPHNSSELDEATLELALTTCSHTL
MAB_0250|M.abscessus_ATCC_1997 AMMFGLRTTARIAETPSMRAVLGKILRPRNPSDDLEETLVAALENNSHTL
MSMEG_3444|M.smegmatis_MC2_155 TMLEGFRIAREIGAAAAMAPWCGGELAPGPAV-ADDESLRRFICDSLSSY
MAV_4980|M.avium_104 LMIEGLRIGRKIGMSQALDPWRAEELAPGDDA-VDDAALRSYIQRSVASY
MMAR_4427|M.marinum_M AAAAGVQLCREIGNSAPLRPFAKREVMPGG---LAGAELERFVRDGASTY
Mvan_0327|M.vanbaalenii_PYR-1 AAVAAVELCREIGNSAPLRPFAKREVMPGN---LRGPDLERFVRDAASSY
Mflv_3085|M.gilvum_PYR-GCK IMLAGIKLARAIAAQAPLTPWVARELAPGPDA-TTDDELLDYIHRCHNTV
TH_4204|M.thermoresistible__bu TTANLLRRMRSVFEQSPIAERISHETFPGPHIRSDDE-LVDAALDGGYCG
.. : .: * *
Mb1310|M.bovis_AF2122/97 YHPMGTCRMGS--DEASVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAP
Rv1279|M.tuberculosis_H37Rv YHPMGTCRMGS--DEASVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAP
MUL_4004|M.ulcerans_Agy99 YHPLGTCRMGS--DEASVVDRQLRVRGVDGLRVADASVMPSTVRGHTHAP
MAB_0250|M.abscessus_ATCC_1997 YHPVGTCRMGA--DDASVVTPDLTVRGVQGLRVVDASVIPSLIRGHTHAP
MSMEG_3444|M.smegmatis_MC2_155 YHSSGTCAMGD--SDESVVDTALRVHGLAGLRVADASVMPSLPSNNPMAT
MAV_4980|M.avium_104 FHPVGTCAMGT--GPESVVDNQLRLHGIDNLRVIDASVMPSLPSNNTAAT
MMAR_4427|M.marinum_M WHQSGTAKMGR--DDMSVVDAKLKVHGMENLRVADSSIMPRITTGNTMAP
Mvan_0327|M.vanbaalenii_PYR-1 WHQTCTAKMGR--DAMSVVDAALNVYGVKGLRVADGSIMPRVTTGNTMAP
Mflv_3085|M.gilvum_PYR-GCK YHPAATARMGSPSDPMAVLDPQLRVKGVRGLRVVDASAMPKLPAVNPNIT
TH_4204|M.thermoresistible__bu YHAIGTCAMGP--SDDDVVDPQLRVRGVDGLRVVDCSVLPVMVAGNLNGP
:* *. ** . *: * : *: .*** * * :* : .
Mb1310|M.bovis_AF2122/97 SVLIGEKAADLIRS----
Rv1279|M.tuberculosis_H37Rv SVLIGEKAADLIRS----
MUL_4004|M.ulcerans_Agy99 SVLIGAKAADLIRN----
MAB_0250|M.abscessus_ATCC_1997 SVLLGEKAADLILSPQP-
MSMEG_3444|M.smegmatis_MC2_155 VYGIAERAADLIGG----
MAV_4980|M.avium_104 VYAIAERGADLVRLG---
MMAR_4427|M.marinum_M CVVIGERAAEIVKADHGL
Mvan_0327|M.vanbaalenii_PYR-1 CVVIGERAADIIRKEHAL
Mflv_3085|M.gilvum_PYR-GCK VMTMAEKCAELIRTG---
TH_4204|M.thermoresistible__bu IMAVAWRAADLIRQDL--
:. : *:::